Journal
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
Volume 92A, Issue 3, Pages 1218-1224Publisher
WILEY-LISS
DOI: 10.1002/jbm.a.32463
Keywords
titanium dioxide nanotube; bone implant; osseointegration; mechanical strength; histology
Funding
- Region Skane, Sweden (ALF)
- von Liebig Center for Entrepreneurship Foundation
- Iwama Endowed Fund at the University of California San Diego
- Whitaker International Fellowship Program
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Implant topography is critical to the clinical Success of bone-anchored implants, yet little is known how nano-modified implant topography affects osseointegration. We investigate the in vivo bone bonding of two titanium implant surface: titanium dioxide (TiO(2)) nanotubes and TiO(2) gritblasted surfaces. In previous in vitro studies, the topography of the TiO(2) nanotubes improved osteoblast proliferation and adhesion compared with gritblasted titanium Surfaces. After four weeks of implantation in rabbit tibias, pull-out testing indicated that TiO(2) nanotubes significantly improved bone bonding strength by as much as nine-fold compared with TiO(2) gritblasted surfaces. Histological analysis confirmed greater bone-implant contact area, new bone formation, and calcium and phosphorus levels on the nanotube surfaces. It is anticipated that further studies will contribute to a better understanding of the effect of implant nanotopography on in vivo bone formation and bonding strength. (C) 2009 Wiley Periodicals, Inc. J Biomed Mater Res 92A: 1218-1224, 2016
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