Article
Oncology
Ramy Abdlaty, Lilian Doerwald-Munoz, Thomas J. Farrell, Joseph E. Hayward, Qiyin Fang
Summary: Skin cancer is prevalent in the USA, Canada, and Australia, and radiation therapy, while effective, can have side effects such as skin erythema. Monitoring erythema is important, and hyperspectral imaging provides an objective way to do so. The Dawson relative erythema index showed high correlation with clinical visual assessment scores, demonstrating its potential as a valuable tool in skin cancer treatment.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2021)
Article
Oncology
Jolien Robijns, Leen Van Bever, Sanne Hermans, Marithe Claes, Joy Lodewijckx, Melissa Lenaerts, Laura Tuts, Eline Vandaele, Evelien Vinken, Leen Noe, Katleen Verboven, Annelies Maes, Anne-Sophie van de Velde, Paul Bulens, Philippe Bulens, Laura van den Bergh, Jeroen Mebis
Summary: The study demonstrated that the novel multi-active emollient significantly reduced the severity of ARD according to RTOG grading. The impact on quality of life was minimal, and treatment satisfaction was high in both groups.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Optics
Yingwen Zhang, Duncan England, Benjamin Sussman
Summary: This article presents a snapshot hyperspectral imaging technique that utilizes quantum ghost spectroscopy, allowing high spectral resolution without sacrificing spatial resolution and improving resource efficiency.
Article
Optics
Hang Yuan, Pengfei Zhang, Feng Gao
Summary: Compressive sensing has been introduced to accelerate data acquisition in confocal Raman imaging, with unsupervised compressive imaging methods able to maintain high spatial and spectral fidelity simultaneously, as well as smooth transitions at boundaries.
Review
Oncology
Sofiane Allali, Youlia Kirova
Summary: Skin toxicity is a major complication in the management of early-stage breast cancer during irradiation. Understanding and managing these toxicities are crucial for improving patient outcomes.
Article
Polymer Science
Nicholas T. H. Farr, Sameer F. Hamad, Euan Gray, Christopher M. Magazzeni, Fodio Longman, David E. J. Armstrong, Joel P. Foreman, Frederik Claeyssens, Nicola H. Green, Cornelia Rodenburg
Summary: The distribution of methylene and ether bridges affects the mechanical properties of phenolic resin. This study demonstrates the capability of a novel SEM technique, SEHI, to characterize and map these bridges at the nanoscale within the resin.
Review
Plant Sciences
Rijad Saric, Viet D. Nguyen, Timothy Burge, Oliver Berkowitz, Martin Trtilek, James Whelan, Mathew G. Lewsey, Edhem Custovic
Summary: Our ability to manipulate the genome exceeds our capacity to measure genetic changes on plant traits. Plant scientists have been using imaging approaches, specifically hyperspectral imaging, to define plant responses to environmental conditions and optimize crop management.
TRENDS IN PLANT SCIENCE
(2022)
Article
Optics
David R. Smith, Siddarth Shivkumar, Jeff Field, Jesse W. Wilson, Herve Rigneault, Randy A. Bartels
Summary: Impulsive stimulated Raman scattering (ISRS) is a powerful technique for studying low-frequency Raman vibrational modes, and this study introduces a simple strategy for ISRS spectroscopy and hyperspectral imaging using spectral filters.
Article
Optics
Thomas Gretzinger, Krunal Radhanpura, Philip Fairman, Mark Berman, David Farrant
Summary: Terahertz radiation combines spectroscopy and imaging to reveal concealed objects and identify materials. A compact fiber-coupled hyperspectral imaging reflection system is developed for security and industrial applications. The system can measure objects up to 150 mm in diameter with a depth range of up to 255 mm, allowing for 3-dimensional mapping and simultaneous acquisition of spectral data. Spectral information between 0.2-1.8 THz is extracted from a hyperspectral image to identify specific materials in different humidity environments.
Article
Optics
Keisuke Ozawa
Summary: This study aims to develop an efficient identification method for overlapping plastic sheets using short-wavelength infrared hyperspectral imaging. The method is based on the Lambert-Beer law and is simple to implement. The identification performance and tolerance of the proposed method against measurement errors are also discussed.
Article
Chemistry, Multidisciplinary
Ewelina Lipiec, Janina Kaderli, Jan Kobierski, Roland Riek, Katarzyna Skirlinska-Nosek, Kamila Sofinska, Marek Szymonski, Renato Zenobi
Summary: Abnormal aggregation of amyloid-beta is a complex and heterogeneous process, and a new approach using TERS has provided detailed molecular structure information of single amyloid-beta aggregates, revealing a beta-sheet rearrangement. This study will contribute to a better understanding of the etiology of Alzheimer's disease.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Oncology
Boris Jansen-Winkeln, Michelle Dvorak, Hannes Koehler, Marianne Maktabi, Matthias Mehdorn, Claire Chalopin, Michele Diana, Ines Gockel, Manuel Barberio
Summary: Good bowel oxygenation is crucial for anastomotic healing after colorectal resections. Hyperspectral imaging has the potential to be used as a clinical tool for assessing tissue oxygenation during surgery, as shown in this study involving 105 patients.
Article
Chemistry, Applied
Naiyue Hu, Wei Li, Chenghang Du, Zhen Zhang, Yanmei Gao, Zhencai Sun, Li Yang, Kang Yu, Yinghua Zhang, Zhimin Wang
Summary: This study investigated the potential of using hyperspectral imaging to predict wheat micronutrient content, with results showing higher prediction accuracy for wheat kernels compared to flour, and good predictions for Ca, Mg, Mo, and Zn.
Article
Physics, Multidisciplinary
Sylvianne D. C. Roscam Abbing, Radoslaw Kolkowski, Zhuang-Yan Zhang, Filippo Campi, Lars Lotgering, A. Femius Koenderink, Peter M. Kraus
Summary: Direct control over the amplitude and phase patterns of extreme-ultraviolet pulses is achieved through nanoengineered solid samples, enabling sub-fundamental wavelength resolution imaging and metrology of nanostructures.
PHYSICAL REVIEW LETTERS
(2022)
Article
Health Care Sciences & Services
Diana Heimes, Philipp Becker, Daniel G. E. Thiem, Robert Kuchen, Solomiya Kyyak, Peer W. Kaemmerer
Summary: This study found a strong correlation between HSI and MAT in assessing collateral perfusion, with HSI proving to reliably differentiate between perfusion and occlusion. The results suggest that HSI could be a useful tool for non-medical personnel and provide an objective and reproducible method for assessing collateral perfusion.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Oncology
Jesse Aronowitz, Linda Ding, Jennifer Yates, Yang Zong, Larry Zheng, Zhong Jiang, Jessica Yancey, Kriti Mittal, Thomas J. Fitzgerald
Summary: In this retrospective study of 8 patients, stereotactic body radiotherapy (SBRT) was found to be effective and well-tolerated in controlling gross hematuria caused by urothelial carcinoma of the kidney. Treatment led to cessation of bleeding without significant adverse effects, although it was associated with a moderate decline in renal function.
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
(2021)
Article
Oncology
Lynn Million, Andrea Hayes-Jordan, Yueh-Yun Chi, Sarah S. Donaldson, Suzanne Wolden, Carol Morris, Stephanie Terezakis, Fran Laurie, Karen Morano, T. J. Fitzgerald, Torunn I. Yock, David A. Rodeberg, James R. Anderson, Rose Anne Speights, Jennifer O. Black, Cheryl Coffin, Mary Beth McCarville, Simon C. Kao, Douglas S. Hawkins, Sheri L. Spunt, R. Lor Randall
Summary: The ARST0332 trial for pediatric and young adults with NRSTS utilized risk-based treatment to achieve high local control rates, particularly after R0 resection. Most patients were able to undergo delayed R0/R1 resection after neoadjuvant therapy, leading to improved survival outcomes.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Review
Oncology
John M. Varlotto, Zhuoxin Sun, Bonnie Ky, Jenica Upshaw, Sharyn Katz, Thomas J. Fitzgerald, Heather Wakelee, Maximilian Diehn, David A. Mankoff, Christine Lovely, Chandra Belani, Kurt Oettel, Gregory Masters, Suresh Ramalingam, Nathan A. Pennell
Summary: The ECOG-ACRIN EA5181 trial is investigating the use of concomitant immunotherapy during chemo/radiation for locally advanced non-small cell lung cancer (LA-NSCLC) to reduce local failure risk and improve overall survival. This study is at the forefront of exploring the potential benefits of combining immunotherapy with standard treatment in LA-NSCLC patients.
Editorial Material
Oncology
Thomas J. FitzGerald
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Oncology
Prema Rassiah, Natia Esiashvili, Arthur J. Olch, Chia-Ho Hua, Ken Ulin, Andrea Molineu, Karen Marcus, Mahesh Gopalakrishnan, Susha Pillai, Nataliya Kovalchuk, An Liu, Greg Niyazov, Jose Penagaricano, Fred Cheung, Adam C. Olson, Cheng-Chia Wu, Harish K. Malhotra, Iain J. MacEwan, Jacqueline Faught, John C. Breneman, David S. Followill, Thomas J. FitzGerald, John A. Kalapurakal
Summary: The study examined current practice patterns in pediatric total body irradiation (TBI) techniques among COG member institutions. Results showed inconsistencies in practice patterns and a lack of standardization, making it difficult to correlate TBI doses with clinical outcomes effectively.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Oncology
Jeff M. Michalski, Anna J. Janss, L. Gilbert Vezina, Kyle S. Smith, Catherine A. Billups, Peter C. Burger, Leanne M. Embry, Patricia L. Cullen, Kristina K. Hardy, Scott L. Pomeroy, Johnnie K. Bass, Stephanie M. Perkins, Thomas E. Merchant, Paul D. Colte, Thomas J. Fitzgerald, Timothy N. Booth, Joel M. Cherlow, Karin M. Muraszko, Jennifer Hadley, Rahul Kumar, Yuanyuan Han, Nancy J. Tarbell, Maryam Fouladi, Ian F. Pollack, Roger J. Packer, Yimei Li, Amar Gajjar, Paul A. Northcott
Summary: In children with average-risk medulloblastoma, reducing the radiation boost volume is safe and does not compromise survival. Decreasing CSI dose in young children leads to inferior outcomes, possibly in a subgroup-dependent manner, but is associated with better neurocognitive outcome. Molecularly informed patient selection may be further explored for late-effect sparing approaches in children with MB.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Review
Oncology
John Michael Varlotto, Zhuoxin Sun, Bonnie Ky, Jenica Upshaw, Thomas J. Fitzgerald, Max Diehn, Christine Lovly, Chandra Belani, Kurt Oettel, Gregory Masters, Matthew Harkenrider, Helen Ross, Suresh Ramalingam, Nathan A. Pennell
Summary: The ECOG-ACRIN EA5181 trial aims to investigate whether adding durvalumab to standard chemo/radiation followed by consolidative durvalumab can improve overall survival and reduce local failure in patients with locally advanced, unresectable non-small cell lung cancer. The trial also explores the synergistic effects of chemotherapy and immunotherapy, radiation therapy history, and the concerns regarding cardiac and pulmonary toxicities.
CLINICAL LUNG CANCER
(2022)
Letter
Hematology
Deborah M. Stephens, Hongli Li, Louis S. Constine, Thomas J. Fitzgerald, John P. Leonard, Brad S. Kahl, Joo Y. Song, Michael L. LeBlanc, Sonali M. Smith, Daniel O. Persky, Jonathan W. Friedberg
Review
Oncology
Linda Ding, Carla Bradford, I-Lin Kuo, Yankhua Fan, Kenneth Ulin, Abdulnasser Khalifeh, Suhong Yu, Fenghong Liu, Jonathan Saleeby, Harry Bushe, Koren Smith, Camelia Bianciu, Salvatore LaRosa, Fred Prior, Joel Saltz, Ashish Sharma, Mark Smyczynski, Maryann Bishop-Jodoin, Fran Laurie, Matthew Iandoli, Janaki Moni, M. Giulia Cicchetti, Thomas J. FitzGerald
Summary: The future of radiation oncology is promising due to advances in treatment management platforms, improved treatment execution, and the ability to share and analyze data globally. The use of advanced imaging technology has improved disease targeting, reduced treatment times, and increased treatment convenience. Global data exchange allows for collaboration and validation of findings, promoting further advancements in the field.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
James L. Shen, Kevin W. O'Connor, Janaki Moni, Susan Zweizig, Thomas J. Fitzgerald, Eric C. Ko
Summary: This study evaluated the CFS, CSS, and OS of patients with endometrial carcinoma managed with upfront radiation therapy. The results showed that upfront radiation therapy provided excellent CFS, CSS, and OS for patients with endometrial carcinoma. This is important for patients who are unable to undergo surgical intervention.
ADVANCES IN RADIATION ONCOLOGY
(2023)
Review
Oncology
Koren Smith, Kenneth Ulin, Michael Knopp, Stephan Kry, Ying Xiao, Mark Rosen, Jeff Michalski, Matthew Iandoli, Fran Laurie, Jean Quigley, Heather Reifler, Juan Santiago, Kathleen Briggs, Shawn Kirby, Kate Schmitter, Fred Prior, Joel Saltz, Ashish Sharma, Maryann Bishop-Jodoin, Janaki Moni, M. Giulia Cicchetti, Thomas J. FitzGerald
Summary: Clinical trials have become the key method for validating improvements in oncology clinical practice. There have been significant advancements in radiation oncology practice, including the use of advanced technology, image guidance, and artificial intelligence in treatment planning. These improvements have enhanced the quality of patient care and expanded the use of radiation therapy in primary disease settings.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Joshua P. Schiff, Yimei Lee, Yu Wang, Stephanie M. Perkins, Sandy K. Kessel, Thomas J. Fitzgerald, Nicole A. Larrier, Jeff M. Michalski
Summary: Accurate delineation of targets is crucial in craniospinal irradiation treatment, and while technological advances improve conformity, caution is necessary.
ADVANCES IN RADIATION ONCOLOGY
(2023)
Editorial Material
Oncology
T. J. FitzGerald
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
John A. L. Kalapurakal, Suzanne L. Wolden, Daphne N. Haas-Kogan, Nadia N. Laack, Chia-ho C. Hua, Arnold C. E. Paulino, Christine E. S. Hill-Kayser, Bradford S. J. Hoppe, Thomas J. Fitzgerald, COG Radiation Oncology Discipline Com
Summary: Radiation oncology plays a crucial role in the care of children with cancer, aiming to deliver the safest and most effective radiation therapy while minimizing toxicity to normal tissues. The committee provides mentorship to young doctors and actively contributes to the education of the global radiation oncology community. They are leaders in discovering new radiosensitizers, radioprotectors, and advanced radiation therapy technologies to improve outcomes for children with cancer.
PEDIATRIC BLOOD & CANCER
(2023)
Article
Oncology
Rashi Garg, Kimberly Foley, Babak Movahedi, Mark J. Masciocchi, Jacob R. Bledsoe, Linda Ding, Paul Rava, Thomas J. Fitzgerald, Shirin Sioshansi
Summary: The study retrospectively analyzed the outcomes of 27 patients receiving SBRT as a bridging treatment while awaiting LT, and found that SBRT was a safe and effective option with a pCR rate of 62%, without causing additional radiation-related complications, and no significant correlation between tumor size and pCR rate.
ADVANCES IN RADIATION ONCOLOGY
(2021)
