Article
Materials Science, Multidisciplinary
Yongke Shao, Fanyan Deng, Yongyun Chang, Songqing Shi, Huiwu Li, Yao Yuan
Summary: This study synthesized a novel silicon material (CPS) with favorable biocompatibility and bioactivity, which could promote osteogenic differentiation of bone marrow-derived mesenchymal stem cells (rBMSCs) and significantly enhance the healing of critical-sized bone defects in vivo.
FRONTIERS IN MATERIALS
(2022)
Article
Cell Biology
Dawoon Baek, Kwang Hwan Park, Kyoung-Mi Lee, Sujin Jung, Soyeong Joung, Jihyun Kim, Jin Woo Lee
Summary: The study revealed that overexpression of USP53 can enhance osteogenic differentiation of hBMSCs by promoting the degradation of β-catenin through interaction with FBXO31, potentially promoting bone regeneration. Therefore, USP53 may be a promising target for gene therapy in bone regeneration.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Rong Zhou, Fubo Chen, Haixia Liu, Xueqin Zhu, Xueyun Wen, Fang Yu, Guangwei Shang, Shengcai Qi, Yuanzhi Xu
Summary: The study showed that berberine hydrochloride (BBR) can modulate the imbalance between osteogenesis and adipogenesis mediated by Lipopolysaccharide (LPS) from oral pathogenic bacteria, potentially reversing the effects of LPS on gene expression and demonstrating the involvement of AMP-activated protein kinase.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Engineering, Biomedical
Meng Li, Jing Wu, Wenbo Geng, Yulu Yang, Xuan Li, Kun Xu, Ke Li, Yan Li, Qiaojian Duan, Pengfei Gao, Kaiyong Cai
Summary: Localized corrosion of 316L stainless steel reduces the viability, adhesion, proliferation, and osteogenic differentiation abilities of BMSCs. It causes cytotoxicity through the release of metallic ions and generates reactive oxygen species (ROS) around the corrosion pits, leading to oxidative stress and cell membrane depolarization. This study provides insights into corrosion-mediated degradation of cell function and material-cell interactions.
Article
Cell Biology
Juan C. Henao, Adriana Grismaldo, Alfonso Barreto, Viviana M. Rodriguez-Pardo, Claudia Camila Mejia-Cruz, Efrain Leal-Garcia, Rafael Perez-Nunez, Patricio Rojas, Ramon Latorre, Ingrid Carvacho, Yolima P. Torres
Summary: The study demonstrates that TRPM8 channels are expressed in human bone marrow MSCs and are involved in osteogenic differentiation, with agonists promoting osteogenic differentiation and antagonists leading to a decrease in osteogenic differentiation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Huijiao Lv, Tao Wang, Shangkun Zhai, Zhuocheng Hou, Sirui Chen
Summary: Using transcriptomic analysis, we elucidated the transcriptomic changes during the osteogenic differentiation of chicken BMSCs at different time points. DEGs were mainly enriched in cell proliferation pathways during the early stage of osteogenic differentiation and pathways related to TGF-beta signaling during the middle and late stages. This study provides the first insight into the dynamic transcriptome changes during BMSC differentiation into osteoblasts in chickens.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Yijun Wang, Wentao Chen, Liang Zhao, Yadong Li, Zhenyu Liu, Hua Gao, Xiaodong Bai, Baojun Wang
Summary: This study found that high-fat or obesity factors can inhibit the secretion of bone marrow stem cell-derived exosomes and affect the expression of osteogenic markers, leading to abnormal fracture healing. Treatment with exosomes from normal sources can reverse this phenomenon and improve fracture healing caused by obesity.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Cell & Tissue Engineering
Wenting Wang, Weifang Ding, Xuebao Zhang, Shuang Wu, Tianxi Yu, Xin Cui, Yaqi Xie, Diandong Yang, Chunhua Lin
Summary: This study observed the effects of rat-derived bone marrow mesenchymal stem cells (BMSCs) in a rat model of Peyronie's disease (PD) and analyzed the possible mechanism. The results showed that BMSCs treatment in the active phase had better antifibrotic effects compared to the chronic phase, and the mechanism may be related to increased Smad7 expression.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Chemistry, Medicinal
Zhikang Su, Ding Chen, Jiangyon Huang, Zitian Liang, Wen Ren, Zeyu Zhang, Qianzhou Jiang, Tao Luo, Lvhua Guo
Summary: This study found that isoliquiritin (ISL) can improve osteoporosis by promoting autophagy and regulating the MAPK signaling pathway. The experimental results showed that ISL has a therapeutic effect in promoting bone formation without inducing toxicity to vital organs.
PHYTOTHERAPY RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Yi-Xuan Wang, Zhu-Li Peng, Zhi-Wen Sun, Yan-Jun Pan, Hong Ai, Zhi-Hui Mai
Summary: This study investigates the role of miR-20 in promoting osteogenic differentiation in BMSCs and accelerating bone formation in a rabbit maxillary sinus bone defect model. Overexpression of miR-20a increased the levels of osteogenic markers and enhanced calcified nodule deposition in BMSCs, while anti-miR-20a treatment had the opposite effect. In the rabbit model, miR-20a delivery significantly improved bone density, osteoblast numbers, and collagen type 1 secretion compared to Bio-Oss bone powder.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Engineering, Biomedical
Mengting Zheng, Mengjia Weng, Xiaoyu Zhang, Ruomei Li, Qian Tong, Zhenqi Chen
Summary: The study revealed that beta-TCP enhances osteogenic differentiation of BMSCs by inducing macrophage polarization and regulating the Wnt signaling pathway. Macrophages exposed to beta-TCP shifted to the M2 phenotype and exhibited more significant immune responses. This highlights the therapeutic potential of beta-TCP for bone healing through its osteoimmunomodulatory properties.
BIOMEDICAL MATERIALS
(2021)
Article
Cell Biology
Ali Salehi, Mohammad A. Mobarhan, Javad Mohammadi, Hosein Shahsavarani, Mohammad Ali Shokrgozar, Atefeh Alipour
Summary: The study investigated the characteristics of decellularized cabbage leaves and their potential for promoting bone differentiation, as demonstrated by enhanced osteogenic differentiation of BM-MSCs on the scaffold. These results suggest that decellularized cabbage leaves have great potential for tissue engineering applications in bone regeneration.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Orthopedics
Jingwei Zhang, Fanyan Deng, Xiaoliang Liu, Yuwei Ge, Yiming Zeng, Zanjing Zhai, Congqin Ning, Huiwu Li
Summary: Iron addition improves the osteogenic ability of calcium phosphate silicate ceramics, suggesting its potential as a novel material for bone tissue engineering.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2022)
Article
Multidisciplinary Sciences
Keya Ganguly, Sayan Deb Dutta, Min-Soo Jeong, Dinesh K. Patel, Seong-Jun Cho, Ki-Taek Lim
Summary: Proteins extracted from crickets exhibit good biocompatibility and osteoinductive potential, making them valuable for bone tissue engineering applications.
Article
Biochemistry & Molecular Biology
Tongtong Chen, Hanqi Wang, Chaoyin Jiang, Yong Lu
Summary: This study reveals that under oxidative stress conditions, PKD1 may alleviate the inhibitory effect of oxidative stress on osteogenesis of rat BM-MSCs through TAZ activation.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Hanjun Li, Xiuguo Han, Shengbing Yang, Yongjie Wang, Yang Dong, Tingting Tang
Summary: FOXP1, transactivated by ERK/JNK-c-JUN/c-FOS, drives osteosarcoma development by regulating the p53-P21/RB signaling cascade, suggesting it as a potential therapeutic target.
Article
Engineering, Biomedical
Minqi Wang, Hanjun Li, Yiqi Yang, Kai Yuan, Feng Zhou, Haibei Liu, Qinghui Zhou, Shengbing Yang, Tingting Tang
Summary: This study demonstrates the creation of a scaffold with dual functions of osteo-induction and bacterial inhibition through the release of BMP2, which significantly promotes osteoblast differentiation and prevents infection. The bioprinted scaffold shows potential for repairing infectious bone defects.
BIOACTIVE MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Yiqi Yang, Kai Huang, Minqi Wang, Qishan Wang, Haishuang Chang, Yakun Liang, Qing Wang, Jie Zhao, Tingting Tang, Shengbing Yang
Summary: The study presents an intelligent near-infrared-triggered nitric oxide nanogenerator that enhances angiogenesis, inhibits bacterial infection, and maintains the stability of HIF-1 alpha protein for treating diabetic ulcers.
ADVANCED MATERIALS
(2021)
Correction
Engineering, Biomedical
Bo Tian, Tao Jiang, Zhanying Shao, Zanjing Zhai, Haowei Li, Qiming Fan, Xuqiang Liu, Zhengxiao Ouyang, Tingting Tang, Qing Jiang, Minghao Zheng, Kerong Dai, An Qin, Yongping Yu, Zhenan Zhu
Article
Chemistry, Multidisciplinary
Kai Huang, Jinbing Wang, Qinghao Zhang, Kai Yuan, Yiqi Yang, Fupeng Li, Xiaojiang Sun, Haishuang Chang, Yakun Bang, Jie Zhao, Tingting Tang, Shengbing Yang, Yakun Liang
Summary: Persistent bacteria, such as intracellular and biofilm bacteria, pose challenges in clinical treatment due to their resistance to antibiotics. In this study, a nanoscale gallium-based metal-organic framework (GaMOF) was developed to address this issue. The GaMOF nanoparticles could penetrate cell membranes and disrupt bacteria Fe metabolism, enhancing the potency of antibiotics and eradicating the two types of elusive bacteria. The results showed that the synthesized GaMOF had good biosafety and could alleviate inflammation caused by intracellular bacteria in vivo.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Correction
Biophysics
Bin 'en Nie, Haiyong Ao, Jianliang Zhou, Tingting Tang, Bing Yue
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Biotechnology & Applied Microbiology
Han Qiao, Jingtian Mei, Kai Yuan, Kai Zhang, Feng Zhou, Tingting Tang, Jie Zhao
Summary: This study reveals the crucial roles of zinc and oxygen homeostasis in dendritic cells (DCs) during the immune progression of rheumatoid arthritis (RA). It proposes a DC-targeting immune-regulating strategy using ZnO2/Catalase@liposome-Mannose nanoparticles (ZnCM NPs) to induce the transformation of immunogenic DCs (igDCs) into tolerogenic DCs (tDCs) and inhibit T-cell activation. The study demonstrates the promising potential of DC-targeting nanoplatforms in RA treatment and provides insights into ion homeostasis regulation for immune diseases.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Kai Huang, Fupeng Li, Kai Yuan, Yiqi Yang, Haishuang Chang, Yakun Liang, Xuzhou Yan, Jie Zhao, Tingting Tang, Shengbing Yang
Summary: This study presents a novel nanotheranostic agent that can synergistically detect and eliminate drug-resistant bacteria, while reducing inflammation and promoting wound healing with no obvious adverse effects in vivo.
APPLIED MATERIALS TODAY
(2022)
Article
Orthopedics
Kai Yuan, Kai Zhang, Yiqi Yang, Yixuan Lin, Feng Zhou, Jingtian Mei, Hanjun Li, Jie Wei, Zhifeng Yu, Jie Zhao, Tingting Tang
Summary: This study evaluated the interbody fusion efficacy and biocompatibility of a graft-free cage made of poly-etheretherketone/calcium silicate composite/porous tantalum (PEEK/CS/pTa cage) compared with a PEEK/CS cage with an autogenous bone graft in a goat model. The results showed that the graft-free PEEK/CS/pTa cage demonstrated similar fusion performance to the PEEK/CS cage with autogenous bone graft and had good biological safety.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2022)
Article
Chemistry, Multidisciplinary
Kai Yuan, Kai Huang, Yiqi Yang, Yixuan Lin, Yihao Liu, Fupeng Li, Yakun Liang, Haishuang Chang, Yuhui Chen, Tingting Tang, Shengbing Yang
Summary: Increasing evidence highlights the crucial role of antibiotic tolerance in the development of antibiotic resistance, refractory infection, and infection recurrence. This study identifies and confirms the phenotype of increased production of H2S in antibiotic-tolerant Staphylococcus aureus (S. aureus) as essential for maintaining antibiotic tolerance. Furthermore, a photoacoustic probe based on a bismuth metal-organic framework (Bi-MOF) was successfully developed for detecting infection and an antibiotic enhancer that targets bacterial endogenous H2S to eradicate antibiotic-tolerant bacteria. Bi-MOF enables early in situ and precise photoacoustic imaging of infection by generating Bi2S3 inside bacteria. Additionally, Bi-MOF enhances the efficiency of methicillin in eradicating tolerant S. aureus by downregulating intracellular H2S levels.
Article
Chemistry, Applied
Xiaoyan Li, Xinsheng Niu, Yaowei Chen, Kai Yuan, Wenjun He, Shengbing Yang, Tingting Tang, Deng-Guang Yu
Summary: Chitosan-functionalized nanosilica was electrosprayed on a spin-coated base layer to form a composite coating with a micro-nano protruding surface, showing good antibacterial properties and sustained release effect. Nanosilica with uniform size was prepared by sol-gel method and coated with quaternized chitosan. The composite coating exhibited a unique micro-nano surface structure and the contact sterilization of chitosan quaternary ammonium salt played a synergistic effect, resulting in good sterilization effect on drug-resistant Staphylococcus aureus and controlled sustained release of quaternized chitosan.
PROGRESS IN ORGANIC COATINGS
(2023)
Article
Engineering, Biomedical
Yixuan Lin, Yiqi Yang, Kai Yuan, Shengbing Yang, Shuhong Zhang, Hanjun Li, Tingting Tang
Summary: This study reports a three-dimensional bioprinted osteosarcoma model that incorporates osteosarcoma cells and a mimicked extracellular matrix. Compared to traditional models, this model shows significant differences in cell cycle, metabolism, and other cellular pathways, and is more sensitive to therapies targeting the autophagy pathway.
BIOACTIVE MATERIALS
(2022)
Article
Cell Biology
Yiqi Yang, Kai Yuan, Yihao Liu, Qishan Wang, Yixuan Lin, Shengbing Yang, Kai Huang, Tianyou Kan, Yuxin Zhang, Mingming Xu, Zhifeng Yu, Qiming Fan, Yugang Wang, Hanjun Li, Tingting Tang
Summary: In this study, the researchers identified AMPKa1 as a critical factor regulating the senescence and lineage commitment of mesenchymal stem cells (MSCs) and found that AMPKa1 activation can prevent age-related bone loss and promote MSC osteogenic commitment with increased IGF-1 secretion. The study provides mechanistic insight into the protective effect of AMPKa1 against skeletal aging by promoting bone-derived IGF-1 secretion.
CELL PROLIFERATION
(2023)
Article
Engineering, Biomedical
Fupeng Li, Kai Huang, Jinbing Wang, Kai Yuan, Yiqi Yang, Yihao Liu, Xianhao Zhou, Keyu Kong, Tao Yang, Jian He, Chunjie Liu, Haiyong Ao, Fengxiang Liu, Qian Liu, Tingting Tang, Shengbing Yang
Summary: This study developed a biocompatible titanium alloy with antibiofilm and anti-aseptic loosening properties by utilizing gallium as a component. The alloy exhibited outstanding antibiofilm properties both in vitro and in vivo, and it could also inhibit osteoclast differentiation by targeting iron metabolism, thus preventing aseptic loosening.
BIOMATERIALS RESEARCH
(2023)
Article
Cell & Tissue Engineering
Yiqi Yang, Yixuan Lin, Minqi Wang, Kai Yuan, Qishan Wang, Pei Mu, Jingke Du, Zhifeng Yu, Shengbing Yang, Kai Huang, Yugang Wang, Hanjun Li, Tingting Tang
Summary: Diabetic osteoporosis (DOP) is characterized by osteocyte death through iron-dependent programmed cell death called ferroptosis. The diabetic microenvironment enhances osteocyte ferroptosis by promoting lipid peroxidation, iron overload, and aberrant activation of the ferroptosis pathway. Heme oxygenase-1 (HO-1) is upregulated in ferroptotic osteocytes in DOP, and its expression is controlled by the interaction between the transcription factors NRF2 and c-JUN. Targeting ferroptosis or HO-1 effectively rescues osteocyte death in DOP and improves trabecular deterioration.
