☆ 4.2 Article

Identification of Regional Mechanical Anisotropy in Soft Tissue Analogs

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME (2011)

Journal

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME

Volume 133, Issue 9, Pages -

Publisher

ASME

DOI: 10.1115/1.4005170

Keywords

anisotropy; heterogeneous; inverse mechanics; soft tissues; biaxial testing

Categories

Biophysics Engineering, Biomedical

Funding

NIH [R21-EB-009788]

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Abstract

In a previous work (Raghupathy and Barocas, 2010, Generalized Anisotropic Inverse Mechanics for Soft Tissues,J. Biomech. Eng., 132(8), pp. 081006), a generalized anisotropic inverse mechanics method applicable to soft tissues was presented and tested against simulated data. Here we demonstrate the ability of the method to identify regional differences in anisotropy from full-field displacements and boundary forces obtained from biaxial extension tests on soft tissue analogs. Tissue heterogeneity was evaluated by partitioning the domain into homogeneous subdomains. Tests on elastomer samples demonstrated the performance of the method on isotropic materials with uniform and nonuniform properties. Tests on fibroblast-remodeled collagen cruciforms indicated a strong correlation between local structural anisotropy (measured by polarized light microscopy) and the evaluated local mechanical anisotropy. The results demonstrate the potential to quantify regional anisotropic material behavior on an intact tissue sample. [DOI: 10.1115/1.4005170]

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