Journal
JOURNAL OF BIOMEDICAL OPTICS
Volume 19, Issue 7, Pages -Publisher
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.JBO.19.7.077001
Keywords
spectroscopy; terahertz; tissue diagnostics
Funding
- NSAF [U1230128]
- NSFC [61205100]
- Key Foundation of CAEP [2012A0401016]
- CPSF [2014M552542XB]
- NSF of Chongqing [cstc2012jjB0081]
- Incubation Foundation of Interdisciplinary Laboratory of Physics and Biomedicine
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The refractive indices, absorption coefficients, and complex dielectric constants of paraffin-embedded brain glioma and normal brain tissues have been measured by a terahertz time-domain spectroscopy (THz-TDS) system in the 0.2- to 2.0-THz range. The spectral differences between gliomas and normal brain tissues were obtained. Compared with normal brain tissue, our results indicate that paraffin-embedded brain gliomas have a higher refractive index, absorption coefficient, and dielectric constant. Based on these results, the best THz frequencies for different methods of paraffin-embedded brain glioma imaging, such as intensity imaging, coherent imaging with continuum THz sources, and THz pulsed imaging with short-pulsed THz sources, are analyzed. (C) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License.
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