Article
Materials Science, Ceramics
Tingting Wu, Teliang Lu, Haishan Shi, Jinchao Wang, Jiandong Ye
Summary: Introducing silicon (Si) and strontium (Sr) ions into calcium phosphate cement (CPC) using strontium doped calcium silicate (Sr-CS) can enhance osteogenesis and angiogenesis while suppressing osteoclastogenesis, making it a promising strategy for osteoporotic bone repair. In this study, the 20Sr-CS/CPC extract showed increased proliferation, ALP activity, osteogenesis-related gene and protein expression, as well as enhanced angiogenesis and suppressed osteoclastogenesis. It has great potential for stimulating osteoporotic bone regeneration.
CERAMICS INTERNATIONAL
(2023)
Article
Engineering, Biomedical
Haishan Shi, Xiaoling Ye, Jing Zhang, Tingting Wu, Tao Yu, Changren Zhou, Jiandong Ye
Summary: Investigation of thermostability in ion-doped octacalcium phosphate revealed that Fe-OCP and Sr-OCP exhibited different properties and ion release at various temperatures, with adjusted thermostability enhancing protein adsorption and cellular behavior. This work lays the foundation for developing bioactive materials for tissue repair utilizing ion doping strategy.
BIOACTIVE MATERIALS
(2021)
Article
Materials Science, Ceramics
Mengen Zhao, Chao Zhang, Chenyu Gao, Zhaoying Wu
Summary: In this study, strontium-doped bioactive glass nanoparticles loaded with alendronate were fabricated and evaluated for their potential in bone regeneration in osteoporosis. These nanoparticles showed excellent bioactivity and ability to promote osteoblast differentiation while inhibiting osteoclast differentiation. They also promoted the regeneration of new bone when implanted in vivo.
JOURNAL OF NON-CRYSTALLINE SOLIDS
(2023)
Article
Nanoscience & Nanotechnology
Hao Liu, Ranli Gu, Wei Li, Lijun Zeng, Yuan Zhu, Boon Chin Heng, Yunsong Liu, Yongsheng Zhou
Summary: A cell-free scaffold engineering strategy that integrates strontium and highly bioactive serum exosomes has been developed for the treatment of large bone defects. The scaffold can maintain bone morphological characteristics and accelerate bone formation through controlled release of strontium, while the serum exosomes extracted from the fracture rabbit model promote osteogenesis and angiogenesis. The SrTi scaffold + BF EXO composite significantly accelerates bone repair in the radial critical bone defect of rabbits.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
T. Lu, X. Yuan, L. Zhang, F. He, X. Wang, J. Ye
Summary: In this study, zinc doping was introduced into BCP scaffolds to regulate the balance between pro-osteogenesis and anti-osteoclastogenesis, thereby improving bone repair effect. The results showed that zinc doping could modulate the differentiation of osteoblasts and osteoclasts, and enhance osteoinduction activity and accelerate new bone formation. This study is of great significance for the development of more osteoinductive calcium phosphate-based materials for bone regeneration.
MATERIALS TODAY CHEMISTRY
(2023)
Article
Environmental Sciences
Lifeng Chen, Zihao Jiao, Xiangbiao Yin, Wenlong Li, Xinpeng Wang, Shunyan Ning, Yuezhou Wei
Summary: This study synthesized a porous zirconium phosphate adsorbent using a sol-gel process and evaluated its performance in removing radioactive Sr2+ in wastewater. The experimental results demonstrated that the adsorbent exhibited excellent selectivity and high adsorption capacity, indicating its promising application prospects.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2022)
Article
Biochemistry & Molecular Biology
Xiaofeng Cao, Wufei Ge, Yihu Wang, Ming Ma, Ying Wang, Bing Zhang, Jianing Wang, Yanchuan Guo
Summary: In this study, 3D porous composite scaffolds made of MgNH4PO4·H2O and SrHPO4 were fabricated using 3D printing technique to improve radiopacity. The results showed that higher SrHPO4 contents led to higher radiopacity, with a content of 9.34% achieving radiopacity equivalent to a 6.8 mm Al ladder. The composite scaffolds exhibited sustainable degradation and released Mg, Sr, and P elements over a 28-day experiment period, showing potential for bone repair applications.
Article
Materials Science, Ceramics
Elisa Boanini, Massimo Gazzano, Katia Rubini, Paolo P. Mazzeo, Adriana Bigi
Summary: The study investigated the substitution of strontium for calcium in alpha-CaHPO4 and beta-SrHPO4, as well as the influence of synthesis methods on the structures. The results showed that strontium substitution in alpha-CaHPO4 can reach up to 100%, while in beta-SrHPO4 it is limited to about 20%. Additionally, powder X-ray analysis revealed that beta-SrHPO4 crystallizes with a monoclinic cell in the space group P21/c.
CERAMICS INTERNATIONAL
(2021)
Article
Materials Science, Multidisciplinary
Gulhan Isik, Ahmet Engin Pazarceviren, Zafer Evis, Aysen Tezcaner
Summary: This study aimed to develop a biocompatible and osteoconductive bone cement. The results showed that the addition of silk fibroin improved the physical, mechanical, and biological properties of the cement, and promoted osteogenic differentiation of bone cells.
JOURNAL OF MATERIALS RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Hailiang Xu, Lei Zhu, Fang Tian, Chengwen Wang, Weidong Wu, Botao Lu, Liang Yan, Shuaijun Jia, Dingjun Hao
Summary: In this study, a novel strontium-modified calcium phosphate cement (SMPC) was developed by introducing tristrontium silicate, which showed better injectability and a shorter setting time compared to traditional calcium phosphate cement (CPC). SMPC also promoted cell proliferation and differentiation, and facilitated bone regeneration in vivo. Therefore, 5% SMPC is a promising substitute material for bone repair with excellent physicochemical properties and biological activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Materials Science, Biomaterials
Xinyuan Yuan, Tingting Wu, Teliang Lu, Jiandong Ye
Summary: In this study, Zn/Sr-doped calcium silicate/calcium phosphate cements were prepared to enhance bone regeneration. The doping of Zn and Sr had little effect on the physicochemical properties of the cements, but it significantly promoted osteogenesis. Among the different compositions, 10Zn/20Sr-CS/CPC showed the best in vitro osteogenic performance.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Materials Science, Multidisciplinary
Xiaohong Yin, Qi Li, Yirong Hong, Xiaowen Yu, Xianyan Yang, Zhaonan Bao, Mengfei Yu, Huayong Yang, Zhongru Gou, Bin Zhang
Summary: Due to the personalized large defect and bone absorption, the regeneration of alveolar cleft remains a great challenge. This study developed high-precision pore structure bioceramic scaffolds to repair the alveolar cleft and systematically compared their physicochemical properties and bone repair performances with pure tricalcium phosphate scaffolds. The results showed that the strontium-doped scaffolds exhibited excellent mechanical stability and promoted new bone ingrowth in the alveolar cleft. This study suggests that the biodegradable Ca-phosphate bioceramics scaffolds prepared by 3D printing technique demonstrate significance in promoting the reconstruction of the alveolar cleft.
MATERIALS & DESIGN
(2022)
Article
Engineering, Environmental
Xingge Yu, Xiuhui Wang, Dejian Li, Ruilong Sheng, Yifeng Qian, Rui Zhu, Xudong Wang, Kaili Lin
Summary: This study developed an injectable organic-inorganic nanocomposite GelMA/Sr-CSH hydrogel system, which improved the mechanical properties of GelMA hydrogels by incorporating Sr-CSH nanofibers. In vitro and in vivo experiments demonstrated that GelMA/Sr-CSH hydrogels facilitated cell adhesion, proliferation, and expression of osteogenic genes, accelerating bone regeneration. This research is of great significance for in-situ bone regeneration.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Engineering, Biomedical
Benjamin Kruppke, Christiane Heinemann, Annett Gebert, Marcus Rohnke, Manuel Weiss, Anja Henss, Hans-Peter Wiesmann, Thomas Hanke
Summary: The research found that high strontium-containing brushite may benefit bone regeneration, with different mineral compositions, mass changes, and effects on ion concentration and pH in the cell culture medium.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Article
Materials Science, Multidisciplinary
Meng Li, Jiawei Jiang, Wenbin Liu, Xiaolong Huang, Xiaopei Wu, Wenying Wei, Hao Zhu, Jinyong Zhang, Jun Xiao, Honglian Dai
Summary: This study designs a bioadaptive ceramic scaffold for bone defect repair, incorporating bioactive components and bionic structures, which exhibits good mechanical properties and bone regeneration capacity.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2023)