Study of mutation and misfolding of Cu-Zn SOD1 protein

Computational Studies of the Metal-Binding Site of the Wild-Type and the H46R Mutant of the Copper, Zinc Superoxide Dismutase

(2012) Raúl Mera-Adasme et al.   INORGANIC CHEMISTRY

Amyotrophic lateral sclerosis: a new missense mutation in the SOD1 gene

(2012) Rosanna Tortelli et al.   NEUROBIOLOGY OF AGING

Structure and Dynamics of Amyloid-β Segmental Polymorphisms

(2012) Workalemahu M. Berhanu et al.   PLoS One

Structural Instability and Cu-Dependent Pro-Oxidant Activity Acquired by the Apo Form of Mutant SOD1 Associated with Amyotrophic Lateral Sclerosis

(2011) Furi Kitamura et al.   BIOCHEMISTRY

Pyrimidine-2,4,6-trione Derivatives and Their Inhibition of Mutant SOD1-Dependent Protein Aggregation. Toward a Treatment for Amyotrophic Lateral Sclerosis

(2011) Guoyao Xia et al.   JOURNAL OF MEDICINAL CHEMISTRY

ALS-Causing SOD1 Mutations Promote Production of Copper-Deficient Misfolded Species

(2011) Philbert Ip et al.   JOURNAL OF MOLECULAR BIOLOGY

Local Unfolding of Cu, Zn Superoxide Dismutase Monomer Determines the Morphology of Fibrillar Aggregates

(2011) Feng Ding et al.   JOURNAL OF MOLECULAR BIOLOGY

Biochemical properties and in vivo effects of the SOD1 zinc-binding site mutant (H80G)

(2011) Marjatta Son et al.   JOURNAL OF NEUROCHEMISTRY

Mixed ligand complexes of essential metal ions with L-glutamine and succinic acid in SLS-water mixtures

(2011) Hima Bindu et al.   JOURNAL OF THE SERBIAN CHEMICAL SOCIETY

Decreased stability and increased formation of soluble aggregates by immature superoxide dismutase do not account for disease severity in ALS

(2011) K. A. Vassall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disrupted Zinc-Binding Sites in Structures of Pathogenic SOD1 Variants D124V and H80R

(2010) Sai V. Seetharaman et al.   BIOCHEMISTRY

SOD1 Mutations Targeting Surface Hydrogen Bonds Promote Amyotrophic Lateral Sclerosis without Reducing Apo-state Stability

(2010) Roberth Byström et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disulfide-Reduced ALS Variants of Cu, Zn Superoxide Dismutase Exhibit Increased Populations of Unfolded Species

(2010) Can Kayatekin et al.   JOURNAL OF MOLECULAR BIOLOGY

Interaction studies of cysteine with Li+, Na+, K+, Be2+, Mg2+, and Ca2+ metal cation complexes

(2010) R. Shankar et al.   JOURNAL OF PHYSICAL ORGANIC CHEMISTRY

Folding Catalysis by Transient Coordination of Zn2+to the Cu Ligands of the ALS-Associated Enzyme Cu/Zn Superoxide Dismutase 1

(2010) Lina Leinartaitė et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Role for Copper in the Toxicity of Zinc-Deficient Superoxide Dismutase to Motor Neurons in Amyotrophic Lateral Sclerosis

(2009) Kari A. Trumbull et al.   ANTIOXIDANTS & REDOX SIGNALING

Structural and biophysical properties of metal-free pathogenic SOD1 mutants A4V and G93A

(2009) Ahmad Galaleldeen et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Thermodynamic Description of Polymorphism in Q- and N-Rich Peptide Aggregates Revealed by Atomistic Simulation

(2009) Joshua T. Berryman et al.   BIOPHYSICAL JOURNAL

Variation in aggregation propensities among ALS-associated variants of SOD1: Correlation to human disease

(2009) Mercedes Prudencio et al.   HUMAN MOLECULAR GENETICS

Loss of Metal Ions, Disulfide Reduction and Mutations Related to Familial ALS Promote Formation of Amyloid-Like Aggregates from Superoxide Dismutase

(2009) Zeynep A. Oztug Durer et al.   PLoS One

Role of mutant SOD1 disulfide oxidation and aggregation in the pathogenesis of familial ALS

(2009) C. M. Karch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamical roles of metal ions and the disulfide bond in Cu, Zn superoxide dismutase folding and aggregation

(2008) F. Ding et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA