Adaptive Designs for Confirmatory Clinical Trials with Subgroup Selection

Explaining temporal trends in annualised relapse rates in placebo groups of randomised controlled trials in relapsing multiple sclerosis: systematic review and meta-regression

(2013) Simon M Steinvorth et al.   Multiple Sclerosis Journal

Group sequential enrichment design incorporating subgroup selection

(2013) Baldur P. Magnusson et al.   STATISTICS IN MEDICINE

Inflation in the number of eligibility criteria for industry-sponsored phase II cancer clinical trial: Illustration over a 20-year period

(2012) Stéphanie Clisant et al.   Contemporary Clinical Trials

A conditional error function approach for subgroup selection in adaptive clinical trials

(2012) T. Friede et al.   STATISTICS IN MEDICINE

Shrinkage estimation in two-stage adaptive designs with midtrial treatment selection

(2012) Máximo Carreras et al.   STATISTICS IN MEDICINE

Optimizing randomized trial designs to distinguish which subpopulations benefit from treatment

(2011) M. Rosenblum et al.   BIOMETRIKA

New Strategies for Treatment of KRAS Mutant Metastatic Colorectal Cancer

(2010) H. Prenen et al.   CLINICAL CANCER RESEARCH

An R package for implementing simulations for seamless phase II/III clinical trials using early outcomes for treatment selection

(2010) Nick Parsons et al.   COMPUTATIONAL STATISTICS & DATA ANALYSIS

Adjusted significance levels for subgroup analyses in clinical trials

(2010) Bart Spiessens et al.   Contemporary Clinical Trials

An adaptive seamless phase II/III design for oncology trials with subpopulation selection using correlated survival endpoints†

(2010) Martin Jenkins et al.   PHARMACEUTICAL STATISTICS

Design and Analysis Considerations in Clinical Trials With a Sensitive Subpopulation

(2010) Yan D. Zhao et al.   Statistics in Biopharmaceutical Research

Adaptive patient enrichment designs in therapeutic trials

(2009) Sue-Jane Wang et al.   BIOMETRICAL JOURNAL

Confirmatory adaptive designs with Bayesian decision tools for a targeted therapy in oncology

(2009) Werner Brannath et al.   STATISTICS IN MEDICINE

Unbiased Estimation of Selected Treatment Means in Two-Stage Trials

(2008) Jack Bowden et al.   BIOMETRICAL JOURNAL

Wild-TypeKRASIs Required for Panitumumab Efficacy in Patients With Metastatic Colorectal Cancer

(2008) Rafael G. Amado et al.   JOURNAL OF CLINICAL ONCOLOGY

Exploring changes in treatment effects across design stages in adaptive trials

(2008) Tim Friede et al.   PHARMACEUTICAL STATISTICS