Article
Materials Science, Multidisciplinary
Bahar Aslanbay Guler, Zeliha Demirel, Esra Imamoglu
Summary: From a bioengineering perspective, incorporating microalgae into chemobrionic structures can lead to functional materials with potential in various applications. In this study, the incorporation of Arthrospira platensis microalgae was successfully achieved, resulting in the development of a bioactive and biomimetic material called biochemobrionic. Various characterization analyses confirmed the presence of microalgal biomass and extract, and it was demonstrated that the incorporation of A. platensis extract improved the mechanical strength of the chemobrionics. Cytotoxicity, biodegradability, and antioxidant activity assays further revealed the bioactive potential of the extract-incorporated biochemobrionics.
APPLIED MATERIALS TODAY
(2023)
Review
Chemistry, Multidisciplinary
Sohrab Mofakhami, Erfan Salahinejad
Summary: BCP microspheres have desirable characteristics such as shape, bioresorbability, bioactivity, biocompatibility, osteogenesis, and angiogenesis, which can be controlled by phase ratio, porosity, and surface roughness. The manufacturing methods, properties, and applications of BCP microspheres are reviewed in this paper, providing insights for future developments in biomedicine, especially in bone tissue regeneration and delivery applications.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Engineering, Biomedical
M. Ethan Brown, Jennifer L. L. Puetzer
Summary: This study investigates the effect of compressive mechanical boundary conditions and the addition of beta-tricalcium phosphate (beta TCP) on the development of zonal ligament-to-bone entheses. The results show that compressive boundary clamps and beta TCP can guide ligament fibroblasts to produce zonal gradients in collagen organization, mineralization, and matrix composition, closely resembling immature ligament-to-bone attachments. This culture system provides a promising platform for understanding and promoting enthesis regeneration in graft repair and engineered replacements.
ACTA BIOMATERIALIA
(2022)
Article
Engineering, Biomedical
Elisa Fiume, Alessandro Schiavi, Gissur Orlygsson, Cristina Bignardi, Enrica Verne, Francesco Baino
Summary: Proper microstructural and transport properties are crucial for scaffold design in tissue engineering applications. Evaluating permeability remains a challenge, while pore characteristics are relatively easier to assess.
ACTA BIOMATERIALIA
(2021)
Article
Engineering, Biomedical
Evangelos Daskalakis, Fengyuan Liu, Boyang Huang, Anil A. Acar, Glen Cooper, Andrew Weightman, Gordon Blunn, Bahattin Koc, Paulo Bartolo
Summary: This study explores a novel osseointegrated prosthetic solution using modular bone bricks, investigating the impact of different architectures and material compositions on the performance of the prosthesis. Results showed that reinforced bone bricks with specific filament patterns exhibited improved mechanical and biological properties, with the best outcomes achieved with certain combinations of materials and structures.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2021)
Article
Biophysics
Jian He, Zhidong Lin, Xulin Hu, Luyao Xing, Gaofeng Lian, Dongliang Chen, Junling An, Chengdong Xiong, Xiangchun Zhang, Lifang Zhang
Summary: The study developed bioactive scaffolds with favorable mechanical properties and osteogenesis promotion, which could be a promising alternative to bone cement in bone tissue engineering.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Biophysics
Ahmed El-Fiqi, Joong-Hyun Kim, Hae-Won Kim
Summary: The study successfully prepared highly bioactive bone cement microspheres, which have the potential to serve as bone defect fillers to promote bone regeneration. These microspheres have a large specific surface area, sustained release of soluble silicate ions, and high protein adsorption capacity. The experimental results demonstrate that these cement microspheres exhibit excellent bioactivity both in vitro and in vivo, accelerating new bone formation.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Review
Green & Sustainable Science & Technology
Mohd Faiz Muaz Ahmad Zamri, Raihana Bahru, Rashid Amin, Muhammad Umar Aslam Khan, Saiful Izwan Abd Razak, Shukur Abu Hassan, Mohammed Rafiq Abdul Kadir, Nadirul Hasraf Mat Nayan
Summary: The utilization of waste-derived materials in tissue engineering applications shows outstanding biocompatibility and biodegradability, contributing to environmental sustainability by reducing waste disposal, increasing source availability, and minimizing manufacturing cost. The desirable properties and potentials of waste materials create significant opportunities for their implementation in tissue engineering, as summarized in recent research on the subject.
JOURNAL OF CLEANER PRODUCTION
(2021)
Article
Materials Science, Multidisciplinary
Jiaolong Wang, Qin Zhao, Shihang Zheng, Jinyang Wang, Liangliang Fu, Can Wang, Zifan Zhao, Yufeng Zhang
Summary: Macrophages play a crucial role in bone regeneration, and the CD301b+ macrophages exhibit significant effects in the osteoinduction of calcium phosphate ceramics, promoting the osteogenic differentiation of mesenchymal stem cells and potentially serving as a novel therapeutic target for bone regeneration.
APPLIED MATERIALS TODAY
(2021)
Article
Nanoscience & Nanotechnology
Zhi Zhou, Yunshan Fan, Yingying Jiang, Sheng Shi, Chao Xue, Xinyu Zhao, Shuo Tan, Xin Chen, Chaobo Feng, Yancheng Zhu, Jiajun Yan, Zifei Zhou, Yunfei Zhao, Junjian Liu, Feng Chen, Shisheng He
Summary: Inspired by bone biomineralization, a biomimetic strategy is achieved for the preparation of mineralized ALP nanoparticles. This approach significantly enhances bone marrow mesenchymal stem cell proliferation and osteogenic differentiation, and can be applied for constructing mineralized protein-based bioactive materials for tissue regeneration.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Materials Science, Ceramics
Tianxing Gong, Tingyu Li, Lisha Meng, Yadong Chen, Tao Wu, Jingqiu Zhou, Guoxiu Lu, Zhiguo Wang
Summary: In this study, a phase-separation-hydration method was used to fabricate a PVDF scaffold, which exhibited superior piezoelectric properties, mechanical compatibility with bone, and biocompatibility with osteoblast cells.
CERAMICS INTERNATIONAL
(2022)
Article
Materials Science, Ceramics
Mateo Escobar Jaramillo, Claudia Patricia Ossa Orozco
Summary: This study optimized the auto-ignited microwave molten salt synthesis of multiphase calcium phosphates using surface response methodology and genetic algorithms. The resulting CaP nanopowders showed good cytocompatibility, bioactivity, and controllable dimensions.
CERAMICS INTERNATIONAL
(2021)
Article
Engineering, Biomedical
Hongshi Ma, Chen Yang, Zhenjiang Ma, Xiaoyue Wei, Muhammad Rizwan Younis, Hanbo Wang, Wentao Li, Zhiyong Wang, Wenhao Wang, Yongxiang Luo, Peng Huang, Jinwu Wang
Summary: This study utilizes bioinspired calcium silicate nanowires and alginate composite hydrogels as building blocks to construct multiscale hierarchical bioactive scaffolds, and successfully promotes tissue regeneration from tendon to bone.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Materials Science, Ceramics
Hyeon Jin Kim, Kummara Madhusudana Rao, K. S. V. Krishna Rao, Sung Soo Han
Summary: Bioactive hydrogels with enhanced bone-like apatite formation were developed using a calcium-free phosphate approach. The structure and properties of the hydrogels were validated through analysis techniques. The hydrogels exhibited a porous structure with a fibrous topology, promoting cell growth and adhesion. The phosphate functionality within the hydrogels facilitated rapid biomineralization.
CERAMICS INTERNATIONAL
(2023)
Article
Green & Sustainable Science & Technology
Szymon Skibinski, Joanna P. Czechowska, Maciej Guzik, Vladyslav Vivcharenko, Agata Przekora, Patryk Szymczak, Aneta Zima
Summary: Poly(3-hydroxybutyrate) (P(3HB)) and medium chain length PHA (mcl-PHA) blends were used as coatings on beta tricalcium phosphate (beta TCP) scaffolds, and their physicochemical properties were investigated. The blends showed high open porosity and improved compressive strength on the scaffolds. The wettability of the coatings could be tailored by modifying the composition of the blends. In vitro biocompatibility tests showed that all evaluated scaffolds were nontoxic, and the hydrophilicity of the surface positively influenced cell adhesion and proliferation.
SUSTAINABLE MATERIALS AND TECHNOLOGIES
(2023)