Article
Urology & Nephrology
Sehoon Park, Jina Park, Eunjeong Kang, Jang Wook Lee, Yaerim Kim, Minsu Park, Kwangsoo Kim, Hyo Jeong Kim, Miyeun Han, Jang-Hee Cho, Jung Pyo Lee, Sik Lee, Soo Wan Kim, Sang Min Park, Dong-Wan Chae, Ho Jun Chin, Yong Chul Kim, Yon Su Kim, Insun Choi, Hajeong Lee
Summary: This study investigated the socioeconomic impact of kidney donation on living donors in the Korean National Health Insurance System. The results showed that living kidney donors may experience unemployment and deteriorating economic status after donation. These findings should be considered in conjunction with potential long-term health outcomes after donation.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2022)
Article
Transplantation
Eric Goffin, Alexandre Candellier, Priya Vart, Marlies Noordzij, Miha Arnol, Adrian Covic, Paolo Lentini, Shafi Malik, Louis J. Reichert, Mehmet S. Sever, Bruno Watschinger, Kitty J. Jager, Ron T. Gansevoort
Summary: This study found that kidney transplant recipients have a higher risk of developing a more severe course of COVID-19 compared to hemodialysis patients, especially within the first year post-transplant. Therefore, specific infection mitigation strategies are needed for this group of patients.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Immunology
Yimam Getaneh, Fentabil Getnet, Abdur Rashid, Li Kang, Qingfei Chu, Sisi Li, Feng Yi, Yiming Shao
Summary: This study investigated the spectrum of opportunistic infections (OIs) and malignancies among women living with HIV in Ethiopia. The results showed that the prevalence of OIs or malignancies was high, and the incidence rates of candidiasis, lymphoma, cervical cancer, and tuberculosis were notable. The risk of OIs was higher in patients with lower CD4 count and higher viral load. The study highlighted the need to enhance the diagnosis and treatment of these co-morbidities.
EMERGING MICROBES & INFECTIONS
(2023)
Article
Microbiology
Robert Breitkopf, Benedikt Treml, Zoran Bukumiric, Nicole Innerhofer, Margot Fodor, Sasa Rajsic
Summary: This study aimed to identify potential risk factors for mortality after liver transplantation and to examine the role of fungal infections. The findings showed that short-term mortality after liver transplantation is mainly determined by infectious and procedural complications, with fungal infections becoming a growing concern. Further research is needed to determine the ideal perioperative antimycotic prophylaxis.
Article
Immunology
Agnieszka Tomaszewska, Madan Jagasia, Eric Beohou, Steffie van der Werf, Didier Blaise, Edward Kanfer, Noel Milpied, Peter Remenyi, Fabio Ciceri, Jean H. Bourhis, Patrice Chevallier, Carlos Solano, Gerard Socie, Benedetto Bruno, Alessandro Rambaldi, Luca Castagna, Nicolaus Kroger, Paolo Corradini, Boris Afanasyev, Marco Ladetto, Dietger Niederwieser, Christof Scheid, Henrik Sengeloev, Frank Kroschinsky, Ibrahim Yakoub-Agha, Helene Schoemans, Christian Koenecke, Olaf Penack, Zinaida Peric, Hildegard Greinix, Rafael F. Duarte, Grzegorz W. Basak
Summary: A retrospective analysis of 3839 adult patients with B-cell malignancies undergoing alloHCT found that adding rituximab to reduced intensity conditioning regimens did not significantly impact major transplant outcome variables. However, the lack of data on chronic GVHD in this study limits the conclusions that can be drawn.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Urology & Nephrology
Yeoungjee Cho, Kai-Ming Chow, Philip Kam-Tao Li, Naomi Runnegar, David W. Johnson
Summary: Peritoneal dialysis is an important treatment option for patients with kidney failure, providing various benefits such as enhanced participation in daily activities, flexibility in schedules, cost savings, and improved quality of life. However, the utilization of peritoneal dialysis has remained static or declining in certain regions due to concerns about PD-related infections. This review aims to provide an overview of the definition, epidemiology, risk factors, prevention, and treatment of PD-related infections based on current evidence.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Transplantation
Sandip Mitra, Anuradha Jayanti, Priya Vart, Armando Coca, Maurizio Gallieni, Marius Altern Ovrehus, Karsten Midtvedt, Samar Abd ElHafeez, Iliaria Gandolfini, Stefan Buttner, Casper F. M. Franssen, Marc H. Hemmelder
Summary: This study highlights the effective management of KRT patients with mild COVID-19 through supported outpatient care and vigilance of respiratory symptoms. Risk factors for mortality upon readmission after discharge from initial triage include older age, smoking history, higher frailty score, and shortness of breath at first presentation. Thus, a risk-stratified clinical approach is important for optimal resource utilization during the ongoing pandemic.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Immunology
Francesca Gurrieri, Silvia Corbellini, Giorgio Piccinelli, Alessandro Turra, Enrico Morello, Michele Malagola, Domenico Russo, Arnaldo Caruso, Maria Antonia De Francesco
Summary: Saprochaete capitata, an arthroconidial yeast found in both the environment and human subjects, is increasingly associated with invasive infections in patients with acute leukemia. The resistance of Saprochaete spp. to antifungal drugs makes treatment difficult, emphasizing the importance of early diagnosis and appropriate management of these pathogens for the poor prognosis associated with fungal invasive infections.
Article
Oncology
Daniel N. Willis, Mary Claire McGlynn, Patrick J. Reich, Robert J. Hayashi
Summary: This study evaluated the risk of bloodstream infections (BSI) and death in pediatric oncology patients, finding that BSI is a significant cause of mortality in this population. Younger age, specific diagnoses, ethnicity, and history of hematopoietic stem cell transplant (HSCT) were identified as risk factors for BSI. The mortality rate for patients with BSI was 6.5%. Patients with febrile neutropenia had a lower mortality rate compared to those without. These findings highlight the importance of BSI prevention to reduce the risk of death in pediatric oncology patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Urology & Nephrology
David Al-Adra, Talal Al-Qaoud, Kevin Fowler, Germaine Wong
Summary: Cancer is a significant concern after kidney transplantation, with poor outcomes once developed and limited screening and treatment strategies available for this high-risk population. Understanding patients' experiences and knowledge can help inform the epidemiology and burden of cancer in kidney transplant recipients.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Immunology
Satomi Doi, Mayu Sekiguchi, Ryo Motoya, Junichiro Kanazawa, Masumi Sato, Hiroshi Harada, Nobuyuki Fukuzawa, Yoshiki Wada, Tetsuo Hirano
Summary: This study examined the association between recipients' feelings of guilt for the donor and depressive symptoms before living kidney transplantation. The results showed that feelings of guilt for donors were associated with depressive symptoms, especially cognitive factors.
TRANSPLANTATION PROCEEDINGS
(2022)
Article
Urology & Nephrology
Emilio Sanchez-Alvarez, Minerva Rodriguez-Garcia, Francesco Locatelli, Carmine Zoccali, Alejandro Martin-Malo, Juergen Floege, Markus Ketteler, Gerard London, Jose L. Gorriz, Boleslaw Rutkowski, Anibal Ferreira, Drasko Pavlovic, Jorge B. Cannata-Andia, Jose L. Fernandez-Martin
Summary: High-flux dialysis is associated with lower all-cause and cardiovascular mortality risks, but facilities using these membranes more extensively do not show better survival outcomes.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Multidisciplinary Sciences
Shatha A. AbuTaha, Tasbeeh Al-Kharraz, Souad Belkebir, Adham Abu Taha, Sa'ed H. Zyoud
Summary: This study investigates the clinical characteristics, microbial profiles, and antibiotic resistance patterns in hemodialysis patients with bloodstream infections (BSIs). The findings show a high proportion of multidrug-resistant organisms (MDRO) causing BSIs in Palestinian patients. Combination therapy with vancomycin and gentamicin is effective in treating these infections.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Wojciech Figiel, Grzegorz Niewinski, Michal Grat, Marek Krawczyk, Jan Stypulkowski, Zbigniew Lewandowski, Maciej Krasnodebski, Waldemar Patkowski, Krzysztof Zieniewicz
Summary: Despite the importance of perioperative hyperoxygenation in preventing postoperative infections, this study found that it should not be used for prophylaxis of infections after liver transplantation due to the lack of efficacy.
Article
Urology & Nephrology
Vianda S. Stel, Rianne W. de Jong, Anneke Kramer, Anton M. Andrusev, Jose M. Baltar, Myftar Barbullushi, Samira Bell, Pablo Castro de la Nuez, Harijs Cernevskis, Cecile Couchoud, Johan De Meester, Bjorn O. Eriksen, Liliana Garneata, Eliezer Golan, Jaakko Helve, Marc H. Hemmelder, Kristine Hommel, Kyriakos Ioannou, Faical Jarraya, Nino Kantaria, Julia Kerschbaum, Kirill S. Komissarov, Angela Magaz, Lucile Mercadal, Mai Ots-Rosenberg, Runolfur Palsson, Axel Rahmel, Helena Rydell, Manuela Savino, Nurhan Seyahi, Maria F. Slon Roblero, Olivera Stojceva-Taneva, Arjan van der Tol, Evgueniy S. Vazelov, Edita Ziginskiene, Oscar Zurriaga, Raymond C. Vanholder, Ziad A. Massy, Kitty J. Jager
Summary: There are significant variations in the frequency of dialysis and kidney transplantation among patients with kidney failure in Europe, as well as in the regularity of comprehensive conservative management (CCM). Different countries show distinct levels of utilization of kidney replacement therapy and CCM, indicating a need for improvement in treatment options for patients with kidney failure.
KIDNEY INTERNATIONAL
(2021)
Article
Medical Laboratory Technology
Laurence Bessueille, Lynn Kawtharany, Thibaut Quillard, Claudia Goettsch, Anne Briolay, Nirina Taraconat, Stephane Balayssac, Veronique Gilard, Saida Mebarek, Olivier Peyruchaud, Francois Duboeuf, Caroline Bouillot, Anthony Pinkerton, Laura Mechtouff, Rene Buchet, Eva Hamade, Kazem Zibara, Caroline Fonta, Emmanuelle Canet-soulas, Jose luis Millan, David Magne
Summary: This study found that the activation of tissue-nonspecific alkaline phosphatase (TNAP) precedes and predicts calcification in atherosclerotic plaques, and TNAP inhibition prevents plaque calcification and protects arteries from atherosclerosis. The study also discovered that TNAP inhibition reduces blood levels of cholesterol and triglycerides, and ameliorates plaque calcification, thereby protecting arteries.
TRANSLATIONAL RESEARCH
(2023)
Article
Critical Care Medicine
Antoine Duclos, Cecile Payet, Loredana Baboi, Bernard Allaouchiche, Laurent Argaud, Frederic Aubrun, Julien Bohe, Frederic Dailler, Jean-Luc Fellahi, Jean-Jacques Lehot, Vincent Piriou, Thomas Rimmele, Delphine Terragrossa, Stephanie Polazzi, Claude Guerin
Summary: This study found that the familiarity level between nurses in the ICU has a significant impact on patient outcomes, with higher familiarity associated with lower risk of patient deaths.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Review
Gastroenterology & Hepatology
Jean-Pierre Chouraqui, Christophe Dupont, Andre Briend, Dominique Darmaun, Noel Peretti, Alain Bocquet, Martin Chalumeau, Arnaud De Luca, Francois Feillet, Marie-Laure Frelut, Dominique Guimber, Alexandre Lapillonne, Agnes Linglart, Jean-Christophe Roze, Umberto Simeoni, Dominique Turck
Summary: Reducing the burden of noncommunicable diseases (NCDs) is a global public health priority, and improving diet quality is recognized as an effective approach. The Nutri-Score (N-S) front-of-pack labeling logo helps consumers identify healthier prepackaged foods. Studies have shown that the N-S is an efficient tool for raising consumer awareness, understanding, and purchasing of healthier options, potentially reducing NCD prevalence. The N-S is currently voluntary in 7 European countries, but discussions are ongoing to establish a harmonized mandatory label. However, the impact of the N-S on children's dietary patterns and health needs further investigation, especially considering their specific nutritional requirements.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2023)
Article
Transplantation
Robin Lengton, Esmee M. van der Willik, Esther N. M. de Rooij, Yvette Meuleman, Saskia Le Cessie, Wieneke M. Michels, Marc Hemmelder, Friedo W. Dekker, Ellen K. Hoogeveen
Summary: This study investigated the association between residual estimated glomerular filtration rate (eGFR), dialysis adequacy, or serum phosphate level and chronic kidney disease-associated pruritus (CKD-aP) in incident dialysis patients. The results showed that higher residual eGFR and lower serum phosphate level, but not the dialysis dose, were related to a lower burden of CKD-aP in dialysis patients.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Benoit Cosset, Monica Sigovan, Sara Boccalini, Fadi Farhat, Philippe Douek, Loic Boussel, Salim Aymeric Si-Mohamed
Summary: This study aimed to investigate the feasibility of identifying and characterizing the three most common types of endoleaks in a thoracic aorta aneurysm model using bicolor K-edge imaging and a biphasic contrast agent injection. The results showed that bicolor K-edge imaging allows for the bicolor characterization of thoracic aorta endoleaks in a single acquisition.
DIAGNOSTIC AND INTERVENTIONAL IMAGING
(2023)
Review
Genetics & Heredity
Charles R. Lefevre, Francois Labarthe, Diane Dufour, Caroline Moreau, Marie Faoucher, Paul Rollier, Jean-Baptiste Arnoux, Marine Tardieu, Lena Damaj, Claude Bendavid, Anne-Frederique Dessein, Cecile Acquaviva-Bourdain, David Cheillan
Summary: Primary Carnitine Deficiency (PCD) will be included in the expansion of the French newborn screening program in 2023. Screening for PCD is complex and has a wide clinical spectrum. Some countries struggle with high false positive rates and have even removed PCD from their screening programs. To understand the risks and benefits, we reviewed the literature and identified hurdles and current practices in PCD newborn screening worldwide. In addition, we address the optimized screening algorithm for the implementation of PCD screening in France.
INTERNATIONAL JOURNAL OF NEONATAL SCREENING
(2023)
Article
Cardiac & Cardiovascular Systems
Camelia Acatrinei, Caroline Martin-Bonnet, Gilles Rioufol, Francis Bessiere
Summary: This case report describes a patient with Fontan circulation who developed IART and initial poor haemodynamic tolerance. Both IART ablation and transcatheter aortic valve replacement were performed during the same procedure, resulting in improved haemodynamics and control of the arrhythmia.
EUROPEAN HEART JOURNAL-CASE REPORTS
(2023)
Review
Peripheral Vascular Disease
Narasimha Anaganti, Atrayee Chattopadhyay, Mathilde Di Filippo, M. Mahmood Hussain
Summary: This review provides an overview of new developments in gene editing technology, particularly in using CRISPR/Cas9-mediated gene editing to study lipoprotein assembly and secretion.
CURRENT ATHEROSCLEROSIS REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Laurent Jacquin, Marion Battault, Nathan Mewton, Adrien Mantout, Cyrille Bergerot, Karim Tazarourte, Marion Douplat
Summary: The aim of this study was to describe the outcomes and associated factors in patients admitted to emergency departments with oxygen supply/demand imbalance, without considering troponin results or restrictive criteria for type 2 myocardial infarction. A retrospective cohort of 824 patients was analyzed, and in-hospital mortality, 3-year mortality, and major adverse cardiovascular events were reported as outcomes. The results showed that acute myocardial injury and type 2 myocardial infarction were significantly associated with in-hospital mortality, but did not have higher long-term mortality or major cardiovascular events after discharge.
JOURNAL OF CARDIOVASCULAR MEDICINE
(2023)
Article
Critical Care Medicine
Thomas Metayer, Chloe Dumot, Florian Bernard, Pierre-Jean Le Reste, Anne-Laure Bernat, Helene Cebula, Charles-Henry Mallereau, Charles Peltier, Caroline le Guerinel, Denis Vivien, Michel Piotin, Evelyne Emery, Vianney Gillard, Arthur Leclerc, Elsa Magro, Francois Proust, Isabelle Pelissou-Guyotat, Stephane Derrey, Sorin Aldea, Charlotte Barbier, Alin Borha, Lawrence Nadin, Anais R. Briant, Thomas Gaberel
Summary: This study aimed to compare the functional outcomes of surgical evacuation in patients with ruptured middle cerebral artery aneurysm (MCAa) and intracerebral hematoma. The study found that clipping the aneurysm and concomitant hematoma evacuation can achieve better functional outcomes compared to endovascular therapy (EVT) followed by surgical evacuation.
NEUROCRITICAL CARE
(2023)
Article
Multidisciplinary Sciences
Martin Schwarzer, Umesh Kumar Gautam, Kassem Makki, Anne Lambert, Tomas Brabec, Amelie Joly, Dagmar Srutkova, Pierre Poinsot, Tereza Novotna, Stephanie Geoffroy, Pascal Courtin, Petra Petr Hermanova, Renata C. Matos, Jonathan J. M. Landry, Celine Gerard, Anne-Laure Bulteau, Tomas Hudcovic, Hana Kozakova, Dominik Filipp, Marie -Pierre Chapot-Chartier, Marek Sinkora, Noel Peretti, Ivo Gomperts Boneca, Mathias Chamaillard, Hubert Vidal, Filipe De Vadder, Francois Leulier
Summary: The intestinal microbiota plays a role in postnatal growth, and Lactiplantibacillus plantarum strain LpWJL has been found to support growth in undernourished animals. This strain stimulates insulin-like growth factor-1 (IGF-1) and insulin production and activity. Cell walls from LpWJL, as well as specific molecules, can promote growth despite undernutrition. NOD2 in intestinal epithelial cells is necessary for LpWJL-mediated IGF-1 production and growth promotion in malnourished animals.
Review
Medicine, General & Internal
Franck Zekre, Anita Duncan, Audrey Laurent, Maud Tusseau, Remi Pescarmona, Sophie Collardeau-Frachon, Camille Ohlmann, Sebastien Viel, Philippe Reix, Sarah Benezech, Alexandre Belot
Summary: Biological disease-modifying anti-rheumatic drugs (bDMARDs) targeting IL-6 and IL-1 beta are commonly used as a first-line therapy for systemic-onset juvenile idiopathic arthritis (sJIA), but they may increase the risk of pulmonary alveolar proteinosis (PAP). We report a new case of PAP-MAS successfully treated with Janus Kinase inhibitors (JAKi) and review previous clinical descriptions of this condition. Among the analyzed articles, the incidence of PAP-MAS among sJIA patients ranged from 1.28% to 12.9%. JAKi shows promise in treating lung disease associated with sJIA.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Urology & Nephrology
Li Luo, Yuanhang Yang, Lyanne M. Kieneker, Roemer J. Janse, Alessandro Bosi, Faizan Mazhar, Rudolf A. de Boer, Geertruida H. de Bock, Ron T. Gansevoort, Juan-Jesus Carrero
Summary: This study investigated the association between albuminuria and cancer incidence, independent of kidney function. The results showed that higher albuminuria is associated with an increased risk of cancer, regardless of estimated glomerular filtration rate (eGFR). This study highlights the potential value of using albuminuria as a marker for certain cancer screening programs.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Critical Care Medicine
Damien Contou, Gaetan Beduneau, Charlotte Rabault, Romain Sonneville, Antoine Marchalot, Remi Coudroy, Damien Roux, Martin Cour, Julien Massol, Sebastien Preau, Nicolas de Prost
Summary: This study aimed to assess the sensitivity of skin biopsy in adult patients with meningococcal purpura fulminans. The results showed that skin biopsy combined with conventional culture and meningococcal PCR had a global sensitivity of 88%, and should be considered even after the initiation of antimicrobial treatment.
Article
Critical Care Medicine
Antoine Gaillet, Elie Azoulay, Etienne de Montmollin, Maite Garrouste-Orgeas, Yves Cohen, Claire Dupuis, Carole Schwebel, Jean Reignier, Shidasp Siami, Laurent Argaud, Christophe Adrie, Bruno Mourvillier, Stephane Ruckly, Jean-Marie Forel, Jean-Francois Timsit
Summary: Despite antiviral therapy (ART), 800,000 deaths still occur yearly and globally due to HIV infection. In parallel with the good virological control and the aging of this population, multiple comorbidities [HIV-associated-non-AIDS (HANA) conditions] may now be observed.