Article
Biophysics
An Sermon, Ivan Zderic, Roberto Khatchadourian, Simon Scherrer, Matthias Knobe, Karl Stoffel, Boyko Gueorguiev
Summary: This study analyzed the biomechanical impact of bone cement augmentation on PFNA and TFNA head elements in a human cadaveric model with poor bone quality. The results showed that all types of implants demonstrated higher fixation strength and cut-out resistance after augmentation, with TFNA blades showing the highest values. Bone cement augmentation significantly increases the cut-out resistance of instrumented TFNA and PFNA head elements, making it a valid supplementary treatment option for poor bone quality.
JOURNAL OF BIOMECHANICS
(2021)
Article
Food Science & Technology
Natalia Wawrzyniak, Anna Gramza-Michalowska, Pawel Kurzawa, Pawel Kolodziejski, Joanna Suliburska
Summary: This study aimed to investigate the effect of CaCO3-enriched pumpkin on calcium status in ovariectomized rats. The results showed that CaCO3-enriched pumpkin increased calcium content in femurs and improved bone recovery in ovariectomized rats. Additionally, enriched pumpkin contributed to calcium accumulation in the kidneys, especially when combined with alendronate.
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2023)
Article
Medicine, Research & Experimental
Kui Huang, Ya-Qiong Sun, Xiao-Feng Chen, Feng Tian, Fan Cheng, Qian-Long Gong, Ke-Bin Liu
Summary: Psoralen extracted from Psoraleacorylifolia promotes bone formation and accelerates fracture healing in osteoporotic animals by increasing BMP-2 and ER-alpha levels, and OPG/RANKL ratio.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Nutrition & Dietetics
Mengjie Yuan, Frank B. Hu, Yanping Li, Howard J. Cabral, Sai Krupa Das, Jude T. Deeney, Xinyi Zhou, Julie M. Paik, Lynn L. Moore
Summary: The study found that higher intake of total dairy, milk, and cheese is associated with lower risks of fracture in females, while yogurt intake is not associated with fracture risk.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Engineering, Biomedical
Xinggui Tian, Deepak B. B. Raina, Corina Vater, David Kilian, Tilman Ahlfeld, Ivan Platzek, Ute Nimtschke, Magnus Taegil, Lars Lidgren, Alexander Thomas, Uwe Platz, Klaus-Dieter Schaser, Alexander C. C. Disch, Stefan Zwingenberger
Summary: The study investigated the use of an injectable CaS/HA cement to enhance the anchoring of pedicle screws in osteoporotic vertebrae. The results showed that the cement had good distribution and interdigitation ability without leakage. Augmentation significantly increased the maximum pull-out force of the screws.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2022)
Article
Biotechnology & Applied Microbiology
Deepak Bushan Raina, Vetra Markeviciute, Mindaugas Stravinskas, Joeri Kok, Ida Jacobson, Yang Liu, Erdem Aras Sezgin, Hanna Isaksson, Stefan Zwingenberger, Magnus Taegil, Sarunas Tarasevicius, Lars Lidgren
Summary: This study presents a novel method for augmenting a lag-screw in pertrochanteric fractures (TFs), potentially reducing the risk of fracture fixation failure and reoperation in osteoporotic patients.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Medicine, General & Internal
Yang Jiang, Wei Zhang, Shihao Huang, Qing Huang, Haoyi Ye, Yurong Zeng, Xin Hua, Jinhui Cai, Zhifeng Liu, Qingyu Liu
Summary: This study aimed to develop a radiomics nomogram for the preoperative prediction of new vertebral fractures (NVFs) after vertebral augmentation (VA). The radiomics features were extracted from MRI images and combined with the presence of intravertebral cleft and number of previous vertebral fractures to develop a predictive model. The nomogram showed good predictive performance, successfully categorizing patients into high- or low-risk subgroups.
Article
Pharmacology & Pharmacy
Kyosuke Sakaida, Kazuhiro Omori, Masaaki Nakayama, Hiroki Mandai, Saki Nakagawa, Hidefumi Sako, Chiaki Kamei, Satoshi Yamamoto, Hiroya Kobayashi, Satoki Ishii, Mitsuaki Ono, Soichiro Ibaragi, Keisuke Yamashiro, Tadashi Yamamoto, Seiji Suga, Shogo Takashiba
Summary: The study found that the fungal secondary metabolite (+)-terrein has potential therapeutic application against osteoporosis by improving bone density and suppressing osteoclastogenesis through RANKL signal transduction inhibition.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
An Sermon, Ladina Hofmann-Fliri, Ivan Zderic, Yash Agarwal, Simon Scherrer, Andre Weber, Martin Altmann, Matthias Knobe, Markus Windolf, Boyko Gueorguiev
Summary: Cement augmentation enhances the fixation stability of TFNA blades and screws, with non-augmented blades performing better than screws in the anteroposterior off-centre position. In the setting of poor bone quality, augmentation and central positioning significantly increase failure load.
MEDICINA-LITHUANIA
(2021)
Article
Biochemistry & Molecular Biology
Sung-Ju Lee, Hyun Yang, Seong Cheol Kim, Dong Ryun Gu, Jin Ah Ryuk, Seon-A Jang, Hyunil Ha
Summary: Radix Asteris, a traditional Chinese medicine, has been historically used to treat respiratory conditions. This research reveals its potential in managing osteoporosis by inhibiting osteoclast differentiation and protecting against bone degradation. The study also identifies specific constituents in Radix Asteris that regulate bone and fat metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Dong Ryun Gu, Hyun Yang, Seong Cheol Kim, Youn-Hwan Hwang, Hyunil Ha
Summary: Angelica dahurica radix has traditional use in China and Korea for treating headaches, cold-damp pain, and skin diseases. This study found that the water extract of Angelica dahurica radix effectively inhibits osteoclast differentiation and alleviates bone loss.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Orthopedics
L. Henry Goodnough, Harsh Wadhwa, Seth S. Tigchelaar, Malcolm R. DeBaun, Michael J. Chen, Matt L. Graves, Michael J. Gardner
Summary: Cement augmentation in geriatric intertrochanteric fractures improves construct stability and outcomes based on biomechanical and early clinical studies. These findings suggest a significant role for cement augmentation in preventing mechanical failure in high-risk patient populations.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2022)
Article
Clinical Neurology
Ahmed Meleis, M. Benjamin Larkin, Dhiego Chaves de Almeida Bastos, Matthew T. Muir, Ganesh Rao, Laurence D. Rhines, Charles E. Cowles, Claudio E. Tatsui
Summary: The study demonstrated that percutaneous fixation with cement-augmented pedicle screws in patients with pathological spine fractures can significantly improve mechanical back pain with a low failure rate, and is associated with spontaneous facet fusion in some patients. Further research is needed to determine both short-term benefits and long-term outcomes.
NEUROSURGICAL FOCUS
(2021)
Article
Orthopedics
Yang Jiang, Jinhui Cai, Yurong Zeng, Haoyi Ye, Tingqian Yang, Zhifeng Liu, Qingyu Liu
Summary: This study aimed to develop a machine learning model based on radiomics signature and clinical factors to accurately predict the occurrence of new vertebral fractures in patients with osteoporotic vertebral compression fractures (OVCFs) undergoing vertebral augmentation (VA). The results showed that the model performed well in predicting the occurrence of new vertebral fractures.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Integrative & Complementary Medicine
Dibachehr Rahmani, Bahareh Faal, Hakimeh Zali, Saeed Hesami Tackallou, Zahra Niknam
Summary: The simultaneous supplementation of L. reuteri and CaF2 NPs has favorable effects in reducing post-menopausal bone loss.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2023)
Correction
Engineering, Biomedical
Bo Tian, Tao Jiang, Zhanying Shao, Zanjing Zhai, Haowei Li, Qiming Fan, Xuqiang Liu, Zhengxiao Ouyang, Tingting Tang, Qing Jiang, Minghao Zheng, Kerong Dai, An Qin, Yongping Yu, Zhenan Zhu
Article
Orthopedics
Feng Zhou, Xuequan Han, Liao Wang, Weituo Zhang, Junqi Cui, Zihao He, Kai Xie, Xu Jiang, Jingke Du, Songtao Ai, Qi Sun, Haishan Wu, Zhifeng Yu, Mengning Yan
Summary: The study showed that in the group with subchondral cysts, patients had increased osteoclastogenesis and nerve distribution in subchondral bone, leading to increased joint pain. The volume of subchondral cyst-like component was associated with joint pain, and subchondral osteoclastogenesis and nerve distribution were positively correlated with joint pain in this group.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2022)
Article
Biotechnology & Applied Microbiology
Mingming Xu, Jingke Du, Junqi Cui, Shuangyan Zhang, Shuhong Zhang, Mingwu Deng, Wenjie Zhang, Hanjun Li, Zhifeng Yu
Summary: CEFFE mitigated immobilization-induced bone loss by reducing osteocyte apoptosis. It increased osteocyte survival and inhibited osteocyte apoptosis by activating the ERK signaling pathway in vitro.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Orthopedics
Teng Ye, Feng Xue, Hai Hu, Zihao He, Minqi Wang, Zhifeng Yu, Bizeng Zhao, Linyang Chu
Summary: This study investigates the alterations in subchondral trabecular bone and microstructural properties during the development of developmental dysplasia of the hip (DDH). The results indicate that the deterioration of the subchondral bone along with aberrant bone remodeling may contribute to the progression of DDH. Furthermore, the inhibition of stress transmission from the articular cartilage to the subchondral bone leads to cartilage degeneration and accelerated DDH progression. Improving the subchondral bone could be a potential therapeutic approach for DDH.
Article
Chemistry, Multidisciplinary
Kai Huang, Jinbing Wang, Qinghao Zhang, Kai Yuan, Yiqi Yang, Fupeng Li, Xiaojiang Sun, Haishuang Chang, Yakun Bang, Jie Zhao, Tingting Tang, Shengbing Yang, Yakun Liang
Summary: Persistent bacteria, such as intracellular and biofilm bacteria, pose challenges in clinical treatment due to their resistance to antibiotics. In this study, a nanoscale gallium-based metal-organic framework (GaMOF) was developed to address this issue. The GaMOF nanoparticles could penetrate cell membranes and disrupt bacteria Fe metabolism, enhancing the potency of antibiotics and eradicating the two types of elusive bacteria. The results showed that the synthesized GaMOF had good biosafety and could alleviate inflammation caused by intracellular bacteria in vivo.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Correction
Biophysics
Bin 'en Nie, Haiyong Ao, Jianliang Zhou, Tingting Tang, Bing Yue
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Biotechnology & Applied Microbiology
Han Qiao, Jingtian Mei, Kai Yuan, Kai Zhang, Feng Zhou, Tingting Tang, Jie Zhao
Summary: This study reveals the crucial roles of zinc and oxygen homeostasis in dendritic cells (DCs) during the immune progression of rheumatoid arthritis (RA). It proposes a DC-targeting immune-regulating strategy using ZnO2/Catalase@liposome-Mannose nanoparticles (ZnCM NPs) to induce the transformation of immunogenic DCs (igDCs) into tolerogenic DCs (tDCs) and inhibit T-cell activation. The study demonstrates the promising potential of DC-targeting nanoplatforms in RA treatment and provides insights into ion homeostasis regulation for immune diseases.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Orthopedics
Tianyou Kan, Zihao He, Jingke Du, Mingming Xu, Junqi Cui, Xuequan Han, Dake Tong, Hanjun Li, Mengning Yan, Zhifeng Yu
Summary: Through animal experiments and in vitro cell experiments, it was found that irisin can promote bone fracture healing by enhancing osteogenesis and angiogenesis, which is of great significance in understanding the interaction between muscle and bone during fracture healing.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2022)
Article
Orthopedics
Kai Yuan, Kai Zhang, Yiqi Yang, Yixuan Lin, Feng Zhou, Jingtian Mei, Hanjun Li, Jie Wei, Zhifeng Yu, Jie Zhao, Tingting Tang
Summary: This study evaluated the interbody fusion efficacy and biocompatibility of a graft-free cage made of poly-etheretherketone/calcium silicate composite/porous tantalum (PEEK/CS/pTa cage) compared with a PEEK/CS cage with an autogenous bone graft in a goat model. The results showed that the graft-free PEEK/CS/pTa cage demonstrated similar fusion performance to the PEEK/CS cage with autogenous bone graft and had good biological safety.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2022)
Article
Chemistry, Applied
Xiaoyan Li, Xinsheng Niu, Yaowei Chen, Kai Yuan, Wenjun He, Shengbing Yang, Tingting Tang, Deng-Guang Yu
Summary: Chitosan-functionalized nanosilica was electrosprayed on a spin-coated base layer to form a composite coating with a micro-nano protruding surface, showing good antibacterial properties and sustained release effect. Nanosilica with uniform size was prepared by sol-gel method and coated with quaternized chitosan. The composite coating exhibited a unique micro-nano surface structure and the contact sterilization of chitosan quaternary ammonium salt played a synergistic effect, resulting in good sterilization effect on drug-resistant Staphylococcus aureus and controlled sustained release of quaternized chitosan.
PROGRESS IN ORGANIC COATINGS
(2023)
Article
Cell Biology
Yiqi Yang, Kai Yuan, Yihao Liu, Qishan Wang, Yixuan Lin, Shengbing Yang, Kai Huang, Tianyou Kan, Yuxin Zhang, Mingming Xu, Zhifeng Yu, Qiming Fan, Yugang Wang, Hanjun Li, Tingting Tang
Summary: In this study, the researchers identified AMPKa1 as a critical factor regulating the senescence and lineage commitment of mesenchymal stem cells (MSCs) and found that AMPKa1 activation can prevent age-related bone loss and promote MSC osteogenic commitment with increased IGF-1 secretion. The study provides mechanistic insight into the protective effect of AMPKa1 against skeletal aging by promoting bone-derived IGF-1 secretion.
CELL PROLIFERATION
(2023)
Article
Engineering, Biomedical
Fupeng Li, Kai Huang, Jinbing Wang, Kai Yuan, Yiqi Yang, Yihao Liu, Xianhao Zhou, Keyu Kong, Tao Yang, Jian He, Chunjie Liu, Haiyong Ao, Fengxiang Liu, Qian Liu, Tingting Tang, Shengbing Yang
Summary: This study developed a biocompatible titanium alloy with antibiofilm and anti-aseptic loosening properties by utilizing gallium as a component. The alloy exhibited outstanding antibiofilm properties both in vitro and in vivo, and it could also inhibit osteoclast differentiation by targeting iron metabolism, thus preventing aseptic loosening.
BIOMATERIALS RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Yiqi Yang, Mingming Xu, Tianyou Kan, Yao Wang, Shuhong Zhang, Mingwu Deng, Wenjie Zhang, Hanjun Li, Zhifeng Yu
Summary: This study finds that CEFFE from adipose tissues can effectively attenuate bone loss caused by hyperactive osteoclasts and inhibit osteoclast formation. The cationic protein fraction of CEFFE, CEFFE-Cation, is identified as the main inhibitory component and has superior antioxidant capacity and ability to mitigate Ca2+ oscillation.
ADVANCED THERAPEUTICS
(2023)
Article
Cell & Tissue Engineering
Yiqi Yang, Yixuan Lin, Minqi Wang, Kai Yuan, Qishan Wang, Pei Mu, Jingke Du, Zhifeng Yu, Shengbing Yang, Kai Huang, Yugang Wang, Hanjun Li, Tingting Tang
Summary: Diabetic osteoporosis (DOP) is characterized by osteocyte death through iron-dependent programmed cell death called ferroptosis. The diabetic microenvironment enhances osteocyte ferroptosis by promoting lipid peroxidation, iron overload, and aberrant activation of the ferroptosis pathway. Heme oxygenase-1 (HO-1) is upregulated in ferroptotic osteocytes in DOP, and its expression is controlled by the interaction between the transcription factors NRF2 and c-JUN. Targeting ferroptosis or HO-1 effectively rescues osteocyte death in DOP and improves trabecular deterioration.