Article
Oncology
Hector Teran-Navarro, Andrea Zeoli, David Salines-Cuevas, Marco Marradi, Noemi Montoya, Elena Gonzalez-Lopez, Javier Gonzalo Ocejo-Vinyals, Mario Dominguez-Esteban, Jose Luis Gutierrez-Banos, Felix Campos-Juanatey, Sonsoles Yanez-Diaz, Almudena Garcia-Castano, Fernando Rivera, Ignacio Duran, Carmen Alvarez-Dominguez
Summary: The study proposes a novel immunotherapy using gold nanoparticles bound to a bacterial toxin peptide as nanovaccines, showing promising results in pre-clinical experiments on bladder cancer. These nanovaccines activate the immune system, block tumor immunosuppression, and reduce tumor size. The potential of this immunotherapy can be extended to other solid tumors with lymphocyte infiltration.
Article
Food Science & Technology
Mei Bai, Jinming Dai, Wei Hu, Changzhu Li, Haiying Cui, Lin Lin
Summary: This study demonstrates the potential of Litsea cubeba essential oil (LC-EO) and its main component, citral, as anti-virulence agents targeting listeriolysin O (LLO) of Listeria monocytogenes. The results show that citral can significantly decrease the hemolytic activity of LLO by inducing conformational changes and forming covalent bonds with specific residues. This research provides a new approach for the development of LLO-targeting anti-virulence agents and expands the application of LC-EO in food microbiological safety.
Article
Chemistry, Applied
Ozioma Forstinus Nwabor, Sudarshan Singh, Dwi Marlina Syukri, Supayang Piyawan Voravuthikunchai
Summary: Extracts of E. camaldulensis demonstrated antimicrobial and antioxidant activities, with high levels of phenolic and flavonoid compounds. Additionally, the extracts showed significant effects on nitrite production and oxidative stress, making them a potential source of preservatives and functional food additives.
Review
Biochemistry & Molecular Biology
Fleurdeliz Maglangit, Yi Yu, Hai Deng
Summary: Pathogenic bacteria pose threats but also provide potential for pharmaceuticals. Discovering new antibiotics and exploiting pathogenic bacteria could lead to a new era of antibiotic discovery.
NATURAL PRODUCT REPORTS
(2021)
Article
Chemistry, Applied
Arturo Cano-Flores, Marina Espinoza, Guillermo Delgado
Summary: Aspergillus niger and Cunninghamella blakesleeana favored the formation of benzofuran derivatives or benzopyran derivatives through biotransformation or acid-catalyzed chemical transformation of glabranin. Compound 6 was further biooxidized at C-4'. The biotransformation of 7-O-methylglabranin mimicked the biosynthesis of the last compound. Some compounds exhibited moderate antiproliferative activity against selected human cancer cell lines, with glabranin being the most active.
NATURAL PRODUCT RESEARCH
(2022)
Article
Environmental Sciences
Afifa Belaid, Afef Braiek, Sana Alibi, Wafa Hassen, Asma Beltifa, Adel Nefzi, Hedi Ben Mansour
Summary: This study synthesized several analogs of DS4 and found that the N terminus of the original peptide is crucial for its antibacterial and anti-proliferative effects, while sequences broken down on the C-terminal side exhibited more notable hemolytic activity.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Oncology
Zehua He, Qingfeng Chen, Wanrong He, Junyue Cao, Shunhan Yao, Qingqiang Huang, Yu Zheng
Summary: This study analyzed the metabolic heterogeneity of epithelial cells in hepatocellular carcinoma (HCC) and identified potential biomarkers. It found that the glycolytic subtype of HCC cells with high ALDOA expression is associated with an immunosuppressive tumor microenvironment and predicts worse clinical outcomes.
FRONTIERS IN ONCOLOGY
(2023)
Article
Environmental Sciences
Qianqian Lu, Xinzhu Zhou, Ruidan Liu, Guojing Shi, Ningning Zheng, Guanghai Gao, Yingying Wang
Summary: Chlorella is a dominant species during harmful algal blooms (HABs) and poses significant threats to the environment and drinking water safety. Bacterial algicides have shown promise in controlling HABs, but our understanding of their effects on Chlorella and algal metabolism is limited.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Review
Immunology
Wolfgang Eisenreich, Thomas Rudel, Juergen Heesemann, Werner Goebel
Summary: Persistence is a potent survival strategy common to almost all bacteria, allowing a subpopulation to withstand adverse conditions and revive once the stress is removed. Various factors and pathways contribute to the formation of persistence, even in stress-free bacterial populations, with growth potentially induced by stress conditions.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Chemistry, Medicinal
Paramita Sarkar, Debajyoti Basak, Riya Mukherjee, Julia E. Bandow, Jayanta Haldar
Summary: The study reports a new class of antibiotics, alkyl-aryl-vancomycins (AAVs), with high potency against vancomycin-resistant enterococci and staphylococci. The lead compound, AAV-qC10, is bactericidal, weakly dependent on bacterial metabolism, and capable of eradicating non-growing cells of MRSA. AAV-qC10 not only inhibits cell wall biosynthesis like vancomycin, but also depolarizes and permeabilizes the bacterial membrane, impairing bacterial growth through multiple pathways.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Agricultural Engineering
Triya Mukherjee, S. Venkata Mohan
Summary: This study examines the role of magnetite at the interface of Bacillus subtilis-electrode and its effect on gene expression and product formation. The results show that magnetite can enhance acidogenesis and promote product formation, with different loadings of magnetite leading to different types and amounts of products. The findings suggest that the interaction between magnetite and specific enzymes plays an important role in biocatalytic activity.
BIORESOURCE TECHNOLOGY
(2022)
Article
Agricultural Engineering
Baihui Cui, Zhihua Chen, Dabin Guo, Yu Liu
Summary: This study investigated the pyrolysis of microalgal-bacterial granular sludge and found that it can produce bio-oil and biochar with high yield under specific conditions. The chemical properties and kinetic mechanisms were also analyzed.
BIORESOURCE TECHNOLOGY
(2022)
Article
Engineering, Environmental
Changcai Wu, Zhinan Wang, Yan Ma, Junyu Luo, Xueke Gao, Jun Ning, Xiangdong Mei, Dongmei She
Summary: This study investigated the effects of the neonicotinoid insecticide thiamethoxam on bacterial communities and metabolic functions in two types of soils. Thiamethoxam treatment significantly affected soil bacterial abundance, reduced microbial diversity, and temporarily altered the bacterial community structure. The study also identified changes in the populations of certain beneficial and pollutant-degrading bacteria, as well as the increased abundance of biodegradation and pesticide degradation genes, including cytochrome P450. The conclusions of this study will contribute to safety evaluations and degradation-related research on neonicotinoid insecticides in soil.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Review
Plant Sciences
Fabiola Gonzalez-Castelazo, Luis E. Soria-Jasso, Ivan Torre-Villalvazo, Raquel Carino-Cortes, Victor M. Munoz-Perez, Mario I. Ortiz, Eduardo Fernandez-Martinez
Summary: Metabolic syndrome predisposes individuals to chronic non-communicable diseases and traditional herbal therapies, particularly those from the Rubiaceae family, show promise in preventing and treating these conditions through their antioxidative, anti-inflammatory, and metabolic regulatory properties.
Article
Materials Science, Paper & Wood
Raymond Leopold Heydorn, David Lammers, Martina Gottschling, Katrin Dohnt
Summary: The advances in bioprocess design, genetic engineering, and media optimization have enabled enhanced bacterial cellulose (BC) production and its application for diverse purposes. Numerous approaches were conducted to investigate alternative carbon or nitrogen sources from industrial by-products for BC biosynthesis, which not only affect the BC production but also its properties. This study highlights beneficial effects of food industry by-products for BC biosynthesis and elucidates concomitantly occurring structural polymer alterations to enable further studies dealing with alternative substrates for structurally tailored BC production.
Article
Nanoscience & Nanotechnology
Angelika Kwiatkowska, Ludomira H. Granicka, Anna Grzeczkowicz, Radoslaw Stachowiak, Pawel Bacal, Kamil Sobczak, Marek Darowski, Maciej Kozarski, Jacek Bielecki
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2018)
Article
Agriculture, Dairy & Animal Science
Tomasz Jagielski, Katarzyna Roeske, Zofia Bakula, Tomasz Piech, Lukasz Wlazlo, Mariola Bochniarz, Piotr Woch, Henryk Krukowski
JOURNAL OF DAIRY SCIENCE
(2019)
Article
Biotechnology & Applied Microbiology
Tomasz Jagielski, Henryk Krukowski, Mariola Bochniarz, Tomasz Piech, Katarzyna Roeske, Zofia Bakula, Lukasz Wlazlo, Piotr Woch
MICROBIAL BIOTECHNOLOGY
(2019)
Correction
Agriculture, Dairy & Animal Science
Tomasz Jagielski, Katarzyna Roeske, Zofia Bakula, Tomasz Piech, Lukasz Wlazlo, Mariola Bochniarz, Piotr Woch, Henryk Krukowski
JOURNAL OF DAIRY SCIENCE
(2019)
Article
Oncology
Bozena Katarzyna Budziszewska, Aleksander Salomon-Perzynski, Katarzyna Pruszczyk, Joanna Barankiewicz, Agnieszka Pluta, Grzegorz Helbig, Anna Janowska, Marta Kuydowicz, Lukasz Bolkun, Jaroslaw Piszcz, Elzbieta Patkowska, Marzena Watek, Piotr Malecki, Sylwia Kosciolek-Zgodka, Edyta Cichocka, Grzegorz Charlinski, Anna Irga-Staniukiewicz, Jan Maciej Zaucha, Agnieszka Piekarska, Tomasz Gromek, Marek Hus, Karol Wojcik, Malgorzata Razny, Mariola Sedzimirska, Bartosz Pula, Sebastian Giebel, Sebastian Grosicki, Agnieszka Wierzbowska, Ewa Lech-Maranda
Summary: The study evaluated a novel low-intensity regimen for elderly AML patients unfit for intensive chemotherapy, showing that LD-AC+cladribine led to positive outcomes in terms of objective response rate and overall survival, with predictable toxicity profile.
Review
Biochemistry & Molecular Biology
Angelika Kwiatkowska, Monika Drabik, Agata Lipko, Anna Grzeczkowicz, Radoslaw Stachowiak, Anna Marszalik, Ludomira H. Granicka
Summary: This review paper discusses the application of nanomaterials in wound dressings, particularly metallic nanoparticles, and their use as antimicrobial factors. The paper also explores the multiple molecular pathways, cell types, and agents involved in wound healing, as well as the categorization of wound dressings and the materials and membrane constructs used in them. Furthermore, the paper examines the role of bacteria in wound healing and the antibacterial mechanism of nanoparticles. Overall, the review provides valuable insights into the potential of nanocomposite materials in improving wound healing processes.
Article
Multidisciplinary Sciences
Zofia Bakula, Valentine B. I. Wuyep, Lukasz Bartocha, Anna Vyazovaya, Eugene I. Ikeh, Jacek Bielecki, Igor Mokrousov, Tomasz Jagielski
Summary: Nigeria has the highest burden of tuberculosis in Africa and ranks 6th globally. However, few studies have examined the molecular epidemiology of Mycobacterium tuberculosis in the country. This study analyzed the genetic structure of drug-resistant tuberculosis in central Nigeria and found that the Cameroon and T lineages were the most prevalent, with no association between the Cameroon lineage and drug resistance.
Article
Biochemistry & Molecular Biology
Tomasz Milek, Anna Grzeczkowicz, Agata Lipko, Leszek Oleksinski, Angelika Kwiatkowska, Marcin Strawski, Monika Drabik, Radoslaw Stachowiak, Jerzy Goliszewski, Ludomira H. Granicka
Summary: This study presents an approach to develop a dressing platform with an alginate layer incorporated with oxygenating elements, providing a safe and even contact surface for wound healing. The results showed that the presence of cross-linked alginate with oxygenating factor significantly improved the viability and morphology of human fibroblasts cultured on the membranes. The characterization techniques, such as SEM and AFM, confirmed the presence of oxygenating and cross-linking factors in the layer coating material.
Article
Chemistry, Organic
Krystyna Maslowska-Jarzyna, Alessio Cataldo, Anna Marszalik, Ilona Ignatikova, Stephen J. Butler, Radoslaw Stachowiak, Michal J. Chmielewski, Hennie Valkenier
Summary: This study investigated the transport of bicarbonate and chloride ions by carbazoles with two amido/thioamido groups using a bicarbonate-sensitive probe. The researchers found a significant concentration dependence of the transporters. Based on insights into anion transport mechanisms, the compounds were tested for antimicrobial activity and showed a strong correlation with their ion transport properties.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Microbiology
Anna Marszalik, Karolina Sidor, Agnieszka Krasnicka, Marta Wroblewska, Tomasz Skirecki, Tomasz Jagielski, Radoslaw Stachowiak
Summary: Acinetobacter baumannii is a Gram-negative saprophytic rod with strong environmental adaptability, causing hospital infections and posing a threat to patients. Due to its increasing drug resistance, controlling and preventing its infections has become more challenging.
ADVANCEMENTS OF MICROBIOLOGY
(2021)
Article
Microbiology
Katarzyna Roeske, Aleksandra Zasun, Justyna Cieslik, Marta Wroblewskaz, Tomasz Jagielski
ADVANCEMENTS OF MICROBIOLOGY
(2020)
Article
Nanoscience & Nanotechnology
Magdalena Antosiak-Iwanska, Pawel Bacal, Beata Kazimierczak, Angelika Kwiatkowska, Ewa Godlewska, Anna Grzeczkowicz, Radoslaw Stachowiak, Jacek Bielecki, Ludomira Granicka
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2020)
Meeting Abstract
Oncology
Rafal Machowicz, Anna Waszczuk-Gajda, Magdalena Witkowska, Agnieszka Piekarska, Piotr Boguradzki, Piotr Smolewski, Malgorzata Razny, Wanda Knopinska-Posluszny, Edyta Cichocka, Wojciech Sydor, Michal Gorka, Joanna Drozd-Sokolowska, Bartosz Garus, Patrycja Mensah-Glanowska, Krzysztof Madry, Renata Guzicka-Kazimierczak, Slawomir Rejowski, Patrycja Zielinska, Dorota Zdunczyk, Bozena Katarzyna Budziszewska, Paulina Marszalek-Gibas, Adam Hajduk, Karol Lis, Aleksandra Bogucka-Fedorczuk, Lukasz Bolkun, Katarzyna Brzezniakiewicz-Janus, Dominik Bursa, Monika Gasik, Justyna Gil, Katarzyna Kurowska, Malgorzata Paszkowska-Kowalewska, Katarzyna Romanowska-Prochnicka, Emilian Snarski, Monika Swacha, Agnieszka Szymczyk, Alina Swiderska, Karolina Chromik, Agnieszka Konska, Mateusz Ziarkiewicz, Katarzyna Popko, Mateusz Staniak, Katarzyna Kobylinska, Przemyslaw Biecek, Jadwiga Dwilewicz-Trojaczek, Grzegorz Basak, Wieslaw Wiktor-Jedrzejczak
PEDIATRIC BLOOD & CANCER
(2020)
Article
Biotechnology & Applied Microbiology
Katarzyna Roeske, Radoslaw Stachowiak, Tomasz Jagielski, Michal Kaminski, Jacek Bielecki
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
(2018)