Article
Chemistry, Multidisciplinary
D. Chakraborty, D. Musib, R. Saha, A. Das, M. K. Raza, V Ramu, S. Chongdar, K. Sarkar, A. Bhaumik
Summary: This research demonstrates the synthesis of a stable phosphonate ligand-based fluorescent copper-MOF with excellent photocytotoxic effect against lung cancer cells and antibacterial efficacy against both Gram-positive and Gram-negative microorganisms. This MOF also shows good fluorescence properties for cancer cell imaging.
MATERIALS TODAY CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Esther G. Kaye, Karishma Kailass, Oleg Sadovski, Andrew A. Beharry
Summary: In this study, phenalenone derivatives were synthesized with electron-donating groups to red-shift the absorption spectrum, and bromine(s) were added to enhance singlet oxygen production via the heavy-atom effect. Among the derivatives, OE19 showed the longest absorption wavelength, green fluorescence, and efficient singlet oxygen production, demonstrating potential for photodynamic cancer therapy.
ACS MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Optics
Xu Zhi, Wenhui Xiang, Ying Qian
Summary: The photosensitizer Lys-PtzFP was designed and synthesized with a unique phenothiazine-anchored strategy, showing high specificity for lysosomes, good photostability, and low cytotoxicity. Under irradiation, Lys-PtzFP can produce singlet oxygen in lysosomes and induce apoptosis.
JOURNAL OF LUMINESCENCE
(2021)
Review
Oncology
Masaki Kaibori, Kosuke Matsui, Mikio Hayashi
Summary: Lactosomes (TM) are biocompatible nanoparticles that can be used for cancer tissue imaging and drug delivery. They can be loaded with imaging probes and anticancer agents, functioning as a photosensitizer for both diagnosis and photodynamic therapy, ultimately improving the quality of life for patients.
Review
Biochemistry & Molecular Biology
Xi Qiang, Lijun Wang, Jianfeng Niu, Xiangzhong Gong, Guangce Wang
Summary: Phycobiliprotein, a natural product found in various seaweeds, has numerous biological activities and is commonly used in medical applications for its anti-oxidation, anti-tumor, anti-inflammatory, and immune-enhancing properties. However, high-purity phycobiliproteins are notably more expensive than common varieties. This report provides a comprehensive analysis on the structural composition and applications of phycobiliproteins in fluorescent probes and photodynamic therapy.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Applied
Jing-Wen Fan, Shao-Hu Xu, Ying Han, Cao-Guo Yan, Qing Wang
Summary: In this study, a protein structure-dependent probe, OTB, was designed for human serum albumin (HSA) with the assistance of molecular simulation. OTB exhibited favorable selective HSA sensitivity and strong HSA binding ability. Interestingly, the WP5-OTB complex, formed by the cationic molecule OTB and water-soluble pillar [5]arene (WP5), showed improved HSA responsiveness and stronger HSA binding ability compared to OTB alone. The WP5-OTB complex self-assembled into a supramolecular fluorescent probe, demonstrating favorable HSA-induced bioimaging property, pH-sensitive drug delivery property, and photodynamic activity.
Review
Chemistry, Inorganic & Nuclear
Chenxu Yan, Yutao Zhang, Zhiqian Guo
Summary: Recent advances in molecularly NIR fluorescent probes for nanotheranostics have attracted increasing attention due to their potential in bridging in vivo imaging and therapeutic capability within a unimolecular system. The unique advantages of near-infrared (NIR) fluorescence imaging, such as low background, deep penetration, and minimal tissue damage, make it a promising tool for in vivo chemotherapy and phototherapy. The focus is on design strategy and functionalization of high-performance fluorophores, with discussions on current challenges and future prospects in bringing forth clinical applications for personalized treatment.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Pharmacology & Pharmacy
Jose Garces-Garces, Miguel Sanchez-Martos, Gema Martinez-Navarrete, Eduardo Fernandez-Jover, Mirela Encheva, Martin Leon, Javier Ortiz, Angela Sastre-Santos, Fernando Fernandez-Lazaro
Summary: The synthesis and characterization of two new water soluble perylenediimides, PDI-1 and PDI-2, with potential applications in anticancer activities were described. These compounds demonstrated high fluorescence quantum yield in water and showed selective cytotoxicity toward cancer cells when exposed to specific light wavelength. The findings provide a strong foundation for the future exploration of PDI-1 and PDI-2 as effective photosensitizers in photodynamic therapy.
Article
Biochemistry & Molecular Biology
Takashi Kanamori, Yuto Miki, Masataka Katou, Shun-ichiro Ogura, Hideya Yuasa
Summary: We have developed a glucose-linked biphenyl photosensitizer with brighter fluorescence and enhanced photodamaging effect against cancer cells. This photosensitizer can pass through glucose transporters, allowing for selective uptake and potential use in cancer photodynamic therapy.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Article
Nanoscience & Nanotechnology
Xu Cheng, Yingran Xu, Yong Zhang, Chaochao Jia, Bing Wei, Ting Hu, Rupei Tang, Conghu Li
Summary: The organic-inorganic hybrid nanosystem composed of nanoscale hydroxyapatite, poly(acrylic acid), and indocyanine green, further modified with glucose for targeting, showed promising efficacy against malignant tumors. The nanosystem demonstrated good stability, sustained drug release, enhanced cellular uptake through glucose transporter-mediated endocytosis, and induced cell toxicity and apoptosis through photothermal and photodynamic effects. In vivo tests confirmed good hemocompatibility and biosafety, leading to effective tumor growth inhibition, suggesting potential for clinical trials.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Chemistry, Applied
Lin Yuan, Yingbin Su, Hailin Cong, Bing Yu, Youqing Shen
Summary: BODIPY and its derivative multifunctional small molecule probes are widely used in biomedical materials due to their unique molecular structure, high brightness, and effective anti-tumor effects. The derivatives formed by BODIPY and metal or metal ions can regulate their optical properties and solve the autotoxicity problem of metal drugs in tumor treat-ment. The derivatives formed by combining BODIPY with other molecules provide more choices for integrated diagnosis and treatment. This review focuses on the latest research achievements of BODIPY derivatives in imaging and photodynamic therapeutic effects in aqueous solution or cells.
Article
Medicine, Research & Experimental
Kang Chen, Baoli Yin, Quanneng Luo, Yi Liu, Yi Wang, Yan Liao, Yuhang Li, Xu Chen, Bo Sun, Ning Zhou, Hongwen Liu, Chuang Peng, Sulai Liu, Wei Cheng, Guosheng Song
Summary: Pancreatic cancer is a highly malignant disease with deep location and hypoxic microenvironment, which poses challenges to photodynamic therapy. Researchers designed a novel photosensitizer that can induce photodynamic therapy effect on deep pancreatic tumors under excitation by 808 nm laser. They also built an endoscopic platform monitored by NIR-II fluorescence imaging for minimally invasive endoscopically guided intervention photodynamic therapy. The results showed that this treatment method has potential for inhibiting pancreatic cancer.
Article
Chemistry, Multidisciplinary
Daisuke Tsuji, Atsushi Nakayama, Riko Yamamoto, Shuji Nagano, Takashi Taniguchi, Ryota Sato, Sangita Karanjit, Naoki Muguruma, Tetsuji Takayama, Kohji Itoh, Kosuke Namba
Summary: This study investigated the photo-induced cytotoxicities of various TAP derivatives. Among the derivatives, 2-p-nitrophenyl-TAP showed significant cytotoxicity to HeLa cells under UV irradiation but no cytotoxicity without UV. In addition, the photo-induced cytotoxicity of 2-p-nitirophenyl-TAP was found to be cancer cell selective and effective against HeLa cells and HCT 116 cells. Therefore, small molecule dyes with selective and efficient photo-induced cytotoxicity have been developed.
COMMUNICATIONS CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Tiago H. S. Souza, Camila G. Andrade, Fernanda Cabral, Jose F. Sarmento-Neto, Julio S. Reboucas, Beate S. Santos, Martha S. Ribeiro, Regina C. B. Q. Figueiredo, Adriana Fontes
Summary: Photodynamic inactivation (PDI) is a promising alternative for cutaneous leishmaniasis (CL) treatment due to the adverse effects of current chemotherapy and drug resistance. ZnTnHex-2-PyP4+ is a stable porphyrin with high photosensitizing potential for PDI, showing immediate inactivation of promastigotes and intense effects on parasites' mitochondria. This study highlights the potential of ZnTnHex-2-PyP4+ for further evaluation in vivo against CL and other microorganisms.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2021)
Article
Agriculture, Multidisciplinary
Shumao Cui, Cailing Chen, Jiayu Gu, Bingyong Mao, Hao Zhang, Jianxin Zhao, Wei Chen
Summary: The study genetically engineered Lactobacillus plantarum ST-III to express GFP and studied its distribution in the intestine of mice using fluorescence imaging. The results showed that the genetically modified strain could survive in the intestine and be detected at various time points. The fluorescence intensity was found to have a linear relationship with the viable count of the strain, suggesting that fluorescence intensity can be used to estimate the amount of the strain in the intestinal tract.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2021)
Article
Biochemistry & Molecular Biology
Mohammad A. Saad, Marvin Xavierselvan, Hamza A. Sharif, Scott Selfridge, Robert Pawle, Mark Varvares, Srivalleesha Mallidi, Tayyaba Hasan
Summary: The study introduces a dual function antibody conjugate for multimodal infrared imaging in cancer diagnostics and therapies, combining fluorescence and photoacoustic imaging capabilities. In vitro experiments demonstrate the potential use of this approach in precision imaging and treatment. Further investigation is warranted for clinical translation.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2022)
Article
Oncology
Ilya Turchin, Shazia Bano, Mikhail Kirillin, Anna Orlova, Valeriya Perekatova, Vladimir Plekhanov, Ekaterina Sergeeva, Daria Kurakina, Aleksandr Khilov, Alexey Kurnikov, Pavel Subochev, Marina Shirmanova, Anastasiya Komarova, Diana Yuzhakova, Alena Gavrina, Srivalleesha Mallidi, Tayyaba Hasan
Summary: A new approach of combined optoacoustic and fluorescence imaging was developed to trace photosensitizer kinetics and vascular effects in vivo. The study demonstrated the enhancement of photosensitizer accumulation in tumor and alterations in tumor vasculature structure after treatment. The results suggest that the multifunctional liposomal platform combined with multimodal imaging offers an efficient and personalized platform to improve cancer treatment outcomes.
Article
Dermatology
Taylor A. Bullock, Jeffrey Negrey, Bo Hu, Christine B. Warren, Tayyaba Hasan, Edward Maytin
Summary: The study found that oral VD3 pretreatment significantly improves the clinical response of AK patients to PDT, and this treatment shows good tolerance.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Letter
Dermatology
Simon Cao, Oleg Kruglov, Oleg Akilov
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Microbiology
Jacquelyn R. McDonald, Bryan C. Jensen, Aakash Sur, Iris L. K. Wong, Stephen M. Beverley, Peter J. Myler
Summary: This study reveals the abundant distribution of histone variants and PTMs in the chromatin landscape of Leishmania tarentolae, contributing to our understanding of the epigenetic markers associated with transcription, DNA replication, and chromosome segregation in these early diverging eukaryotes.
Article
Biochemistry & Molecular Biology
Mohammad Ahsan Saad, Robert Pawle, Scott Selfridge, Leslie Contreras, Marvin Xavierselvan, Christopher D. D. Nguyen, Srivalleesha Mallidi, Tayyaba Hasan
Summary: This study reports the synthesis and characterization of water-soluble silicon-centered naphthalocyanine dyes with high photoacoustic signal amplitude, which have the potential to be used as contrast agents for molecular photoacoustic imaging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Tiago R. Ferreira, Ehud Inbar, Jahangheer Shaik, Brendan M. Jeffrey, Kashinath Ghosh, Deborah E. Dobson, Stephen M. Beverley, David Sacks
Summary: Leishmania, a parasitic protozoa that causes various diseases collectively known as leishmaniases, has been found to undergo sexual reproduction inside the sand fly vector midgut. This study provides the first high resolution, whole-genome sequencing analysis of self-mating in Leishmania, revealing that self-hybridization can occur with comparable frequency as interstrain mating under experimental lab conditions, leading to important genomic alterations that can potentially take place within every naturally infected sand fly.
Article
Genetics & Heredity
Lon-Fye Lye, Katherine L. Owens, Soojin Jang, Joseph E. Marcus, Erin A. Brettmann, Stephen M. Beverley
Summary: RNA interference (RNAi) is a powerful tool for functional genetic tests and has been successfully applied to the study of L. braziliensis. We developed RNAi knockdown constructs using Gateway(TM) recombinase technology and found that the efficacy of RNAi increased with stem length. Co-selection for RNAi against APRT1 using APP could enhance the efficacy of RNAi against reporter constructs.
Article
Microbiology
Gloria Polanco, Nichollas E. Scott, Lon F. Lye, Stephen M. Beverley
Summary: This study leveraged an ultradeep proteomic approach to investigate two virulence-associated genes in Leishmania, revealing significant quantitative differences and phenotypic changes linked to LPG2 or FUT1. The work advanced knowledge by identifying potential proteins underlying persistence-without-pathology phenotype and mitochondrial dysfunction in mutants, shedding light on new therapeutic targets.
MICROBIOLOGY SPECTRUM
(2022)
Article
Dermatology
Taylor A. Bullock, Judith A. Mack, Jeffrey Negrey, Urvashi Kaw, Bo Hu, Sanjay Anand, Tayyaba Hasan, Christine B. Warren, Edward V. Maytin
Summary: This study found an association between VDR genetic polymorphisms and breast cancer, melanoma, squamous cell carcinoma, and actinic keratosis. By analyzing two VDR polymorphic sites, certain genotypes were found to be associated with high serum calcidiol levels and reduced actinic keratosis incidence. Additionally, the Poly-A allele was found to be a risk allele for squamous cell carcinoma.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Dermatology
Zhen Han, Xiwei Wu, Hanjun Qin, Yate-Ching Yuan, Jasmine Zain, D. Lynne Smith, Oleg E. Akilov, Steven T. Rosen, Mingye Feng, Christiane Querfeld
Summary: This study investigated the effects of CD47 and PD-L1 immune checkpoint blockades on cutaneous T-cell lymphoma (CTCL). The results showed that dual targeting of CD47 and PD-L1 enhanced immune activity and suppressed tumor growth.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Chemistry, Physical
S. J. Davis, Y. Zhao, T. C. Yu, E. Maytin, S. Anand, T. Hasan, B. W. Pogue
Summary: Translating experimental techniques between scientific disciplines is challenging but beneficial. This article describes how research on the COIL laser led to the development of a diagnostic tool for PDT, a promising cancer treatment. The link between these two fields is the excited state of molecular oxygen, singlet oxygen, which powers the COIL laser and kills cancer cells during PDT. The article traces the development of an ultrasensitive dosimeter for singlet oxygen, which is a crucial step towards improving PDT outcomes.
JOURNAL OF PHYSICAL CHEMISTRY B
(2023)
Article
Nanoscience & Nanotechnology
Caroline Coradi Tonon, Alessandra Nara de Souza Rastelli, Chathuna Bodahandi, Goutam Ghosh, Tayyaba Hasan, Qianfeng Xu, Alexander Greer, Alan M. Lyons
Summary: Limited options exist for the treatment of periodontitis, and current methods like scaling and root planing are not sufficient. This study evaluated the effectiveness of a new superhydrophobic antimicrobial photodynamic therapy device as an adjuvant to scaling and root planing. The device significantly reduced periodontal pathogens, improved clinical parameters, and showed promising healing outcomes.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Cell Biology
Oleg E. Akilov
Summary: This review analyzes the current state of diagnostic, prognostic, and disease state-monitoring biomarkers of extracorporeal photopheresis (ECP), and outlines the future direction of ECP biomarker discovery. It is of importance to researchers and clinicians seeking to optimize ECP therapy for cutaneous T-cell lymphoma.
Article
Hematology
Amy Xiao, Colleen J. Beatty, Sonal Choudhary, Oleg E. Akilov
Summary: This article presents a case of CD5+ PCDLBCL-LT, where the patient had a small single pink-bluish nodule on the thigh. The patient was successfully treated with localized radiation therapy and rituximab, achieving complete response. Early identification of PCDLBCL-LT is crucial for optimal therapy and prognosis.
HEMATOLOGY REPORTS
(2023)
