Article
Materials Science, Multidisciplinary
Ling Ren, Xiaohe Xu, Hui Liu, Ke Yang, Xun Qi
Summary: The study aimed to comprehensively evaluate the short-and long-term biosafety of Cu-bearing titanium alloys, considering the impact of copper ion release. The results indicated compliance with ISO standards, with a safe release rate at parts per billion levels, demonstrating satisfactory biocompatibility.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2021)
Article
Engineering, Biomedical
Bronson A. Gregory, Cort H. Thompson, Joseph W. Salatino, Mia J. Railing, Ariana F. Zimmerman, Bhavna Gupta, Kathleen Williams, Joseph A. Beatty, Charles L. Cox, Erin K. Purcell
Summary: This study characterized the structural and functional changes in neurons surrounding implanted electrodes in the motor cortex of rats. The findings suggest that the abnormal morphology and altered function of these neurons may contribute to the signal loss and instability observed with chronically implanted electrodes.
ACTA BIOMATERIALIA
(2023)
Article
Materials Science, Multidisciplinary
Danil Barilyuk, Andrey Bazlov, Natalia Arkharova, Tatyana Teplyakova, Anton Konopatsky, Sergey Prokoshkin
Summary: Four novel superelastic alloys, Ti-41Zr-12Nb, Ti-42Zr-11Nb, Ti-43Zr-10Nb, Ti-44Zr-10Nb, were obtained and studied for their microstructure and mechanical properties, showing pronounced superelastic behavior after thermomechanical treatment. Among them, Ti-41Zr-12Nb demonstrated the highest ductility and is considered one of the most promising alloys in the Ti-Zr-Nb system.
Article
Materials Science, Biomaterials
Yuan Liu, Qin Hu, Yu Pan, Yinghui Wang, Lei Jiang, Honglei Lin, Donghong Lin, Hui Cheng
Summary: This study compared the biocompatibilities of cast and digitally manufactured dental metals in a 3D oral mucosal model by measuring metal ion release levels and conducting biological assessments. The results showed that digital manufacturing methods possess better chemical stability and biocompatibility. Cobalt, tungsten, and manganese appear to be potential inducements for the apoptotic and autophagic effects of cobalt-chromium alloy.
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Review
Engineering, Biomedical
Sen Chen, Ruiqi Zhao, Xuyang Sun, Hongzhang Wang, Lei Li, Jing Liu
Summary: This review provides a comprehensive summary of the current knowledge on liquid metal toxicology and biocompatibility, focusing on Ga and Bi-based liquid metals. It discusses the challenges and suggests further investigation to clarify toxicological mechanisms and strategies to avoid adverse effects. The review aims to promote the healthy and sustainable development of liquid metal-based materials, particularly in healthcare applications.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Francisco L. G. Marin, G. Gilberto Bejarano, Giovanny Torres Lindarte
Summary: Titanium alloys are commonly used for bone implants due to their high biocompatibility and chemical stability. However, their ability to resist bacteria adhesion and biofilm formation is limited. In this study, a nanocomposite coating made of TiAlVN(Ag)x was deposited on the titanium alloy substrates using magnetron sputtering technique. The coated substrates exhibited significant bactericidal effect without affecting their hardness and cell viability. The coatings showed high inhibition against Pseudomonas aeruginosa bacteria and good compatibility with human osteoblasts.
MATERIALS CHEMISTRY AND PHYSICS
(2022)
Article
Engineering, Biomedical
Carolina da Silva Dias, Mariana Correa Rossi, Emanuel V. P. Apolonio, Gustavo dos Santos Rosa, Joao Pedro Hubbe Pfeifer, Carlos Alberto Hussni, Marcos Jun Watanabe, Ana Liz Garcia Alves
Summary: This study evaluated the influence of magnesium in porous Ti-Nb-Sn alloys on the behavior of mesenchymal stem cells derived from equine bone marrow. The alloy showed mechanical properties close to cortical bone values, and the release of magnesium ions may have potential antioxidant defense capabilities. The study demonstrated the potential of using magnesium in the development of biomedical materials for bone regeneration.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Horia Opris, Gabriel Armencea, Avram Manea, Ileana Mitre, Mihaela Baciut, Florin Onisor, Florica Imre-Lucaci, Adriana Vulpoi, Sergiu Vacaras, Bran Simion, Cristian Dinu
Summary: The study found 1.06 ppm titanium in the adjacent soft tissues surrounding the titanium plates used in jaw surgery, suggesting that plate removal may be a feasible option for patients to avoid local complications.
APPLIED SCIENCES-BASEL
(2021)
Review
Materials Science, Multidisciplinary
Salikh Omarov, Nurlan Nauryz, Didier Talamona, Asma Perveen
Summary: Developing biomaterials with appropriate physiochemical and mechanical properties for biomedical applications is challenging. This paper provides an in-depth review of the requirements for biomedical surfaces, potential biomaterial candidates, and surface modification techniques. Both subtractive and additive methods are discussed, along with their pros and cons. Overall, this study presents a comprehensive compendium of scientific works and research trends in the field of surface modification and biocompatible alloys.
Article
Engineering, Biomedical
Qi Wu, Bin Chen, Xin Yu, Zhen Wang, Zhongyang Sun, Jiahua Duan, Hao Ding, Weiwei Wu, Nirong Bao, Jianning Zhao
Summary: This study created an original mouse model by implanting a helmet-like structure on the mouse calvaria and administering Co(II)/Cr(III) ions, which resulted in local macrophage infiltration and lymphocyte aggregates, providing new insights into the pathogenic mechanism of artificial joint failure.
ACTA BIOMATERIALIA
(2023)
Article
Materials Science, Multidisciplinary
Azadeh Valinattaj Omran, Chaimaa Mahi, Romain Vayron, Celine Falentin-Daudre, Fabien Benedic
Summary: This study investigated the characteristics of nanocrystalline diamond films synthesized at low surface temperature on Ti-6Al-4V substrates for biomedical applications. The surface roughness of the substrates was varied by different polishing grits. Regardless of the polishing protocol, nanocrystalline diamond coatings with comparable morphology and purity to those on silicon substrates were achieved. However, the polishing protocol significantly affected the roughness and hardness of the films, with the finest polishing grit leading to increased hardness values.
Review
Engineering, Biomedical
Masoud Sarraf, Erfan Rezvani Ghomi, Saeid Alipour, Seeram Ramakrishna, Nazatul Liana Sukiman
Summary: Commercially pure titanium and titanium alloys are widely used in biomedical applications due to their excellent mechanical properties, corrosion resistance, biocompatibility, and antibacterial properties. Future research will focus on advanced manufacturing technologies, effects of alloying elements on biocompatibility, and the role of titanium in regenerative and nanomedicine applications.
BIO-DESIGN AND MANUFACTURING
(2022)
Article
Chemistry, Multidisciplinary
Lei Sun, Xuzhuo Chen, Ruiguo Chen, Zhibo Ji, Haizhang Mu, Chun Liu, Jinlan Yu, Jiarong Wang, Rong Xia, Shanyong Zhang, Yin Xu, Kun Ma, Lunguo Xia
Summary: A special honeycomb-like large tube over small tube double-layered nanotube structure was used to achieve the time-dependent controllable release of antibacterial Ag ions, which can lead to the balance of antibacterial effect and osteogenesis properties.
Review
Chemistry, Physical
Yuncheng Wu, Hao Zhou, Ye Zeng, Hongxing Xie, Dongxu Ma, Zhoucheng Wang, Hanfeng Liang
Summary: This review summarizes the recent advances in the design and preparation methods of Cu-doped Ti and Ti alloy implants. The antibacterial and mechanical properties, corrosion resistance and biocompatibility of Cu-doped Ti implants from different methods are systematically reviewed. Cu-doped Ti implants have shown enhanced bone repair and regeneration, angiogenesis, and antibacterial capability.
Article
Chemistry, Physical
Mostafa Alhamad, Valentim A. R. Barao, Cortino Sukotjo, Lyndon F. Cooper, Mathew T. Mathew
Summary: The study indicates a strong correlation between Ti-ion concentration and corrosion rate in titanium alloys, suggesting that high Ti-ion concentration may exacerbate corrosion and increase the risk of adverse tissue reactions associated with implants.
Review
Nanoscience & Nanotechnology
Monica Paesa, Teresa Alejo, Felicito Garcia-Alvarez, Manuel Arruebo, Gracia Mendoza
Summary: This article reviews recent strategies based on nanotechnology for the early diagnosis and treatment of osteoarthritis (OA). OA is a complex joint pathology that requires novel therapeutic approaches, and nanotechnology offers new possibilities. The article also highlights key pathways involved in OA initiation and progression as potential targets for treatment, as well as current therapeutic strategies.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2023)
Article
Engineering, Environmental
Esun Selvam, Pavel A. Kots, Borja Hernandez, Abhinav Malhotra, Weiqi Chen, Jose M. Catala-Civera, Jesus Santamaria, Marianthi Ierapetritou, Dionisios G. Vlachos
Summary: Chemical upcycling technologies, particularly catalytic pyrolysis, show great promise in combating plastic waste accumulation. A study demonstrates that coupling microwave heating with solid acid promoters can enhance transport, minimize coke formation, and achieve high yields of olefins in a slurry reactor, operating at lower temperatures. Techno-economic analysis and life cycle assessment indicate the potential of this technology.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Belen Rubio-Ruiz, Ana M. Perez-Lopez, Laura Uson, M. Carmen Ortega-Liebana, Teresa Valero, Manuel Arruebo, Jose L. Hueso, Victor Sebastian, Jesus Santamaria, Asier Unciti-Broceta
Summary: Bioorthogonal metallocatalysis allows for nonenzymatic catalytic transformations in living environments. However, most metals are deactivated by reactive biomolecules inside cells, limiting their catalytic activity. In this study, cytocompatible alloyed AuPd nanoparticles were developed for efficient bioorthogonal depropargylations in biological media. Encapsulation of the nanoparticles in mesoporous silica nanorods or a biodegradable PLGA matrix enhanced their intracellular catalytic performance and enabled the release of anticancer drug paclitaxel inside cancer cells. This work demonstrates the potential of nanoalloy encapsulation for mediating new-to-life reactions in cells.
Article
Chemistry, Multidisciplinary
Ramiro Quiros-Ovies, Maria Laborda, Natalia Martin Sabanes, Lucia Martin-Perez, Sara Moreno-Da Silva, Enrique Burzuri, Victor Sebastian, Emilio M. Perez, Jesus Santamaria
Summary: This article introduces a method for efficient exfoliation of MoS2 layers by utilizing its excellent MW absorption properties. The method involves rapid heating to induce near-instantaneous evaporation of a low boiling point solvent, leading to the separation of MoS2 layers with high efficiency. The method shows high yields, good quality, and large area coverage.
Article
Energy & Fuels
Daniel Antoran, Dario Alvira, M. Eser Peker, Hugo Malon, Silvia Irusta, Victor Sebastian, Joan J. Manya
Summary: The study focuses on the potential application of waste hemp-hurd-derived carbons as anodes in sodium-ion batteries. The carbons were produced through a scalable process involving pyrolysis of biomass, chemical activation, and heating. The best performing carbon material exhibited excellent initial coulombic efficiency, reversible charge capacities, cyclic stability, and rate capability, which can be attributed to its unique textural and structural features.
Article
Pharmacology & Pharmacy
Guillermo Landa, Teresa Alejo, Theo Sauzet, Julian Laroche, Victor Sebastian, Frederic Tewes, Manuel Arruebo
Summary: Compared to parenteral administration, direct pulmonary administration of colistin maximizes lung drug deposition and reduces systemic side effects. However, the current method of aerosolizing the prodrug colistin methanesulfonate (CMS) results in slow conversion to colistin, limiting its effectiveness. This study synthesized nanoparticle carriers loaded with colistin using different techniques, finding that nanoprecipitation of pure colistin showed the highest drug loading and had the potential to reach the entire lung.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
J. Bonet-Aleta, J. L. Hueso, L. Sanchez-Uriel, M. Encinas-Gimenez, S. Irusta, P. Martin-Duque, G. Martinez, J. Santamaria
Summary: In this study, inorganic nanocatalysts were used to target and deplete glucose and glutathione, key biomolecules for tumor cells, and generate reactive oxidative species, representing a novel and promising strategy against cancer. A ternary assembled nanohybrid based on Au and CuFe2O4 was developed to simultaneously deplete glucose and glutathione and generate reactive oxidative species. This hybrid heterostructure maintained the glucose oxidase-like activity of Au and prevented its deactivation in the presence of glutathione, presenting a promising alternative for potential anticancer therapy within the tumor microenvironment.
MATERIALS TODAY CHEMISTRY
(2023)
Article
Nanoscience & Nanotechnology
Laura Gabriela Miranda Calderon, Teresa Alejo, Sabas Santos, Gracia Mendoza, Silvia Irusta, Manuel Arruebo
Summary: The study reported the efficacy of antibody-functionalized poly(d,l-lactide-co-glycolide) (PLGA) nanoparticles (NPs)loaded with rifampicin (RIF) against Staphylococcus aureus and Escherichia coli in different scenarios. The antibody was functionalized on the surface of the PLGA-based NPs, allowing selective binding to the Gram-positive bacterium. The antibody-functionalized NPs showed superior eradication of S. aureus, reduction of intracellular pathogens, and inhibition of biofilm formation compared to non-functionalized NPs.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Pharmacology & Pharmacy
Guillermo Landa, Laura G. Miranda-Calderon, Alex Gomez, Marta Perez, Victor Sebastian, Manuel Arruebo, Isabelle Lamarche, Frederic Tewes, Silvia Irusta, Gracia Mendoza
Summary: The increasing prevalence of non-healing infected wounds has become a serious concern in clinical practice. This study evaluated the effectiveness of combining natural antiseptics with standard care antiseptic in treating Staphylococcus aureus infections. The results showed that the combination treatment had superior bactericidal effects both in vitro and in vivo.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Monica Paesa, Fernando Almazan, Cristina Yus, Victor Sebastian, Manuel Arruebo, Luis M. Gandia, Santiago Reinoso, Ismael Pellejero, Gracia Mendoza
Summary: This study investigates the antimicrobial performance of polyoxometalate-stabilized gold nanoparticles against Escherichia coli and Staphylococcus aureus, finding that one particular composite exhibits excellent bactericidal efficiency without harming mammalian cells.
Article
Chemistry, Multidisciplinary
Przemyslaw Gajda-Morszewski, Anna Poznanska, Cristina Yus, Manuel Arruebo, Malgorzata Brindell
Summary: Lactoferrin is a glycoprotein found in milk with various therapeutic properties. This study aimed to optimize the encapsulation of lactoferrin to protect it during delivery to the intestines. The encapsulated lactoferrin demonstrated high efficiency and suitable morphology, and partially preserved its integrity and iron scavenging properties against enzymatic digestion.
Article
Multidisciplinary Sciences
Yeonsu Kwak, Cong Wang, Chaitanya A. Kavale, Kewei Yu, Esun Selvam, Reyes Mallada, Jesus Santamaria, Ignacio Julian, Jose M. Catala-Civera, Himanshu Goyal, Weiqing Zheng, Dionisios G. Vlachos
Summary: This study demonstrates propane dehydrogenation (PDH) in a microwave-heated reactor, achieving efficient, stable, and selective catalytic reactions by changing the heating mode. Catalysts under microwave heating exhibit higher activity and resistance to deactivation compared to conventional reactors. The influence of temperature gradients and nanoscale temperature inhomogeneities on reaction performance is analyzed computationally.
