Article
Multidisciplinary Sciences
Ali Rostamian, Keivan Fallah, Yasser Rostamiyan
Summary: This study investigates the effects of endovascular techniques (coiling and stenting) on the hemodynamics and rupture of cerebral aneurysms. Computational Fluid Dynamics were used to compare the blood flow inside the aneurysm with and without stent deformation and coiling. The results show that coiling reduces the mean wall shear stress (WSS) by up to 20%, while stent deformation can reduce the mean WSS by up to 71%. Additionally, it is found that blood bifurcation occurs inside the aneurysm without endovascular treatment, but occurs at the ostium section when the ICA aneurysm is deformed by the stent.
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Martino Pepe, Gianluigi Napoli, Eugenio Carulli, Marco Moscarelli, Cinzia Forleo, Palma Luisa Nestola, Giuseppe Biondi-Zoccai, Arturo Giordano, Stefano Favale
Summary: There is a link between autoimmune diseases and in-stent restenosis (ISR) after percutaneous coronary intervention (PCI). Patients with insulin-dependent diabetes mellitus, rheumatoid arthritis, systemic lupus erythematosus, and other autoimmune diseases face higher rates of ISR. Endothelial dysfunction appears to be the principal common pathogenic pathway for ISR, influenced by immune system disorders and systemic inflammation.
Article
Cardiac & Cardiovascular Systems
Huilin Hu, Shijun Wang, Guanmin Tang, Changlin Zhai, Liang Shen
Summary: This study found that anemia is closely associated with post-PCI ISR, and patients with lower hemoglobin levels are at a higher risk of ISR.
BMC CARDIOVASCULAR DISORDERS
(2021)
Article
Computer Science, Interdisciplinary Applications
Yue Che, Jiawei Zhao, Xuelan Zhang, Mingyao Luo, Xiran Cao, Liancun Zheng, Chang Shu
Summary: In this study, the hemodynamic performances of different parallel graft techniques for left subclavian artery (LSA) reconstruction were evaluated. The results showed that periscope technique may cause more serious flow obstruction to LSA and increase the risk of stroke, while the retrograde curvature of the chimney stent may prompt stent displacement. Additionally, the flatter chimney stent increases the risk of vascular wall damage.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2023)
Review
Biotechnology & Applied Microbiology
Wansong Hu, Jun Jiang
Summary: This article describes the relationship between in-stent restenosis (ISR) and hypersensitivity reactions in patients with coronary heart disease (CHD) after percutaneous transluminal coronary intervention (PCI). With the emergence of drug-eluting stents (DES), the efficacy and prognosis of CHD patients have greatly improved, but the components of DESs can still induce hypersensitivity reactions and lead to long-term adverse cardiovascular events.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Engineering, Mechanical
Navid Freidoonimehr, Maziar Arjomandi, Anthony Zander, Rey Chin
Summary: This study investigates the effects of stent design on flow behaviour near the artery wall, using a novel technique to visualize flow and wall shear stress within stent struts. Different stent patterns are analyzed for their impacts on the risk of restenosis in coronary arteries, aiming to improve stent designs for better patient outcomes.
EXPERIMENTS IN FLUIDS
(2021)
Article
Health Care Sciences & Services
Ferenc Tamas Nagy, Dorottya Gheorghita, Lalli Dharmarajan, Gabor Braunitzer, Alexandru Achim, Zoltan Ruzsa, Mark Adam Antal
Summary: This study aimed to investigate the periodontal status of patients undergoing percutaneous coronary intervention (PCI) for restenotic lesions. The results showed that the periodontal state was significantly worse in the PCI group compared to the healthy controls, and each periodontal stage increased the odds of belonging to the PCI group. In addition, patients undergoing PCI for in-stent restenosis exhibited more severe forms of periodontal disease compared to those stented for de novo lesions. The potential causality between periodontal disease and restenosis needs to be studied further.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Evan Shlofmitz, Rebecca Torguson, Cheng Zhang, Gary S. Mintz, Aaphtaab Dheendsa, Nauman Khalid, Yuefeng Chen, Anees Musallam, Toby Rogers, Hayder Hashim, Itsik Ben-Dor, Hector M. Garcia-Garcia, Ron Waksman
Summary: The study showed that the use of IVUS guidance in patients with in-stent restenosis can reduce the rate of major adverse cardiac events at 1 year, supporting routine IVUS use for stent implantation in ISR lesions.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Chemistry, Analytical
Antonio Rodriguez, Pablo Barroso, Alberto Olmo, Alberto Yufera
Summary: Assessing the viability of bioimpedance sensing to detect atheromatous plaque formation in implantable stents was the focus of this study. Simulations in COMSOL Multiphysics were performed using both non-pathological and pathological models, taking into account the flow of blood. The results showed that the proposed bioimpedance sensing system could successfully detect the presence of atheromatous plaque based on the measured current intensity in the electrodes. This simple algorithm approach eliminates the need for complex image reconstruction and computational processing.
Article
Cardiac & Cardiovascular Systems
Ayman Elbadawi, Alexander T. Dang, Ingy Mahana, Mohammed Elzeneini, Fernando Alonso, Subhash Banerjee, Dharam J. Kumbhani, Islam Y. Elgendy, Gary S. Mintz
Summary: This study compared the clinical outcomes of PCI for ISR lesions versus de novo lesions and found that ISR lesions were associated with a higher incidence of adverse cardiac events, including myocardial infarction, target vessel revascularization, and stent thrombosis. Future efforts should focus on preventing and treating ISR lesions.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Yating Zhu, Fen Li, Hongpeng Zhang, Hui Song, Xiaodan Ma, Long Cao, Wenjun Zhang, Wei Guo
Summary: This study analyzed the hemodynamic characteristics of the MIBSG devices through numerical simulation analyses. The results showed that the MIBSG exhibited improved hemodynamic features in most cases. The findings are of great significance for optimizing stent-graft design and predicting long-term outcomes.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Engineering, Biomedical
Jing Wang, Hong-Lin Qian, Sheng-Yu Chen, Wei-Pin Huang, Dan-Ni Huang, Hong-Ye Hao, Ke-Feng Ren, Yun-Bing Wang, Guo-Sheng Fu, Jian Ji
Summary: MicroRNAs have been identified as potent gene medicine for regulating endothelial cells and smooth muscle cells in response to vascular injury. In this study, a microRNA-eluting cardiovascular stent was developed using a self-healing encapsulation process based on an amphipathic triblock copolymer network, effectively inhibiting in-stent restenosis.
BIOACTIVE MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Alistair McQueen, Javier Escuer, Andre Fensterseifer Schmidr, Ankush Aggarwal, Simon Kennedy, Christopher McCormick, Keith Oldroyd, Sean McGinty
Summary: Research indicates that the severity and time-course of restenosis are critically dependent on drug delivery strategy, and simply ramping up drug dose or prolonging drug release time is not sufficient to improve stent efficacy. Factors such as level of stent over-expansion and stent design features also influence restenosis development.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Surgery
Yun-Feng Han, Tao Wang, Yun-Peng Ling, Hong Zhao
Summary: Carotid jugular fistula and pseudoaneurysm are common complications after gunshot injury to the carotid artery, and endovascular therapy such as stent graft implantation can be successful in blocking the fistula and pseudoaneurysm cavity. However, the risk of in-stent restenosis or occlusion should be carefully monitored to prevent treatment failure.
ANNALS OF VASCULAR SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Hector Tamez, Eric A. Secemsky, Linda R. Valsdottir, Issam D. Moussa, Yang Song, Charles A. Simonton, C. Michael Gibson, Jeffrey J. Popma, Robert W. Yeh
Summary: The study evaluated the long-term outcomes of patients undergoing PCI for ISR and found that ISR PCI was associated with worse long-term outcomes compared to de novo lesion PCI, with higher risks of MACCE, mortality, MI, repeat revascularisation, TVR, and stroke. New strategies are needed to minimize ISR.