Journal
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
Volume 5, Issue 4, Pages 401-408Publisher
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jbn.2009.1049
Keywords
Lipid Based Drug Delivery Systems; Protein; Peptide; Water-in-Oil Emulsion; SLN; FTIR; DSC; Interfaces; Protein Physical Stability; Lysozyme
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Lipid based systems are a promising delivery system for many drug molecules, including labile compounds such as peptides and proteins. However, in the development of these systems the effect on the physical stability is rarely taken into account. Physical changes are often correlated with changes in biological activity but are generally much easier to assess. The present paper illustrates the use of a combination of techniques, differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), and intrinsic tryptophan fluorescence, to determine structural changes of proteins in lipid based systems such as solid lipid nanoparticles and emulsions.
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