Article
Cell Biology
Hyun Jin Kim, Jiae Lee, Gong-Rak Lee, Narae Kim, Hye In Lee, Minjeong Kwon, Nam Young Kim, Jin Ha Park, Ye Hee Kang, Hyeong Ju Song, TaeSoo Kim, Dong Min Shin, Woojin Jeong
Summary: FN inhibits osteoclastogenesis by blocking CaMKIV and calcineurin, reducing the risk of bone diseases like osteoporosis.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Engineering, Biomedical
Wei Zhang, Xingzhi Zhou, Weiduo Hou, Erman Chen, Chenyi Ye, Mo Chen, Qian Lu, Xiaohua Yu, Weixu Li
Summary: In this study, a molecular therapeutic strategy mediated by a SIRT-1 agonist was reported to reverse the imbalance in bone homeostasis by regulating osteogenesis and osteoclastogenesis simultaneously. The sustained release of SRT2104 from mineral coated acellular matrix microparticles effectively enhanced osteogenic differentiation and mineralization, while attenuating the formation and function of excessive osteoclasts by integrating multiple vital upstream signals. Animal models also demonstrated the accelerated healing and improved osseointegration of osteoporotic bone defects.
BIOACTIVE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Guan-Yin Zhu, Ya-Hui Liu, Wei Liu, Xin-Qi Huang, Bo Zhang, Zi-Li Zheng, Xin Wei, Jia-Zhuang Xu, Zhi-He Zhao
Summary: The study utilized surface-directed epitaxial crystallization to construct a specific nano-topographical structure on a poly(epsilon-caprolactone) substrate, enhancing the formation of the CaP layer. Experimental results demonstrated a significant enhancement in osteogenic differentiation and proliferation of bone marrow mesenchymal stromal cells on the biomineralized nano-topological surface, showing potential for designing bone repair scaffolds.
Article
Engineering, Biomedical
Zhangling Nie, Zhiqiao Hu, Xiaodong Guo, Yu Xiao, Xian Liu, Joost D. de Bruijn, Chongyun Bao, Huipin Yuan
Summary: Innate immune responses, specifically M2 macrophages and osteoclastogenesis, play important roles in material-induced bone formation. The study found that M0 macrophages fused to osteoclasts when treated with M-CSF, RANKL, and IL-4, and this osteoclast formation was enhanced with IL-4 treatment. M2 macrophages and osteoclasts produced osteogenic factors that induced osteogenic differentiation of osteogenic precursor cells and led to bone formation.
ACTA BIOMATERIALIA
(2023)
Article
Materials Science, Multidisciplinary
Jiaolong Wang, Qin Zhao, Shihang Zheng, Jinyang Wang, Liangliang Fu, Can Wang, Zifan Zhao, Yufeng Zhang
Summary: Macrophages play a crucial role in bone regeneration, and the CD301b+ macrophages exhibit significant effects in the osteoinduction of calcium phosphate ceramics, promoting the osteogenic differentiation of mesenchymal stem cells and potentially serving as a novel therapeutic target for bone regeneration.
APPLIED MATERIALS TODAY
(2021)
Article
Chemistry, Physical
Jinjie Wu, Cong Feng, Menglu Wang, Hongfeng Wu, Xiangdong Zhu, Xiangfeng Li, Xuening Chen, Xingdong Zhang
Summary: This study investigated the effects of biphasic calcium phosphate (BCP) ceramics with different whiskered surfaces on macrophage polarization and functional status. The results showed that BCP ceramics with short and hollow whiskers (BCP-HW) were more conducive to protein adsorption and macrophage elongation compared to those with long and solid whiskers (BCP-W). BCP-HW ceramics down-regulated the expression of M1 macrophage markers and promoted the expression of M2 macrophage markers and growth factors. The conditioned medium derived from the co-culture of macrophages and whiskered ceramics could promote the expression of bone markers in pre-osteoblasts. In an intramuscular implantation model, BCP-HW ceramics drove the switch of macrophages to the M2 phenotype and induced ectopic bone formation.
Article
Nanoscience & Nanotechnology
Maki Nakamura, Katsuya Ueda, Yumiko Yamamoto, Kaoru Aoki, Minfang Zhang, Naoto Saito, Masako Yudasaka
Summary: Carbon nanohorns (CNHs) have been explored for drug delivery systems due to their unique properties, with OxCNH-CaP-IBN composite nanoparticles showing stronger cell-suppressive effects by releasing IBN through CaP dissociation.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Biochemistry & Molecular Biology
Takuma Matsubara, Kazuma Yasuda, Kana Mizuta, Hiroka Kawaue, Shoichiro Kokabu
Summary: Osteoclasts and osteoblasts are the key cells regulating bone homeostasis. Imbalance between increased bone resorption by osteoclasts and decreased bone formation by osteoblasts leads to osteoporosis and other metabolic bone diseases. Src has been identified as an essential factor for bone resorption and a suppressor of bone formation. However, developing effective therapies targeting Src is challenging due to its widespread expression and involvement in various biological processes. Understanding the molecular mechanism of Src in bone is crucial for the treatment of bone metabolic diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Hyunji Cho, Jisoo Lee, Seoyoung Jang, Jungsun Lee, Tong In Oh, Youngsook Son, EunAh Lee
Summary: The calcium concentration gradient near the BRC may play a role in bone remodeling by acting on BMSCs through CaSR, affecting proliferation and differentiation, and influencing the coupling mechanism between osteoblasts and osteoclasts.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Vishwa Deepak, Shu-Ting Yang, Ziqing Li, Xinhua Li, Andrew Ng, Ding Xu, Yi-Ping Li, Merry Jo Oursler, Shuying Yang
Summary: This study identifies a negative function of IFT80 in osteoclasts by regulating the stabilization and degradation of Cbl-b and TRAF6, thereby affecting osteoclast formation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Medicine, Research & Experimental
Yan Wu, Dan Li, Mingzheng Li
Summary: Current studies have discovered that specific physicochemical properties of sintered calcium phosphate (CaP) ceramics can stimulate bone formation in non-osseous sites, known as osteoinductive biomaterials. The underlying mechanism of osteoinduction remains unclear, inhibiting the design of biomaterials with enhanced osteogenic potential. Recent evidence suggests that osteoclasts may play a critical role in osteoinduction by recruiting mesenchymal stem cells (MSCs) and enhancing their osteogenic differentiation. However, it is still unknown whether osteoclasts can initiate biomaterial-induced ectopic bone formation.
MEDICAL HYPOTHESES
(2023)
Article
Engineering, Biomedical
Xiaogang Wang, Yuanman Yu, Luli Ji, Zhen Geng, Jing Wang, Changsheng Liu
Summary: Calcium phosphate-based materials, commonly used in bone graft substitutes, play a crucial role in bone healing. Recent studies have shown that osteoclast behaviors can greatly influence osteogenesis, with an appropriate Ca/P ratio promoting osteoclast differentiation and bone healing. This suggests the potential of manipulating osteoclast-mediated osteogenesis for improving osseointegration in materials.
BIOACTIVE MATERIALS
(2021)
Review
Engineering, Biomedical
I. Lodoso-Torrecilla, J. J. J. P. van den Beucken, J. A. Jansen
Summary: Synthetic calcium phosphate ceramics are widely used for bone regenerative treatments due to their bioactivity and osteoconductive properties. Injectable CPCs are appealing for minimally invasive surgery and filling irregular bone defects, but their poor degradability can be addressed by introducing macroporosity to accelerate new bone formation.
ACTA BIOMATERIALIA
(2021)
Article
Engineering, Biomedical
Zhurong Tang, Siyu Chen, Yilu Ni, Rui Zhao, Xiangdong Zhu, Xiao Yang, Xingdong Zhang
Summary: The study identified the important role of Na+, K+-ATPase (NKA) in the osteoinductivity of biphasic calcium phosphate bioceramic (BCP), demonstrating the therapeutic potential of targeting NKA in osteoporotic bone regeneration. The approach was cost-saving, identified an unrevealed bone regenerating target, and held significant value in identifying an anabolic agent.
ACTA BIOMATERIALIA
(2021)
Article
Biochemistry & Molecular Biology
Feng Shi, Xin Fang, Teng Zhou, Xu Huang, Ke Duan, Jianxin Wang, Shuxin Qu, Wei Zhi, Jie Weng
Summary: This study investigated the effect of macropore size and shape on the osteoinductivity of hydroxyapatite ceramics scaffolds. The results showed that scaffolds with spherical macropores and larger pore sizes had higher new bone production and more uniform new bone distribution. Additionally, the mechanical load of the host tissue was found to play a key role in the microfluidic pathway mechanism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Orthopedics
Hiromichi Hirai, Yoshiharu Nakaya, Yoshitada Usami, Atsushi Nakano, Takashi Fujishiro, Sachio Hayama, Masahiro Mizutani, Masashi Neo
JOURNAL OF ORTHOPAEDIC SCIENCE
(2023)
Article
Orthopedics
Gen Nakamura, Toshito Yasuda, Hiroaki Shima, Kosho Togei, Yoshihiro Hirai, Masashi Neo
Summary: The study aimed to determine the normal length and shape of the Achilles tendon (AT) and investigate correlating factors. Measurements were taken from 100 asymptomatic patients using magnetic resonance imaging. The results showed that 73% of the patients had an AT length within the range of 30-55 mm, and there was no correlation between tendon length and patient height. The study also found a strong correlation between AT length and the area of Kager's fat pad.
JOURNAL OF ORTHOPAEDIC SCIENCE
(2023)
Article
Orthopedics
Akihiko Hasegawa, Teruhisa Mihata, Kunimoto Fukunishi, Yasuo Itami, Akihiro Uchida, Masashi Neo
Summary: This study retrospectively investigated the graft tear rate, timing of graft tear, and the impact of graft tears on clinical outcomes after arthroscopic superior capsule reconstruction (SCR). The overall graft tear rate was 11.7%, with the majority of graft tears occurring within 6 months after surgery. Patients with graft tears had significantly inferior postoperative clinical scores compared to those without graft tears.
JOURNAL OF SHOULDER AND ELBOW SURGERY
(2023)
Article
Orthopedics
Akihiko Hasegawa, Teruhisa Mihata, Nobuyuki Yamamoto, Norimasa Takahashi, Kazumasa Takayama, Akihiro Uchida, Masashi Neo
Summary: This study examined the relationship between postoperative graft integrity and clinical outcomes in patients with irreparable rotator cuff tears. The results showed that the thickness and tear size of the graft can affect the clinical outcomes. Patients with large graft tears had inferior postoperative clinical scores compared to those with intact grafts of sufficient thickness.
JOURNAL OF SHOULDER AND ELBOW SURGERY
(2023)
Article
Orthopedics
Yoshinori Okamoto, Hitoshi Wakama, Junya Matsuyama, Kaito Nakamura, Shuhei Otsuki, Masashi Neo
Summary: This study evaluated the association between the sagittal alignment of the pelvis and residual knee flexion contracture after total knee arthroplasty (TKA). The study found that a pelvic incidence >= 55 degrees and the femoral component flexion angle (FFA) were predictive factors for a residual flexion contracture >= 10 degrees.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2023)
Article
Pharmacology & Pharmacy
Tomoyuki Yamada, Ryuji Kato, Yoshio Ijiri, Masami Nishihara, Masashi Neo
Summary: This study evaluated the risk of hepatic disorders in patients taking concomitant acetaminophen and immune checkpoint inhibitors (ICI) using a disproportionality analysis. The results showed that the risk of hepatic disorders was higher in patients taking concomitant acetaminophen and ICI compared to those only taking acetaminophen.
INTERNATIONAL JOURNAL OF CLINICAL PHARMACY
(2023)
Article
Pharmacology & Pharmacy
Ryosuke Ota, Takeo Hata, Atsushi Hirata, Takeshi Hamada, Masami Nishihara, Masashi Neo, Takahiro Katsumata
Summary: This retrospective cohort study examined the interaction between methotrexate and glucocorticoids in patients with rheumatoid arthritis using bDMARDs. The results showed that the interaction between the doses of methotrexate and glucocorticoids significantly influenced the risk of bacterial infections. Higher doses of glucocorticoids were a significant risk factor for bacterial infections when high doses of methotrexate were used.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Letter
Clinical Neurology
Kaito Nakamura, Yoshinori Okamoto, Hitoshi Wakama, Junya Matsuyama, Takashi Ishitani, Shuhei Otsuki, Masashi Neo
EUROPEAN SPINE JOURNAL
(2023)
Article
Clinical Neurology
Kaito Nakamura, Yoshinori Okamoto, Hitoshi Wakama, Junya Matsuyama, Takashi Ishitani, Shuhei Otsuki, Masashi Neo
Summary: This retrospective case-control study found an association between global spinal malalignment and rapid progression of hip arthrosis. Significant differences were identified in pelvic tilt, sagittal vertical axis, and T1 pelvic angle between the rapid progression group and the non-rapid progression group. Logistic regression analysis and ROC curve analysis showed that pelvic tilt, sagittal vertical axis, and T1 pelvic angle were predictive of rapid progression of hip arthrosis.
EUROPEAN SPINE JOURNAL
(2023)
Article
Orthopedics
Yoshihiro Hirai, Hiroaki Shima, Kosho Togei, Toshito Yasuda, Masashi Neo
Summary: Hallux valgus surgery and open reduction of the lesser metatarsophalangeal joints with metatarsal shortening osteotomy can help treat severe hallux valgus with lesser metatarsophalangeal joint dislocation effectively.
JOURNAL OF FOOT & ANKLE SURGERY
(2023)
Article
Clinical Neurology
Yoshinori Okamoto, Hitoshi Wakama, Junya Matsuyama, Kaito Nakamura, Takafumi Saika, Shuhei Otsuki, Masashi Neo
Summary: This study evaluated the association between preoperative global alignment and proportion score and low back pain after total hip arthroplasty. The results showed that patients with a relative pelvic version below -7 degrees and a relative lumbar lordosis below -15 degrees were more likely to experience low back pain after THA. The measurement of relative pelvic version may be a useful predictor of THA outcome.
EUROPEAN SPINE JOURNAL
(2023)
Letter
Clinical Neurology
Takashi Fujishiro, Takuya Obo, Masahiro Mizutani, Yoshiharu Nakaya, Sachio Hayama, Yoshitada Usami, Masashi Neo
WORLD NEUROSURGERY
(2023)
Article
Orthopedics
Shuhei Otsuki, Shunsuke Sezaki, Yoshinori Okamoto, Takashi Ishitani, Hitoshi Wakama, Masashi Neo
Summary: This study evaluated the safety and efficacy of a novel meniscal scaffold for the treatment of irreparable meniscal injuries. The results showed that the scaffold could tolerate shear forces and had therapeutic potentials for irreparable meniscal tears in humans.
Article
Orthopedics
Yasuo Itami, Orr Limpisvasti, Michelle H. McGarry, Nilay A. Patel, Charles C. Lin, Thomas Dooney, Teruhisa Mihata, Masashi Neo, Thay Q. Lee
Summary: The purpose of this study was to compare the biomechanical characteristics of a new locking loop stitch (LLS) to the traditional Krackow stitch. The LLS showed less deformation, higher stiffness, and higher yield load compared to the Krackow stitch. Therefore, LLS can be a viable alternative to the Krackow stitch for graft fixation.
CLINICS IN ORTHOPEDIC SURGERY
(2023)
Article
Chemistry, Medicinal
T. Amadutsumi, Y. Urashima, K. Urashima, K. Suzuki, K. Kurachi, M. Nishihara, M. Neo, M. Myotoku, T. Kobori, T. Obata
Summary: This study investigated the interaction between levetiracetam (LEV) and enteral nutrients (ENs). Co-administration of LEV with Terumeal (R) Soft, an EN, reduced the absorption of LEV, which could be prevented by administering Terumeal (R) Soft 2 hours after LEV administration. Semi-solid Racol (R) NF altered the absorption of LEV, while liquid Racol (R) NF did not affect LEV pharmacokinetics.