4.5 Review

Lipid Nanoparticles for Drug Delivery to the Brain: In Vivo Veritas

Journal

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
Volume 5, Issue 4, Pages 344-350

Publisher

AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jbn.2009.1043

Keywords

Brain Drug Delivery; Blood-Brain Barrier (BBB); Neurovascular Unit (NVU); Colloids; Lipid Colloidal Dispersions; Solid Lipid Nanoparticles (SLN)

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The present article is not aimed at extensively reviewing the literature on lipid nanoparticles, already described in monographs of recent redaction, but will provide a compilation of in vivo evidences supporting their potentiality in overcoming the blood-brain barrier problem. The advantages of using lipid over polymer carriers will be also discussed.

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