Article
Biochemistry & Molecular Biology
Gero Knapp, Jonas Pawelke, Christian Heiss, Sera Elmas, Vithusha Vinayahalingam, Thaqif Elkhassawna
Summary: Insufficient research has been conducted on the biocompatibility of synthetic bioactive bone substitute materials after traumatic bone fractures. This study examined over 290 patients who underwent surgical treatment for acute fractures and found that the use of calcium phosphate-based bone substitutes improved bone healing and reduced complications. This effect was particularly significant in geriatric patients.
Article
Biochemistry & Molecular Biology
Jennifer Blankenburg, Johannes Vinke, Bianca Riedel, Sergej Zankovic, Hagen Schmal, Michael Seidenstuecker
Summary: In this study, the adaptation of biological shapes in 3D printing of ceramic-based scaffolds was investigated. By adjusting the layer rotation angle, sample shapes with a rotation angle of only 1 degree were successfully printed. The maximum failure load of the samples was increased by changing the strand diameter and arrangement.
Article
Biotechnology & Applied Microbiology
Shi-Yong Wang, Ru-Bin Yao, Kai-Shun Yang, Huang-Chien Liang, Chen-Ying Su, Hsu-Wei Fang, Sher-Wei Lim
Summary: The study investigated the potential of vancomycin-loaded Bicera (TM) as a bone substitute to prevent implant-associated osteomyelitis and postoperative infection. Results showed that vancomycin-loaded Bicera (TM) effectively inhibited the growth of MRSA and facilitated new bone growth in bone defects.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Yuan-Zhe Jin, Guang-Bin Zheng, Minjoon Cho, Jae Hyup Lee
Summary: Whitlockite showed slightly higher bone volume percentage compared with tricalcium phosphate in the posterolateral fusion model, although none of the materials successfully fused with surrounding bone tissue. Whitlockite did not induce ectopic bone formation in the abdominal pouch model.
BIOMATERIALS RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Hsiao-Hung Chiang, Chen-Ying Su, Ling-Hsiang Hsu, Min-Hsuan Yang, Hsu-Wei Fang
Summary: Calcium sulfate/calcium phosphate (CS-CP)-based bone substitutes in premixed putty form have the potential to be effective in clinical applications, but there is a risk of disintegration when in contact with blood or body fluids. By adding varying amounts of hydroxypropyl methylcellulose (HPMC) to the premixed putty, researchers found that a higher concentration of HPMC led to decreased disintegration. This suggests that CS-CP pre-mixed putty with glycerin and HPMC could be a suitable bone substitute with good anti-washout properties for clinical use.
APPLIED SCIENCES-BASEL
(2021)
Review
Orthopedics
Jean-Michel Cognet, Olivier Mares
Summary: Distal radius malunion can affect wrist function due to non-anatomical consolidation of a fracture, requiring imaging assessment and possibly surgical intervention for restoration of anatomy, with the aid of computerization for planning.
ORTHOPAEDICS & TRAUMATOLOGY-SURGERY & RESEARCH
(2021)
Review
Engineering, Biomedical
Oznur Demir-Oguz, Aldo R. Boccaccini, Dagnija Loca
Summary: Calcium phosphate bone cements (CPCs) have valuable properties such as bioactivity, osteoconductivity, injectability, and moldability, but their low mechanical performance limits their clinical application. Adding bioactive glasses (BGs) as a secondary powder phase can improve the injectable properties of CPCs and enhance the degradation rate, in vitro osteogenic differentiation, cell response, and tissue-material interaction.
BIOACTIVE MATERIALS
(2023)
Article
Orthopedics
Nusret Kose, Zeynel M. Asfuroglu, Aydan Kose, Varol Sahinturk, Mevlut Gurbuz, Aydin Dogan
Summary: Experimental study demonstrates that silver ion-doped calcium phosphate-based bone graft substitution can stimulate bone growth, combat infection, and effectively treat chronic osteomyelitis in an animal model.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Article
Chemistry, Physical
Jeong-Kui Ku, Il-hyung Kim, Jung Hee Shim, Yu Ha Kim, Baek Hyun Kim, Young-Kyun Kim, Pil-Young Yun
Summary: This study compares the biomechanical properties and bone regeneration of whitlockite with hydroxyapatite or beta-tricalcium phosphate-based materials. The results show that whitlockite has excellent volumetric stability and osteoconductivity, and it is similar to the other materials in terms of new bone formation.
Article
Multidisciplinary Sciences
Johannes G. G. Dobbe, Peter Kloen, Simon D. Strackee, Geert J. Streekstra
Summary: The study concluded that oblique double-cut rotation osteotomy (ODCRO) is more effective than oblique single-cut rotation osteotomy in correcting complex bone deformations, with virtual preoperative planning minimizing residual alignment errors. Although an increased transverse translation may occur in some cases, the method restored most of the length errors.
SCIENTIFIC REPORTS
(2021)
Article
Environmental Sciences
Ki-Jin Jung, Swapan Kumar Sarkar, Woo-Jong Kim, Bo-Ram Kim, Jong-Seok Park, Byong-Taek Lee
Summary: This study demonstrates the potential applications of multichannel granular bone substitutes in orthopedic conditions such as bone tumor, fracture, and bone defect with arthroplasty. Clinical investigation and radiographic observation showed that the bone substitute stabilizes and gradually regenerates the bone defect. Radiographic findings confirmed homogeneous three-dimensional bone regeneration. These high-strength multichannel granules can be used as versatile bone substitutes for various orthopedic conditions.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Chemistry, Multidisciplinary
Joo-Seong Kim, Tae-Sik Jang, Suk-Young Kim, Won-Pyo Lee
Summary: This study evaluated the effect of a commercialized octacalcium phosphate (OCP)-based synthetic bone substitute material (Bontree(R)) in vitro, in vivo, and in clinical cases. Bontree(R) suppressed RANKL and increased ALP activity, showing a high new bone formation ability. Clinical application demonstrated a 100% success rate for ridge or sinus augmentation using Bontree(R).
APPLIED SCIENCES-BASEL
(2021)
Article
Surgery
Conor Gouk, Melissa Bairstow, Michael Thomas, Ezekiel Tan, Fraser Taylor, Randy Bindra
Summary: This study compared the outcomes of early internal fixation and late corrective osteotomy in patients with distal radius fractures. The results showed that the patient-measured outcome of corrective osteotomy was not inferior to early internal fixation.
ANZ JOURNAL OF SURGERY
(2022)
Article
Biophysics
Fupo He, Jin Rao, Jielin Zhou, Wenhao Fu, Yao Wang, Yihang Zhang, Fei Zuo, Haishan Shi
Summary: Magnesium calcium phosphate composite bioceramic scaffolds were fabricated using 3D printing technology with Mg3(PO4)2 and β-Ca3(PO4)2 as starting materials. The porosity and compressive strength of the scaffolds could be adjusted by altering the sintering temperature and the formula of starting materials. The Ca3Mg3(PO4)4-based bioceramic scaffolds, prepared from 60 wt% Mg3(PO4)2 and 40 wt% β-Ca3(PO4)2, showed the highest compressive strength and stimulated cellular growth and osteoblastic differentiation.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Engineering, Biomedical
Agneta Vezenkova, Janis Locs
Summary: With the increase in global population, the demand for bone substitutes is growing. Calcium phosphate cements (CPCs) have the potential for various applications in bone regeneration due to their ability to self-set and resorb. However, finding an osteoinductive material that is suitable for injection remains a challenge.
BIOACTIVE MATERIALS
(2022)
Article
Clinical Neurology
Carola Hedberg-Oldfors, Robert Meyer, Kay Nolte, Yassir Abdul Rahim, Christopher Lindberg, Kristjan Karason, Inger Johanne Thuestad, Kittichate Visuttijai, Mats Geijer, Matthias Begemann, Florian Kraft, Eva Lausberg, Lea Hitpass, Rebekka Gotzl, Elizabeth J. Luna, Hanns Lochmuller, Steffen Koschmieder, Michael Gramlich, Burkhard Gess, Miriam Elbracht, Joachim Weis, Ingo Kurth, Anders Oldfors, Cordula Knopp
Article
Rheumatology
Helena Forsblad-d'Elia, Lucy Law, Karin Bengtsson, Johan Smeds, Maria Ketonen, Bjorn Sundstrom, Lotta Ljung, Mats Geijer, Stefan Soderberg, Per Lindqvist
Summary: The research examined biomechanical properties of the common carotid artery in patients with ankylosing spondylitis (AS), finding that strain and stiffness were associated with factors like age, disease characteristics, and traditional risk factors for cardiovascular disease. Strain showed associations with AS-related factors and age, whereas stiffness was only associated with age, indicating different pathogenic vascular processes.
JOURNAL OF RHEUMATOLOGY
(2021)
Article
Orthopedics
Sverrir Kiernan, Mats Geijer, Martin Sundberg, Gunnar Flivik
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2020)
Review
Radiology, Nuclear Medicine & Medical Imaging
Pawel Szaro, Mats Geijer, Nektarios Solidakis
INSIGHTS INTO IMAGING
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Simon Gotestrand, Anders Bjorkman, Isabella M. Bjorkman-Burtscher, Rana Ab-Fawaz, Ingvar Kristiansson, Bjorn Lundin, Mats Geijer
Summary: The study compared the visualization of wrist ligaments on 3T MRI between 3D and 2D sequences, with 3D sequences showing superior performance in visualizing the foveal attachment.
Article
Engineering, Biomedical
Joeri Kok, Aurimas Sirka, Yang Liu, Sarunas Tarasevicius, Juozas Belickas, Magnus Tagil, Lars Lidgren, Hanna Isaksson, Deepak Bushan Raina
Summary: The study demonstrates that CaS/HA can improve the fixation of a dynamic hip screw, with more significant results in synthetic bone compared to human femoral heads. Further research is needed to confirm the differences observed in human bone specimens.
MEDICAL ENGINEERING & PHYSICS
(2021)
Article
Engineering, Biomedical
Elin Tornquist, Sophie Le Cann, Erika Tudisco, Alessandro Tengattini, Edward Ando, Nicolas Lenoir, Johan Hektor, Deepak Bushan Raina, Magnus Tagil, Stephen A. Hall, Hanna Isaksson
Summary: This study compares the visualization and contrast-to-noise ratio of neutron and x-ray tomography in imaging bone and metallic implants, and highlights the benefits of combining both modalities through joint histogram analysis. The results demonstrate the differences in how neutrons and x-rays interact with tissues and implants, offering insights for future refinement of segmentation techniques and obtaining novel specimen-specific information.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Simon Gotestrand, Anders Bjorkman, Isabella M. Bjorkman-Burtscher, Ingvar Kristiansson, Elenya Aksyuk, Pawel Szaro, Karin Markenroth Bloch, Mats Geijer
Summary: Compared to 3T MR, visualization of anatomical structures at 7T showed significantly higher visibility of cartilage, trabecular bone, tendons, nerves, and ligaments. Image quality was also significantly superior at 7T, except for artefacts.
EUROPEAN RADIOLOGY
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Mats Geijer, Henrik S. Thomsen
Summary: Acta Radiologica celebrates its 100th anniversary in 2021, evolving from single-author verbose monographs to a truly international cadre of multi-author collaborations. The journal has seen significant increases in published articles, issues per year, and printed pages over the past century. The Foundation has established two prizes to encourage academic research, and the growing number of manuscript submissions indicates a promising future for the journal.
Review
Radiology, Nuclear Medicine & Medical Imaging
Mats Geijer, Fatih Inci, Nektarios Solidakis, Pawel Szaro, Bariq Al-Amiry
Summary: Over the last 100 years, musculoskeletal radiology has evolved from basic bone radiography to a dedicated subspecialty covering all imaging modalities. It heavily relies on cross-sectional and functional imaging and plays a vital role in tumor diagnosis and joint diseases. These developments are reflected in Acta Radiologica, as highlighted in this review.
Article
Rheumatology
Adrian Wiginder, Carin Sahlin-Ingridsson, Mats Geijer, Anders Blomberg, Karl A. Franklin, Helena Forsblad-d'Elia
Summary: In this study, it was found that patients with ankylosing spondylitis (AS) did not have a higher prevalence of obstructive sleep apnoea (OSA) compared to matched controls. AS patients with OSA had higher BMI, were older, and had lesser chest expansion due to more severe AS compared to patients without OSA.
CLINICAL RHEUMATOLOGY
(2022)
Article
Orthopedics
Elisabeth Brogren, Antonio Abramo, Magnus Tagil
Summary: This study compared bone remodeling and radiological instability between total ulna head replacement and partial ulna head replacement in distal radioulnar joint arthroplasty. The results showed that there was more extensive bone resorption beneath the prosthetic head in total ulna head prosthesis compared to partial ulna head prosthesis at 1-year post surgery. The filling ratio did not affect bone resorption, and there was no difference in radiological instability between the two prosthetic designs.
JOURNAL OF WRIST SURGERY
(2022)
Article
Rheumatology
Elisabet Lindqvist, Tor Olofsson, Anna Joud, Mats Geijer, Johan K. Wallman, Elisabeth Mogard
Summary: The study aimed to investigate the agreement between clinical diagnoses of axial spondyloarthritis (axSpA) and fulfilment of the Assessment of SpondyloArthritis international Society (ASAS) axSpA and modified New York (mNY) classification criteria, and to compare disease/health status among axSpA subtypes. The study found an overall good concordance between clinical axSpA diagnoses and classification criteria fulfilment, with weaker concordance among axSpA subtypes. Clinical undifferentiated axSpA diagnoses could not serve as a proxy to identify non-radiographic axSpA, highlighting the importance of thorough classification in axSpA subtype research.
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
(2023)
Article
Cell & Tissue Engineering
S. Sebastian, F. Tandberg, Y. Liu, D. B. Raina, M. Taegil, M. Collin, L. Lidgren
Summary: This in vitro study evaluated a biphasic calcium sulphate/hydroxyapatite biomaterial as a carrier for dual delivery of rifampicin with vancomycin or gentamicin. The results showed that the composite material exhibited good injectability and setting time, with sustained release of rifampicin and antibiotics. It demonstrated excellent antibacterial and antibiofilm effects against Staphylococcus aureus strains.
BONE & JOINT RESEARCH
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ahmed Samir, Heba Said Gharraf, Ayman Ibrahim Baess, Rania Ahmed Sweed, Khaled Matrawy, Mats Geijer, Adel Shalabi, Yasmine Tarek
Summary: This study aimed to evaluate the significance of splenic volume in COVID-19 patients and correlate it with the volume of lung changes. The results showed that splenomegaly was not statistically correlated with the severity of the disease, but splenic atrophy or progressive splenomegaly was correlated with severe COVID-19 presentation and cytokine storm.
EGYPTIAN JOURNAL OF RADIOLOGY AND NUCLEAR MEDICINE
(2022)
