Article
Biochemical Research Methods
Babak Ghafaryasl, Koenraad A. Vermeer, Jeroen Kalkman, Tom Callewaert, Johannes F. de Boer, Lucas J. van Vliet
Summary: Optical coherence tomography (OCT) is widely used for capturing structural information of tissues for clinical tasks such as diagnosing retinal and vascular diseases. Recently, there has been a growing interest in the field of ophthalmology for utilizing optical tissue properties for diagnosis and disease progression.
BIOMEDICAL OPTICS EXPRESS
(2021)
Article
Biochemical Research Methods
Hsun-Chia Hsu, Keitha Wear, Tjoshua Pfefer, William C. Vogt
Summary: Phantom-based performance test methods are crucial for the development and clinical translation of emerging photoacoustic microscopy devices. A dermis-mimicking tissue-mimicking material (TMM) based on polyacrylamide hydrogels was developed for constructing image quality phantoms to evaluate PAM systems. The TMM was optically characterized over a range of wavelengths and acoustically characterized with a confident extrapolation throughout the usable band of the PAM system, showing broad tunability with specific formulations to mimic human dermis.
BIOMEDICAL OPTICS EXPRESS
(2022)
Article
Chemistry, Physical
Paulina Listewnik, Monika Ronowska, Michal Wasowicz, Valery V. Tuchin, Malgorzata Szczerska
Summary: The research investigates the stability of fabricated porous phantoms, which can be used as a lung phantom in optical systems. Measurements were performed multiple times over 6-month intervals using the same measuring system to determine scattering and absorption parameters.
Article
Multidisciplinary Sciences
Min-Su Kim, Ki-Yup Nam, Young Hoon Hwang, Min-Woo Lee, Woo-Hyuk Lee, Hyung-Bin Lim, Jung-Yeul Kim
Summary: It was found that Weiss ring located near the optic disc can affect the measurement of peripapillary retinal nerve fiber layer (pRNFL) thickness, especially in the inferior quadrant and average values. Therefore, it is important to consider the presence of Weiss ring when analyzing pRNFL thickness.
SCIENTIFIC REPORTS
(2022)
Article
Biochemical Research Methods
Johannes Kuebler, Vincent S. Zoutenbier, Gijs Buist, Joerg Fischer, Arjen Amelink, Johannes F. de Boer
Summary: Optical coherence tomography (OCT) is used for imaging tissue structures, and calibrating intensity values can provide information on the tissue's optical properties. This study explores the feasibility of extracting the focus position from OCT scans using the system's chromatic aberration.
BIOMEDICAL OPTICS EXPRESS
(2023)
Article
Acoustics
Anastasia Antoniou, Christakis Damianou
Summary: The study found that Polyacrylamide (PAA) and agar-based phantoms are capable of accurately replicating critical properties of human tissues, especially for MRgFUS technology. PAA gels offer optical transparency for direct visualization of coagulative lesions, while agar has low preparation costs and is suitable for MRgFUS applications.
Article
Computer Science, Information Systems
Mukhit Kulmaganbetov, Ryan J. Bevan, Nantheera Anantrasirichai, Alin Achim, Irina Erchova, Nick White, Julie Albon, James E. Morgan
Summary: This study successfully classified the structural composition of OCT phantoms through texture analysis of OCT images. By comparing the subtle changes in light scattering of OCT images, different phantom textures could be accurately distinguished.
Article
Biochemical Research Methods
Mengyang Zhao, Mingwei Zhou, Xu Cao, Jinchao Feng, Brian W. Pogue, Keith D. Paulsen, Shudong Jiang
Summary: A new type of long-lasting phantom was developed with commercially available materials, which is easy to fabricate and has good control in optical properties. It also provides contrast for CT and MRI. The fabrication time is short and the optical properties are stable, suitable for multimodality imaging studies involving CT or MRI.
JOURNAL OF BIOMEDICAL OPTICS
(2023)
Article
Optics
Howard Peng Sin Heng, Chi Shu, Wei Zheng, Zhiwei Huang
Summary: We report the development of a novel coaxial double-clad-fiber (DCF) and graded-index (GRIN) fiberoptic Raman probe for enhancing in vivo epithelial tissue Raman measurements. The probe can acquire high-quality Raman spectra from various oral tissues within sub-seconds and detect subtle biochemical differences between different epithelial tissues, suggesting its potential for in vivo diagnosis and characterization.
Article
Engineering, Biomedical
Lina Hacker, Heidrun Wabnitz, Antonio Pifferi, T. Joshua Pfefer, Brian W. Pogue, Sarah E. Bohndiek
Summary: This perspective paper discusses the lack of accepted standards and suitable phantoms for the technical validation of biophotonic instrumentation, emphasizing the need for standardization and criteria in this field. By reviewing literature and developments, the paper identifies unmet needs and proposes a set of criteria for the standardization of biophotonic instrumentation.
NATURE BIOMEDICAL ENGINEERING
(2022)
Article
Biochemical Research Methods
Shuang Chang, Jessica Handwerker, Giovanna A. Giannico, Sam S. Chang, Audrey K. Bowden
Summary: This study introduces a method for fabricating birefringent tissue phantoms using PDMS and demonstrates its application in mimicking bladder wall layers. PDMS allows precise control of tissue scattering and thickness, and exhibits controllable birefringent properties.
JOURNAL OF BIOMEDICAL OPTICS
(2022)
Article
Biotechnology & Applied Microbiology
Gongpu Lan, Qun Shi, Yicheng Wang, Guoqin Ma, Jing Cai, Jinping Feng, Yanping Huang, Boyu Gu, Lin An, Jingjiang Xu, Jia Qin, Michael D. Twa
Summary: This study analyzed the natural frequency of corneal tissue using optical coherence tomography-based elastography. The results showed that the natural frequency can reveal local variations in tissue structure and can differentiate different types of tissues. This method could provide additional information on corneal properties and be a useful tool for clinical detection of ocular disease and evaluation of treatment outcomes.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Francesco Romano, Salvatore Parrulli, Maurizio Battaglia Parodi, Marco Lupidi, Matteo Cereda, Giovanni Staurenghi, Alessandro Invernizzi
Summary: This study assessed OCT features of repair tissue in neovascular age-related macular degeneration patients with RPE tear, finding that most eyes showed signs of tissue repair during follow-up. Visual outcomes were predominantly predicted by the number of injections, RPE-SHT reflectivity, and presence of SMH.
SCIENTIFIC REPORTS
(2021)
Article
Optics
Jianan Fang, Kun Huang, E. Wu, Ming Yan, Heping Zeng
Summary: This article introduces an infrared 3D imaging system capable of detecting three-dimensional structure and reflectivity information. The system operates at single-photon sensitivity and femtosecond timing resolution, enabling imaging under low-light conditions. By nonlinear frequency upconversion and recording with a silicon camera, the presented system achieves high lateral and depth resolutions for 3D reconstruction. Additionally, a numerical denoiser based on spatiotemporal correlation allows the retrieval of object profile and reflectivity even with a detected flux below 0.05 photons/pixel/second. This infrared 3D imager features high detection sensitivity, precise timing resolution, and wide-field operation, offering new possibilities in life and material sciences.
LIGHT-SCIENCE & APPLICATIONS
(2023)
Article
Biochemical Research Methods
Johannes Kuebler, Vincent S. Zoutenbier, Arjen Amelink, Joerg Fischer, Johannes F. de Boer
Summary: The study presents a method for compensating the confocal function and accurately determining the attenuation coefficient from OCT data. Through extensive measurement series, the optimal focus plane difference is determined for models with different scatterer concentrations, enabling calculation of the attenuation coefficient corrected for the confocal function. The method demonstrates good reproducibility in determining the attenuation coefficient for layers with identical scatter concentrations in a multi-layered phantom.
BIOMEDICAL OPTICS EXPRESS
(2021)
Article
Neurosciences
Hyounguk Jang, Stanley Huang, Daniel X. Hammer, Lin Wang, Harmain Rafi, Meijun Ye, Cristin G. Welle, Jonathan A. N. Fisher
Article
Engineering, Biomedical
Srikanth Vasudevan, Jesse Vo, Benjamin Shafer, Ahhyun S. Nam, Benjamin J. Vakoc, Daniel X. Hammer
JOURNAL OF NEURAL ENGINEERING
(2019)
Article
Materials Science, Multidisciplinary
Andrew C. Lamont, Michael A. Restaino, Abdullah T. Alsharhan, Zhuolin Liu, Daniel X. Hammer, Ryan D. Sochol, Anant Agrawal
OPTICAL MATERIALS EXPRESS
(2020)
Article
Biochemical Research Methods
Andrew J. Bower, Tao Liu, Nancy Aguilera, Joanne Li, Jianfei Liu, Rongwen Lu, John P. Giannini, Laryssa A. Huryn, Alfredo Dubra, Zhuolin Liu, Daniel X. Hammer, Johnny Tam
Summary: The study developed an imaging platform combining multimodal AO-SLO with AO-OCT to compare four different modalities for imaging RPE cells in the same eye. Consistent cellular structure information was obtained across modalities, with variations in RPE cell contrast explored in a subject-, location-, and even cell-dependent manner. The benefit of using multiple modalities to infer the cellular structure of the RPE mosaic in an affected eye was illustrated through multimodal imaging in a patient with choroideremia.
BIOMEDICAL OPTICS EXPRESS
(2021)
Article
Geriatrics & Gerontology
Joanne Li, Tao Liu, Oliver J. Flynn, Amy Turriff, Zhuolin Liu, Ehsan Ullah, Jianfei Liu, Alfredo Dubra, Mary A. Johnson, Brian P. Brooks, Robert B. Hufnagel, Daniel X. Hammer, Laryssa A. Huryn, Brett G. Jeffrey, Johnny Tam
Summary: A 3-year longitudinal study on a patient with oligocone trichromacy (OT) revealed persistent dark cones within and near the macula, but the patient had normal visual acuity, retinal sensitivity, and color vision. The findings suggest that a retina with predominant dark cones can support near normal central retinal function for at least 3 years, indicating that cones can survive under non-ideal conditions.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Optics
Somayyeh Soltanian-Zadeh, Kazuhiro Kurokawa, Zhuolin Liu, Furu Zhang, Osamah Saeedi, Daniel X. Hammer, Donald T. Miller, Sina Farsiu
Summary: Cell-level quantitative features of retinal ganglion cells (GCs) are important biomarkers for neurodegenerative diseases, with adaptive optics OCT enabling in vivo imaging. Weakly supervised deep learning-based automated segmentation of GC layer somas from AO-OCT volumes is as good as or even better than human experts, showing increased structure-function correlation in glaucoma subjects.
Article
Chemistry, Multidisciplinary
Christopher T. Le, Dongyi Wang, Ricardo Villanueva, Zhuolin Liu, Daniel X. Hammer, Yang Tao, Osamah J. Saeedi
Summary: This study introduces the application of adaptive optics-optical coherence tomography (AO-OCT) in studying ocular diseases, proposing a novel bidirectional long short-term memory (LSTM)-based network for 3D-2D segmentation of blood vessels. By comparing it with a standard 2D UNet segmentation network, the proposed LSTM-UNet model shows statistically significant improvements in AUC and recall, demonstrating enhanced performance in automated vessel segmentation within AO-OCT volumes.
APPLIED SCIENCES-BASEL
(2021)
Article
Biochemical Research Methods
Zhuolin Liu, Furu Zhang, Kelvy Zucca, Anant Agrawal, Daniel X. Hammer
Summary: This research describes a multimodal and multifunctional adaptive optics system that combines scanning laser ophthalmoscopy and optical coherence tomography for simultaneous retinal imaging. The system achieves high resolution and sensitivity and provides functional assessment of retinal cells and structures. It is a powerful platform for studying various retinal and neurological diseases.
BIOMEDICAL OPTICS EXPRESS
(2022)
Article
Biochemical Research Methods
Somayyeh Soltanian-Zadeh, Zhuolin Liu, Yan Liu, Ayoub Lassoued, Catherine A. Cukras, Donald T. Miller, Daniel X. Hammer, Sina Farsiu
Summary: Objective quantification of photoreceptor cell morphology using AO-OCT is crucial for early and accurate diagnosis of retinal neurodegenerative diseases. We propose a comprehensive deep learning framework to automate the process of segmenting individual cone cells in AO-OCT scans, achieving human-level performance in assessing cone photoreceptors.
BIOMEDICAL OPTICS EXPRESS
(2023)
Article
Biochemical Research Methods
Ramkumar Sabesan, Kate Grieve, Daniel X. Hammer, Na Ji, Susana Marcos
Summary: This article introduces a special issue commemorating the 25th anniversary of adaptive optics in biomedical research.
BIOMEDICAL OPTICS EXPRESS
(2023)
Meeting Abstract
Clinical Neurology
K. L. Kovalick, C. Chen, Z. Liu, O. Saeedi, D. X. Hammer, D. M. Harrison
MULTIPLE SCLEROSIS JOURNAL
(2023)
Meeting Abstract
Ophthalmology
Ruth E. Woehlke, Daniel X. Hammer, Anant Agrawal, Robert F. Cooper
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Multidisciplinary Sciences
Daniel X. Hammer, Anant Agrawal, Ricardo Villanueva, Osamah Saeedi, Zhuolin Liu
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Proceedings Paper
Ophthalmology
Nikita Kedia, Zhuolin Liu, Ryan Sochol, Daniel X. Hammer, Anant Agrawal
OPHTHALMIC TECHNOLOGIES XXVIII
(2018)
Proceedings Paper
Neuroimaging
Srikanth Vasudevan, Doe Kumsa, Pavel Takmakov, Cristin G. Welle, Daniel X. Hammer
CLINICAL AND TRANSLATIONAL NEUROPHOTONICS; NEURAL IMAGING AND SENSING; AND OPTOGENETICS AND OPTICAL MANIPULATION
(2016)