Review
Biotechnology & Applied Microbiology
Ali Mahnavi, Mina Shahriari-Khalaji, Bahareh Hosseinpour, Mostafa Ahangarian, Amir Aidun, Simona Bungau, Syed Shams ul Hassan
Summary: Different biomaterials and methods have been used in tissue engineering for repairing damaged bones. However, the weakness in cellular activity or osteoconductivity sometimes limits their optimal use. To address this issue, surface modification techniques, such as polydopamine coating, have been employed. Polydopamine not only covers the weakness of scaffolds but also enhances their osteoconductivity. The hydrophilic layer created by polydopamine allows bone cells to anchor and adhere well to the surfaces, while the catechol and amine groups make the surfaces chemically active, resulting in increased osteoconductivity.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mahyar Sameti, Kai Clarke, Prerona Dewan, Kenyatta S. Washington, Somayeh Talebzadeh, Yi Liao, Chris A. Bashur
Summary: Low collagen blends show excellent anti-thrombogenic properties and different platelet interactions compared to high collagen samples. The blended collagen scaffolds retain a significant percentage of collagen and exhibit better endothelial cell spreading compared to gelatin scaffolds. The interaction between collagen and synthetic materials during processing is essential for these functional benefits.
MACROMOLECULAR BIOSCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Ryan Y. Nguyen, Aidan T. Cabral, Alejandro Rossello-Martinez, Alessandro Zulli, Xiangyu Gong, Qiuting Zhang, Jing Yan, Michael Mak
Summary: This study develops a collagen hydrogel that induces the formation of heterogeneous mesoscopic architectures, known as collagen islands. These island-containing gels have highly tunable inclusions and mechanical properties, with regional enrichment in collagen concentration at the cell-scale. The collagen island architectures are used to investigate mesenchymal stem cell behavior and demonstrate alterations in cell migration and osteogenic differentiation. Moreover, induced pluripotent stem cells cultured in island-containing gels show sufficient architecture to induce mesodermal differentiation. Overall, this work highlights the importance of complex mesoscopic tissue architectures as bioactive cues in regulating cell behavior and presents a novel collagen-based hydrogel for tissue engineering applications.
ADVANCED MATERIALS
(2023)
Review
Engineering, Biomedical
Kai Tang, Meng-Lin Luo, Wei Zhou, Li-Na Niu, Ji-Hua Chen, Fu Wang
Summary: Stable soft tissue integration is crucial for long-term implant stability, preventing peri-implantitis, and protecting underlying bone tissue. Zirconia abutments are preferred over titanium for aesthetic restoration, but achieving soft tissue attachment remains challenging. This review discusses advances in zirconia surface treatment and structural design that can enhance soft tissue integration.
BIOACTIVE MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Pei Zhuang, Zachary Greenberg, Mei He
Summary: A novel 3D printable nanocomposite starch hydrogel was developed with enhanced biocompatibility for promoting 3D cell growth, utilizing gelatin nanoparticles and collagen. The unique rheological properties of the hydrogel, along with the homogeneous microporous structure containing collagen fibers and gelatin nanoparticles, support cell attachment and proliferation. The cell metabolic activity study confirmed the remarkable enhancement of biological function of the developed starch hydrogel, making it a highly desirable bio-ink for advancing 3D tissue engineering.
ADVANCED MATERIALS TECHNOLOGIES
(2021)
Article
Chemistry, Physical
Mehdi Shams, Mohammad Karimi, Vafa Jahangir, Milad Mohammadian, Ali Salimi
Summary: Nanofibrous polyethersulfone (PESf) scaffolds modified with fluorapatite nanoparticles (FAn) showed improved hydrophilicity, roughness, porosity, and biodegradation. The inclusion of FAn led to enhanced viability, growth, proliferation, and differentiation of human bone marrow mesenchymal stem cells (hBMMSCs). The surface topography and release of bioactive ions contributed to the positive effects on cell-surface interactions, biocalcification, and osteogenesis.
SURFACES AND INTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Marc Martinez-Miguel, Miquel Castellote-Borrell, Mariana Kober, Adriana R. Kyvik, Judit Tomsen-Melero, Guillem Vargas-Nadal, Jose Munoz, Daniel Pulido, Edgar Cristobal-Lecina, Solene Passemard, Miriam Royo, Marta Mas-Torrent, Jaume Veciana, Marina Giannotti, Judith Guasch, Nora Ventosa, Imma Ratera
Summary: By utilizing the quatsomes colloidal system, hierarchical nanostructures of RGD peptide can be achieved, leading to significantly enhanced cell adhesion. This novel approach enables the hierarchical immobilization of biomolecules on surfaces, providing a new strategy for tissue engineering.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Biophysics
Vinu Vijayan, Rachita Lakra, Purna Sai Korrapati, Manikantan Syamala Kiran
Summary: In this study, a rare earth lanthanum oxide nanoparticle reinforced collagen biomatrix was developed and evaluated for its bioactivity. The results showed that the biomatrix had good structural integrity, mechanical strength, and resistance to degradation. The lanthanum oxide nanoparticle promoted endothelial cell activation and angiogenesis, and enhanced cell migration. Therefore, this study provides a new approach for developing rare earth-based biomaterials with biological effects.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Review
Biochemistry & Molecular Biology
Olivier Schussler, Pierre E. Falcoz, Juan C. Chachques, Marco Alifano, Yves Lecarpentier
Summary: The clinical impact of cell therapy after myocardial infarction is limited by low cell engraftment, cell death in inflammatory and poor angiogenic areas, and secondary migration. Enhancing integrin interaction with cells through a three-dimensional material, especially when applied epicardially, may improve outcomes. Using collagen as a polymer backbone for tissue engineering shows promise in creating contractile tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Marta Redondo, Rafaela Presa, Pedro L. Granja, Marco Araujo, Aureliana Sousa
Summary: This study successfully developed degradable Konjac glucomannan (KGM) hydrogels for 3D cell culture and achieved cell-material interactions by modifying and grafting bioactive peptides into KGM. The results show great potential for the further application of KGM in tissue engineering.
MATERIALS TODAY CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Jose Almeida-Pinto, Matilde R. Lagarto, Pedro Lavrador, Joao F. Mano, Vitor M. Gaspar
Summary: Breakthroughs in precision cell surface engineering tools support the development of programmable living assemblies with valuable features for tackling complex biological problems, particularly in cell-cell interactions and sorting. Advancements in cell surface modification technologies can expand the bioengineering toolset and unlock new possibilities for personalized cell therapeutics. Combining cell surface modifications with biofabrication technologies can generate living materials with tissue/organ-mimetic bioactivities and therapeutic potential.
Review
Chemistry, Medicinal
Jonathan Ardhianto Panggabean, Sya'ban Putra Adiguna, Mutia Hardhiyuna, Siti Irma Rahmawati, Nina Hermayani Sadi, Gunawan Pratama Yoga, Eva Nafisyah, Asep Bayu, Masteria Yunovilsa Putra
Summary: Aquatic-based collagens have great potential in biomedical applications, especially in tissue engineering, due to their superior characteristics compared to mammalian-based collagen. They are biocompatible, biodegradable, easy to extract, and pose a low immunological risk. The utilization of aquatic-based collagen also offers advantages such as fewer religious restrictions and lower production costs, while promoting environmental sustainability through aquatic waste utilization.
Article
Engineering, Biomedical
Settimio Pacelli, Aparna R. Chakravarti, Saman Modaresi, Siddharth Subham, Kyley Burkey, Cecilia Kurlbaum, Madeline Fang, Christopher A. Neal, Adam J. Mellott, Aishik Chakraborty, Arghya Paul
Summary: The study utilized polydopamine (pDA) treatment as a binding platform to create a versatile gelatin-alginate (Gel-Alg) hydrogel, effectively controlling stem cell adhesion and osteogenic differentiation, demonstrating the potential application value in tissue engineering.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Article
Engineering, Biomedical
R. J. J. de Wit, D. J. van Dis, M. E. Bertrand, D. Tiemessen, S. Siddiqi, E. Oosterwijk, A. F. T. M. Verhagen
Summary: The development of ready-to-use biomaterials and scaffolds is crucial for the advancement of scaffold-based tissue engineering in clinical practice. Decellularization of hard tissues using supercritical carbon-dioxide followed by washing steps is an effective method that reduces handling time and preserves important tissue components. This alternative method shows promise for decellularization and sterilization of dense materials.
ACTA BIOMATERIALIA
(2023)
Article
Chemistry, Physical
Kenichi Nagase
Summary: PNIPAAm is a well-known stimuli-responsive polymer in the biomedical field due to its ability to undergo hydration and dehydration reactions with temperature variations, leading to interactions with biomolecules, proteins, and cells. The temperature-dependent property of PNIPAAm makes it functional for various biomedical applications, particularly in bioseparation and tissue engineering.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2021)
Review
Materials Science, Multidisciplinary
Olivia L. Lanier, Adam G. Monsalve, Peter S. McFetridge, Jon Dobson
INTERNATIONAL MATERIALS REVIEWS
(2019)
Article
Engineering, Biomedical
Andrea M. Matuska, M. Franklin Dolwick, Peter S. McFetridge
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2018)
Article
Orthopedics
Adam W. Anz, Ronna S. Parsa, Maria F. Romero-Creel, Abigail Nabors, Melissa S. Tucker, Robert M. Harrison, Andrea M. Matuska
ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
(2019)
Article
Multidisciplinary Sciences
Rebecca M. Irwin, Lawrence J. Bonassar, Itai Cohen, Andrea M. Matuska, Jacqueline Commins, Brian Cole, Lisa A. Fortier
Article
Cell & Tissue Engineering
Aurore B. Van de Walle, Marc C. Moore, Peter S. McFetridge
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2020)
Article
Orthopedics
Jacqueline Commins, Rebecca Irwin, Andrea Matuska, Margaret Goodale, Michelle Delco, Lisa Fortier
Summary: The study indicates that BioCartilage has the chemical composition and architecture to support cell adherence and migration and to provide bioactive proteins, which should have advantages in cartilage repair beyond its role as a scaffold.
Article
Engineering, Biomedical
Aurore B. Van de Walle, Peter S. McFetridge
Summary: This study explored the use of variable pulse frequency flow field for the regeneration of a human scaffold as a vascular graft, showing significant impact on SMC and EC function and helping with cell repopulation and remodeling of the scaffold. By comparing the effects of variable pulse frequency and constant frequency, it was found that variable frequency can increase SMC proliferation rate and promote EC re-endothelialization. The final results demonstrated positive recellularization and remodeling of the human-derived scaffold towards an arterial vessel.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Article
Engineering, Biomedical
Marc C. Moore, Paul P. Bonvallet, Sita M. Damaraju, Heli N. Modi, Ankur Gandhi, Peter S. McFetridge
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2020)
Article
Orthopedics
Adam W. Anz, Andrea Matuska, Joseph L. Edison, Siraj F. Abdullah, Travis J. Dekker, Hillary A. Plummer, Kenny Brock, Michael D. Goodlett
ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
(2020)
Article
Orthopedics
Eric A. Branch, Andrea M. Matuska, Hillary A. Plummer, Robert M. Harrison, Adam W. Anz
Summary: The study demonstrates that multipotent viable stem cells can be harvested from knee synovial fluid and concentrated using a buffy coat-based PRP processing device. The clinical relevance lies in the fact that PRP devices can be utilized to extract stem cells from effusion fluids, highlighting the need for further investigation into methods involving effusion fluid associated with ACL injuries and OA.
ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
(2021)
Article
Biochemistry & Molecular Biology
Olivia L. Lanier, Joseph M. Ficarrotta, Isaac Adjei, Dayita Wable, Camryn Lewis, Christopher Nacea, Blanka Sharma, Jon Dobson, Peter McFetridge
Summary: Researchers have developed a magnetically triggerable polymeric microparticle platform for on-demand release of complex human placental proteins, aiming to provide a more comprehensive regenerative response. The experiments demonstrate that the proteins retain function after being magnetically released.
MACROMOLECULAR BIOSCIENCE
(2021)
Article
Veterinary Sciences
Stanley E. Kim, Peter S. McFetridge, Jennifer E. Hagen
VETERINARY SURGERY
(2020)
Meeting Abstract
Cell & Tissue Engineering
H. D. Zomer, P. McFetridge, P. S. Cooke
TISSUE ENGINEERING PART A
(2022)
Article
Cell Biology
Andrea M. Matuska, Marina L. Klimovich, Adam W. Anz, Luga Podesta, John R. Chapman
Summary: The study aimed to evaluate the wound healing mechanisms of different autologous serum preparation methods, and found that ethanol-free autologous serum (E(-)AS) could better stimulate growth factor release, support bone marrow mesenchymal stem cell proliferation, and stimulate the release of growth factors and cytokines from platelet-rich plasma compared to ethanol-containing autologous serum (E(+)AS).
WOUND REPAIR AND REGENERATION
(2021)