Article
Clinical Neurology
Ji-Hoon Na, Heung Dong Kim, Young-Mock Lee
Summary: This study retrospectively analyzed the effectiveness of corpus callosotomy in pediatric patients with intractable epilepsy and mitochondrial dysfunction. The results showed that corpus callosotomy was safe and effective in reducing seizure frequency in both groups, with slightly better outcomes observed in the group without mitochondrial dysfunction.
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2022)
Article
Behavioral Sciences
Fatema Malbari, Huirong Zhu, James J. Riviello, Dave Clarke
Summary: The management of anti-seizure medication in pediatric BTRE varies greatly according to sub-specialty and experience of the providers. Further studies and potential guidelines are needed to identify the most appropriate management of ASMs for BTRE.
EPILEPSY & BEHAVIOR
(2021)
Article
Clinical Neurology
Johanna Heugenhauser, Sarah Iglseder, Armin Muigg, Johannes Kerschbaumer, Guenther Stockhammer, Martha Nowosielski, Iris Unterberger
Summary: This case series supports the growing evidence that perampanel may become a promising add-on AED for the treatment of refractory BTRE as well as for seizure control in SMART-syndrome. Overall, a reduction in seizure frequency was observed in four out of five patients, with a responder rate of 40%. Both cases with symptomatic epilepsy associated with SMART-syndrome were successfully treated with perampanel.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Sandeep Kandregula, Danielle Terrell, Robbie Beyl, Anne Freelin, Bharat Guthikonda, Christina Notarianni, Jamie Toms
Summary: Based on the analysis of the latest Kids' Inpatient Database, this study found that non-White and Hispanic populations had lower rates of surgical treatment for pediatric medically intractable epilepsy, with higher utilization of the emergency department.
NEUROSURGICAL FOCUS
(2022)
Article
Oncology
Yilong Zheng, Yuxiu Yang, Min Hui Ng, Adrienne Yu Hsiang Chew, Chun Peng Goh, Christopher Yuan Kit Chua, Rahul Rathakrishnan, Yvonne Ang, Andrea Li Ann Wong, Balamurugan Vellayappan, Kejia Teo, Vincent Diong Weng Nga, Tseng Tsai Yeo, Mervyn Jun Rui Lim
Summary: The presence of perioperative seizures in patients undergoing surgical resection of brain metastases is independently associated with overall mortality, suggesting it may be a prognostic marker of poor outcome.
FRONTIERS IN ONCOLOGY
(2022)
Article
Clinical Neurology
Smruti K. Patel, Justin L. Gibson, Mykhailo Lovha, James L. Leach, Ravindra Arya, Jeffrey R. Tenney, Katherine D. Holland, Gewalin Aungaroon, Hansel M. Greiner, Jesse Skoch, Francesco T. Mangano
Summary: The study retrospectively analyzed 5 pediatric patients who underwent PQD surgery for the treatment of posterior quadrant subhemispheric epilepsy. The results showed that all patients underwent complete disconnection of the posterior quadrant without complications. In the postoperative follow-up, 4 patients (80%) had an Engel score of I, while the remaining patient had an Engel score of IIB.
OPERATIVE NEUROSURGERY
(2022)
Editorial Material
Oncology
Alberto S. Pappo, Seth E. Karol, Kelsey C. Bertrand
Summary: This manuscript highlights the significant progress in the diagnosis and treatment of pediatric cancers, especially the application of precision oncology and tumor-agnostic approach. It also emphasizes the use of genomics and cell-free DNA in the treatment of medulloblastoma, as well as the important role of monoclonal antibody therapy in treating B-cell leukemia and neuroblastoma.
Article
Clinical Neurology
Kenichiro Asano, Seiko Hasegawa, Masashi Matsuzaka, Hiroki Ohkuma
Summary: This study retrospectively analyzed the incidence of BTE in 601 patients with metastatic brain tumors, finding that significant risk factors for BTE included young age, male sex, breast cancer, tumors involving eloquent areas, brain edema, dissemination, and giant tumors.
JOURNAL OF NEUROSURGERY
(2022)
Article
Oncology
Shannon Green, Victoria D. Vuong, Paritosh C. Khanna, John R. Crawford
Summary: This study demonstrates the feasibility of using pre-diagnostic neuroimaging to predict the growth velocity of pediatric brain tumors. It also indicates that high-grade tumors have a faster growth rate than low-grade tumors.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Finn Jelke, Giulia Mirizzi, Felix Kleine Borgmann, Andreas Husch, Redouane Slimani, Gilbert Georg Klamminger, Karoline Klein, Laurent Mombaerts, Jean-Jacques Gerardy, Michel Mittelbronn, Frank Hertel
Summary: Raman spectroscopy (RS) is an effective method for discriminating meningioma from healthy dura mater in fresh tissue samples, providing a quick and reliable diagnostic tool with potential for guided surgery.
SCIENTIFIC REPORTS
(2021)
Article
Engineering, Electrical & Electronic
Anton D. Shutov, Joseph T. Harrington, Hanlin Zhu, Da-Wei Wang, Delong Zhang, Vladislav V. Yakovlev
Summary: Raman spectroscopy provides a non-invasive, chemically-specific optical imaging of biological objects without using endogenous labels. Nonlinear Raman spectroscopy allows faster imaging with improved spatial resolution and axial sectioning capability. The report introduces a novel use of nonlinear Raman spectroscopy as a sensor of local nano-environment, where time-resolved coherent anti-Stokes Raman spectrograms are sensitive to small variations in local structural changes not normally observed with conventional Raman spectroscopy.
IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS
(2021)
Review
Neurosciences
Mingguo Xie, Xiongfei Wang, Zejun Duan, Guoming Luan
Summary: Brain tumors involving cortical neurons can often lead to seizures, especially intractable focal seizures. Low-grade epilepsy-associated neuroepithelial tumors (LEATs), such as ganglioglioma (GG) and dysembryoplastic neuroepithelial tumor (DNET), have common clinicopathological features including seizure onsets at a young age, involvement of the temporal lobe, and a slow growth pattern. Surgical treatments with complete resection of tumors and epileptogenic zones offer the best chance for seizure control and recurrence-free survival in patients with LEATs. However, there is ongoing debate among experts regarding the classification and diagnosis of LEAT entities.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Medicine, General & Internal
Aashim Bhatia, Vincent Kyu Lee, Yongxian Qian, Michael J. Paldino, Rafael Ceschin, Jasmine Hect, James M. Mountz, Dandan Sun, Gary Kohanbash, Ian F. Pollack, Regina Jakacki, Fernando Boada, Ashok Panigrahy
Summary: Na-23 MRI can be used to compare sodium concentrations between pediatric gliomas and non-neoplastic brain tissues. Dual echo Na-23 MRI improves tissue conspicuity of bound sodium concentration relative to TSC imaging.
Article
Clinical Neurology
Anneliesse A. Braden, Sarah E. Weatherspoon, Talitha Boardman, Theresa Williard, Abigail Adkins, Savannah K. Gibbs, James W. Wheless, Shalini Narayana
Summary: This study assessed the safety of TMS functional mapping in a clinical pediatric population and provided important insights into its use in patients with refractory epilepsy, brain tumor, or cranial metal.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Harry T. Chugani
Summary: When interpreting clinical F-18-FDG PET scans of the brain in children, hypometabolism is typically seen, with occasional focal areas of hypermetabolism that may not necessarily indicate seizure activity. Various conditions can cause focal hypermetabolism on F-18-FDG PET studies, and it is important for radiologists and nuclear medicine physicians to be aware of these to accurately assess the findings.
JOURNAL OF NUCLEAR MEDICINE
(2021)