Journal
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
Volume 25, Issue 8, Pages 843-854Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/09205063.2014.911542
Keywords
epoxypropoxy coumarin; UV-triggerable bead; proteinoid
Funding
- Small and Medium Business Administration (SMBA, Korea) [S2127757]
- Korea Evaluation Institute of Industrial Technology (KEIT) [S2127757] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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UV-triggerable bead was prepared by coating the surface of alginate bead with a photo-responsive proteinoid. Epoxypropoxy coumarin (EPC) was covalently attached to a basic proteinoid composed of lysine and serine (PLS), and the PLS-EPC conjugate was used as a photo-responsive coat of the bead. EPC residues of PLS-EPC conjugate on the bead surface were photo-cross-linked upon the irradiation of lambda = 365 nm, and then FITC-dextran was loaded as a fluorescence dye in the bead coated with photo-cross-linked PLS-EPC conjugate. Upon the irradiation of lambda = 254 nm, the degree of release from the bead was enhanced possibly because the cross-linked network of PLS-EPC conjugate coating layer is photo-cleaved. The UV-triggerable bead developed in the present study could be applied to a UV-responsive drug carrier.
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