Article
Chemistry, Multidisciplinary
Yongwoo Jang, Taegyu Park, Eunyoung Kim, Jong Woo Park, Dong Yeop Lee, Seon Jeong Kim
Summary: By utilizing the cellular redox system, a CNT yarn supercapacitor with maximum area capacitance was developed and demonstrated excellent performance under physiological conditions. Implanted NAD/BQ/CNT yarn electrodes in a rat's abdominal cavity showed stable in vivo electrical performance of a supercapacitor. These findings suggest a promising platform for implantable energy storage devices using redox biomolecules.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Nutrition & Dietetics
Andrea Benzi, Alessia Grozio, Sonia Spinelli, Laura Sturla, Andreas H. Guse, Antonio De Flora, Elena Zocchi, Joerg Heeren, Santina Bruzzone
Summary: Nicotinamide adenine dinucleotide (NAD(+)) plays a critical role in energy metabolism regulation as both a coenzyme and substrate for various enzymes. CD38, as an enzyme synthesizing Ca2+-mobilizing second messenger and a major NAD(+)-consumer, can impact NAD(+) levels. This review explores recent studies on the modulation of CD38 expression and activity, and the resulting changes in NAD(P)(H) levels in adipose tissue.
Review
Pharmacology & Pharmacy
Yumeng Zhu, Ping Xu, Xuan Huang, Wen Shuai, Li Liu, Shuai Zhang, Rui Zhao, Xiuying Hu, Guan Wang
Summary: Nicotinamide phosphoribosyltransferase (NAMPT) plays a significant role in mammals by synthesizing nicotinamide mononucleotide (NMN) for metabolic homeostasis and cell survival, serving as a key protein in the host's defense mechanism. Neurodegenerative diseases pose a serious threat to human health, but effective drugs are limited. NAMPT has active biological functions in neurogenesis, making it a powerful therapeutic target for neurodegenerative diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Mariajose Metcalfe, Brian T. David, Brett C. Langley, Caitlin E. Hill
Summary: Spinal cord injury leads to tissue damage and functional deficits. Administering NR can increase NAD+ levels in the injured spinal cord, protect tissue, and improve motor function.
EXPERIMENTAL NEUROLOGY
(2023)
Review
Nutrition & Dietetics
Qin Song, Xiaofeng Zhou, Kexin Xu, Sishi Liu, Xinqiang Zhu, Jun Yang
Summary: Nicotinamide mononucleotide (NMN) is a precursor for NAD+ biosynthesis, and supplementation has shown to increase NAD+ concentration and alleviate aging-related disorders. While most studies have been conducted in cell or animal models, several human clinical trials are currently evaluating the safety and physiological effects of NMN supplementation.
ADVANCES IN NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Cuiting Liao, Li Zhang, Rong Jiang, Juanjuan Xu, Jiarui Tang, Kai Hu, Shifang Jiang, Longhui Li, Yongqiang Yang, Jiayi Huang, Li Tang, Longjiang Li
Summary: The expression of NADK is positively correlated with APAP-induced acute liver injury, and inhibition of NADK can alleviate liver injury by increasing hepatic NAD(+) level and improving antioxidant capacity.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
JuKyung Lee, Han Na Suh, Saeyoung Ahn, Hye Bin Park, Jeong Yoon Lee, Hyung Jin Kim, Sang Hee Kim
Summary: This study developed electrocatalytic sensors for analyzing NADH in whole blood, which exhibited stability and a limit of detection of 3.5 μM. These sensors have the potential for extensive applications.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Multidisciplinary
Seong-Min Jo, Frederik R. Wurm, Katharina Landfester
Summary: A team of researchers has developed an artificial enzyme combination that continuously converts oxygen and water into NAD(+), eliminating the need for additional organic substrates. The NAD(+) produced can be used in artificial glucose metabolism sensing and in the treatment of Methemoglobinemia by converting non-oxygen binding methemoglobin to oxygen-binding hemoglobin.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Biochemical Research Methods
Ryo Matsuyama, Tomoyo Omata, Michiharu Kageyama, Ryota Nakajima, Masanobu Kanou, Kei Yamana
Summary: Nicotinamide adenine dinucleotide (NAD(+)) is an essential coenzyme for energy production. Associations between NAD(+) and aging-related diseases have been reported, and NAD(+) precursors are acknowledged as anti-aging supplements. However, there have been few studies on the link between aging or aging-related diseases and human blood NAD(+) concentration due to the instability and difficulty in measuring NAD(+). This study aimed to develop a simpler quantitative NAD(+) measurement method.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Tom Meyer, Dor Shimon, Sawsan Youssef, Gal Yankovitz, Adi Tessler, Tom Chernobylsky, Anat Gaoni-Yogev, Rita Perelroizen, Noga Budick-Harmelin, Lawrence Steinman, Lior Mayo
Summary: This study reveals that NAD(+) generation via the salvage pathway regulates immune function of astrocytes. CD38, as the main NADase, is up-regulated in reactive astrocytes in models of neuroinflammation and MS. Inhibition of CD38 activity increases NAD(+) levels, suppresses proinflammatory transcriptional reprogramming, impairs chemotactic potential to inflammatory monocytes, and ameliorates EAE.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Harshani Nadeeshani, Jinyao Li, Tianlei Ying, Baohong Zhang, Jun Lu
Summary: The demand for anti-aging health products, such as nicotinamide mononucleotide (NMN), has been increasing due to the rising elderly population. NMN, as a precursor of nicotinamide adenine dinucleotide (NAD+), can potentially slow down the aging process by elevating NAD+ levels in the body. Studies have shown promising therapeutic effects of NMN supplementation for age-induced complications, but further clinical investigations are needed to determine its effectiveness and safety.
JOURNAL OF ADVANCED RESEARCH
(2022)
Article
Biochemical Research Methods
Yan Liu, Chengting Luo, Ting Li, Wenhao Zhang, Zhaoyun Zong, Xiaohui Liu, Haiteng Deng
Summary: The study demonstrates that NMNH is a potent enhancer of NAD(+) and suppresses glycolysis, the TCA cycle, and cell growth. NMNH, produced through a chemical method, is more effective than NMN in increasing NAD(+) levels in vivo and in vitro, mediated by NMNAT.
JOURNAL OF PROTEOME RESEARCH
(2021)
Review
Nutrition & Dietetics
Taichi Nagahisa, Shotaro Kosugi, Shintaro Yamaguchi
Summary: The intestine, particularly its NAMPT-mediated NAD(+) biosynthesis pathway, plays a crucial role in regulating intestinal homeostasis and GLP-1 secretion. Boosting the intestinal AMPK-NAMPT-NAD(+)-SIRT pathway has gained attention as a novel strategy to improve impaired glucose tolerance. This review explores the regulatory mechanisms and importance of intestinal NAMPT-mediated NAD(+) biosynthesis in obesity and aging, and discusses the potential therapeutic strategies for postprandial glucose dysregulation.
Article
Biochemistry & Molecular Biology
David P. Buckley, Marie E. Migaud, John J. Tanner
Summary: ox-NADs are redox inactive derivatives of NAD that accumulate in cells under stress and may act as potential inhibitors of enzymes. Molecular dynamics simulations reveal distinct conformational preferences of ox-NADs in solution, which could aid in identifying enzymes targeted by ox-NADs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Elizabeth A. Novak, Erin C. Crawford, Heather L. Mentrup, Brian D. Griffith, David M. Fletcher, Meredith R. Flanagan, Corinne Schneider, Brian Firek, Matthew B. Rogers, Michael J. Morowitz, Jon D. Piganelli, Qian Wang, Kevin P. Mollen
Summary: This study demonstrates that the downregulation of PGC1 alpha and the decrease in NAD+ levels are associated with the pathogenesis of inflammatory bowel disease. Treatment with an NAD+ precursor can alleviate colitis symptoms and restore mitochondrial function by increasing the activity of PGC1 alpha. These findings highlight the importance of PGC1 alpha in intestinal epithelial health and suggest a potential therapeutic approach for IBD patients using nicotinamide riboside.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Engineering, Electrical & Electronic
Zhan-Yu Chen, Ankur Gogoi, Shao-Yu Lee, Yuan Tsai-Lin, Po-Wei Yi, Ming-Kuan Lu, Chih-Cheng Hsieh, JinChang Ren, Stephen Marshall, Fu-Jen Kao
IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS
(2019)
Article
Optics
Julius Tschannerl, Jinchang Ren, Huimin Zhao, Fu-Jen Kao, Stephen Marshall, Peter Yuen
OPTICS AND LASERS IN ENGINEERING
(2019)
Article
Chemistry, Analytical
Khalil Ur Rehman, Subir Das, Yih-Fan Chen, Fu-Jen Kao
METHODS AND APPLICATIONS IN FLUORESCENCE
(2020)
Article
Biochemical Research Methods
Subir Das, Khalil Ur Rehman, Guan-Yu Zhuo, Fu-Jen Kao
JOURNAL OF BIOMEDICAL OPTICS
(2020)
Article
Medicine, Research & Experimental
Wei-Chung Chen, Yu-Jen Chen, Shih-Ting Lin, Wei-Han Hung, Ming-Che Chan, I-Chen Wu, Ming-Tsang Wu, Chie-Tong Kuo, Subir Das, Fu-Jen Kao, Guan-Yu Zhuo
EXPERIMENTAL BIOLOGY AND MEDICINE
(2020)
Article
Engineering, Biomedical
Nirmal Mazumder, Fu-Jen Kao
Summary: The research utilized a Stokes vector-based SHG microscope to measure and characterize the complete polarization state of collagen type I and skeletal muscle fiber, reconstructing various polarization parameters using Stokes values to quantify the polarization properties of SH light. Furthermore, measurements were extended to different input polarization states in order to investigate the molecular structure of SHG active molecules such as collagen type I and myosin.
LASERS IN MEDICAL SCIENCE
(2021)
Article
Physics, Applied
Khalil Ur Rehman, Subir Das, Fu-Jen Kao
Summary: The work demonstrates contrast enhancement through polarization-resolved pump-probe microscopy by measuring spontaneous fluorescence loss induced by stimulated emission. The pump-probe measurement is compared with conventional fluorescence polarization microscopy, resulting in different anisotropy values attributed to the multiphoton mechanism. The pump-probe technique promises higher temporal resolution in lifetime measurements and enables more precise determination of the fluorescent molecules' rotational diffusion time constant.
APPLIED PHYSICS EXPRESS
(2021)
Article
Physics, Applied
Guan-Yu Zhuo, K. U. Spandana, K. M. Sindhoora, Yury Kistenev, Fu-Jen Kao, Viktor V. Nikolaev, Hale Zuhayri, Natelya A. Krivova, Nirmal Mazumder
Summary: This paper discusses the application of a compact MNLO microscope in clinical research for label-free non-invasive molecular imaging, providing insights into molecular properties and disease progression in biological systems and organs. The integration of nonlinear optical phenomena with multidimensional imaging allows for addressing complex biomedical questions.
JOURNAL OF APPLIED PHYSICS
(2021)
Article
Materials Science, Multidisciplinary
Shuai-Yan Chen, Zhi-Teng Su, Dan-Jae Lin, Ming-Xin Lee, Ming-Che Chan, Subir Das, Fu-Jen Kao, Guan-Yu Zhuo
Summary: By utilizing polarization engineering in SHG imaging, deeper penetration depths and improved imaging quality of tissues with different thicknesses can be achieved through the adjustment of polarization direction and form. This method is simple, effective, and highly sensitive to tissue anisotropy.
RESULTS IN PHYSICS
(2021)
Article
Physics, Applied
Subir Das, Yun-Yu Hsu, Ying-Rue Kao, Bao-Yu Hsieh, Fu-Jen Kao
Summary: In this study, a synchronous time delay technique is presented to control the illuminating laser pulses and the generation of ultrasonic waves for visualizing the ultrasound waveform through the Schlieren imaging method. The proposed technique allows for two-dimensional mapping of the ultrasound waveform in a temporally evolved manner, and the critical physical parameters such as the speed and spatial pulse length of the ultrasonic waves can be visualized and calculated through image analysis.
APPLIED PHYSICS LETTERS
(2022)
Article
Physics, Applied
F. S-S Chien, A. Herawati, C-M Ho, H-L Hsiao, T-S Lim, C. R. Wang, K-K Ng, S. Das, F-J Kao, M-C Wu
Summary: The photon-induced deactivation of traps in MAPbI(3) has a significant impact on charge relaxation behavior. Through analyzing steady-state and time-resolved photoluminescence spectroscopy, it was found that three types of traps (T-L, T-H, and T-GB) in MAPbI(3) films can be deactivated by photons. Different thresholds were observed for the deactivation of these traps, with T-L and T-H having low and high energy thresholds, respectively, while T-GB had a lower energy threshold. The deactivation of these traps led to changes in photoluminescence quantum yield and recombination time.
JOURNAL OF PHYSICS D-APPLIED PHYSICS
(2023)
Proceedings Paper
Engineering, Electrical & Electronic
N. Mazumder, K. M. Sindhoora, F-J Kao
Summary: The study utilized SHG microscopy integrated with a Stokes polarimeter to investigate the microscopic structure of non-centrosymmetric molecules in detail and perform quantitative polarization measurements. The findings suggest that this technology has wide application potential in the field of biomedicine.
XXI INTERNATIONAL CONFERENCE AND SCHOOL ON QUANTUM ELECTRONICS: LASER PHYSICS AND APPLICATIONS
(2021)
Article
Optics
Che-Lun Hsu, Subir Das, Yen-Hsiang Wu, Fu-Jen Kao
Summary: The study investigates the spectral response of VCSEL diodes using a modified OBIC microscopy, with varying irradiation wavelengths for analysis. The ultrafast mode-locked laser provides a broad wavelength range for investigating the photocurrent responses of VCSEL samples, revealing a redshifted spectral response for ESD damaged VCSELs.
Proceedings Paper
Engineering, Electrical & Electronic
Khalil Ur Rehman, Subir Das, Fu-Jen Kao
2020 OPTO-ELECTRONICS AND COMMUNICATIONS CONFERENCE (OECC 2020)
(2020)
Proceedings Paper
Engineering, Electrical & Electronic
Subir Das, Fu-Jen Kao
2020 OPTO-ELECTRONICS AND COMMUNICATIONS CONFERENCE (OECC 2020)
(2020)