Synthesis, Swelling and Drug-Release Behaviour of a Poly(N,N-diethylacrylamide-co-(2-dimethylamino) ethyl methacrylate) Hydrogel

In this study, poly(N,N-diethylacrylamide-co-(2-dimethylamino) ethyl methacrylate) (poly(DEA-co-DMAEMA)) hydrogels were synthesized by changing the initial DEA/DMAEMA mol ratio. The hydrogels were characterized by Fourier transform infrared (FT-IR) spectroscopy and scanning electron microscopy (SEM). In comparison with the PDEA hydrogel, the equilibrium swelling ratio (ESR) and lower critical solution temperature (LCST) of the hydrogels increase with the increase of DMAEMA content in the feed. The deswelling and reswelling kinetics and cytotoxicity of the different composition ratios of DEA to DMAEMA in the co-polymerized hydrogels were also investigated in detail. The absorption and release behaviour of the model drug, bovine serum albumin, were found to be dependent on hydrogel composition and environment temperature, which suggests that these materials have potential application as intelligent drug carriers. (c) Koninklijke Brill NV. Leiden, 2011