Journal
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
Volume 93B, Issue 1, Pages 141-149Publisher
WILEY
DOI: 10.1002/jbm.b.31568
Keywords
tissue scaffold; poly(1,8-octanediol-co-citrate); elastomer; permeability; degradation
Funding
- NIAMS NIH HHS [R01 AR053379, R01 AR 053379] Funding Source: Medline
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Poly(1,8-octanediol-co-citric acid) (POC) is a synthetic biodegradable elastomer that can be processed into three-dimensional (3D) scaffolds for tissue engineering. We investigated the effect of designed porosity on the mechanical properties, permeability, and degradation profiles of the POC scaffolds. For mechanical properties, scaffold compressive data were fitted to a one-dimensional (1D) nonlinear elastic model, and solid tensile data were fitted to a Neohookean incompressible nonlinear elastic model. Chondrocytes were seeded on scaffolds to assess the biocompatibility of POC. Increased porosity was associated with increased degradation rate, increased permeability, and decreased mechanical stiffness, which also became less nonlinear. Scaffold characterization in this article will provide design guidance for POC scaffolds to meet the mechanical and biological parameters needed for engineering soft tissues such as cartilage. (C) 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 93B: 141-149, 2010
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