Article
Agriculture, Multidisciplinary
Mayuree Kanlayavattanakul, Puxvadee Chaikul, Mattaka Kongkow, Tawin Iempridee, Nattaya Lourith
Summary: This study evaluated the antioxidant, anti-tyrosinase, and anti-inflammatory activities of sea holly extracts. The extracts showed promising results for anti-aging purposes, including antioxidant, anti-melanogenesis, collagen stimulating, anti-inflame, and anti-senescence activities.
CHEMICAL AND BIOLOGICAL TECHNOLOGIES IN AGRICULTURE
(2023)
Article
Biochemistry & Molecular Biology
Opeyemi Joshua Olatunji, Oladipupo Odunayo Olatunde, Titilope John Jayeoye, Sudarshan Singh, Sirinporn Nalinbenjapun, Sasikarn Sripetthong, Warangkana Chunglok, Chitchamai Ovatlarnporn
Summary: This study investigated the antioxidant, antimicrobial, anticancer, and phytochemical profiling of extracts from the leaves and stem/root of Acanthus ebracteatus. The results showed that the extracts contained various bioactive compounds and exhibited high antioxidant and anticancer activities.
Article
Chemistry, Medicinal
Bui Thi Mai Anh, Tran Thi Thuy Nga, Hoang Thi Tuyet Lan, Nguyen Thi Mai, Phan Thi Thanh Huong, Bui Huu Tai, Nguyen Xuan Nhiem, Phan Van Kiem
Summary: This study reported the isolation and identification of one new flavone glycoside and ten known compounds from the aerial parts of A. ebracteatus. Among them, three alkaloids and two phenolic glycosides showed moderate cytotoxic activity against two cancer cell lines.
NATURAL PRODUCT COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Hemant Singh, Indu Yadav, Wajid Mohammad Sheikh, Aniruddha Dan, Zenab Darban, Showkat Ahmad Shah, Narayan Chandra Mishra, Syed Shahabuddin, Shabir Hassan, Showkeen Muzamil Bashir, Mukesh Dhanka
Summary: This research focuses on fabricating biological macromolecule-based hydrogel with desirable antibacterial, antioxidant, controlled drug release, cytocompatibility, and wound healing properties. The nanocomposite hydrogel loaded with 500 mu g/ml NC exhibited excellent performance in treating full-thickness wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Multidisciplinary Sciences
Vanuchawan Wisuitiprot, Kornkanok Ingkaninan, Panlop Chakkavittumrong, Wudtichai Wisuitiprot, Nitra Neungchamnong, Ruttanaporn Chantakul, Neti Waranuch
Summary: Androgenic alopecia is commonly caused by testosterone metabolism, leading to hair loss. Approved medications like Finasteride and Minoxidil may have side effects, but Acanthus ebracteatus Vahl extract and verbascoside could potentially promote dermal papilla cell growth and have anti-inflammatory effects.
SCIENTIFIC REPORTS
(2022)
Article
Materials Science, Biomaterials
Souvik Ghosh, Swati Haldar, Sumeet Gupta, Samrat Chauhan, Vishal Mago, Partha Roy, Debrupa Lahiri
Summary: This study successfully developed a low-cost, structurally and functionally graded biodegradable polymeric scaffold, which achieved scar-free regeneration of full-thickness skin wounds. The scaffold showed good biocompatibility and tissue regeneration effects, indicating its potential as an effective wound healing product.
BIOMATERIALS ADVANCES
(2022)
Article
Biotechnology & Applied Microbiology
Katarina Kacvinska, Veronika Pavlinakova, Petr Polacek, Lenka Michlovska, Veronika Hefka Blahnova, Eva Filova, Martin Knoz, Bretislav Lipovy, Jakub Holoubek, Martin Faldyna, Zdenek Pavlovsky, Monika Vicenova, Michaela Cvanova, Jiri Jarkovsky, Lucy Vojtova
Summary: The treatment of complete loss of skin thickness usually requires expensive cellular materials and limited skin grafts. This paper presents a modified acellular bilayer scaffold with polydopamine (PDA), which mimics the missing dermis and basement membrane. Similar to treatment with native porcine skin, this scaffold can be used as an implant for full-thickness skin wounds, eliminating the need for skin grafts.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Polymer Science
Duo Kang, Wenhai Wang, Yanmei Li, Yi Ma, Yadong Huang, Jufang Wang
Summary: In this study, a multifunctional biological macromolecule hydrogel was developed to accelerate full-thickness healing of skin wounds. The hydrogel exhibited sufficient mechanical strength, fatigue resistance, and various healing properties. It was constructed with multiple crosslinking networks to enhance its suitability for clinical applications. Additionally, the hydrogel demonstrated potent antibacterial and vascularization capabilities. Animal experiments confirmed that this biological macromolecule hydrogel has great potential as an acute wound-healing dressing.
Article
Biochemistry & Molecular Biology
M. C. Linju, M. R. Rekha
Summary: The present study developed a L-proline conjugated chitosan scaffold for wound healing. The scaffold was characterized by various tests and showed no cytotoxicity. In vitro experiments demonstrated that the modified scaffold promoted wound closure and collagen deposition. These findings suggest that the L-proline conjugated scaffold has potential as a wound dressing to improve wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Biomedical
Sarah Al-Maawi, Sandra Rother, Norbert Halfter, Karen M. Fiebig, Juliane Moritz, Stephanie Moeller, Matthias Schnabelrauch, Charles James Kirkpatrick, Robert Sader, Hans-Peter Wiesmann, Dieter Scharnweber, Vera Hintze, Shahram Ghanaati
Summary: This study aimed to functionalize a collagen-based scaffold with high-sulfated hyaluronan and investigate its properties in vitro and in vivo. The results showed that covalent binding of high-sulfated hyaluronan to collagen released only a marginal amount of the hyaluronan, while electrostatic binding released more. The covalent binding scaffolds showed reduced release of vascular endothelial growth factor and transforming growth factor beta 1, but increased release of interleukin-8 and epithelial growth factor compared to other scaffolds. In vivo, the covalent binding scaffolds reduced the proinflammatory macrophage response and did not induce multinucleated giant cell formation, while maintaining a stable structure and integration into the implantation region. This functionalized collagen scaffold has potential as a stable biomaterial for full-thickness skin regeneration.
BIOACTIVE MATERIALS
(2022)
Article
Engineering, Biomedical
Shen Guo, Minghao Yao, Dan Zhang, Yuanmeng He, Rong Chang, Yikun Ren, Fangxia Guan
Summary: The study developed a one-step synthetic hydrogel based on quaternized chitosan, tannic acid, and ferric iron, with high adhesiveness, antibacterial activity, and photothermal property. In mouse models, it showed effective wound closure and accelerated wound healing, demonstrating great potential for clinical applications in wound management.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Pharmacology & Pharmacy
Mansi Budhiraja, Sobiya Zafar, Sohail Akhter, Majed Alrobaian, Md Abdur Rashid, Md. Abul Barkat, Sarwar Beg, Farhan J. Ahmad
Summary: This study developed a combinational drug delivery system by embedding mupirocin-loaded chitosan microspheres in a collagen scaffold containing Piper betle extract, aiming to improve wound healing. The results showed that this method effectively promoted wound healing and exhibited good antibacterial effects.
Article
Multidisciplinary Sciences
Lianglong Chen, Chaoyang Huang, Yu Zhong, Yujia Chen, Huihui Zhang, Zijun Zheng, Ziwei Jiang, Xuerong Wei, Yujie Peng, Lei Huang, Libin Niu, Yanbin Gao, Jun Ma, Lei Yang
Summary: In this study, a compound network with physical-chemical double cross-linking was constructed using chemical cross-linking and the intertwining of ADM and chito-san chains under freezing conditions. The heparin-modified composite scaffold with good biocompatibility and cell/tissue affinity significantly promoted cell adhesion and proliferation to achieve adequate fixation and slow down the release of CGF. Polydopamine nanoparticles with excellent photothermal conversion ability promoted the survival of rat autologous skin grafts. In conclusion, this multifunctional composite scaffold shows great potential in delivering CGF to promote healing of full-thickness skin defects.
Article
Ophthalmology
Christopher Donovan, Devon Cogswell, Mei Sun, Sheila Adams, Marcel Y. Avila, Curtis E. Margo, Manuel Koch, Edgar M. Espana
Summary: The role of collagen XII in corneal injury repair and function restoration is investigated in this study. Incisional and debridement injuries were created in adult mice model to study the effects of collagen XII on wound closure and scar formation. The results showed that collagen XII is a regulator of wound closure, and its absence delays the wound healing process. Collagen XII regulates fibrillogenesis, CD68 cell lineage infiltration, and myofibroblast survival following injury. In vitro studies suggest that collagen XII interacts with fibronectin and LTBP1 to regulate early matrix deposition. Overall, understanding the function of collagen XII in wound healing has significant translational value in clinical applications.
EXPERIMENTAL EYE RESEARCH
(2023)
Article
Materials Science, Multidisciplinary
Rachita Lakra, Manikantan Syamala Kiran, Purna Sai Korrapati
Summary: Collagen plays a crucial role in wound healing, and furfural stabilized collagen has been found to have good blood compatibility and compatibility with tissue. Animal experiments have shown that the use of furfural stabilized collagen can promote cellular activities and facilitate wound recovery.
