Article
Biotechnology & Applied Microbiology
Pratik Kandangwa, Ryo Torii, Peter D. Gatehouse, Spencer J. Sherwin, Peter D. Weinberg
Summary: The distribution of atherosclerosis is affected by hemodynamic wall shear stress. This study examined the influence of dynamic motion and non-Newtonian blood rheology on the transverse wall shear stress in coronary arteries. The results showed that dynamic motion had little effect on time average wall shear stress, but significantly affected oscillatory wall shear stress. Additionally, changes in curvature caused time-varying vortical structures, which further influenced transverse wall shear stress. Non-Newtonian rheology also played a significant role. Incorporating dynamic geometry and non-Newtonian rheology into models can improve the accuracy of transverse wall shear stress maps in coronary arteries.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Nhien Tran-Nguyen, Francesca Condemi, Andrew Yan, Stephen Fremes, Piero Triverio, Laura Jimenez-Juan
Summary: This prospective study used computational fluid dynamics to investigate how graft hemodynamics may vary among different types of grafts one month after coronary artery bypass graft (CABG) surgery. The study found differences in abnormal wall shear stress area among different types of grafts, suggesting a possible influence on long-term graft failure rates.
ANNALS OF BIOMEDICAL ENGINEERING
(2022)
Article
Cardiac & Cardiovascular Systems
Vincenzo Tufaro, Ryo Torii, Emrah Erdogan, Pieter Kitslaar, Bon-Kwon Koo, Roby Rakhit, Grigoris Karamasis, Christos Costa, Patrick Serruys, Daniel A. Jones, Anthony Mathur, Andreas Baumbach, Jean-Paul Aben, Christos Bourantas
Summary: A user-friendly software for real-time calculation of wall shear stress (WSS) showed high accuracy and reproducibility in assessing WSS distribution. The software significantly reduced simulation time compared to conventional methods.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Giulio Russo, Daniela Pedicino, Claudio Chiastra, Ramona Vinci, Maurizio Lodi Rizzini, Lorenzo Genuardi, Mohammad Sarraf, Alessia d'Aiello, Marco Bologna, Cristina Aurigemma, Alice Bonanni, Antonio Bellantoni, Fabrizio D'Ascenzo, Pellegrino Ciampi, Aniello Zambrano, Luca Mainardi, Myriana Ponzo, Anna Severino, Carlo Trani, Massimo Massetti, Diego Gallo, Francesco Migliavacca, Francesco Maisano, Amir Lerman, Umberto Morbiducci, Francesco Burzotta, Filippo Crea, Giovanna Liuzzo
Summary: This study aimed to provide a comprehensive description of haemodynamic and biological characteristics of unstable and stable coronary artery plaques and investigate the correlation between wall shear stress (WSS) and molecular pathways. The results showed that nine genes were significantly overexpressed in unstable patients compared to stable patients, with four genes displaying different levels between intact fibrous cap (IFC) and ruptured fibrous cap (RFC) groups. Additionally, higher WSS was observed in the RFC group and significant correlations were found between certain genes and WSS values in the RFC group. These findings suggest the importance of WSS profiling in characterizing plaque instability.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Engineering, Biomedical
Nhien Tran-Nguyen, Andrew T. T. Yan, Stephen Fremes, Piero Triverio, Laura Jimenez-Juan
Summary: Coronary artery bypass graft surgery, a common treatment for coronary artery disease, can suffer from graft failure, and the underlying mechanisms are not fully understood. In this study, computational fluid dynamics simulations were used to investigate the relationship between graft hemodynamics and surgical outcomes. Results showed that abnormal wall shear stress (WSS) area one month after surgery correlated with graft lumen remodeling one year after surgery, suggesting that shear-related mechanisms may play a role in post-operative graft remodeling and explain differences in failure rates between arterial and venous grafts.
ANNALS OF BIOMEDICAL ENGINEERING
(2023)
Article
Computer Science, Interdisciplinary Applications
Harry J. Carpenter, Mergen H. Ghayesh, Anthony C. Zander, Peter J. Psaltis
Summary: This study investigates the relationship between twelve multi-directional/topological wall shear stress (WSS) derived metrics and the formation of coronary plaques using computational fluid dynamics (CFD) and dynamic fluid-structure interaction (FSI) frameworks. The results highlight the importance of multi-directional and topological WSS metrics in atherosclerosis related mechanotransduction and near-wall transport processes. Further research is needed to explore the mechanisms of atherosclerosis and longitudinal changes in coronary dynamics.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2023)
Article
Clinical Neurology
Weiying Zhong, Yiming Du, Hong Kuang, Ming Liu, Feng Xue, Xue Bai, Donghai Wang, Wandong Su, Yunyan Wang
Summary: This study found that low wall shear stress, low aneurysm pressure, and increased low shear area were significantly associated with aneurysm wall enhancement on vessel wall magnetic resonance imaging in unruptured cerebral aneurysms.
FRONTIERS IN NEUROLOGY
(2022)
Article
Computer Science, Interdisciplinary Applications
Ramtin Gharleghi, Arcot Sowmya, Susann Beier
Summary: In this study, a deep learning technique was proposed as an alternative method to calculate blood flow-induced shear stresses in coronary bifurcations. The model showed high fidelity predictions and significantly reduced computational cost compared to traditional computational fluid dynamics methods.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Kristine Dilba, Dianne H. K. van Dam-Nolen, Suze-Anne Korteland, Anja G. van der Kolk, Mohamed Kassem, Daniel Bos, Peter J. Koudstaal, Paul J. Nederkoorn, Jeroen Hendrikse, M. Eline Kooi, Frank J. H. Gijsen, Anton F. W. van der Steen, Aad van der Lugt, Jolanda J. Wentzel
Summary: In this study, ulcers in carotid plaques were not exclusively located at regions exposed to the highest WSS, OSI, or RRT. However, high WSS and low RRT regions had significantly higher odds of ulceration within the plaque, even after adjustment for wall thickness.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Engineering, Biomedical
Nicholas A. T. Fogell, Miten Patel, Pan Yang, Roosje M. Ruis, David B. Garcia, Jarka Naser, Fotios Savvopoulos, Clint Davies Taylor, Anouk L. Post, Ryan M. Pedrigi, Ranil de Silva, Rob Krams
Summary: This study presents vessel-specific fluid-structure interaction (FSI) models of three coronary arteries, using directly measured experimental geometries and boundary conditions. FSI models have been extended to include coronary bending to investigate its effect on shear and strain. The results showed significant changes in all computed shear stress metrics between FSI with and without bending compared to CFD.
ANNALS OF BIOMEDICAL ENGINEERING
(2023)
Article
Cardiac & Cardiovascular Systems
Alessandro Candreva, Maurizio Lodi Rizzini, Victor Schweiger, Diego Gallo, Rocco A. Montone, Michael Wurdinger, Julia Stehli, Thomas Gilhofer, Alexander Gotschy, Ruschitzka Frank, Barbara E. Stahli, Claudio Chiastra, Umberto Morbiducci, Christian Templin
Summary: The study aimed to investigate the relationship between local anatomy and hemodynamic profiles of coronary artery segments affected by SCAD. The results showed that the healed SCAD segments exhibited high curvature/torsion and disturbances in blood flow.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Biology
Mariia Timofeeva, Andrew Ooi, Eric K. W. Poon, Peter Barlis
Summary: Stenoses in coronary arteries are often asymmetric, which has significant effects on blood flow behavior downstream of the stenosis. Eccentricity causes the flow to deflect away from the model's centerline, leading to the development of secondary flow. The consideration of both the degree of eccentricity and the degree of stenosis could improve patient stratification.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Muhammad Owais Khan, Justin S. Tran, Han Zhu, Jack Boyd, Rene R. Sevag Packard, Ronald P. Karlsberg, Andrew M. Kahn, Alison L. Marsden
Summary: Biomechanical forces may play a key role in saphenous vein graft disease after coronary artery bypass graft surgery. Computational fluid dynamic modeling has the potential to identify high-risk patients who may benefit from more aggressive medical therapy and closer surveillance. Further studies are needed to develop clinically available tools for predicting SVG failure post-CABG.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Bang-Sia Chen, Rong-Ching Wu, Pao-Hsin Liu
Summary: The purpose of this study was to investigate the restenosis effect in patients with coronary bifurcation stenting, and the relationship between the bifurcation angles and three types of stenting techniques. The study used computational fluid dynamics analysis to compare the two types of arterial shapes, and found that the bifurcation angle was directly proportional to the risk of restenosis.
APPLIED SCIENCES-BASEL
(2023)
Article
Biology
Peshala T. Gamage, Pengfei Dong, Juhwan Lee, Yazan Gharaibeh, Vladislav N. Zimin, Luis A. P. Dallan, Hiram G. Bezerra, David L. Wilson, Linxia Gu
Summary: In this study, hemodynamic alterations in heavily calcified coronary arteries following stent deployment and post-dilations were quantified using in silico and ex-vivo approaches. Results showed that post-dilations are necessary for lumen gain and hemodynamic restoration towards hemostasis, mitigating risks associated with in-stent restenosis and stent thrombosis. Additionally, computational fluid dynamics simulations indicated that areas near malapposed stent struts are more prone to in-stent restenosis.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Engineering, Biomedical
Ingrid S. Lan, Ju Liu, Weiguang Yang, Judith Zimmermann, Daniel B. Ennis, Alison L. Marsden
Summary: This study validates the accuracy and reliability of the cardiovascular FSI formulation in an in vitro flow circuit, which is important for simulating vascular hemodynamics in patients.
ANNALS OF BIOMEDICAL ENGINEERING
(2023)
Article
Biophysics
Jonathan Pham, Sofia Wyetzner, Martin R. R. Pfaller, David W. W. Parker, Doug L. L. James, Alison L. L. Marsden
Summary: We propose svMorph, a framework for interactive virtual sculpting of patient-specific vascular anatomic models. Our tools allow the creation of tortuosity, aneurysms, and stenoses in tubular vascular geometries via geometric operations on the surface mesh and vessel centerline curves. The tortuosity tool uses the physics-based Oriented Particles method and linear blend skinning for smooth, elastic-like deformations.
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME
(2023)
Article
Engineering, Biomedical
Victoria Yuan, Francesco De Gaetano, Kasra Osouli, Alison L. Marsden, Maria Laura Costantino
Summary: This study developed a computational model to simulate Norwood patients and evaluate the effects of Berlin Heart support on patient hemodynamics. The results showed that increasing device volume and rate can increase cardiac output, but have minimal impact on arterial oxygen content. Specific BH settings are recommended for patients with pulmonary hypertension and those treated with milrinone post-operatively. The findings emphasize that oxygen delivery does not increase with BH rate or volume and highlight the adaptability of the model to analyze BH support in different clinical situations.
Article
Computer Science, Interdisciplinary Applications
O. Z. Tikenogullari, M. Peirlinck, H. Chubb, A. M. Dubin, E. Kuhl, A. L. Marsden
Summary: Single ventricle patients, including those with hypoplastic left heart syndrome (HLHS), may develop arrhythmias, electrical dyssynchrony, and ventricular failure. The relationship between ventricular enlargement and electrical dysfunction in HLHS physiology is poorly understood. Computational modeling was used to characterize this relationship and found that right ventricle enlargement negatively affects QRS duration and interventricular dyssynchrony, while left ventricle enlargement can partially compensate for this dyssynchrony.
COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING
(2023)
Letter
Public, Environmental & Occupational Health
Alison Marsden
JOURNAL OF PUBLIC HEALTH
(2023)
Letter
Public, Environmental & Occupational Health
Premila Webster, Keith Neal, Alison Marsden
JOURNAL OF PUBLIC HEALTH
(2023)
Letter
Public, Environmental & Occupational Health
Alison Marsden
JOURNAL OF PUBLIC HEALTH
(2023)
Article
Cardiac & Cardiovascular Systems
Karthik Menon, Jongmin Seo, Ryuji Fukazawa, Shunichi Ogawa, Andrew M. Kahn, Jane C. Burns, Alison L. Marsden
Summary: The current treatment for coronary aneurysms caused by Kawasaki disease is primarily based on the size of the aneurysm, overlooking the hemodynamic factors that affect the risk of myocardial ischemia. Computational hemodynamics simulations were performed for 15 KD patients, and ischemic risk was evaluated using parameters such as fractional flow reserve, wall shear stress, and residence time. The study found that the ratio of maximum-to-minimum aneurysmal lumen diameter predicted ischemic risk better than the aneurysm Z-score.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2023)
Article
Engineering, Biomedical
Aaron L. Brown, Fannie M. Gerosa, Jing Wang, Tzun Hsiai, Alison L. Marsden
Summary: Mechanical forces play a crucial role in coordinating cardiac morphogenesis, yet much remains unknown about their interactions with mechano-transduction pathways. Due to the complexity of cardiac mechanobiology, multiple experimental and analytical techniques are required for a complete understanding. This review focuses on computational modeling as a tool to investigate mechanobiological pathways in cardiac development. Recent studies show that understanding spatial and temporal patterns of biomechanical forces is crucial, and computational modeling provides an effective and efficient means to obtain such detail. Multidisciplinary studies combining all three tools yield the most compelling results.
CURRENT OPINION IN BIOMEDICAL ENGINEERING
(2023)
Article
Engineering, Biomedical
Alexander D. Kaiser, Nicole K. Schiavone, Christopher J. Elkins, Doff B. McElhinney, John K. Eaton, Alison L. Marsden
Summary: The immersed boundary (IB) method is used in this study to simulate fluid-structure interaction (FSI) problems around heart valves. Physical experiments and numerical simulations were conducted, and the results showed excellent qualitative and quantitative agreement between the two, providing comparable experimental data for further validation studies of FSI simulations.
ANNALS OF BIOMEDICAL ENGINEERING
(2023)
Article
Engineering, Multidisciplinary
Erica L. Schwarz, Martin R. Pfaller, Jason M. Szafron, Marcos Latorre, Stephanie E. Lindsey, Christopher K. Breuer, Jay D. Humphrey, Alison L. Marsden
Summary: This study implements a comprehensive, three-dimensional constrained mixture theory into a finite element fluid-structure interaction solver for simulating vascular growth and remodeling. The resulting solver allows long-term predictions of changing hemodynamics, vessel wall morphology, tissue composition, and material properties, enhancing the understanding of disease progression in complex environments.
COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING
(2023)
Article
Computer Science, Interdisciplinary Applications
Kathrin Baumler, Evan H. Phillips, Noelia Grande Gutierrez, Dominik Fleischmann, Alison L. Marsden, Craig J. Goergen
Summary: This study investigated the progression of false lumen thrombus over 7 days and found that flow stagnation is the predominant factor driving thrombus formation in the false lumen.
COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING
(2023)
Article
Multidisciplinary Sciences
Weiguang Yang, Timothy A. Conover, Richard S. Figliola, Guruprasad A. Giridharan, Alison L. Marsden, Mark D. Rodefeld
Summary: Patients with single ventricle defects undergoing the Fontan procedure often face Fontan failure, and long-term cavopulmonary assist devices using rotary pump technologies are being developed to prevent and treat this failure. This study aims to assess the performance of a viscous impeller pump for Fontan patients and validate flow simulations using in-vitro data. The results show that the pump design provides low resistance and minimal pressure loss in the failed condition, making it clinically acceptable for Fontan patients.
SCIENTIFIC REPORTS
(2023)
Review
Biophysics
Erica L. Schwarz, Luca Pegolotti, Martin R. Pfaller, Alison L. Marsden
Summary: Physics-based computational models of the cardiovascular system have wide-ranging applications in studying cardiovascular diseases, allowing for simulations of hemodynamics, tissue mechanics, and physiology. These models are used not only for surgical planning, but also for understanding disease progression, guiding design, and generating testable hypotheses. Recent advances in modeling methodology have improved the accuracy and impact of simulations, benefiting clinical care and medical device design in congenital and acquired cardiovascular diseases.
BIOPHYSICS REVIEWS
(2023)
Proceedings Paper
Computer Science, Interdisciplinary Applications
Kathrin Baumler, Judith Zimmermann, Daniel B. Ennis, Alison L. Marsden, Dominik Fleischmann
Summary: This study investigated the impact of tear size on hemodynamics in a Type B aortic dissection using simulation models. The results showed that alterations in tear size significantly affected flow ratios, pressure differences, and systolic pressure drops. Compared to rigid wall simulations, fluid structure interaction simulations resulted in decreased flow ratios, dampening of flow waveforms, smaller negative pressure differences, and decreased pressure drops at entry and exit tears.
COMPUTER METHODS, IMAGING AND VISUALIZATION IN BIOMECHANICS AND BIOMEDICAL ENGINEERING II
(2023)