Review
Cell Biology
Che-Hao Tseng, Kavya M. Shah, I-Jen Chiu, Li-Li Hsiao
Summary: Diabetic kidney disease is one of the most prevalent complications of type 2 diabetes mellitus, causing a significant burden on patients worldwide. Recent studies have highlighted the relationship between autophagy and diabetic kidney disease, suggesting autophagy as a potential therapeutic target.
Article
Biochemistry & Molecular Biology
Itaru Monno, Yoshio Ogura, Jing Xu, Daisuke Koya, Munehiro Kitada
Summary: This study found that 8 weeks of treadmill exercise training significantly reduced kidney injuries in type 2 diabetic obese rats, suppressing tubulointerstitial fibrosis, inflammation, and oxidative stress, promoting autophagy, and restoring mitochondrial abnormalities.
Article
Biochemistry & Molecular Biology
Zaida Abad-Jimenez, Sandra Lopez-Domenech, Celia Garcia-Gargallo, Teresa Vezza, Segundo Angel Gomez-Abril, Carlos Morillas, Pedro Diaz-Pozo, Rosa Falcon, Celia Banuls, Victor M. Victor, Milagros Rocha
Summary: This cohort study explored the molecular mechanisms involved in energy homeostasis in leukocytes of obese subjects one year after Roux-en-Y gastric bypass (RYGB) surgery. The surgery resulted in improved metabolic outcomes, reduced systemic inflammation, altered intracellular inflammatory pathways, enhanced autophagy/mitophagy markers, and decreased mitochondrial membrane potential.
Article
Biochemistry & Molecular Biology
Irma Magaly Rivas Serna, Michelle Beveridge, Michaelann Wilke, Edmond A. Ryan, Michael Thomas Clandinin, Vera Christine Mazurak
Summary: GM3 is involved in cell signaling, inflammation, and insulin resistance. The transport of intestinal-derived gangliosides to other tissues may impact the same inflammatory signals seen in conditions like Type 2 Diabetes. This study found that the composition of gangliosides in plasma and chylomicrons is altered in individuals with T2DM after a meal.
Article
Biochemistry & Molecular Biology
F. Canet, P. Diaz-Pozo, C. Luna-Marco, M. Fernandez-Reyes, T. Vezza, M. Marti, J. D. Salazar, I Roldan, C. Morillas, S. Rovira-Llopis, M. Rocha, V. M. Victor
Summary: This study evaluated the bioenergetic and redox state of peripheral blood mononuclear cells (PBMCs) from type 1 diabetes (T1D) patients and found impaired mitochondrial function, oxidative stress, and abnormal autophagy in leukocytes. These mechanisms contribute to an increased risk of atherosclerosis by augmenting leukocyte-endothelial interactions.
Article
Medicine, Research & Experimental
Michel Paul Johan Teuben, Arne Hollman, Taco Blokhuis, Roman Pfeifer, Roy Spijkerman, Henrik Teuber, Hans-Christoph Pape, Luke Petrus Hendrikus Leenen
Summary: The study revealed that surgery for intra-abdominal injuries leads to an early decrease in leukocyte numbers in peripheral blood, while splenectomy in severely injured patients is associated with a persistent state of prominent leukocytosis after trauma.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2021)
Article
Integrative & Complementary Medicine
Xiaomei Yang, Xuke Han, Qing Wen, Xianliang Qiu, Huan Deng, Qiu Chen
Summary: Keluoxin may have a protective effect against diabetic nephropathy by improving renal function, reducing blood glucose and lipid levels, and alleviating renal histopathological changes in rats with DN, similar to Irbesartan. Its mechanism involves regulating autophagy, alleviating kidney injury, and potentially serving as a therapy for DN.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Article
Medicine, Research & Experimental
Federica Barutta, Beatrice Corbetta, Stefania Bellini, Simonetta Guarrera, Giuseppe Matullo, Michela Scandella, Casper Schalkwijk, Coen D. Stehouwer, Nish Chaturvedi, Sabita S. Soedamah-Muthu, Marilena Durazzo, Gabriella Gruden
Summary: The study showed an inverse and independent association between miR-146a-5p levels and diabetes chronic complications in DM1 patients, particularly with cardiovascular diseases and retinopathy, suggesting miR-146a-5p may be a novel candidate biomarker for DM1 complications.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Yang Yang, Pu Xiang, Qi Chen, Ying Luo, Hong Wang, Huan Li, Lu Yang, Congli Hu, Jiahua Zhang, Yuke Li, Hui Xia, Zhihao Chen, Junqing Yang
Summary: The study found that PGD2 is related to brain damage caused by T2D, possibly through the regulation of the imbalance of autophagy by the expression of DP1 and DP2 receptors. The experimental results indicate that DP1 promotes autophagy to alleviate T2D brain damage, while DP2 inhibits autophagy to exacerbate T2D brain damage.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Peripheral Vascular Disease
Jacob. K. K. Kresovich, Zongli Xu, Katie. M. M. O'Brien, Christine. G. G. Parks, Clarice. R. R. Weinberg, Dale. P. P. Sandler, Jack. A. A. Taylor
Summary: This study found that shifts in lymphocyte subsets occur before the development of hypertension, followed by changes to neutrophils and additional lymphocytes.
Article
Biochemistry & Molecular Biology
Yun-xia Du, Yan-tao Zhao, Yong-xin Sun, Ai-hua Xu
Summary: High glucose inhibits the viability and osteogenic function of osteoblasts by inducing ferroptosis. Acid sphingomyelinase-mediated autophagy activation induces osteoblast ferroptosis through the degradation of GPX4. Inhibiting acid sphingomyelinase can alleviate ferroptosis and autophagy and improve osteogenic function.
MOLECULAR MEDICINE
(2023)
Article
Endocrinology & Metabolism
Rong Huang, Huiying Wang, Ziyang Shen, Tingting Cai, Yunting Zhou, Yuming Wang, Wenqing Xia, Bo Ding, Rengna Yan, Huiqin Li, Jindan Wu, Jianhua Ma
Summary: This study found that increased glycemic variability is associated with osteoporosis in patients with type 2 diabetes. Age, gender, BMI, LDL-C, and SUA were also identified as factors related to osteoporosis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Ran Cui, Zheng Zhao, Zhaoliang Fei, Yinghua Li, Wenxue Gao
Summary: This study found a relationship between anemia and osteoporosis in male and female T2DM patients, emphasizing the need for diabetic patients with anemia to be wary of osteoporosis.
ARCHIVES OF OSTEOPOROSIS
(2021)
Article
Pharmacology & Pharmacy
A. Klisic, A. Scepanovic, J. Kotur-Stevuljevic, A. Ninic
Summary: This study aimed to investigate the association between some novel indexes and glycated hemoglobin (HbA1c) in patients with prediabetes and T2D.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Obstetrics & Gynecology
Yong-dan Ma, Zhi-hui Cui, Dan Zhao, Yi-cheng Wang, Li-xue Zhang, Xue-qin Zhang, Wen-jing Guo, Dong-zhi Yuan, Jin-hu Zhang, Li-min Yue, Li Nie
Summary: This study revealed a significant decrease in endometrial glycogen concentration in T2DM mice, leading to embryo implantation issues, although endometrial AMPK was not found to be overactivated. Insulin treatment partially resolved embryo implantation defects, while metformin improved blood glucose without significant effects on local endometrial glucose metabolism.
REPRODUCTIVE SCIENCES
(2021)
Article
Ophthalmology
Jose Vicente Garcia-Marques, Cristian Talens-Estarelles, Santiago Garcia-Lazaro, Alejandro Cervino
Summary: This study developed and validated new metrics to objectively assess the lipid layer thickness (LLT) through the analysis of grey intensity values obtained from videokeratography. The new metrics showed high performance in correlation with LLT, sensitivity, specificity, and accuracy, and could be used as an easy, repeatable, objective, and accessible method to improve the detection and monitoring of dry eye disease and meibomian gland dysfunction.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Roberto Zaldivar, Roger Zaldivar, Pablo Adamek, Alejandro Cervino
Summary: This study assessed the use of intraoperative OCT to detect and adjust high vault during ICL implantation surgery. The results showed that intraoperative vault adjustment using OCT was effective in significantly changing the vault value, and it was correlated with white-to-white distance and pre-rotation vault. The postoperative vault values decreased gradually over time.
JOURNAL OF CATARACT AND REFRACTIVE SURGERY
(2022)
Review
Andrology
Teresa Vezza, Pedro Diaz-Pozo, Francisco Canet, Aranzazu M. de Maranon, Zaida Abad-Jimenez, Celia Garcia-Gargallo, Ildefonso Roldan, Eva Sola, Celia Banuls, Sandra Lopez-Domenech, Milagros Rocha, Victor M. Victor
Summary: This review explores the molecular mechanisms of mitochondrial fusion and fission processes, their role in type 2 diabetes, and the therapeutic potential of targeting mitochondrial dynamics in this complex metabolic disorder.
WORLD JOURNAL OF MENS HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Fernando Alegre, Alberto Marti-Rodrigo, Miriam Polo, Dolores Ortiz-Masia, Celia Banuls, Marcello Pinti, Angeles Alvarez, Nadezda Apostolova, Juan V. Esplugues, Ana Blas-Garcia
Summary: Efavirenz, an anti-HIV drug, triggers inflammation and fibrogenesis in hepatocytes and hepatic stellate cells, while macrophages seem to counteract these deleterious effects.
Article
Biochemistry & Molecular Biology
Zaida Abad-Jimenez, Sandra Lopez-Domenech, Celia Garcia-Gargallo, Teresa Vezza, Segundo Angel Gomez-Abril, Carlos Morillas, Pedro Diaz-Pozo, Rosa Falcon, Celia Banuls, Victor M. Victor, Milagros Rocha
Summary: This cohort study explored the molecular mechanisms involved in energy homeostasis in leukocytes of obese subjects one year after Roux-en-Y gastric bypass (RYGB) surgery. The surgery resulted in improved metabolic outcomes, reduced systemic inflammation, altered intracellular inflammatory pathways, enhanced autophagy/mitophagy markers, and decreased mitochondrial membrane potential.
Article
Ophthalmology
Cristian Talens-Estarelles, Jose Vicente Garcia-Marques, Alejandro Cervino, Santiago Garcia-Lazaro
Summary: The study aimed to identify the impact of computer use on dry eye and its association with ocular parameters. The results showed that individuals with more severe dry eye symptoms were more likely to experience an increase in symptoms during computer use, while those with poorer tear stability were more likely to experience a reduction in tear stability.
CLINICAL AND EXPERIMENTAL OPTOMETRY
(2023)
Article
Nursing
Carmen Grau-Del Valle, Jose Francisco Marco-Exposito, Neus Bosch-Sierra, Begona Zaragoza-Villena, Eva Sola, Inmaculada Montoya-Castilla, Carlos Morillas, Celia Banuls
Summary: This study aimed to evaluate perceived stress, concern about hypoglycaemia, and the level of knowledge of management of type 1 diabetes mellitus in relation to glycaemic control, gender, and age. The results showed that perceived stress was significantly associated with glycosylated haemoglobin and concern about hypoglycaemia. The level of knowledge was associated with lower glycosylated haemoglobin, fewer hypoglycaemic episodes, and less perceived stress. Age was negatively correlated with perceived stress and positively correlated with unrecognised hypoglycaemic episodes. These findings underscore the importance of addressing the psychological needs of patients with type 1 diabetes mellitus.
JOURNAL OF CLINICAL NURSING
(2023)
Article
Ophthalmology
Carlos Palomino-Bautista, Alejandro Cervino, Ricardo Cuina-Sardina, David Carmona-Gonzalez, Alfredo Castillo-Gomez, Ruben Sanchez-Jean
Summary: This study aimed to assess the depth of field in patients after cataract surgery and bilateral implantation of a trifocal intraocular lens. The results showed that the trifocal lens significantly improved visual acuity at different distances and provided wide depth of field values. The patient satisfaction rates were also high.
Article
Biochemistry & Molecular Biology
Nadezda Apostolova, Teresa Vezza, Jordi Muntane, Milagros Rocha, Victor M. Victor
Summary: Type 2 diabetes mellitus is closely linked to oxidative stress, mitochondrial dysfunction, and alterations in autophagy and mitophagy. Despite progress in understanding the molecular events associated with these processes, effective therapeutic strategies targeting these mechanisms are yet to be implemented.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Biochemistry & Molecular Biology
Noelia Diaz-Morales, Monica Cavia-Saiz, Ma Dolores Rivero-Perez, Inmaculada Gomez, Gonzalo Salazar-Mardones, Isabel Jaime, Maria L. Gonzalez-SanJose, Pilar Muniz
Summary: Melanoidins isolated from bakery by-products are promising sustainable ingredients for bakery products. The addition of melanoidins affected the color, texture, odor profile, and antioxidant capacity of the bakery food models in different ways, depending on the quantity and type of melanoidin. The melanoidins from soft bread showed stronger effects compared to those from common bread. Furthermore, the melanoidins did not exhibit cytotoxicity or alter reactive oxygen species levels in Caco-2 cells, suggesting their potential as safe and sustainable ingredients.
Article
Biochemistry & Molecular Biology
Delia Acevedo-Leon, Segundo Angel Gomez-Abril, Pablo Sanz-Garcia, Nuria Estan-Capell, Celia Banuls, Guillermo Saez
Summary: This study analyzed tumor, inflammatory, and oxidative stress markers in colorectal cancer patients and a control group. The results suggest that urinary 8-oxodG and F2-IsoPs, as well as serum CAT, GSH, and GSSG, can serve as markers for evaluating oxidative stress and clinical follow-up in CRC patients.
Review
Biochemistry & Molecular Biology
Ana Blas-Garcia, Nadezda Apostolova
Summary: Chronic liver disease (CLD) is a global health problem with no effective treatments currently available. Oxidative stress plays a crucial role in the development of liver fibrosis. Inhibition of reactive oxygen species (ROS)-mediated effects and modulation of antioxidant responses have emerged as potential targets to prevent or ameliorate liver injury. However, dietary supplements with antioxidant properties have not been effective in reducing fibrosis in clinical trials. Therefore, novel and more specific therapeutic approaches are needed to alleviate oxidative stress and reduce liver fibrosis.
Editorial Material
Biology
Jose-Maria Sanchez-Gonzalez, Carlos Rocha-de-Lossada, Alejandro Cervino
Review
Endocrinology & Metabolism
Susana Rovira-Llopis, Clara Luna-Marco, Laura Perea-Galera, Celia Banuls, Carlos Morillas, Victor M. Victor
Summary: This review analyzed the effects of time-restricted eating (TRE) on glycemic parameters. The meta-analysis results showed that TRE can reduce HbA1c and insulin levels, and the timing of food intake is a crucial factor in the beneficial effect of TRE on fasting glucose levels.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2023)