Review
Biochemistry & Molecular Biology
Shasha Yin, Liu Liu, Wenjian Gan
Summary: The mechanistic target of rapamycin (mTOR) regulates cell growth, proliferation, and metabolism by integrating various environmental inputs, controlling processes like nucleotide, protein, and lipid synthesis, autophagy, and apoptosis. Dysregulation of mTOR pathway is linked to diseases like cancers, metabolic disorders, and neurodegenerative diseases, often caused by genetic alterations or post-translational modifications. Research on PTMs-mediated regulation of mTOR signaling and targeting mTOR pathway and PTM-related enzymes for disease treatment has advanced significantly in recent years.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Paolo Zanoni, Grigorios Panteloglou, Alaa Othman, Joel T. Haas, Roger Meier, Antoine Rimbert, Marta Futema, Yara Abou Khalil, Simon F. Norrelykke, Andrzej J. Rzepiela, Szymon Stoma, Michael Stebler, Freerk van Dijk, Melinde Wijers, Justina C. Wolters, Nawar Dalila, Nicolette C. A. Huijkman, Marieke Smit, Antonio Gallo, Valerie Carreau, Anne Philippi, Jean-Pierre Rabes, Catherine Boileau, Michele Visentin, Luisa Vonghia, Jonas Weyler, Sven Francque, An Verrijken, Ann Verhaegen, Luc Van Gaal, Adriaan van der Graaf, Belle V. van Rosmalen, Jerome Robert, Srividya Velagapudi, Mustafa Yalcinkaya, Michaela Keel, Silvija Radosavljevic, Andreas Geier, Anne Tybjaerg-Hansen, Mathilde Varret, Lucia Rohrer, Steve E. Humphries, Bart Staels, Bart van de Sluis, Jan Albert Kuivenhoven, Arnold von Eckardstein
Summary: This study identified a novel mechanism of posttranscriptional regulation of LDLR activity in humans and found associations of genetic variants of RBM25 with LDL-cholesterol levels.
CIRCULATION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Kathleen Saavedra, Karla Leal, Nicolas Saavedra, Yalena Prado, Isis Paez, Carmen G. Ubilla, Gabriel Rojas, Luis A. Salazar
Summary: The expression of hsa-miR-20a-5p was repressed after atorvastatin treatment in hypercholesteremic patients and in HepG2 cells. In HepG2 cells, repression of hsa-miR-20a-5p increased LDLR gene and protein expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Peripheral Vascular Disease
Sang Joon Ahn, Ibra S. Fancher, Sara T. Granados, Natalia F. Do Couto, Chueh-Lung Hwang, Shane A. Phillips, Irena Levitan
Summary: Studies have shown that endothelial Kir2.1 channels play a significant role in vasodilation, while high cholesterol levels inhibit this function. Through mouse models and human experiments, it was further confirmed that there is a negative correlation between high LDL cholesterol levels and FIV, and the regulatory mechanism of Kir2.1 in this process was explored.
Review
Hematology
Mitri K. Khoury, Huan Yang, Bo Liu
Summary: Macrophages play a key functional role in the pathogenesis of various cardiovascular diseases by accumulating within the vessel wall and leading to sustained local inflammatory responses. Recent findings focus on the origin, survival/death, and phenotypic switching of macrophages within vessel walls.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yuanlu Shu, Xiang Zhao, Changshun Yang, Yan Yan, Yao Zheng, Xijie Wang, Chengfeng Qiu
Summary: Recent evidence suggests that elevated serum PK levels are associated with the likelihood of hypercholesterolemia and hypertriglyceridemia. A nonlinear relationship between serum PK and HDL-C levels was observed. Higher levels of PK may be a risk factor for cardiovascular diseases.
LIPIDS IN HEALTH AND DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Aleksandra Jawiarczyk-Przybylowska, Justyna Kuliczkowska-Plaksej, Katarzyna Kolackov, Agnieszka Zembska, Jowita Halupczok-Zyla, Malgorzata Rolla, Michal Miner, Marcin Kaluzny, Marek Bolanowski
Summary: The study reveals that the polymorphisms of the FTO gene are associated with lipid metabolism and an increased risk of cardiovascular diseases in patients with acromegaly. Furthermore, these polymorphisms also have an impact on IGF-1 synthesis. Larger scale investigations are needed for more precise evidence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Zhuojun Wu, Vera Jankowski, Joachim Jankowski
Summary: Despite the use of medication for the prevention of cardiovascular diseases, it remains the leading cause of death globally. Non-enzymatic post-translational modifications of proteins and lipoproteins play a significant role in the development of cardiovascular diseases. Factors such as renal insufficiency and metabolic imbalance contribute to the increased frequency of these modifications. Understanding these modifications can provide new insights for risk assessment, prevention, and treatment of cardiovascular diseases.
MOLECULAR ASPECTS OF MEDICINE
(2022)
Review
Medicine, Research & Experimental
Xiaohan Liu, Peiyi Luo, Weiyun Zhang, Shuxian Zhang, Shulong Yang, Fenfang Hong
Summary: Pyroptosis is a pro-inflammatory type of regulated cell death that is closely related to the formation and development of atherosclerosis. It not only causes local inflammation, but also amplifies the inflammatory response, leading to plaque instability and eventually resulting in acute cardiovascular events.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
Wenqian Zhou, He Cai, Jia Li, He Xu, Xiang Wang, Hongbo Men, Yang Zheng, Lu Cai
Summary: MED13 plays critical roles in cell cycle regulation, development, growth, myocardial energy metabolism, and non-metabolic cardiovascular diseases. It is a potential therapeutic target for metabolic disorders and cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Hematology
Oriane Marmontel, Yara Abou-Khalil, Olivier Bluteau, Bertrand Cariou, Valerie Carreau, Sybil Charriere, Eleonore Divry, Antonio Gallo, Philippe Moulin, Francois Paillard, Noel Peretti, Jean-Pierre Rabes, Mathilde Varret, Alain Carrie, Mathilde Di Filippo
Summary: This study investigated the phenotype of 21 adult patients who carried rare LDLR and APOE variants in a French cohort. The results showed that LDLR+APOE carriers had higher blood lipid levels and a higher incidence of premature atherosclerotic cardiovascular diseases compared to LDLR carriers alone.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yu-Jin Kwon, Gyung-Min Lee, Kwang-Hyeon Liu, Dong-Hyuk Jung
Summary: The study showed that Korean red ginseng reduces serum ceramide levels in postmenopausal women with hypercholesterolemia, indicating its potential benefit in preventing cardiovascular disease.
Article
Medicine, Research & Experimental
Haoteng Ke, Zexing Chen, Xuanbin Zhao, Chaobo Yang, Tao Luo, Wen Ou, Lizi Wang, Haiqiong Liu
Summary: Activation transcription factor 3 (ATF3), a member of the ATF/cyclic adenosine monophosphate response element binding family, has been shown to play multiple roles in the development and progression of cardiovascular diseases. It can have detrimental effects but also function as a cardioprotective molecule. This review aims to explore the protective effects and mechanisms of ATF3 on cardiac dysfunction, providing evidence for the prevention and cure of cardiovascular diseases.
Article
Medicine, Research & Experimental
Miriam Solomon, Vito Fodera, Annette Eva Langkilde, Perry Elliott, Fabrizio Tagliavini, Trevor Forsyth, Oxana Klementieva, Vittorio Bellotti
Summary: This report presents recommendations for addressing translational challenges in amyloid disease research. Key suggestions include improving cross-cultural communication between basic science and clinical research, increasing the influence of scientific societies and journals, improving the dissemination of negative results, and strengthening the ethos of science.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Giusy Rita Caponio, David Q. -H. Wang, Agostino Di Ciaula, Maria De Angelis, Piero Portincasa
Summary: Hypercholesterolemia is a key pathophysiological factor predisposing to an increased risk of developing cardiovascular disease worldwide. Controlling plasma cholesterol levels and other metabolic risk factors is crucial for preventing the overall burden of disease arising from cardiovascular disease-related morbidity and mortality.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
