Article
Biochemistry & Molecular Biology
Deniz Ceylanli, Ahmet Ozer Sehirli, Sevgi Gencosman, Kerem Terali, Huseyin Sah, Nurhayat Gulmez, Serkan Sayiner
Summary: This study found that ALA has potential protective benefits against 5-FU-induced gastrointestinal mucositis. ALA can reduce inflammation and oxidative stress caused by mucositis, promote tissue repair, and have significant implications for cancer patients, especially those receiving 5-FU therapy.
Review
Nutrition & Dietetics
Ruey-Yu Hsieh, I-Chen Huang, Chiehfeng Chen, Jia-Ying Sung
Summary: Alpha-lipoic acid (ALA) improves symptoms in patients with diabetic sensorimotor peripheral neuropathy (DSPN) by reducing oxidative stress and improving microcirculation. A meta-analysis of randomized controlled trials (RCTs) evaluated the effects of orally-administered ALA versus placebo in patients with DSPN, finding that ALA treatment had favorable effects on sensory symptoms, total symptoms' score (TSS), neurological disability score (NDS), and global satisfaction. However, it did not produce favorable results for vibration perception, nerve conduction, and neuropathy impairment.
Article
Environmental Sciences
Ahmed Massoud, Moustafa SaadAllah, Naief A. Dahran, Nasr Elsayed Nasr, Ismael El-Fkharany, Mohamed S. Ahmed, Khalaf F. Alsharif, Ehab Kotb Elmahallawy, Aly Derbalah
Summary: The toxicity of organophosphorus insecticides, such as malathion, is a major global health concern. This study investigated the effects of prolonged exposure to low doses of malathion on enzyme activity and histopathology in animal models. The results showed significant changes in enzyme activity and various organ pathologies in rats treated with malathion for an extended period.
FRONTIERS IN ENVIRONMENTAL SCIENCE
(2022)
Review
Immunology
Sahar Sheikholeslami, Shaghayegh Khodaverdian, Masoumeh Dorri-Giv, Seyyed Mohammad Hosseini, Shokoufeh Souri, Razzagh Abedi-Firouzjah, Hamed Zamani, Leila Dastranj, Bagher Farhood
Summary: This study reviewed the potential role of alpha-lipoic acid in alleviating radiation-induced toxicities in healthy cells/tissues. Experimental results showed that this radio-protective agent could alleviate radiation-induced toxicities through mechanisms such as anti-oxidant, antiapoptosis, and anti-inflammatory effects. Co-treatment of alpha-lipoic acid with radiotherapy could ameliorate the radiation-induced toxicities in healthy cells/tissues.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Qingxiu Liu, Wenxiang Li, Shimeng Huang, Lihong Zhao, Jianyun Zhang, Cheng Ji, Qiugang Ma
Summary: The study investigated the effectiveness of alpha-lipoic acid with different optical rotation in alleviating inflammation and oxidative stress in laying hens induced by oxidized fish oil. The results showed that the addition of alpha-lipoic acid reduced the levels of inflammatory factors, increased the activity of antioxidant indexes, and decreased the content of oxidative factor MDA. Moreover, R-form of alpha-lipoic acid was more effective than S-form. These findings provide basic data for the potential development of alpha-lipoic acid as a chiral dietary additive for laying hens.
Article
Food Science & Technology
Wei Wang, Dandan Zhang, Lei Sun, Zihao Zhang, Yiwen Zhang, Yongteng Zhang, Yunhai Zhang, Mianqun Zhang
Summary: In this study, we found that supplementing oocytes with alpha lipoic acid (ALA) can reverse cyclophosphamide (CY)-induced oocyte meiotic maturation failure. ALA supplementation effectively protects oocytes from CY-exposed deterioration by suppressing oxidative stress-induced DNA damage and apoptosis.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Nutrition & Dietetics
Shihui Guo, Kai Yan, Xi Fang, Yingdong Ni, Wenqiang Ma, Ruqian Zhao
Summary: The supplementation of alpha-lipoic acid was found to reduce plasma triglyceride levels and hepatic triglyceride content in Sprague-Dawley rats. This reduction in hepatic lipid deposition was associated with changes in lipid metabolism-related gene expression and miRNA-mediated regulatory mechanisms.
Article
Biochemistry & Molecular Biology
Mateusz Zwierz, Adrian Chabowski, Klaudia Sztolsztener
Summary: This study investigated the potential therapeutic effects of alpha-lipoic acid on the inflammatory response during the development and progression of simple steatosis into steatohepatitis. The results showed that alpha-lipoic acid supplementation attenuated inflammation and had a potential protective effect on the liver.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Review
Chemistry, Medicinal
Nahid Najafi, Soghra Mehri, Mahboobeh Ghasemzadeh Rahbardar, Hossein Hosseinzadeh
Summary: This study discusses the effects of alpha-lipoic acid (alpha-LA) on different components of metabolic syndrome (MetS) and the underlying molecular mechanisms. Alpha-LA has various pharmacological effects, including antidiabetic, antiobesity, hypotensive, and hypolipidemic actions. It can improve the components of MetS, reduce cholesterol biosynthesis and atherosclerosis, and increase insulin secretion and sensitivity.
PHYTOTHERAPY RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Nabil A. Alhakamy, Gamal A. Mohamed, Usama A. Fahmy, Basma G. Eid, Mohammed W. Al-Rabia, Amgad I. M. Khedr, Mohammed Z. Nasrullah, Sabrin R. M. Ibrahim, Ashraf B. Abdel-Naim, Osama A. A. Ahmed, Shadab Md
Summary: This study aimed to design a hydrogel formula loaded with thioctamer, a nanoconjugate of thioctic acid (TA) and glatiramer acetate (GA), and evaluate its efficacy in expedited wound healing in a rat model of diabetic wound. The results demonstrated that thioctamer significantly enhanced wound healing and inhibited inflammation markers, showing its potential as a promising treatment for diabetic wounds.
Article
Environmental Sciences
Hossam G. Tohamy, Mohamed A. Lebda, Kadry M. Sadek, Mohamed S. Elfeky, Yasser S. El-Sayed, Dalia H. Samak, Heba S. Hamed, Tarek K. Abouzed
Summary: Silver nanoparticles have negative effects on the testicles, but cotreatment with alpha-lipoic acid (LA) or Ginkgo biloba (GB) can alleviate these effects. The study demonstrates that LA or GB reduces serum testosterone levels, mitigates oxidative stress and apoptosis markers, and protects the testicles in adult rats exposed to silver nanoparticles.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Kaio Murilo Monteiro Espindola, Everton Luiz Pompeu Varela, Rosyana de Fatima Vieira de Albuquerque, Rosiane Araujo Figueiredo, Savio Monteiro dos Santos, Nivea Silva Malcher, Pamela Suelen da S. Seabra, Andreia do Nascimento Fonseca, Karla Marcely de Azevedo Sousa, Susan Beatriz Batista de Oliveira, Agnaldo da Silva Carneiro, Michael D. Coleman, Marta Chagas Monteiro
Summary: This study evaluated the protective effect of racemic alpha lipoic acid (ALA) and its enantiomers on methemoglobin induction caused by Dapsone (DDS) therapy. The results showed that ALA could effectively inhibit the formation of methemoglobin induced by DDS-NOH and reduce DNA damage. This study suggests that ALA could be used as a treatment in patients who chronically use DDS, including leprosy patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Noha F. Abdelkader, Ahmed I. El-Batal, Yara M. Amin, Asrar M. Hawas, Seham H. M. Hassan, Nihad I. Eid
Summary: This study investigates the neuroprotective effects of gold nanoparticles and alpha-lipoic acid mixture on brain damage caused by radiation in rats. The results show that the mixture can alleviate oxidative stress, DNA damage, and histopathological changes in brain tissues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Dan Wu, Qi Sun, Wei Wei, Yinglong Bai, Lingling Zhai, Lihong Jia
Summary: This study developed an in vitro model using HT-22 mouse hippocampal neuronal cell line to investigate the neurotoxic mechanism of BPA and the protective effect of ALA on Nrf2 inhibition. The results showed that BPA caused oxidative damage to HT-22 cells by impairing mitochondrial function, nNOS, and the keap1/Nrf2 system, thereby affecting synaptic-related proteins and the PKC/ERK/CREB pathway. ALA countered BPA-induced damage via Nrf2 activation, which may be a significant target for the protective action of ALA.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Aaron Priester, Richard Waters, Ashleigh Abbott, Krista Hilmas, Klaus Woelk, Hunter A. Miller, Aria W. Tarudji, Connor C. Gee, Brandon McDonald, Forrest M. Kievit, Anthony J. Convertine
Summary: This study designed a material that can rapidly bind and neutralize reactive oxygen species (ROS) and lipid peroxidation product (LPOx) after traumatic brain injury (TBI). These neuroprotective copolymers (NPCs) showed promise for improved target engagement of multiple biochemical derangements and reduction of post-traumatic oxidative stress, potentially leading to improved TBI therapeutic outcomes.
