Article
Multidisciplinary Sciences
Jianpeng Xue, Yang Pu, Jason Smith, Xin Gao, Chun Wang, Binlin Wu
Summary: The study utilized native fluorescence spectroscopy and machine learning algorithms to detect the different metastatic potentials of prostate cancer cells by analyzing the relative concentrations of key molecular components to classify cancer cells, indicating that changes in the relative concentrations of these fluorophores may serve as potential criteria for detecting prostate cancer cells with different metastatic abilities.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Jinchao Chen, Yedie He, Xiaowei Zeng, Shaoxing Zhu, Fangyin Li
Summary: This study compares clinical characteristics, imaging features, pathology, and treatment regimes in patients with adrenal metastases (AMs) and adrenal benign masses (ABMs). The study found that patients with AMs were older and had higher incidence rates compared to patients with ABMs. AMs tended to have larger tumor sizes and higher attenuation values on pre-contrast CT scans. The combination of origin of first malignancy, enhancement pattern, and CT value in the non-enhanced phase can be used to predict AMs.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Sungun Bang, Dongju Won, Saeam Shin, Kang Su Cho, Jae Won Park, Jongsoo Lee, Young Deuk Choi, Suwan Kang, Seung-Tae Lee, Jong Rak Choi, Hyunho Han
Summary: In our study, we discovered genetic mutations in the DNA of cancer cells obtained from the blood of metastatic prostate cancer patients. These mutations were more common in patients with aggressive and progressing cancer that did not respond to conventional treatment. Compared to the traditional method of measuring prostate-specific antigen (PSA) levels, these genetic mutations were more sensitive in detecting prostate cancer progression. This suggests that a simple blood test could be used to track genetic mutations, identify aggressive cancer subtypes, monitor disease progression, and improve the management of advanced prostate cancer.
Article
Oncology
Sae Rom Chung, Jung Hwan Baek, Young Jun Choi, Tae-Yon Sung, Dong Eun Song, Tae Yong Kim, Jeong Hyun Lee
Summary: This study evaluated clinical strategies based on sonographic features of lymph nodes and found that detecting malignant lymph nodes through FNAC or elevated FNA-Tg had a high malignancy rate, while stratification based on sonographic features was necessary for nodes with indeterminate or benign results. A diagnostic algorithm combining FNAC, FNA-Tg, and ultrasound features was proposed for diagnosing metastatic lymph nodes of differentiated thyroid carcinomas.
Article
Pharmacology & Pharmacy
Patrycja Klos, Magdalena Peruzynska, Magdalena Baskiewicz-Halasa, Paulina Skupin-Mrugalska, Malgorzata Majcher, Magdalena Sawczuk, Bartosz Szostak, Marek Drozdzik, Boguslaw Machalinski, Dariusz Chlubek
Summary: The study compared the anti-cancer activity of free thymoquinone and thymoquinone-loaded liposomes on melanoma cells. The results showed that thymoquinone had different antiproliferative and proapoptotic effects on different melanoma cell lines, and thymoquinone-loaded liposomes exhibited stronger cytotoxicity on the cells.
Article
Biochemistry & Molecular Biology
Eun Shin, Seung Hoon Han, Il-Seok Park, Jee Hye Wee, Joong Seob Lee, Heejin Kim
Summary: The study aimed to differentiate inflammatory and malignant necrotic lymph nodes using differentially expressed miRNAs and genes. The differentially expressed miRNAs in inflammatory and tumor necrosis were associated with cancer-related pathways.
Article
Pediatrics
Paolo Bonvini, Elisabetta Rossi, Angelica Zin, Mariangela Manicone, Riccardo Vidotto, Antonella Facchinetti, Lucia Tombolan, Maria Carmen Affinita, Luisa Santoro, Rita Zamarchi, Gianni Bisogno
Summary: Inflammatory myofibroblastic tumors are locally aggressive malignancies that can occur in various sites, with surgery being the main treatment option and generally having a good prognosis. However, for children with unresectable or metastatic tumors, the outcome is particularly severe and hampered by the lack of predictive biomarkers for therapy effectiveness and disease progression.
FRONTIERS IN PEDIATRICS
(2021)
Article
Oncology
Yuxuan Han, Kazushi Azuma, Shinya Watanabe, Kentaro Semba, Jun Nakayama
Summary: Most studies on breast cancer metastasis have focused on triple-negative breast cancer cells, leading to a poor understanding of the metastatic ability of different subtypes of breast cancer. This research aimed to evaluate the metastatic abilities of HER2-positive breast cancer cell lines through injection experiments. The study identified certain cell lines with strong bone metastasis abilities but weak lung metastasis abilities.
CLINICAL & EXPERIMENTAL METASTASIS
(2022)
Review
Biochemistry & Molecular Biology
Ilaria Giusti, Giuseppina Poppa, Giulia Di Fazio, Sandra D'Ascenzo, Vincenza Dolo
Summary: Cancer is a major cause of mortality, and metastases are often the cause of death. Extracellular vesicles (EVs) released by both normal and cancer cells have been shown to modulate various cancer-related processes. Recent studies have highlighted the role of EVs in pre-metastatic niche formation, metastatic dissemination, and their potential as biomarkers for metastatic diseases in liquid biopsy approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Xavier Rousset, Denis Maillet, Emmanuel Grolleau, David Barthelemy, Sara Calattini, Marie Brevet, Julie Balandier, Margaux Raffin, Florence Geiguer, Jessica Garcia, Myriam Decaussin-Petrucci, Julien Peron, Nazim Benzerdjeb, Sebastien Couraud, Jean Viallet, Lea Payen
Summary: The study established a chicken CAM model to analyze the dissemination and metastasis mechanisms of human tumor cells effectively, providing a novel attempt towards personalized medicine.
Article
Oncology
Elisa Van Raemdonck, G. Floris, P. Berteloot, A. Laenen, I. Vergote, H. Wildiers, K. Punie, P. Neven
Summary: In stage IV breast cancer, the conversion of HER2 status is common and primarily observed in hormone receptor-positive tumors. Patients with a positive-to-negative conversion or negative-to-positive conversion showed significant differences in progression free survival and overall survival compared to patients with consistent HER2 status. This study highlights the importance of re-biopsying metastatic lesions and adjusting treatments based on the latest HER2 results.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Article
Oncology
Mei Lin, Qi Yang, Xiong Zou, Rui You, Chong-Yang Duan, You-Ping Liu, Pei-Yu Huang, Yu-Long Xie, Zhi-Qiang Wang, Ting Liu, Si-Yuan Chen, Yi-Jun Hua, Ming-Yuan Chen
Summary: The study found that biopsy of distant metastasis was not associated with impaired survival outcomes for nasopharyngeal carcinoma patients. Patients who underwent biopsy showed comparable survival rates to those who did not undergo biopsy. Therefore, biopsy of distant metastasis could be considered as another diagnostic option for patients with suspected distant metastasis.
Article
Medicine, Research & Experimental
Zahedin Kheyri, Masoomeh Shiravi Khoozani, Moein Ala
Summary: Gastrointestinal metastasis of melanoma is usually asymptomatic and often affects the small intestine and colon. Our patient presented with dyspepsia and was found to have a black lesion in the stomach during upper gastrointestinal endoscopy. Biopsies confirmed the diagnosis of metastatic melanoma.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2022)
Article
Orthopedics
Marisa Ilag, Christopher Burke, William R. Walter, Mohammad Samim
Summary: This study evaluated the imaging features and technical factors associated with the accuracy of image-guided biopsy for soft tissue metastases, as well as its clinical impact on patient outcomes. The results showed that image-guided biopsy had a high diagnostic yield and frequently influenced clinical management. Soft tissue metastases were most commonly located in the trunk and had poor prognosis.
SKELETAL RADIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ruben Varela-Calvino, Marta Rodriguez-Quiroga, Patricia Dias Carvalho, Flavia Martins, Andre Serra-Roma, Lorena Vazquez-Iglesias, Maria Paez de la Cadena, Sergia Velho, Oscar J. Cordero
Summary: The glycoprotein CD26 with peptidase activity and its soluble counterpart DPP4 are altered in several cancers, indicating a potential role in metastasis development and overall survival outcomes in cancer patients. The inhibition of DPP4 enzyme activity by sitagliptin showed reductions in invasion and motility in colorectal cancer cell lines, shedding light on the molecular mechanisms underlying its antimetastatic effects. However, the specific mechanism of action and potential areas for therapeutic applications of DPP4 inhibitors in cancer treatment remain to be fully elucidated.
Article
Radiology, Nuclear Medicine & Medical Imaging
Seokha Jin, SoHyun Han, Radka Stoyanova, Ellen Ackerstaff, HyungJoon Cho
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2020)
Article
Chemistry, Multidisciplinary
Rui Tang, Alexander Zheleznyak, Matthew Mixdorf, Anchal Ghai, Julie Prior, Kvar C. L. Black, Monica Shokeen, Nathan Reed, Pratim Biswas, Samuel Achilefu
Review
Chemistry, Multidisciplinary
Suman B. Mondal, Shaw-Wei D. Tsen, Samuel Achilefu
ADVANCED FUNCTIONAL MATERIALS
(2020)
Article
Biochemical Research Methods
Ethan Bendau, Jason Smith, Lin Zhang, Ellen Ackerstaff, Natalia Kruchevsky, Binlin Wu, Jason A. Koutcher, Robert Alfano, Lingyan Shi
JOURNAL OF BIOPHOTONICS
(2020)
Article
Engineering, Biomedical
Duanwen Shen, Baogang Xu, Kexian Liang, Rui Tang, Gail P. Sudlow, Christopher Egbulefu, Kevin Guo, Avik Som, Rebecca Gilson, Dolonchampa Maji, Suman Mondal, LeMoyne Habimana-Griffin, Walter J. Akers, Shunqiang Li, Yang Liu, Sharon Bloch, Sid Kurkure, Zohar Nussinov, Alexander Seidel, Shaw-Wei D. Tsen, Samuel Achilefu
NATURE BIOMEDICAL ENGINEERING
(2020)
Article
Engineering, Biomedical
Jingyi Luan, Anushree Seth, Rohit Gupta, Zheyu Wang, Priya Rathi, Sisi Cao, Hamed Gholami Derami, Rui Tang, Baogang Xu, Samuel Achilefu, Jeremiah J. Morrissey, Srikanth Singamaneni
NATURE BIOMEDICAL ENGINEERING
(2020)
Article
Oncology
Mayuresh M. Mane, Ivan J. Cohen, Ellen Ackerstaff, Khalid Shalaby, Jenny N. Ijoma, Myat Ko, Masatomo Maeda, Avi S. Albeg, Kiranmayi Vemuri, Jaya Satagopan, Anna Moroz, Juan Zurita, Larissa Shenker, Masahiro Shindo, Tanner Nickles, Ekaterina Nikolov, Maxim A. Moroz, Jason A. Koutcher, Inna Serganova, Vladimir Ponomarev, Ronald G. Blasberg
MOLECULAR THERAPY-ONCOLYTICS
(2020)
Article
Oncology
Kinan Alhallak, Jennifer Sun, Katherine Wasden, Nicole Guenthner, Julie O'Neal, Barbara Muz, Justin King, Daniel Kohnen, Ravi Vij, Samuel Achilefu, John F. DiPersio, Abdel Kareem Azab
Summary: This study developed nanoparticle-based bispecific T-cell engagers (nanoBiTEs) and nanoparticles targeting multiple cancer antigens (nanoMuTEs), overcoming the major limitations of current T-cell-based immunotherapy. These novel nanoparticles have a long half-life, enabling once-a-week administration while maintaining efficacy, with nanoMuTEs targeting multiple cancer antigens showing greater efficacy in myeloma cells.
Article
Multidisciplinary Sciences
Roberta Zappasodi, Inna Serganova, Ivan J. Cohen, Masatomo Maeda, Masahiro Shindo, Yasin Senbabaoglu, McLane J. Watson, Avigdor Leftin, Rachana Maniyar, Svena Verma, Matthew Lubin, Myat Ko, Mayuresh M. Mane, Hong Zhong, Cailian Liu, Arnab Ghosh, Mohsen Abu-Akeel, Ellen Ackerstaff, Jason A. Koutcher, Ping-Chih Ho, Greg M. Delgoffe, Ronald Blasberg, Jedd D. Wolchok, Taha Merghoub
Summary: By blocking CTLA-4, metabolic fitness and immune cell infiltration in tumours, especially those with low glycolytic activity, can be enhanced. This improves therapeutic outcomes, particularly in tumours with defective glycolysis, by destabilizing T-reg cells and promoting the activity of tumour-specific CD8(+) T cells.
Article
Chemistry, Physical
Megan S. Michie, Baogang Xu, Gail Sudlow, Luke E. Springer, Christine T. N. Pham, Samuel Achilefu
Summary: In this study, NIR dye-peptide conjugates were synthesized and it was found that a peptide-driven strategy can alter the aggregation states of molecular probes in aqueous solutions, leading to effective imaging of inflammatory arthritis joints. The results suggest that peptide plays a dominant role in controlling the photophysical properties of these bioconjugates.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2022)
Article
Hematology
Sena Kim, Sora Lim, Boram Kim, Julie Ritchey, Kiran Vij, Julie Prior, Lynne Marsala, Alyssa Stoner, Feng Gao, Samuel Achilefu, Matthew L. Cooper, John F. DiPersio, Jaebok Choi
Summary: By blocking the IFNGR signaling pathway, S100A9 is upregulated in T cells and acts as a novel suppressor of graft-versus-host disease (GVHD) while preserving graft-versus-leukemia (GVL) effects. In both mouse models of allo-HSCT and xenogeneic human peripheral blood mononuclear cell transplantation, overexpression of S100A9 or administration of anti-IFNGR antibody improved GVHD without compromising GVL and reduced T-cell trafficking to GVHD target organs.
Article
Rheumatology
Shaw-Wei D. Tsen, Luke E. Springer, Krishna Sharmah Gautam, Rui Tang, Kexian Liang, Gail Sudlow, Amir Kucharski, Christine T. N. Pham, Samuel Achilefu
Summary: LS301 selectively accumulates in regions of joint pathology in mouse models of RA, with a positive correlation with disease severity. Whole-body near-infrared imaging with LS301 allows tracking of spontaneous disease remission and therapeutic response after dexamethasone treatment. Histological analysis shows preferential accumulation of LS301 within chondrocytes and articular cartilage in arthritic mice, with colocalization observed between LS301 and pANXA2 in joint tissue.
ARTHRITIS RESEARCH & THERAPY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Anchal Ghai, Alexander Zheleznyak, Matt Mixdorf, Julie O'Neal, Julie Ritchey, Michael Rettig, John DiPersio, Monica Shokeen, Samuel Achilefu
Summary: This study demonstrates the feasibility of [Zr-89]DFO-elotuzumab as a companion diagnostic for CS1-targeted therapies.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Meeting Abstract
Oncology
Roberta Zappasodi, Inna Serganova, Ivan Cohen, Masatomo Maeda, Yasin Senbabaoglu, Masahiro Shindo, Rachana Maniyar, Mayuresh Mane, Avigdor Leftin, McLane Watson, Svena Verma, Matthew Lubin, Myat Kyaw Ko, Arnab Ghosh, Mohsen Abu-Akeel, Ellen Ackerstaff, Jason Koutcher, Ping-Chih Ho, Greg Delgoffe, Ronald Blasberg, Jedd Wolchok, Taha Merghoub
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2020)
Meeting Abstract
Oncology
Roberta Zappasodi, Inna Serganova, Ivan Cohen, Masatomo Maeda, Masahiro Shindo, Yasin Senbabaoglu, Avigdor Leftin, Rachana Maniyar, Svena Verma, Matthew Lubin, Myat Kyaw Ko, Mayuresh M. Mane, Arnab Ghosh, Ellen Ackerstaff, Jason A. Koutcher, Ping-Chih Ho, Greg M. Delgoffe, Ronald Blasberg, Jedd D. Wolchok, Taha Merghoub
