Journal
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
Volume 106, Issue 11, Pages 2963-2972Publisher
WILEY
DOI: 10.1002/jbm.a.36485
Keywords
electrospinning; image analysis; nanofibers orientation; collector geometries; design of experiment
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This study proposes a novel design of a laboratory built static collector using the 3D printing technology. This new collector produces aligned-to-random nanofibers in nanofibrous scaffold through electrospinning process. A design of experiment (DOE), based on response surface, analyzes the effect of the main process parameters; concentration, voltage, and distance; on the responses diameter and orientation. A quantifying approach has been used to investigate the orientation of nanofibers in the produced patterned scaffold through Fourier transforms method. The obtained results have proven a good potential to be used in tissue engineering application, especially for cells requiring specific guidance. (c) 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 2963-2972, 2018.
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