Review
Medicine, General & Internal
Tomonori Yano, Tatsunori Minamide, Kenji Takashima, Keiichiro Nakajo, Tomohiro Kadota, Yusuke Yoda
Summary: Photodynamic therapy using a conventional photosensitizer was replaced by second-generation photosensitizer talaporfin sodium to reduce adverse reactions in treating esophageal cancer. Endoscopic PDT using talaporfin sodium was approved as a salvage treatment for patients with local failure after chemoradiotherapy for esophageal cancer, based on favorable clinical trial results. Further evaluation is needed to determine the importance of PDT in the treatment of esophageal cancer.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Tatsuya Kobayashi, Masayuki Nitta, Kazuhide Shimizu, Taiichi Saito, Shunsuke Tsuzuki, Atsushi Fukui, Shunichi Koriyama, Atsushi Kuwano, Takashi Komori, Kenta Masui, Taketoshi Maehara, Takakazu Kawamata, Yoshihiro Muragaki
Summary: Retrospective analysis showed that talaporfin sodium mediated photodynamic therapy (PDT) could potentially provide survival benefits for recurrent glioblastoma (GBM) patients, and its efficacy is independent of the pre-recurrence pathology.
Article
Medicine, General & Internal
Jiro Akimoto, Shinjiro Fukami, Kenta Nagai, Michihiro Kohno
Summary: PD and PDT using talaporfin sodium have been widely used in Japan for intracranial malignant tumors. However, there is a lack of research on malignant spinal cord tumors, which have poorer clinical outcomes compared to brain tumors. This report presents the first case of using PD and PDT for a malignant spinal cord tumor, showing promising efficacy.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Takaaki Tsuchida, Yuji Matsumoto, Tatsuya Imabayashi, Keigo Uchimura
Summary: Photodynamic therapy (PDT) has been proven effective and safe in treating malignant central airway stenosis. However, the appropriate laser dose for talaporfin PDT remains unclear. This review of cases treated with talaporfin PDT suggests that a laser dose of 100 J/cm2 is feasible for improving airway stenosis in malignant central airway stenosis.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Article
Engineering, Biomedical
Sharmin Akter, Sachiko Saito, Mizuho Inai, Norihiro Honda, Hisanao Hazama, Tomoyuki Nishikawa, Yasufumi Kaneda, Kunio Awazu
Summary: The study found that Laserphyrin (R)-HVJ-E prepared with 15 mM of Laserphyrin (R) had high photocytotoxicity and maintained the ability of HVJ-E to induce direct cytotoxicity. The therapeutic effect of Laserphyrin (R)-HVJ-E was substantially equivalent to that of Laserphyrin (R) alone, even at half the concentration. By combining the cytotoxicities of HVJ-E and PDT, Laserphyrin (R)-HVJ-E showed higher potency than Laserphyrin (R).
LASERS IN MEDICAL SCIENCE
(2021)
Article
Nanoscience & Nanotechnology
Linlin Ren, Chengfang Jiang, Yuqi Zhang, Mengmeng Li, Yan Zhang, Xinli Shi, Qi Wang, Shusheng Zhang, Xinyue Song
Summary: A near-infrared light-controlled DNA nanomachine was constructed for highly sensitive imaging of intracellular microRNA in cancer cells, and it can also perform precise photodynamic therapy on tumors.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Oncology
Makiko Sasaki, Mamoru Tanaka, Yuki Kojima, Hirotada Nishie, Takaya Shimura, Eiji Kubota, Hiromi Kataoka
Summary: Photodynamic therapy (PDT) is an anti-cancer therapy that uses a photosensitizer and specific light irradiation. The combination of TS-PDT and anti-PD-1 antibody shows potential in enhancing anti-tumor immunity. TS-PDT induces cell death and the release/expression of damage-associated molecular patterns (DAMPs) in vitro. In mouse models, the combination treatment inhibits tumor growth compared to single treatments or non-treatment groups.
MOLECULAR THERAPY-ONCOLYTICS
(2023)
Article
Oncology
Asiye GoK Yurttas, Zehra Okat, Tugba Elgun, Kezban Ucar Cifci, Altug Mert Sevim, Ahmet Gul
Summary: Photodynamic therapy (PDT) is an effective cancer treatment method that relies on the production of singlet oxygen. This study aims to investigate the anti-cancer activity of the phthalocyanine L1ZnPC through flow cytometry analysis and q-PCR. The results show that L1ZnPC induces apoptosis in HELA cancer cells and is associated with significant changes in gene expression related to cancer.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Article
Chemistry, Multidisciplinary
Le Yu, Yunjie Xu, Zhongji Pu, Heemin Kang, Mingle Li, Jonathan L. Sessler, Jong Seung Kim
Summary: This study demonstrates the successful activation of cancer cell pyroptosis using a photocatalytic superoxide radical generator, NI-TA, which functions through the caspase-3/gasdermin E pathway. The research also reveals the partial oxygen recycling mechanism of NI-TA and its ability to effectively eliminate cancer cells under hypoxic conditions.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Biochemistry & Molecular Biology
Mamoru Tanaka, Makiko Sasaki, Taketo Suzuki, Hirotada Nishie, Hiromi Kataoka
Summary: The study investigated the efficacy of combining talaporfin PDT with olaparib for gastric cancer treatment, demonstrating excellent synergistic action and significant tumor growth suppression. This combination therapy has the potential to be an effective antitumor treatment for gastric cancer.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
David Kessel
Summary: Photodynamic therapy (PDT) is capable of eradicating neoplastic cells accessible to sufficient light and oxygen. Despite adequate information available for assessing the conditions where PDT might be the therapy of choice, limited access to clinical facilities and barriers to regulatory approval of new agents have restricted its clinical usage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Eric Chekwube Aniogo, Blassan P. George, Heidi Abrahamse
Summary: Cancer resistance is a major concern in cancer treatment. Photodynamic therapy (PDT) and photobiomodulation (PBM) can improve therapeutic outcomes, and PBM may enhance the anti-tumor efficacy of ZnPcS4-PDT on resistant MCF-7 breast cancer cells by inducing autophagy.
Article
Biochemistry & Molecular Biology
Eric Chekwube Aniogo, Blassan P. George, Heidi Abrahamse
Summary: The study utilized photodynamic therapy to treat MCF-7 cells overexpressed with P-glycoprotein, resulting in cell apoptosis with increased externalisation of phosphatidylserine protein and changes in apoptotic protein expression.
Article
Nanoscience & Nanotechnology
Oleksii O. Peltek, Eduard Ageev, Pavel M. Talianov, Anna D. Mikushina, Olga S. Epifanovskaya, Aliaksei Dubavik, Vadim P. Veiko, Kirill Lepik, Dmitry A. Zuev, Alexander S. Timin, Mikhail Zyuzin
Summary: This study investigates the necrosis/apoptosis process of cancerous cells during photothermal therapy (PTT) using nanoscale fluorescence thermometry and local laser heating. The results provide insights for optimizing PTT conditions and improving therapeutic efficiency.
Article
Engineering, Biomedical
Yutong Shao, Miaomiao Chen, Wenlong Chen, Zehui Wang, Mengzhang Sui, Mingyu Tian, Yingnan Wu, Jitao Song, Debin Ji, Fengling Song
Summary: Photodynamic therapy (PDT) utilizes photosensitizers to generate reactive oxygen species (ROS) from oxygen (O-2) under irradiation, leading to DNA damage and cancer cell death. However, apoptosis resistance mechanisms in tumor cells reduce the effectiveness of PDT. This study introduces a hypoxia-activated nanosystem FTPA, which releases the encapsulated PDT photosensitizer 4-DCF-MPYM and an inhibitor TH588. The inhibitor TH588 inhibits DNA repair by reducing the activity of MTH1 enzyme, thus enhancing the therapeutic effect of PDT. The integration of hypoxia activation and apoptosis resistance inhibition achieves precise and augmented tumor PDT.
ADVANCED HEALTHCARE MATERIALS
(2023)