Article
Materials Science, Composites
Blessy Joseph, Neethu Ninan, Rahul Madathiparambil Visalakshan, Clement Denoual, Richard Bright, Nandakumar Kalarikkal, Yves Grohens, Krasimir Vasilev, Sabu Thomas
Summary: Plasma modification and surface immobilization of gold nanoparticles onto 3D printed PCL scaffolds significantly enhance the hydrophilicity and mechanical properties, promoting cell attachment and biocompatibility. This simple and cost-effective technique shows great potential for future applications of scaffolds.
COMPOSITES SCIENCE AND TECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Xuanjun Ning, Jiani Huang, A. Yimuhan, Ningning Yuan, Cheng Chen, Donghai Lin
Summary: This review introduces the preparation methods and ways to improve the mechanical properties of double-network hydrogels, and explores their potential applications in the fields of biomedicine, intelligent sensors, and ion adsorption.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Jacob P. Quint, Mohamadmahdi Samandari, Laleh Abbasi, Evelyn Mollocana, Chiara Rinoldi, Azadeh Mostafavi, Ali Tamayol
Summary: This study presents a nanoengineered skeletal muscle scaffold optimized for muscle progenitors' proliferation and differentiation through controlled release of IGF-1. The nano clay used in the scaffold significantly improved cellular proliferation and differentiation by retaining 50% of the released IGF-1 within the hydrogel niche. The nanofunctionalized scaffold offers a viable option for the treatment of extreme muscle injuries and has potential benefits for translational interventions and clean meat production.
Article
Nanoscience & Nanotechnology
Serena Pilato, Samanta Moffa, Gabriella Siani, Francesca Diomede, Oriana Trubiani, Jacopo Pizzicannella, Daniele Capista, Maurizio Passacantando, Paolo Samori, Antonella Fontana
Summary: The development of 3D nanomaterials with high biocompatibility, precise mechanical characteristics, electrical conductivity, and controlled pore size is crucial for cardiac tissue engineering applications. Hybrid, highly porous tridimensional scaffolds based on chemically functionalized graphene oxide (GO) offer enhanced compositional and structural control. These scaffolds are biocompatible, promote cell adhesion and growth without interfering with cell morphology and cardiac markers, and can be used for repairing damaged heart tissues and cardiac modeling investigations.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Engineering, Biomedical
Yonggang Zhang, Yingjie Zhu, Pamela Habibovic, Huanan Wang
Summary: This review provides an overview of recent progress in the development of advanced scaffolds for bone regeneration based on 1D inorganic micro-/nanobiomaterials, with a focus on their structural design, mechanical properties, and bioactivity. These scaffolds exhibit extraordinary physical and biological properties, offering promising perspectives for future research in bone regeneration.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Serena Pilato, Samanta Moffa, Gabriella Siani, Francesca Diomede, Oriana Trubiani, Jacopo Pizzicannella, Daniele Capista, Maurizio Passacantando, Paolo Samori, Antonella Fontana
Summary: The development of novel three-dimensional (3D) nanomaterials with high biocompatibility, precise mechanical characteristics, electrical conductivity, and controlled pore size is highly sought after for cardiac tissue engineering applications. Hybrid, highly porous tridimensional scaffolds based on chemically functionalized graphene oxide (GO) can provide these unique characteristics and be manufactured using the layer-by-layer technique.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Fangfei Ming, Paul C. Snijders, Hanno H. Weitering
Summary: Switching the crystalline phase of a material via electrostatic control is a proven strategy for developing memory devices. In this study, nonvolatile switching of long bistable nanophase domains in a Sn double-layer structure grown on Si(111) was explored using a scanning tunneling microscope. Two mechanisms for phase switching were identified: continuous tuning of phase stability through the electrical field across the tunnel gap, and lattice instability induced by coupling of hot electrons and surface phonons. This research has implications for phase-change memristor and field effect devices.
Article
Chemistry, Physical
Mina Bayattork, Rangam Rajkhowa, Benjamin James Allardyce, Xungai Wang, Jingliang Li
Summary: This study investigates the effects of pre-freezing treatments at different temperatures (-20℃, -80℃, or -196℃) on the microstructure, mechanical properties, and secondary structure of silk scaffolds prepared from lyophilization of silk hydrogels and silk solutions. The results show that silk hydrogels produce scaffolds with more nanofibrous structures compared to silk solutions. Only silk hydrogels can produce aligned macro-channels, while both silk solutions and hydrogels pre-frozen with liquid nitrogen can generate nanofibrous scaffolds. Silk hydrogel scaffolds are dominated by β-sheets, while silk solution scaffolds are largely amorphous. These findings are important for controlling the microstructure and mechanical properties of silk scaffolds.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Nanoscience & Nanotechnology
Hao Qi, Qingyao Lv, Guanglong Li, Yingdong Qu, Ruiming Su, Keqiang Qiu, Wei Zhang, Bo Yu
Summary: Cryogenic treatment at 77K is applied to improve the strength and plasticity balance of BCC type Al1.4CrFe2Ni2 high entropy alloy. The results show that cryogenic treatment has a significant effect on nanophases, dislocations, and mechanical properties. The nanophase size is reduced by 42.7% and the number is increased by 60% after 24 hours of cryogenic treatment. The dislocation morphology evolves and the dislocation density increases significantly. The cryogenically treated Al1.4CrFe2Ni2 HEA exhibits improved mechanical properties, including higher hardness and fracture strength, while maintaining a high fracture strain of up to 40.8%.
MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING
(2023)
Article
Polymer Science
Martyna Gawel, Patrycja Domalik-Pyzik, Timothy E. L. Douglas, Katarzyna Reczynska-Kolman, Elzbieta Pamula, Kinga Pielichowska
Summary: This study proposes and investigates new scaffolds based on whey protein isolate (WPI) and chitosan (CS) for osteochondral tissue repair. The optimal WPI/CS hydrogels were chosen based on various evaluation criteria, and it was found that the hydrogels with CS incorporated in powder form exhibited superior mechanical properties and those with CS incorporated after dissolution showed enhanced wettability. The introduction of CS powder promoted apatite formation and the CS powder modified WPI hydrogels showed good cytocompatibility, indicating their potential for osteochondral tissue repair.
Article
Chemistry, Multidisciplinary
Tao Meng, Kanjun Ying, Xiufen Yang, Yongpeng Hong
Summary: This study investigated the effects of four different nanomaterials on cement paste and found that the incorporation of nanomaterials could improve the early strength of cement paste specimens and promote the formation of different hydration products at early ages. Different nanomaterials have different mechanisms in cement paste, with nano-calcium carbonate, nano-graphene oxide, and nano-silica promoting the formation of specific hydration products, while nano-titanium dioxide exhibits insignificant nucleation effect and inhibitory effect on portlandite precipitation.
NANOTECHNOLOGY REVIEWS
(2021)
Review
Chemistry, Multidisciplinary
Yanling Hu, Hui Li, Xinyi Lv, Yan Xu, Yannan Xie, Lihui Yuwen, Yingnan Song, Shengke Li, Jinjun Shao, Dongliang Yang
Summary: Diabetic wound infection is a common disease that poses challenges due to the diabetic wound environment and bacterial resistance. Nanobiomaterial-based therapeutic systems with stimuli-responsive performance can address these challenges by delivering therapeutic agents on demand.
Article
Chemistry, Multidisciplinary
Alena Wulf, Rais Mendgaziev, Rawil Fakhrullin, Vladimir Vinokurov, Dmitry Volodkin, Anna S. Vikulina
Summary: One of the main challenges in modern tissue engineering is designing biocompatible scaffolds with finely tuned porous architecture and the ability to load bioactive molecules that guide cell growth and differentiation. This study proposes a strategy to design porous alginate scaffolds by leaching sacrificial vaterite CaCO3 microspheres packed in alginate, resulting in well-tuned architecture. The pore size and interconnectivity of the scaffold depend on the dimensions and packing of the CaCO3 spheres, as well as the concentration of alginate. By varying these parameters, it is possible to achieve almost complete pore interconnectivity or no interconnectivity at all. The mechanical properties of the scaffolds are suitable for cell seeding, with the potential for encapsulation of macromolecules in individual pores to create a multifunctional scaffold. Culturing different cell lines on these scaffolds showed promising results in terms of cell viability and adhesiveness.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Physical
Yao Wang, Yufeng Huang, Wensheng Liu, Baishan Chen, Jiayi Liu, Lei Zhang, Yong Zhang, Yunzhu Ma
Summary: In this study, a nano-Ni3Ta phase-reinforced ultrafine-grain tungsten alloy was fabricated via low-temperature sintering. The alloy exhibited exceptional mechanical properties due to the synergistic effect between nanoscale Ni3Ta phase dispersion and fine-grain strengthening. This approach presents a novel way to develop new tungsten alloys with high strength and toughness.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Article
Chemistry, Multidisciplinary
Maria Sevastaki, Vassilis M. Papadakis, Cosmin Romanitan, Mirela Petruta Suchea, George Kenanakis
Summary: This study presents a novel approach for fabricating eco-friendly ZnO nanoparticles on 3D-printed PLA scaffolds and demonstrates their efficacy in degrading paracetamol in water. The use of traditional Greek liquors and Baker's ammonia enabled the successful synthesis of photocatalytic active ZnO nanostructures. These findings highlight the potential of low-cost, environmentally friendly methods for producing ZnO/PLA structures with high photocatalytic activity for environmental applications.
Review
Neurosciences
Seyed H. Shahcheraghi, Jamshid Ayatollahi, Marzieh Lotfi, Alaa A. A. Aljabali, Mazhar S. Al-Zoubi, Pritam K. Panda, Vijay Mishra, Saurabh Satija, Nitin B. Charbe, Angel Serrano-Aroca, Bojlul Bahar, Kazuo Takayama, Rohit Goyal, Amit Bhatia, Abdulmajeed G. Almutary, Abdullah M. Alnuqaydan, Yachana Mishra, Poonam Negi, Aaron Courtney, Paul A. McCarron, Hamid A. Bakshi, Murtaza M. Tambuwala
Summary: Neuropsychiatric disorders have a significant impact on healthcare systems and economies. Current drug-based treatments for these disorders are often ineffective and costly. Gene therapy, an experimental concept, shows promise in alleviating symptoms, slowing disease progression, and repairing defective genes. While it requires the integration of various scientific disciplines, gene therapy has the potential to be a novel approach for treating neuropsychiatric disorders.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2023)
Review
Biotechnology & Applied Microbiology
Nitin Bharat Charbe, Murtaza Tambuwala, Sushesh Srivatsa Palakurthi, Amol Warokar, Altijana HronniC-JahjefendiC, Hamid Bakshi, Flavia Zacconi, Vijay Mishra, Saurabh Khadse, Alaa A. Aljabali, Mohamed El-Tanani, Angel Serrano-Aroca, Srinath Palakurthi
Summary: This article provides an overview of the latest development and application of 3D bioprinting in regenerating skeletal muscle tissues and restoring the functional abilities of damaged craniofacial tissue. It discusses the limitations of traditional surgical repair and highlights the potential of 3D bioprinting in producing patient-specific functional implants.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Review
Oncology
Nighat Gull, Fareeha Arshad, Gowhar A. Naikoo, Israr Ul Hassan, Mona Zamani Pedram, Arif Ahmad, Alaa A. A. Aljabali, Vijay Mishra, Saurabh Satija, Nitin Charbe, Poonam Negi, Rohit Goyal, Angel Serrano-Aroca, Mazhar S. Al Zoubi, Mohamed El-Tanani, Murtaza M. Tambuwala
Summary: This article introduces hepatocellular carcinoma (HCC) as the fifth most common cancer worldwide and discusses the potential of curcumin as a multifunctional active ingredient in anticancer treatment. The article summarizes the anticancer properties and molecular targets of curcumin in HCC, and discusses the challenges and future prospects of novel plant extracts from Curcuma longa in cancer treatment.
JOURNAL OF GASTROINTESTINAL CANCER
(2023)
Article
Cell Biology
Kenneth Lundstrom, Altijana Hromic-Jahjefendic, Esma Bilajac, Alaa A. A. Aljabali, Katarina Baralic, Nagwa A. Sabri, Eslam M. Shehata, Mohamed Raslan, Ana Claudia B. H. Ferreira, Lidiane Orlandi, Angel Serrano-Aroca, Murtaza M. Tambuwala, Vladimir N. Uversky, Vasco Azevedo, Khalid J. Alzahrani, Khalaf F. Alsharifm, Ibrahim F. Halawani, Fuad M. Alzahrani, Elrashdy M. Redwan, Debmalya Barhl
Summary: This review summarizes major events of SARS-CoV-2 infection route, immune response following host-cell infection as an important factor for disease outcome, as well as comorbidity issues of various tissues and organs arising due to COVID-19. Investigations on alterations of host-cell machinery and viral interactions with multiple intracellular signaling pathways could represent a major factor in more effective disease management.
CELLULAR SIGNALLING
(2023)
Review
Biochemistry & Molecular Biology
Alaa A. Aljabali, Mohammad A. Obeid, Rasha M. Bashatwah, Angel Serrano-Aroca, Vijay Mishra, Yachana Mishra, Mohamed El-Tanani, Altijana Hromic-Jahjefendic, Deepak N. Kapoor, Rohit Goyal, Gowhar A. Naikoo, Murtaza M. Tambuwala
Summary: Nanomaterials have been extensively studied in the medical and industrial sectors, but their potential toxicities have raised concerns. Researchers are interested in how nanoparticles interact with the immune system and their biomolecules. This review examines literature on the immunostimulatory and immunosuppressive effects of nanomaterials and their interactions with immune cells, as well as the possibility of creating stealth nanomaterials that evade the immune system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Joaquin Mulero-Cerezo, Alberto Tunon-Molina, Alba Cano-Vicent, Lorena Perez-Colomer, Miguel Marti, Angel Serrano-Aroca
Summary: This study describes the production of alcoholic and non-alcoholic rose wines using Saccharomyces cerevisiae var. boulardii probiotic yeast for the first time. The viability of S. cerevisiae var. boulardii was assessed before and after fermentation and distillation, and compared to standard S. cerevisiae EC-1118 yeast. The results showed that rose wine made with S. cerevisiae var. boulardii had similar characteristics to commercial wines, and the yeast remained viable even with high alcohol levels and during storage for 6 months.
ARCHIVES OF MICROBIOLOGY
(2023)
Article
Cell Biology
Kenneth Lundstrom, Altijana Hromic-Jahjefendic, Esma Bilajac, Alaa A. A. Aljabali, Katarina Baralic, Nagwa A. Sabri, Eslam M. Shehata, Mohamed Raslan, Sara A. Raslan, Ana Claudia B. H. Ferreira, Lidiane Orlandi, Angel Serrano-Aroca, Vladimir N. Uversky, Sk. Sarif Hassan, Elrashdy M. Redwan, Vasco Azevedo, Khalid J. Alzahrani, Khalaf F. Alsharif, Ibrahim F. Halawani, Fuad M. Alzahrani, Murtaza M. Tambuwala, Debmalya Barh
Summary: The COVID-19 pandemic has led to extensive research and development of drugs and vaccines for SARS-CoV-2. Vaccines based on viral vectors, nucleic acids, and whole viral particles have been particularly successful and have received emergency authorization for global mass vaccination. However, emerging variants have raised concerns about vaccine efficacy.
CELLULAR SIGNALLING
(2023)
Article
Chemistry, Physical
Jose Luis Aparicio-Collado, Qiqi Zheng, Jose Molina-Mateo, Constantino Torregrosa Cabanilles, Ana Vidaurre, Angel Serrano-Aroca, Roser Sabater i Serra
Summary: Electroactive composite materials, consisting of a graphene-based hydrogel with dispersed nanosheets, show promise for musculoskeletal tissue engineering. The nanohybrid hydrogels have an interconnected porous structure and high water-absorption capacity. The addition of graphene nanosheets improves the thermal stability, mechanical properties, and electrical conductivity of the hydrogels. Furthermore, these materials are biocompatible and can induce myoblast proliferation, making them highly suitable for musculoskeletal tissue engineering.
Review
Engineering, Biomedical
Martin Birkett, Abdul Wasy Zia, Dinesh Kumar Devarajan, Soni Mihalis I. Panayiotidis, Thomas J. Joyce, Murtaza M. Tambuwala, Angel Serrano-Aroca
Summary: Diamond-like carbon (DLC) coatings doped with bioactive elements of silver (Ag) and copper (Cu) have attracted increasing attention in recent years, as they have the potential to enhance antimicrobial and mechanical performance. These multi-functional coatings offer great potential to improve wear resistance and antimicrobial properties of load-bearing medical implants.
ACTA BIOMATERIALIA
(2023)
Article
Biochemistry & Molecular Biology
Beatriz Salesa, Patricia Ferrus-Manzano, Alberto Tunon-Molina, Alba Cano-Vicent, Marcelo Assis, Juan Andres, Angel Serrano-Aroca
Summary: Gold nanoparticles (AuNPs) are promising for biomedical applications due to their excellent biosafety. However, their cytotoxicity in human HaCaT cells is time-dependent, and concentrations above 300 μg/mL show toxic activity. Low concentrations of AuNPs do not exhibit significant proliferative or antiviral activity, and gene expression is not modified after exposure to AuNPs for 24 hours. These results indicate that AuNPs are stable inactive materials suitable for biomedical and clinical applications.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Editorial Material
Chemistry, Physical
Roser Sabater Serra, Angel Serrano-Aroca
Article
Chemistry, Multidisciplinary
Alba Cano-Vicent, Alberto Tunon-Molina, Hamid Bakshi, Roser Sabater i Serra, Iman M. M. Alfagih, Murtaza M. M. Tambuwala, Angel Serrano-Aroca
Summary: This study investigated an alginate hydrogel crosslinked with calcium and varying amounts of zinc cations, and explored its properties in terms of anticancer, antiviral, antibacterial, water absorption, and compound release. The results demonstrated that the hydrogel film with the highest zinc content exhibited similar water sorption properties to calcium alginate, and released an appropriate amount of zinc to exert anticancer, antibacterial, and antiviral activities. Moreover, the film was proven to be non-toxic in vitro and in vivo, suggesting its potential for biomedical applications.
Article
Biochemistry & Molecular Biology
Alba Cano-Vicent, Alberto Tunon-Molina, Hamid Bakshi, Iman M. Alfagih, Murtaza M. Tambuwala, Angel Serrano-Aroca
Summary: In this study, a novel calcium alginate/acetic acid film was developed and evaluated for its biological properties. The film exhibited biocompatibility with human keratinocyte cells and Caenorhabditis elegans, and demonstrated antiviral and anticancer properties. The findings suggest that this film has potential applications in the biomedical and pharmaceutical industries for developing broad-spectrum antiviral and anticancer materials.
Review
Biochemistry & Molecular Biology
Altijana Hromic-Jahjefendic, Abas Sezer, Alaa A. A. Aljabali, Angel Serrano-Aroca, Murtaza M. Tambuwala, Vladimir N. Uversky, Elrashdy M. Redwan, Debmalya Barh, Kenneth Lundstrom
Summary: COVID-19 vaccines have been widely used to reduce the incidence and disease severity of COVID-19. Recent concerns have been raised about a possible association between COVID-19 vaccines and myocarditis. Myocarditis can be caused by infections, immune reactions, or toxic exposure. The incidence rate of myocarditis after vaccination is lower than that after SARS-CoV-2 infection, and it is more common in adolescent males following mRNA vaccination.
Review
Pharmacology & Pharmacy
Seyed Hossein Shahcheraghi, Seyed Hadi Shahcheraghi, Marzieh Lotfi, Malihe Lotfi, Seyed Hossein Khaleghinejad, Zara M. Tambuwala, Vijay Mishra, Yachana Mishra, Angel Serrano-Aroca, Alaa A. A Aljabali, Mohamed El-Tanani, Gowhar A. Naikoo, Sai Raghuveer Chava, Nitin B. Charbe, Shivani Bharti, Saravana Kumar Jaganathan, Rohit Goyal, Poonam Negi, Murtaza M. Tambuwala, Oladipo Folorunso
Summary: This review explores the potential of photonic nanoparticles for cancer theranostics, highlighting their unique properties and photonics capabilities. However, the size of the particles is crucial to their absorption of near-infrared light and therapeutic potential. Challenges such as toxicity, immune system clearance, and targeted delivery to the tumor are also discussed. Ongoing research suggests that photonic nanoparticles have potential for cancer theranostics, but further investigation and development are necessary for clinical use.
THERAPEUTIC DELIVERY
(2023)
