Review
Pharmacology & Pharmacy
Pavan S. Upadhyayula, Eleonora F. Spinazzi, Michael G. Argenziano, Peter Canoll, Jeffrey N. Bruce
Summary: Convection enhanced delivery (CED) is a technique used for treating glioma by infusing treatments directly into the brain parenchyma. The manuscript describes the physical principles behind CED, common pitfalls, and optimization methods. The institutional experience using topotecan CED for malignant glioma treatment is highlighted.
Article
Multidisciplinary Sciences
Ahmad Boroumand, Mehrnoush Mehrarya, Ashkan Ghanbarzadeh-Dagheyan, Mohammad Taghi Ahmadian
Summary: Central Nervous System (CNS) malignant tumors are a leading cause of death worldwide. This study investigates the use of focused ultrasound (FUS) waves to enhance drug delivery to brain tumors through ultrasound-assisted convection-enhanced delivery (UCED). The results show that FUS can significantly improve the distribution of drugs in brain tumors and suggest the potential development of FE models of the brain for better evaluation of UCED.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
Caleb Shaw, Cecile Riviere-Cazaux, Kazi Zihan Hossain, Terry C. Burns, M. Rashed Khan
Summary: Optimizing drug delivery to brain tumors requires understanding of molecular diffusion and fluid momentum transfer in the central nervous system. Convection-enhanced delivery (CED) can bypass the blood-brain barrier and deliver drugs to the CNS. Finite element methods can simulate drug distribution. Adding extraction catheters enables biomarker recovery and spatially-directed fluid convection.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Medicine, Research & Experimental
Claire O'Leary, Gabriella Forte, Nadia L. Mitchell, Amir Saam Youshani, Adam Dyer, Martin P. Wellby, Katharina N. Russell, Samantha J. Murray, Nelly Jolinon, Simon A. Jones, Kevin Stacey, Daniel M. Davis, Els Henckaerts, David N. Palmer, Ian Kamaly-Asl, Brian W. Bigger
Summary: This study used an Adeno-Associated Vector (AAV) to deliver the missing enzyme HGSNAT to MPSIIIC mice via intraparenchymal brain injections, and successfully corrected the disease. The use of Hamilton syringes resulted in improved distribution of AAV, despite lower vector doses and titres. Both AAV9 and AAV-TT serotypes primarily transduced neurons. These findings provide valuable information for the design of a clinical trial for MPSIIIC.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Oncology
Randy S. D'Amico, Manish K. Aghi, Michael A. Vogelbaum, Jeffrey N. Bruce
Summary: Convection-enhanced delivery (CED) is a method of targeted, local drug delivery to the central nervous system that shows promise for treating glioblastoma (GBM), although the long-term efficacy of the agents studied remains difficult to assess at present.
JOURNAL OF NEURO-ONCOLOGY
(2021)
Review
Pharmacology & Pharmacy
Chibueze D. Nwagwu, Amanda V. Immidisetti, Michael Y. Jiang, Oluwasegun Adeagbo, David C. Adamson, Anne-Marie Carbonell
Summary: This review discusses the potential of convection-enhanced delivery (CED) in treating high-grade gliomas by directly delivering homogeneous drug concentrations to the site of disease, which can significantly limit systemic toxicity and enhance therapeutic effectiveness.
Article
Biotechnology & Applied Microbiology
Ernesto A. Salegio, Mira Cukrov, Rachel Lortz, Abigail Green, Emily Lambert, Summer Copeland, Marc Gonzalez, Diane E. Stockinger, Jeremy M. Yeung, Granger G. C. Hwa
Summary: This study demonstrated the distribution and transport of AAV5-GFP in the nonhuman primate cerebellum using a single convection-enhanced delivery infusion. The results showed a large volume of distribution and distal transport of the vector. The level of transgene expression was negatively correlated with the antibody titer against the GFP construct.
HUMAN GENE THERAPY
(2022)
Article
Optics
Yury E. Geints, Igor Minin, Oleg Minin
Summary: A perforated microsphere with an air-filled pinhole is studied, and the pinhole isolates the energy backflow region of a resonant mode, leading to an increased efficiency in optical trapping.
Article
Engineering, Biomedical
G. A. Orozco, G. Cordoba, F. Urrea, F. Casanova, J. H. Smith, J. J. Garcia
Summary: The study updated a finite element model of backflow by considering the effect of needle insertion velocity during CED infusions, and obtained the nonlinear mechanical properties of agarose solutions by fitting experimental data. Adjusting the model with additional experimental measurements, the relevance of pre-stress in the tissue surrounding the needle during CED infusions into the brain was revealed.
Article
Oncology
Sabine Mueller, Cassie Kline, Schuyler Stoller, Shannon Lundy, Lauren Christopher, Alyssa T. Reddy, Anu Banerjee, Tabitha M. Cooney, Shannon Raber, Carly Hoffman, Tracy Luks, Eva Wembacher-Schroeder, Nina Lummel, Yalan Zhang, Erin R. Bonner, Javad Nazarian, Annette M. Molinaro, Michael Prados, Javier E. Villanueva-Meyer, Nalin Gupta
Summary: The safety and tolerability of MTX110 delivered by convection-enhanced delivery (CED) were investigated in patients with newly diagnosed diffuse intrinsic pontine glioma (DIPG) who completed focal radiation therapy (RT). Results showed that CED of MTX110 with gadoteridol was well-tolerated in DIPG patients, with a median overall survival (OS) of 26.1 months, supporting further investigation of this strategy in a larger cohort.
Review
Clinical Neurology
Amir H. Faraji, Sibi Rajendran, Andrea S. Jaquins-Gerstl, Hunter J. Hayes, R. Mark Richardson
Summary: This article focuses on the convection-enhanced delivery in stereotactic neurosurgery, highlighting the importance of understanding the biophysical properties of molecular transport in the extracellular space. By addressing current efforts and challenges, the article aims to further refine predictive models for advances in drug delivery techniques to the brain.
WORLD NEUROSURGERY
(2021)
Article
Obstetrics & Gynecology
LaTasha B. Craig, Sushila Arya, Heather R. Burks, Kaitlin Warta, Christen Jarshaw, Karl R. Hansen, Jennifer D. Peck
Summary: This study aimed to evaluate the relationship between semen regurgitation and intrauterine insemination (IUI) outcomes. The results showed that regurgitation during the IUI procedure is not related to pregnancy outcome.
FERTILITY AND STERILITY
(2021)
Editorial Material
Physics, Multidisciplinary
A. J. Bracken, G. F. Melloy
Summary: Critiques and a proposal from Bialynicki-Birula et al in their recent paper "Backflow in relativistic wave equations" (2022) have been addressed. It reiterates that the widely debated quantum probability backflow phenomenon does not have a classical counterpart. It is noted that the backflow in the relativistic Dirac Equation has been extensively examined by us and others in the past.
JOURNAL OF PHYSICS A-MATHEMATICAL AND THEORETICAL
(2023)
Article
Engineering, Multidisciplinary
Hong Zhang, Junfeng Xia, Jianting Zhou, Leng Liao, Yangjian Xiao, Kai Tong, Senhua Zhang
Summary: The resonance-enhanced magnetoelastic(REME) sensor, used to measure the stress in steel, is influenced by stress history, leading to measurement inaccuracies. This study analyzed the principle of the REME method and examined the construction process and stress history of different prestress tendons. It was found that the voltage-prestress relationship was affected by stress history. To address this issue, a prestress evaluation method suitable for prestress steel strands was proposed. The use of precise calibration method resulted in monitoring errors of less than 13.26% and 5.97% in the construction and prestress loss stages, respectively. The simplified calibration method reduced calibration workload by 50% with a minimal increase in monitoring errors of less than 4%. Additionally, the self-calibration method improved monitoring accuracy by avoiding the influence of differences in steel strands.
STRUCTURAL HEALTH MONITORING-AN INTERNATIONAL JOURNAL
(2023)
Article
Mathematics, Applied
J. A. Ferreira, L. Pinto, R. F. Santos
Summary: Convection enhanced drug delivery is a technique that allows therapeutic agents to reach target sites more efficiently through a catheter, particularly useful for treating diseases of the central nervous system. Numerical analysis shows that the fully discrete finite element method proposed for simulating CED is effective and has second order convergence.
JOURNAL OF COMPUTATIONAL AND APPLIED MATHEMATICS
(2022)
Article
Engineering, Biomedical
Fabian A. Urrea, Fernando Casanova, Gustavo A. Orozco, Jose J. Garcia
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2016)
Article
Engineering, Mechanical
Fernando Casanova
ENGINEERING FAILURE ANALYSIS
(2009)
Article
Engineering, Biomedical
Louis C. Vazquez, Erik Hagel, Bradley J. Willenberg, Wei Dai, Fernando Casanova, Christopher D. Batich, Malisa Sarntinoranont
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2012)
Article
Biochemical Research Methods
Fernando Casanova, Paul R. Carney, Malisa Sarntinoranont
JOURNAL OF NEUROSCIENCE METHODS
(2014)
Article
Multidisciplinary Sciences
Fernando Casanova, Paul R. Carney, Malisa Sarntinoranont
Article
Engineering, Mechanical
Fernando Casanova, Yesid Aguilar
Article
Engineering, Mechanical
Renzo Victoria Prado, Beatriz Uquillas, Jose Y. Aguilar, Yesid Aguilar, Fernando Casanova
Article
Mechanics
Gerson Cordoba-Barco, Fernando Casanova, Joao L. Ealo
Article
Thermodynamics
Joyner Caicedo-Zuniga, Fernando Casanova, Jhonathan Duque, Jose Jaime Garcia
Summary: Sugarcane agricultural residue (RAC) has a high potential as an energy source to fight global warming. This study investigated the effects of particle size and moisture content on the energy consumption and bale density during RAC compaction. The findings show that RAC is a viable alternative for replacing high-contaminating materials such as coal in energy generation.
ENERGY CONVERSION AND MANAGEMENT-X
(2022)
Proceedings Paper
Physics, Applied
Ruben Dario Muelas H, J. F. Pazos-Ospina, Gonzalo Fernando Casanova G, Joao L. Ealo
PROCEEDINGS OF THE 2015 ICU INTERNATIONAL CONGRESS ON ULTRASONICS
(2015)
Proceedings Paper
Engineering, Biomedical
Fernando Casanova, Malisa Sarntinoranont
PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE, PTS A AND B
(2012)
Article
Engineering, Multidisciplinary
Fabian Ortega, Arlex Leyton, Fernando Casanova
Article
Engineering, Multidisciplinary
Fernando Casanova
Article
Engineering, Multidisciplinary
Fernando Casanova, John Jairo Coronado