Article
Chemistry, Applied
Younghyun Shin, Yiluo Hu, Sohyun Park, Seunho Jung
Summary: Beta-cyclodextrin cross-linked succinoglycan dialdehyde hydrogels were prepared for hydrophobic drug delivery. The hydrogels exhibited improved storage modulus and compressive strain compared to the control hydrogels. The hydrogels also showed enhanced drug release properties and cell viability, indicating their potential application for drug delivery systems.
CARBOHYDRATE POLYMERS
(2023)
Review
Chemistry, Multidisciplinary
Abhishek Pandey
Summary: The use of cyclodextrins and their derivatives in drug delivery systems can address challenges such as poor solubility and targeted delivery. Cyclodextrin-conjugated nanoparticles offer advantages of enhanced water solubility, targeted drug delivery, and potential for various pharmaceutical applications.
ENVIRONMENTAL CHEMISTRY LETTERS
(2021)
Review
Biochemistry & Molecular Biology
Yashdeep Mukheja, Jaspreet Kaur, Khushboo Pathania, Sangeeta P. Sah, Deepak B. Salunke, Abhay T. Sangamwar, Sandip Pawar
Summary: Lignin, a versatile and abundant biomass-derived polymer, has numerous properties that make it a promising material for biotechnological applications. It offers biocompatibility, high carbon content, low toxicity, and the ability to be converted into composites. Lignin is an environmentally friendly alternative to synthetic plastic and fossil-based materials due to its biodegradability, safety, and sustainability potential.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Fangzhe Liu, Zihan Wang, Hui Guo, Haichao Li, Yulan Chen, Shuang Guan
Summary: This study introduced a double-layer hydrogel with a drug release layer and a mechanical support layer. By incorporating beta-cyclodextrin polymer (beta-CDP), poly(vinyl alcohol) (PVA), and carboxymethyl cellulose sodium (CMC), the hydrogel exhibited improved drug release rate and mechanical strength. The dual-layer structure provides a feasible solution for fabricating high-performance hydrogel dressings with sustained drug release properties.
Article
Engineering, Biomedical
Line Aanerud Omtvedt, Kare Andre Kristiansen, Wenche Iren Strand, Finn Lillelund Aachmann, Berit Lokensgard Strand, Daria Sergeevna Zaytseva-Zotova
Summary: The study developed a hydrogel drug delivery system using natural polysaccharide alginate functionalized with beta-cyclodextrins for local paclitaxel delivery, showing potential as a material for drug delivery systems.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Article
Chemistry, Physical
Anderson F. Sepulveda, Mont Kumpgdee-Vollrath, Margareth K. K. D. Franco, Fabiano Yokaichiya, Daniele R. de Araujo
Summary: This study investigates the morphology and structure of polymeric formulations based on Poloxamer and its interaction with hyaluronic acid and local anesthetics. The results show that hyaluronic acid and the anesthetics do not significantly affect the supramolecular structure but can modulate the viscosity and drug release behavior of the formulations.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Xiaoping Zhang, Yage Sun, Tengling Wu, Xinrui Zhao, Rong Yang, Hongying Wang, Wenguang Liu
Summary: This study proposes a new strategy for treating myocardial infarction by combining liposome/pcircRNA and strontium ions-containing nanoparticles-encapsulated injectable hydrogel and NO-bearing liposome-loaded pericardial adhesive hydrogel patch. This strategy enables intramyocardial gene/ion delivery and epicardial NO delivery to inhibit cardiomyocyte apoptosis, inflammatory response, and promote angiogenesis.
Article
Biochemistry & Molecular Biology
Wenqian Wang, Depeng Shi, Yongfei Zhang, Wenhui Li, Feng Li, Hui Feng, Lichun Ma, Chao Yang, Zhi Peng, Guojun Song, Hongbo Zeng, Lixin Xie
Summary: In this study, an injectable hydrogel with good swelling resistance was synthesized in situ using aminated hyaluronic acid (NHA) and aldehyde beta-cyclodextrin (ACD) via Schiff base reaction. The hydrogel exhibited good mechanical properties and showed long-term drug release, making it a promising option for controlled drug release in disease treatment. The hydrogel also demonstrated good cytocompatibility, antifungal properties, and biocompatibility in ocular tissues.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biochemistry & Molecular Biology
Ping He, Lei Dai, Jiasheng Wei, Xulong Zhu, Jianhui Li, Zhirong Chen, Yonghao Ni
Summary: This article comprehensively summarizes the recent research progress on nanocellulose hydrogels as drug carriers. The study evaluates the influence of nanocellulose on hydrogel properties and drug release behaviors, and highlights the application of nanocellulose hydrogel-based drug carriers in specific routes of administration. It provides a critical review and outlook in the field, aiming to inspire future work on the practical applications of nanocellulose hydrogels in designing controlled drug delivery systems.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Su-Chun How, Ta-Hsien Lin, Chun-Chao Chang, Steven S-S Wang
Summary: In this study, beta-lactoglobulin (β-LG) combined with bovine serum albumin (BSA) was utilized to prepare amyloid-based hydrogels for riboflavin delivery. The presence of BSA enhanced β-LG fibril formation but also interfered with the entanglement of fibril chains, affecting the mechanical properties of the hydrogels. The number of amyloid fibrils was found to positively correlate with the mechanical properties of the hydrogels.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Paula Ossowicz-Rupniewska, Rafal Rakoczy, Anna Nowak, Maciej Konopacki, Joanna Klebeko, Ewelina Swiatek, Ewa Janus, Wiktoria Duchnik, Karolina Wenelska, Lukasz Kucharski, Adam Klimowicz
Summary: The study investigated the potential of bacterial cellulose as a carrier for the transdermal delivery of ibuprofen, showing that ibuprofen incorporated in BC membranes exhibited lower permeation rates compared to its amino acid ester salts. The BC membranes had homogeneous surface morphology, were easy to apply, and were simple to prepare.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Spectroscopy
Mohd. Afzal, Abdullah Alarifi, Abdalnaser Mahmoud Karami, Rashid Ayub, Naaser A. Y. Abduh, Waseem Sharaf Saeed, Mohd. Muddassir
Summary: Drug delivery science is an important field of study that focuses on delivering therapeutic drugs to target cells while minimizing toxicity to healthy tissues. This project specifically investigates the targeted delivery of a polarity-sensitive solvatochromic model drug called ANSA to a model bio-membrane. The drug delivery is facilitated through the binding of ANSA with cyclodextrin as a drug transporter. Through detailed spectroscopic studies, it is found that the dye ANSA can be successfully delivered to the lipid-water interface region of lipid bilayers through encapsulation within cyclodextrin.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Chemistry, Multidisciplinary
Bin Kong, Rui Liu, Jingyang Shan, Meiyan Li, Xingtao Zhou, Yuanjin Zhao
Summary: Developing a safe, minimally invasive, and highly effective alternative for treating bacterial keratitis is important. This paper presents novel nanozyme-loaded frozen reinforced microneedles (FR-MNs) that can deliver nanozyme controllably inside the cornea to treat keratitis. The nanozymes, constructed by iron ion, tannic acid, and poly (vinylpyrrolidone), are incorporated within the microneedles tips. The freezing process enhances the mechanical strength of the microneedles tips. The nanozyme-loaded FR-MNs exhibit superior therapeutic potential in a rat eye infection model compared to conventional eye drops.
Article
Chemistry, Physical
Emiliane Daher Pereira, Sabu Thomas, Fernando Gomes de Souza Junior, Jessica da Silva Cardoso, Sergio Thode Filho, Vitor Correa da Costa, Fabiola da Silveira Maranhao, Nathali Ricardo Barbosa de Lima, Fernanda Veloso de Carvalho, Mostafa Galal Aboelkheir
Summary: The controlled drug delivery system, prepared by inserting ibuprofen and magnetite nanoparticles into the PLA matrix, combines the advantages of kinetic control (polymer) and spatial control (magnetite) to improve patient compliance and comfort, making the treatment more efficient. Various tests were conducted to verify the capacity of the system, showing sustained drug release profile and unchanged magnetic force of the nanoparticles in the PLA/drug systems.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Review
Chemistry, Multidisciplinary
Zhenyu Zhao, Zhen Wang, Gen Li, Zhengwei Cai, Jiezhou Wu, Lei Wang, Lianfu Deng, Ming Cai, Wenguo Cui
Summary: Microfluidic hydrogel microspheres have been widely studied and used in various industries, with a focus on their applications in the medical field for controlled delivery of cells and drugs. These materials enable efficient encapsulation and control of functionalities, promoting collaboration across disciplines and advancing precision medicine and applied materials.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Yuan Yao, Ziyang Xu, Bo Liu, Meng Xiao, Jianhai Yang, Wenguang Liu
Summary: This study reports the development of a self-healing supramolecular polyurethane with high stiffness and toughness, suitable for applications such as adhesives and coatings. By introducing a T-shaped chain extender with double amide hydrogen bonds in the side chain, the stiffness of the polyurethane can be modulated, allowing for autonomous self-healing capabilities.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Engineering, Environmental
Xiaoye Zhao, Jianhai Yang, Yang Liu, Jushan Gao, Ke Wang, Wenguang Liu
Summary: A new supramolecular hydrogel has been developed with excellent anti-fouling properties and controllable rheological behavior, allowing for effective prevention of postoperative abdominal adhesions and recurrent adhesions.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Engineering, Environmental
Yan-Jie Wang, Jia Li, Ziyang Xu, Bo Liu, Yiping Zhao, Li Chen, Wenguang Liu
Summary: A multifunctional tough and self-fusing elastomer tape was fabricated for the first time by simple copolymerization of hydrophobic monomer MEA and weak acid-containing monomer AAc. The elastomer demonstrated high strengths and toughness, self-fusing ability, antibacterial activity, and the capability to seal liquid leakage and stop bleeding, outperforming conventional adhesive tapes.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Engineering, Biomedical
Xi Yu, Yihui Hu, Luxiang Zou, Shifeng Yan, Huimin Zhu, Kunxi Zhang, Wenguang Liu, Dongmei He, Jingbo Yin
Summary: The study developed a bilayered scaffold with segregated hydrophilicity-hydrophobicity to regenerate goat TMJ condyle cartilage, successfully inducing fibrocartilage and hyaline cartilage under the same chondrogenic conditions in vitro. The neocartilage fully covered the defects and consisted of ordered fibrocartilage and hyaline cartilage, resembling the natural condyle cartilage structure. This research offers a new strategy for designing and constructing bilayered scaffolds for the regeneration of complex hierarchical tissues.
ACTA BIOMATERIALIA
(2021)
Article
Chemistry, Multidisciplinary
Ziyang Xu, Chuanchuan Fan, Qian Zhang, Yang Liu, Chunyan Cui, Bo Liu, Tengling Wu, Xiaoping Zhang, Wenguang Liu
Summary: By utilizing a concentration-dependent H-bonding-strengthened mechanism, a self-thickening and self-strengthening strategy is proposed to directly 3D print latently H-bonding-reinforced hydrogels by loading concentrated NAGA monomer into low-strength PNAGA hydrogels. This method generates high-strength and antiswelling hydrogels, overcoming the trade-off between strength and printability.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Polymer Science
Bo Liu, Ziyang Xu, Chuanchuan Fan, Chunyan Cui, Yuan Yao, Meng Xiao, Wenguang Liu
Summary: This study presents a dipole-dipole interaction strategy to fabricate a water-resistant adhesive with strong adhesion to a wide range of substrates. The adhesion strengths are dependent on the length of PEGDA, with shorter PEGDA-crosslinked adhesive demonstrating outstanding water-resistant adhesion.
MACROMOLECULAR RAPID COMMUNICATIONS
(2021)
Review
Polymer Science
Chunyan Cui, Wenguang Liu
Summary: This review discusses the development and various types of wet adhesives, including catechol-based wet adhesives and non-catechol-based wet adhesives, as well as their adhesion mechanisms and advantages and disadvantages.
PROGRESS IN POLYMER SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Jing Yu, Ke Wang, Chuanchuan Fan, Xiaoye Zhao, Jushan Gao, Wanghui Jing, Xiaoping Zhang, Jia Li, Yuan Li, Jianhai Yang, Wenguang Liu
Summary: The introduction of a methylene spacer in the side chain of NAGA to generate a variant monomer, NAAA, results in an unprecedented ultrasoft and highly swollen supramolecular polymer hydrogel, with self-fused capability and excellent antifouling properties achieved by tuning the hydrogen bonding interactions.
ADVANCED MATERIALS
(2021)
Review
Polymer Science
Yuan Yao, Meng Xiao, Wenguang Liu
Summary: Thermoplastic polyurethane (TPU) exhibits high elasticity, tensile strength, and resistance to various conditions, making it suitable for applications in automotive, electronics, medical, coatings, and sports equipment industries. Introduction of self-healing capabilities has significantly improved the service life and recyclability of TPU. Recent research focuses on self-healing supramolecular TPUs, highlighting the importance of balancing mechanical performance and repairability through covalent and non-covalent interactions, while addressing critical issues and challenges associated with this technology.
MACROMOLECULAR CHEMISTRY AND PHYSICS
(2021)
Article
Engineering, Environmental
Yang Liu, Rui Guo, Tengling Wu, Yuanning Lyu, Meng Xiao, Binbin He, Guanwei Fan, Jianhai Yang, Wenguang Liu
Summary: A cell-free and therapeutic drug-free injectable zwitterionic hydrogel with antioxidant ability and intrinsic conductive properties was fabricated, showing positive effects such as promoting cardiovascular growth and reducing cardiac fibrosis after injection into the infarcted region of rats.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Engineering, Environmental
Jia Li, Yanjie Wang, Jianhai Yang, Wenguang Liu
Summary: A novel multifunctional nanocomposite antibacterial hydrogel with high strength and toughness has been successfully prepared, which can specifically recognize the source bacteria and kill 98% of bacteria. This hydrogel implanted in rats can promote the healing of infected wounds and avoid secondary damage.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Engineering, Biomedical
Tengling Wu, Chunyan Cui, Chuanchuan Fan, Ziyang Xu, Yang Liu, Wenguang Liu
Summary: High-strength natural polymer hydrogels are constructed by soaking in tea polyphenols solution, significantly enhancing their mechanical properties for potential applications in tissue engineering scaffolds. The interaction between tea polyphenols and polymer chains plays a key role in improving the mechanical strength of the hydrogels.
BIOACTIVE MATERIALS
(2021)
Article
Engineering, Biomedical
Binbin He, Jianhai Yang, Yang Liu, Xianhua Xie, Huijie Hao, Xiaoli Xing, Wenguang Liu
Summary: The study introduces a novel vitreous substitute based on zwitterionic polymer hydrogel, which exhibits excellent anti-fouling ability and biocompatibility, effectively reducing inflammatory responses and complications.
BIOACTIVE MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Jia Li, Meng Xiao, Yanjie Wang, Jianhai Yang, Wenguang Liu
Summary: The study introduces a robust and antiswelling hydrogel tube with high mechanical strength, swelling stability, and excellent antibacterial ability. The hydrogel also exhibits superior antithrombosis ability, suitable for connecting arteriovenous shunt circuits or being implanted in animal models, showing better patency rates.
ACS APPLIED BIO MATERIALS
(2021)
Article
Materials Science, Multidisciplinary
Si Chen, Xiaoxu Han, Yang Zou, Yuna Shang, Changjun Liu, Xin Jin, Yuan Li, Yuanning Lyu, Zhuodan Zhang, Zhimou Yang, Wenguang Liu, Wei Wang
Summary: This research introduces an injectable hydrogel designed to reverse the adverse microenvironments of a diabetic infarcted heart, showing promising implications in myocardial tissue engineering. The hydrogel demonstrated a remarkable decrease in inflammatory factors, inhibition of autophagy and apoptosis, and promotion of angiogenesis, leading to favorable restoration in heart functions.
Article
Engineering, Biomedical
Mehlika Karamanlioglu, Serap Yesilkir-Baydar
Summary: This study determined the influence and ideal ratios of different amounts of coconut oil in gelatin-based films as wound dressings. Increasing coconut oil content improved the mechanical properties, thermal stability, cell viability, and wound healing ability of the films. CO-2 and CO-4 showed the best performance among the samples.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2024)
Article
Engineering, Biomedical
Yu-Min Chen, Chihoko Tokoda, Yasuhiko Tabata
Summary: The objective of this study is to establish strategies to uniformly proliferate cells in a three-dimensional nonwoven PET/EVOH scaffold by simple adjustments in seeding and culture methods and the scaffold design. The combination of dynamic and static seeding methods resulted in the highest seeding efficiency. Stirring culture allowed cells to proliferate to a greater extent, while opening holes in the scaffold improved cell distribution. Two 1-mm holes were found to be optimal for homogeneous cell proliferation. Different cell types showed similar behavior in the scaffold, indicating the applicability of the established procedure. The nonwoven PET/EVOH scaffold serves as a potential cell culture substrate for efficient cell proliferation.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2024)
Article
Engineering, Biomedical
Majid Saeedi, Katayoun Morteza-Semnani, Jafar Akbari, Seyyed Mobin Rahimnia, Fatemeh Ahmadi, Hanieh Choubdari, Amir Lotfi, Seyyed Mohammad Hassan Hashemi
Summary: In this study, kojic acid loaded chitosan/collagen nanoparticles were produced using an ionic gelation and ultrasonic approach to enhance dermal delivery and anti-pigmentation effects. Increasing the amount of collagen in the nanoparticles led to larger particle size and higher entrapment efficiency of kojic acid. The nanoparticles were found to be spherical in shape and kojic acid was in an amorphous form. Skin permeability tests showed that the nanoparticles delivered more kojic acid to the dermal layers compared to plain gel. The nanoparticles were non-toxic and non-irritating, and exhibited stronger inhibition of melanin formation compared to free kojic acid. These findings suggest that the produced nanoparticles have potential as a nano-vehicle for dermal administration of kojic acid, providing new options for managing hyper-melanogenesis problems.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2024)
Article
Engineering, Biomedical
Hue Thi Nguyen, Anh-Tuan Le, Thanh Thuy Nguyen, Tran Quang Huy, Thuy Thi Thu Nguyen
Summary: In this study, a chitosan and emodin formulation was prepared to enhance the solubility of emodin and exhibited synergic antibacterial activity against drug-resistant bacterial strains. The enhanced solubility of the formulation suggests its potential as a candidate for the treatment of infectious diseases caused by drug-resistant bacterial pathogens.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2024)
Article
Engineering, Biomedical
Jiu Ge, Mengting Li, Jiahui Fan, Christian Celia, Yijun Xie, Qing Chang, Xiaoyong Deng
Summary: Bacterial infections pose a significant threat to human health, and the emergence of multidrug-resistant bacteria has reduced the effectiveness of antibacterial treatments. In this study, chitosan/silver nanoparticle complexes were developed to inhibit bacterial proliferation and induce membrane damage. The results demonstrated that increasing the chitosan concentration enhanced the antibacterial impact, and the nanoparticles showed broad-spectrum antimicrobial activity. The study provides valuable insights into the development of nano-antibacterial agents as a potential substitute for traditional antibiotics in medical applications.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2024)
