Review
Biophysics
Nur Farrahain Nadia Ahmad, Nik Nazri Nik Ghazali, Yew Hoong Wong
Summary: The review discusses advanced stimuli-responsive approaches and the evolution of wearable patch pumps, highlighting key challenges and future development trends in controllable transdermal drug delivery systems. Various advanced delivery strategies and mechanisms, including mechanical, electrical, light, thermal, acoustic, and glucose-responsive approaches, are summarized with representative examples.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Instruments & Instrumentation
Maria Alice Maciel Tabosa, Magdalena Hoppel, Annette L. Bunge, Richard H. Guy, M. Begona Delgado-Charro
Summary: The study shows that drug clearance from the difficult-to-access compartment in the skin can be inferred from systemic pharmacokinetic data, and is closely related to key physical chemical properties of the drug. A multiple regression analysis was used to determine this relationship and demonstrated that the model predictions correlated well with in vitro skin experiments.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2021)
Article
Engineering, Environmental
Hyeongho Min, Sangyul Baik, Jihyun Lee, Da Wan Kim, Jin Ho Song, Ki Hyun Kim, Min-Seok Kim, Changhyun Pang
Summary: This study presents a highly biocompatible adhesive patch with suction-cup-like microcavities for enhanced wet adhesion and biosignal monitoring. The adhesive patch shows enhanced multidirectional adhesion and high water/air permeability on rough skin under dry and wet conditions.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Pharmacology & Pharmacy
Hitesh Kumar Dewangan, Suman Tomar
Summary: Studies have shown that nanovaccines have higher immunogenicity and stability, reducing immunotolerance and eliminating the need for regular vaccinations. They can improve cell-mediated and antibody-mediated immunity as well as immunologic memory, and have important implications for various pathological conditions.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Farzaneh Sabbagh, Beom Soo Kim
Summary: Transdermal drug delivery is an effective method with advantages of avoiding liver and gastrointestinal side effects, maintaining a steady rate of drug delivery, and utilizing patches for administration. With effective design and evaluation, a wide range of drugs can now be administered using this valuable advanced technology, which has roots dating back to ancient China.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Biochemistry & Molecular Biology
Sourav Adhikary, Ashique Al Hoque, Manisheeta Ray, Swastik Paul, Akbar Hossain, Subrata Goswami, Rajib Dey
Summary: An attempt was made to develop a transdermal patch for the delivery of paracetamol, a drug with poor aqueous solubility. Nanoparticles were prepared to enhance the drug's solubility and permeability through nanomedicine approach. Silica nanoparticles were synthesized and characterized, and in vivo studies on mice showed promising results in terms of pain relief efficacy.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Qi Tian, Peng Quan, Liang Fang, Hui Xu, Chao Liu
Summary: The study developed a classification system based on the skin permeation/retention behaviors of drugs, correlating them with physicochemical parameters. Molecular mechanisms of drug skin penetration/retention behaviors were clarified through the selection of four representative model drugs. The study demonstrated the importance of lipiddisrupting effect, enhanced partitioning, and molecular characteristics in determining drug skin absorption.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Sumbal Talib, Naveed Ahmed, Dildar Khan, Gul Majid Khan, Asim Ur Rehman
Summary: The study successfully developed artemether-loaded biopolymeric nanoparticles and loaded them into transdermal patches. The nanoparticles had small particle size and good stability, with release rate controlled by diffusion. Transdermal drug delivery route showed improved drug permeability with the presence of a permeation enhancer.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Putri Wulandari Resky Ananda, Diany Elim, Hilman Syamami Zaman, Wahdaniyah Muslimin, Muhamad Gilang Ramadhan Tunggeng, Andi Dian Permana
Summary: Malaria caused by various Plasmodium strains is a global health issue, and developing effective treatment methods is crucial. This study formulated primaquine into a transdermal patch for the first time, demonstrating good bioadhesive and permeation properties through various evaluations. Additionally, the transdermal patch showed promising drug release and permeation profiles in ex vivo studies.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Engineering, Biomedical
Rohan S. J. Ingrole, Erkan Azizoglu, Maria Dul, James C. Birchall, Harvinder S. Gill, Mark R. Prausnitz
Summary: The powerful concept of microneedles, which involves shrinking standard needles to a micron scale, has led to rapid growth in research and development in this field. Microneedles, produced through various methods, are utilized for delivering molecules and energy to different tissues for a range of applications. With over 1000 papers, 750 patents, and almost 80 clinical trials, the activity in the field of microneedles is robust and growing, with the technology being rapidly developed for novel applications enhancing human health and well-being.
Article
Engineering, Environmental
Jihyun Lee, Bum Soo Lee, Sangyul Baik, Da Wan Kim, No-June Park, Jin Woo Lee, Sim-Kyu Bong, Sang Heon Lee, Su -Nam Kim, Jin Ho Song, Jung Kyu Kim, Gi -Ra Yi, Ki Hyun Kim, Changhyun Pang
Summary: Intelligent bioinspired adhesive devices are important tools for the treatment of various skin diseases. In this study, asymmetric elastomeric adhesive structures mimicking diving beetles and nanoporous hydrogel were fabricated for a skin patch device. This device exhibited reversible and directional adhesion, allowing it to intimately contact non-flat skin with hierarchical roughness.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Physical
Daigo Terutsuki, Kohei Okuyama, Haoyu Zhang, Hiroya Abe, Matsuhiko Nishizawa
Summary: A water-proof anti-drying enzymatic O-2 cathode for a deformable bioelectric skin patch was developed, which combined a thin PDMS membrane with a BOD-modified CF electrode to create a microspace serving as an oxygen reservoir. Even in a soaked condition, the patch could still function properly due to the excellent oxygen-permeability of the PDMS membrane. The patch performance could be recovered within seconds when the oxygen in the reservoir was depleted by soaking.
JOURNAL OF POWER SOURCES
(2022)
Article
Chemistry, Physical
Zihan Zhao, Huaiji Wang, Lingling Yao, Xilin Zhang, Qian Yu, Jun Gu, Yuling Shi
Summary: This study developed a hyaluronic acid-based system, named blocking patch (BP), for efficient local delivery of FK506 to treat psoriasis. BP showed satisfactory transdermal release ability and demonstrated a good anti-inflammatory capacity and inhibition of immune cell activation.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Pharmacology & Pharmacy
Anna Otterbach, Alf Lamprecht
Summary: Dimethyl sulfoxide is a widely used dermal penetration enhancer, but its volatility poses challenges in incorporating it into transdermal patches. Research shows that transdermal systems containing DMSO can enhance drug permeation through skin and inhibit drug recrystallization.
Article
Biochemistry & Molecular Biology
Paulina Bednarczyk, Anna Nowak, Wiktoria Duchnik, Lukasz Kucharski, Paula Ossowicz-Rupniewska
Summary: This study investigated the impact of various enhancers on the permeation and accumulation of transdermal patches. Patches with 5% allantoin exhibited the highest permeability and could potentially serve as an alternative to commercial preparations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)