Article
Nanoscience & Nanotechnology
Weiqiang Wang, Marcos Gil-Garcia, Salvador Ventura
Summary: Grafting biomolecules onto nanostructures' surfaces is a common strategy for targeting pathogenic cells with diagnostic and therapeutic applications. Multivalent nanomaterials for dual- or multitargeting are attracting significant interest due to the limitations of using monofunctionalized nanomaterials. This study presents a modular methodology for obtaining multivalent antibody-functionalized nanomaterials with multitargeting properties, showcasing potential for immunotherapy.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Pharmacology & Pharmacy
Guocheng Xie, Sisi Lin, Feng Wu, Jinyao Liu
Summary: The low bioavailability and side effects of conventional drugs for eye disease have led to the development of efficient drug delivery systems using nanomaterials. This review highlights the unique functions of nanomaterials for carrying and transporting ocular drugs, as well as various strategies to enhance their performance. The current applications and limitations of nanomaterial-based delivery systems in treating ocular diseases are discussed.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Review
Pharmacology & Pharmacy
Nadia Toffoletto, Benilde Saramago, Ana Paula Serro
Summary: The increasing incidence of eye diseases in developed countries is attributed to aging population and changes in lifestyle. Drug-eluting ophthalmic lenses offer a non-invasive and patient-friendly approach for sustained drug delivery to the eye, showing promising results in the treatment of eye pathologies.
Article
Chemistry, Physical
Yao Wang, Yufeng Huang, Wensheng Liu, Baishan Chen, Jiayi Liu, Lei Zhang, Yong Zhang, Yunzhu Ma
Summary: In this study, a nano-Ni3Ta phase-reinforced ultrafine-grain tungsten alloy was fabricated via low-temperature sintering. The alloy exhibited exceptional mechanical properties due to the synergistic effect between nanoscale Ni3Ta phase dispersion and fine-grain strengthening. This approach presents a novel way to develop new tungsten alloys with high strength and toughness.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Article
Chemistry, Multidisciplinary
Ping Xiong, Sangshan Peng, Leyuan Zhang, Aimin Li, Yuyue Chen, Sisi Xiao, Qing He, Guihua Yu
Summary: In this work, a pseudo-nanophase separation strategy enabled by supramolecular interactions was utilized to construct fast and selective ion-transport channels in polymeric membranes. The simplified membrane preparation process and protection of the polymer backbone from chemical degradation resulted in high-performance membranes for aqueous acidic redox flow batteries (RFBs), exhibiting high efficiency and good cycling stability.
Review
Biochemistry & Molecular Biology
Philipp P. Prosseda, Matthew Tran, Tia Kowal, Biao Wang, Yang Sun
Summary: Recent advances in optogenetics have shown promise in the treatment of degenerative eye diseases such as glaucoma and retinitis pigmentosa. Optogenetic strategies aim to restore vision by replacing dysfunctional photoreceptors with light-sensitive proteins in downstream retinal neurons. This approach has the potential to treat various forms of retinal degenerative disorders and also serves as a valuable tool for studying the pathogenesis of these diseases.
Review
Chemistry, Multidisciplinary
Kaffayatullah Khan, Waqas Ahmad, Muhammad Nasir Amin, Sohaib Nazar
Summary: This study utilized a new method based on scientometric analysis to assess the keywords in the research area of nano-silica-modified concrete. It identified the most significant segments of the research and highlighted the challenges associated with using nano-silica. Prediction models were developed for strength estimation, showing good agreement with experimental data. The analysis provides valuable insights and can save time and money in experimental tests.
Article
Engineering, Biomedical
Nathan Lagneau, Pierre Tournier, Fabien Nativel, Yves Maugars, Jerome Guicheux, Catherine Le Visage, Vianney Delplace
Summary: Currently, there is no curative treatment for osteoarthritis (OA), but using mesenchymal stromal cells (MSCs) to alleviate the inflammatory symptoms of OA is gaining attention. MSCs can respond to the pro-inflammatory microenvironment of an OA joint and secrete factors that have anti-inflammatory, anti-apoptotic, immunomodulatory, and pro-regenerative effects. However, the microenvironment of MSCs greatly influences their survival and bioactivity, and using tailored biomaterial scaffolds is crucial for the success of intra-articular MSC-based therapies.
Review
Biochemistry & Molecular Biology
Silvia Vieira, Joana Silva-Correia, Rui L. Reis, J. Miguel Oliveira
Summary: Hydrogels are versatile platforms in tissue engineering with a wide range of applications. Their properties can be tuned through various methods, making them valuable for drug and cell-based therapies as well as fundamental research. The diversity in sources, crosslinking strategies, functionalization methods, and similarity to the extracellular matrix make hydrogels an excellent tool in tissue engineering. This review provides an overview of hydrogel design, processing methods, and the impact of different formulations on cell-biomaterial interactions.
MACROMOLECULAR BIOSCIENCE
(2022)
Article
Pharmacology & Pharmacy
Ye Liu, Haonan Xu, Na Yan, Zhan Tang, Qiao Wang
Summary: Immune ophthalmopathy refers to autoimmune eye diseases, while immunosuppressants can inhibit the body's immune response. Incorporating immunosuppressants into ophthalmic nanodrug delivery systems, such as microparticles, nanoparticles, liposomes, micelles, implants, and in situ gels, has advantages in improving solubility, increasing bioavailability, targeting specific eye tissues, and reducing side effects. This study reviews recent research and applications in this area, providing a reference for the development of ophthalmic drug delivery systems.
Article
Engineering, Environmental
Su-Ji Jeon, Peiguang Hu, Kyoungtea Kim, Caroline M. Anastasia, Hye-In Kim, Christopher Castillo, Colleen B. Ahern, Joel A. Pedersen, D. Howard Fairbrother, Juan Pablo Giraldo
Summary: The lack of understanding of the mechanistic interactions between nanomaterials and plant and algae cell walls hinders the development of nanotechnology in sustainable agriculture. This study investigated the influence of nanoparticle charge on their interactions with model and native cell walls, and found that positively charged carbon dots exhibited strong affinity with cell walls due to ionic bonding, while negatively or neutrally charged carbon dots had negligible interactions. The findings provide insights into the fundamental interactions of nanomaterials with plant and algae cell walls, which can contribute to the advancement of nanoenabled agriculture with reduced environmental impact.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Christian Oliver, Christopher A. Schuh
Summary: Nanophase separation sintering (NPSS) enables low temperature, pressureless sintering through the formation of solid phase necks driven by phase separation. Different activation energies were identified for W-Cr and Cr-Ni systems at two critical temperatures, while Ti-Mg system's poor densification is attributed to the lack of redissolution at high temperatures.
METALLURGICAL AND MATERIALS TRANSACTIONS A-PHYSICAL METALLURGY AND MATERIALS SCIENCE
(2021)
Article
Ophthalmology
Grant A. Justin, Fasika A. Woreta, Marcus H. Colyer, James D. Auran, Ron W. Pelton, Christopher J. Rapuano, Anne M. Menke
Summary: This study reviewed data on ophthalmic trauma malpractice claims in the United States to determine the frequency and causes of litigation. The study found that ophthalmic trauma malpractice claims are rare but result in higher payouts compared to non-trauma settlements, with approximately 40% of cases decided in favor of the plaintiff. Improvements in care could be achieved through careful history-taking, comprehensive ophthalmic examinations, appropriate imaging, meticulous documentation, and early referral to subspecialists.
Article
Biophysics
Weronika Ficerman, Marek Wisniewski, Katarzyna Roszek
Summary: This article summarizes the impact of nanomaterials on the functions of the purinergic signaling pathway in cells, including direct interactions with purinergic receptors, changes in receptor gene expression, activation of inflammatory processes, and induction of cell death. The article points out that although the mechanisms of action have not been fully elucidated, these nano-bio interactions are crucial for toxicity assessment and designing safer nanomaterials.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Review
Engineering, Biomedical
Lu Teng, Yabin Sun, Siying Teng, Peng Hui
Summary: Angiogenesis plays a crucial role in the occurrence and metastasis of various diseases. However, the clinical use of anti-vascular endothelial growth factors (VEGF) drugs is limited. In recent years, nanotechnology has shown potential in inhibiting neovascularization and reducing reactive oxygen species or inflammatory factors. This article aims to review the research progress of nanotechnology in ophthalmology and provide more treatment options for neovascularization-related diseases.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2023)
Article
Multidisciplinary Sciences
Kevin J. McHugh, Dian Li, Jay C. Wang, Leon Kwark, Jessica Loo, Venkata Macha, Sina Farsiu, Leo A. Kim, Magali Saint-Geniez
Article
Chemistry, Multidisciplinary
Jihyeon Yeom, Pedro P. G. Guimaraes, Hyo Min Ahn, Bo-Kyeong Jung, Quanyin Hu, Kevin McHugh, Michael J. Mitchell, Chae-Ok Yun, Robert Langer, Ana Jaklenec
ADVANCED MATERIALS
(2020)
Article
Cell Biology
Xueguang Lu, Lei Miao, Wenting Gao, Ziqi Chen, Kevin J. McHugh, Yehui Sun, Zachary Tochka, Stephanie Tomasic, Kaitlyn Sadtler, Alain Hyacinthe, Yuxuan Huang, Tyler Graf, Quanyin Hu, Morteza Sarmadi, Robert Langer, Daniel G. Anderson, Ana Jaklenec
SCIENCE TRANSLATIONAL MEDICINE
(2020)
Article
Multidisciplinary Sciences
Morteza Sarmadi, Adam M. Behrens, Kevin J. McHugh, Hannah T. M. Contreras, Zachary L. Tochka, Xueguang Lu, Robert Langer, Ana Jaklenec
Editorial Material
Biotechnology & Applied Microbiology
Kevin J. McHugh
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2020)
Review
Pharmacology & Pharmacy
Dhruv Varshney, Sherry Yue Qiu, Tyler P. Graf, Kevin J. McHugh
Summary: Toll-like receptors (TLRs) play a crucial role in cancer immunotherapy, with TLR7 and TLR8 being identified as potential therapeutic targets. Despite challenges such as poor drug solubility and systemic toxicity, biomaterial-based drug delivery systems have shown promise in enhancing the efficacy of TLR7/8 agonists. Additionally, combining TLR7/8 agonists with other therapies, such as checkpoint inhibitors and cancer vaccines, has demonstrated impressive anti-cancer effects.
Article
Biochemistry & Molecular Biology
Amjad Husain, Arogya Khadka, Allen Ehrlicher, Magali Saint-Geniez, Ramaswamy Krishnan
Summary: The study reveals the underlying role of the PI3K/Akt/mTOR signaling pathway in regulating vascular endothelial growth factor-A (VEGF-A) mediated signaling and functions. The pathway is activated on stiffer substrates, amplified by VEGF-A stimulation, and correlated with enhanced endothelial cell (EC) proliferation, contraction, pro-angiogenic secretion, and capillary-like tube formation. These findings have important implications for understanding age-related macular degeneration and provide insight into potential therapeutic pathways.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Yingying Li, Peisen Zhang, Wen Tang, Kevin J. McHugh, Stephen V. Kershaw, Mingxia Jiao, Xiaodan Huang, Sergii Kalytchuk, Collin F. Perkinson, Saisai Yue, Yuanyuan Qiao, Lichong Zhu, Lihong Jing, Mingyuan Gao, Buxing Han
Summary: This study develops CuInSe2@ZnS:Mn quantum dots with intrinsic multifunctionality, which can accurately localize small metastases and act as potent tumor ablation agents.
Review
Cell Biology
Erin M. Euliano, Alexandros A. Sklavounos, Aaron R. Wheeler, Kevin J. McHugh
Summary: This article discusses the clinical success factors for diagnostics and drug delivery systems in low-resource settings and provides recommendations for the clinical translation of future medical technologies.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Biochemical Research Methods
Brett H. Pogostin, Gabriel Saenz, Carson C. Cole, Erin M. Euliano, Jeffrey D. Hartgerink, Kevin J. McHugh
Summary: This study investigates the impact of oxidation state on the release of mannan from a peptide hydrogel. It is found that oxidized mannan is released more slowly from the hydrogel compared to reduced mannan. The slower release rate is attributed to the formation of dynamic imine bonds between oxidized mannan and the hydrogel. In vivo, oxidized mannan is cleared more slowly from the hydrogel. These findings suggest that the oxidation state of mannan affects its release and clearance from the hydrogel, highlighting a potentially important difference between oxidized and reduced mannan.
BIOCONJUGATE CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Tyler P. P. Graf, Sherry Yue Qiu, Dhruv Varshney, Mei-Li Laracuente, Erin M. M. Euliano, Pujita Munnangi, Brett H. H. Pogostin, Tsvetelina Baryakova, Arnav Garyali, Kevin J. J. McHugh
Summary: PULSED is a novel drug delivery system that provides a sequence of doses in a single injection, improving patient adherence and therapeutic efficacy. It utilizes high-resolution 3D printing and soft lithography to form biodegradable polymeric microstructures with an open cavity, which are filled with drug and sealed using contactless heating. The system exhibits versatility and compatibility with various drugs, with the potential to simplify drug formulations at a low cost and scale effectively.
ADVANCED MATERIALS
(2023)
Review
Biotechnology & Applied Microbiology
Tsvetelina H. Baryakova, Brett H. Pogostin, Robert Langer, Kevin J. McHugh
Summary: Improving medication adherence is essential for improving population health. Baryakova and colleagues explore the potential of next-generation drug delivery systems to address common barriers to adherence and discuss the impact of these systems across different diseases.
NATURE REVIEWS DRUG DISCOVERY
(2023)
Review
Pharmacology & Pharmacy
Miusi Shi, Kevin J. McHugh
Summary: The global pharmaceutical market has seen a shift in focus towards peptide, protein, and nucleic acid drugs, which now dominate the top-selling pharmaceutical products. While these biologics offer advantages such as improved drug specificity and enhanced efficacy, they also pose challenges including increased degradation and the need for frequent administration via invasive routes. Controlled-release systems have the potential to address these challenges by providing better control over drug levels, targeting specific tissues, and reducing administration frequency. However, adapting controlled-release devices for biologics has proven challenging due to their poor stability.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Biotechnology & Applied Microbiology
Brett H. Pogostin, Kevin J. McHugh
Summary: Future infectious disease outbreaks are inevitable, requiring effective public health policies and healthcare innovations to maximize readiness. Modern adjuvants play a critical role in enhancing vaccine efficacy, but their development lags behind vaccine engineering. Accelerating safety testing and technology sharing for adjuvants could expedite vaccine testing and deployment in the face of future pandemics.
BIOENGINEERING-BASEL
(2021)
Review
Chemistry, Multidisciplinary
Mei-Li Laracuente, Marina H. Yu, Kevin J. McHugh
JOURNAL OF CONTROLLED RELEASE
(2020)