Journal
JOURNAL OF BIOMEDICAL OPTICS
Volume 19, Issue 7, Pages -Publisher
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.JBO.19.7.071412
Keywords
optical coherence tomography; multimodal imaging; photoacoustic imaging; nonlinear optical microscopy; optical coherence angiography; akinetic swept source
Funding
- Medical University of Vienna
- European projects FAMOS ( FP7) [ICT 317744]
- FUN OCT( FP7 HEALTH) [201880]
- Macular Vision Research Foundation
- Austrian Science Fund (FWF) [S10510-N20]
- Christian Doppler Society (Christian Doppler Laboratory Laser development and their application in medicine)
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In the last 25 years, optical coherence tomography (OCT) has advanced to be one of the most innovative and most successful translational optical imaging techniques, achieving substantial economic impact as well as clinical acceptance. This is largely owing to the resolution improvements by a factor of 10 to the submicron regime and to the imaging speed increase by more than half a million times to more than 5 million A-scans per second, with the latter one accomplished by the state-of-the-art swept source laser technologies that are reviewed in this article. In addition, parallelization of OCT detection, such as line-field and full-field OCT, has shortened the acquisition time even further by establishing quasi-akinetic scanning. Besides the technical improvements, several functional and contrast-enhancing OCT applications have been investigated, among which the label-free angiography shows great potential for future studies. Finally, various multimodal imaging modalities with OCT incorporated are reviewed, in that these multimodal implementations can synergistically compensate for the fundamental limitations of OCT when it is used alone. (C) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License.
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