Article
Chemistry, Applied
Maja D. Markovic, Vesna V. Panic, Sanja Savic, Vukasin Dj Ugrinovic, Rada Pjanovic, Milica M. Spasojevic, Pavle M. Spasojevic
Summary: Materials sensitive to external stimuli are considered safe and effective tools in responding to specific demands in disease therapy. Thermo sensitive hydrogels based on poly(N-isopropylacrylamide) (P(NIPAAM)) have been extensively studied for targeted drug delivery. However, the abundance of stimuli in the human body often requires multiple responsive groups to act simultaneously for optimal therapeutic effects.
MICROPOROUS AND MESOPOROUS MATERIALS
(2022)
Review
Materials Science, Multidisciplinary
Lin Tang, Ling Wang, Xiao Yang, Yiyu Fen, Yu Li, Wei Feng
Summary: PNIPAM-based smart hydrogels are important smart materials with unique thermo-responsive properties and promising applications. This review summarizes the development, fundamental design, synthetic strategies, and potential applications of these materials in various fields.
PROGRESS IN MATERIALS SCIENCE
(2021)
Article
Polymer Science
Gianluca Ciarleglio, Elisa Toto, Maria Gabriella Santonicola
Summary: In this study, conductive composite hydrogels were synthesized by embedding carboxyl-functionalized multi-walled carbon nanotubes (MWCNT-COOH) in a poly(N-isopropylacrylamide) (PNIPAM) matrix through a two-step photopolymerization method. The concentration of the carbon nanotubes was varied to obtain thermo-responsive hydrogels with controlled hydrophilicity and conductivity. The results showed that increasing the nanotube concentration shifted the endothermic peak associated with the temperature-induced volume phase transition (VPT) to higher temperatures, indicating a stronger hydrogen bond dissociation. In PBS solution, the swelling ratios and VPT temperatures were reduced, and the electrical resistivity decreased by a factor of 10 compared to water-swollen hydrogels.
Article
Polymer Science
Xiang Xu, Haihui Li, Jiannan Cheng, Lifen Zhang, Zhenping Cheng
Summary: We presented a near-infrared light-responsive hydrogel material composed of two monomers, an ionic liquid monomer (TVBP) and N-isopropylacrylamide (NIPAM), with a diacrylate crosslinker containing poly(propylene glycol), all of which are temperature sensitive. The ionic liquid monomer TVBP demonstrated the ability to generate high osmotic pressure, enabling the hydrogel to extract fresh water from brackish water. By using photothermal conversion through irradiation with NIR LED light on croconaine dye-doped silica nanoparticles (NIR-800@SiO2 NPs), around 95% of fresh water could be skillfully recovered from the hydrogel. The proposal of this scheme is expected to be a significant reference for continuous water desalination.
Article
Pharmacology & Pharmacy
Ana Dinic, Vesna Nikolic, Ljubisa Nikolic, Snezana Ilic-Stojanovic, Stevo Najman, Maja Urosevic, Ivana Gajic
Summary: The aim of this study was to investigate p(NIPAM) hydrogels cross-linked with ethylene glycol dimethacrylate as carriers for sulfanilamide. The structural characterization before and after sulfanilamide incorporation was done using FTIR, XRD and SEM. The swelling behavior of p(NIPAM) hydrogels of various cross-linking degrees was monitored with respect to temperature and pH, and the release of sulfanilamide was examined. The results showed that p(NIPAM) hydrogels are promising carriers for sulfanilamide due to their thermosensitivity, volume phase transition temperature close to physiological temperature, and satisfactory results for sulfanilamide incorporation and release.
Article
Polymer Science
Yiluo Hu, Yohan Kim, Jae-pil Jeong, Sohyun Park, Younghyun Shin, In Ki Hong, Moo Sung Kim, Seunho Jung
Summary: In this study, temperature/pH-responsive hydrogels based on succinoglycan (SG) and poly(N-isopropylacrylamide) (PNIPAM) were prepared. The hydrogels exhibited improved thermal stability and mechanical properties, and showed potential as a temperature/pH-dependent drug release system.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Polymer Science
Yanrong Luo, Chunlan Lu, Xiaolin Zhang, Shiping Zhan
Summary: In this study, acylated chitosan macromolecular crosslinkers (MCS) were prepared and used as the cross-linking agent to synthesize a series of thermosensitive hydrogels. The hydrogels showed a homogeneous pore structure and a low critical solution temperature of 36.66 celcius, indicating good hydrophilicity. The results suggest that the P(NIPAM-co-MA)/MCS hydrogels have the potential to be applied in biomedical, drug delivery, or absorption fields.
IRANIAN POLYMER JOURNAL
(2023)
Article
Chemistry, Physical
Tiantian Fang, Xifan Chen, Changyu Yang, Yaqi Cao, Junshi Zhang, WenChao Peng, Yang Li, Fengbao Zhang, Xiaobin Fan
Summary: In this study, a smart hydrogel was developed by combining poly(N-isopropylacrylamide) (PNIPAM) with two-dimensional (2D) silicene nanosheets. The resulting silicene/PNIPAM composite hydrogel exhibited dual thermal and near-infrared (NIR) responsive properties, with rapid, reversible, and repeatable NIR light-responsive behaviors. This smart hydrogel holds potential for applications in remote light-controlled devices.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Polymer Science
Parvaneh Gheysoori, Azin Paydayesh, Maryam Jafari, Hamed Peidayesh
Summary: This study focuses on the development of thermoresponsive nanocomposite hydrogels for minimally invasive drug delivery. Gelatin-based hydrogels with poly (N-isopropylacrylamide) (PNIPAM) were prepared using response surface methodology. The PNIPAM nanoparticles showed successful polymerization and a reversible sol-gel transition close to body temperature. These nanocomposite hydrogels demonstrated antibacterial activity and good potential for targeted drug delivery.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Polymer Science
Fanfan Li, Yi Yu, Hanyu Lv, Yameng Wan, Xiaoqiang Gao, Yanxun Li, Yanwu Zhang
Summary: A series of thermo-sensitive block copolymers with superior photo-catalytic properties were prepared via PET-RAFT polymerization. The thermo-sensitive nature, hardness, and hydrophilicity of the copolymers could be regulated by adjusting the molar ratio of AM/NIPAm.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Food Science & Technology
Mengjia Du, Wei Lu, Yin Zhang, Analucia Mata, Yapeng Fang
Summary: Compared to single network hydrogels, interpenetrating network hydrogels generally exhibit more favorable mechanical performance, water holding capacity, and thermal stability. The strengthening mechanisms of interpenetrating network hydrogels are mainly attributed to polysaccharides filling, increased network density, and possible interactions between networks. Furthermore, interpenetrating network hydrogels with tunable mechanical properties have great potential for various food applications.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2021)
Article
Polymer Science
Fang Yin, Pascale Laborie, Barbara Lonetti, Yannick Coppel, Nancy Lauth-de Viguerie, Jean-Daniel Marty, Stephane Gineste
Summary: Doubly thermo-and pH-responsive PNIPAM-b-PDEAEAM polymers were synthesized by RAFT polymerization. The properties of these polymers and corresponding homopolymers in solution depend on pH and the protonation degree of the diethylamino moiety. The behavior of the polymers is also influenced by the nature of the polymer chain ends. At pH 10, both PNIPAM and PDEAEAM blocks contribute to phase transition and form stable spherical nanoobjects. At pH 4, PNIPAM-b-PDEAEAM with longer PDEAEAM length exhibits a two-step thermoresponsive behavior and forms large aggregates with a positively charged shell.
Article
Polymer Science
Giacomo Damonte, Martina Cozzani, Donatella Di Lisa, Laura Pastorino, Alberto Mariani, Orietta Monticelli
Summary: The aim of this study was to improve the properties of hydrogels based on PNIPAAm by combining it with a synthesized star-shaped PCL. The addition of PCL-COOH increased the stiffness of the hydrogels and affected the glass transition temperature. The hydrogels showed good biocompatibility and low cytotoxicity.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Polymer Science
Yiluo Hu, Younghyun Shin, Sohyun Park, Jae-pil Jeong, Yohan Kim, Seunho Jung
Summary: Self-healing and temperature/pH-responsive hydrogels were prepared by using oxidized succinoglycan (OSG) and a poly (N-isopropyl acrylamide-co-acrylamide) [P(NIPAM-AM)] copolymer. OSG, synthesized from succinoglycan (SG) isolated directly from soil microorganisms, showed improved elasticity, thermal stability, self-healing ability, and tensile strength compared to P(NIPAM-AM) hydrogels. The OSG/P(NIPAM-AM) hydrogels also exhibited effective temperature/pH-responsive drug release and non-toxicity, suggesting their potential for biomedical applications such as drug delivery systems, wound healing, scaffolds, and tissue engineering.
Article
Materials Science, Characterization & Testing
Jing Zhang, Pai Peng, Lingdong Chen, Liping Zhao, Jie Feng
Summary: A newly hybrid ion-covalent cross-linked double network (DN) hydrogel with excellent antifouling and mechanical properties was prepared in this study, showing high tensile strength, elastic modulus, preeminent fatigue resistance, as well as good antifouling properties suggested by protein adsorption and cell adhesion experiments. Suitable for applications in tissue scaffolds, implantable devices, and other fields.
Article
Engineering, Biomedical
Mehlika Karamanlioglu, Serap Yesilkir-Baydar
Summary: This study determined the influence and ideal ratios of different amounts of coconut oil in gelatin-based films as wound dressings. Increasing coconut oil content improved the mechanical properties, thermal stability, cell viability, and wound healing ability of the films. CO-2 and CO-4 showed the best performance among the samples.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2024)
Article
Engineering, Biomedical
Yu-Min Chen, Chihoko Tokoda, Yasuhiko Tabata
Summary: The objective of this study is to establish strategies to uniformly proliferate cells in a three-dimensional nonwoven PET/EVOH scaffold by simple adjustments in seeding and culture methods and the scaffold design. The combination of dynamic and static seeding methods resulted in the highest seeding efficiency. Stirring culture allowed cells to proliferate to a greater extent, while opening holes in the scaffold improved cell distribution. Two 1-mm holes were found to be optimal for homogeneous cell proliferation. Different cell types showed similar behavior in the scaffold, indicating the applicability of the established procedure. The nonwoven PET/EVOH scaffold serves as a potential cell culture substrate for efficient cell proliferation.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2024)
Article
Engineering, Biomedical
Majid Saeedi, Katayoun Morteza-Semnani, Jafar Akbari, Seyyed Mobin Rahimnia, Fatemeh Ahmadi, Hanieh Choubdari, Amir Lotfi, Seyyed Mohammad Hassan Hashemi
Summary: In this study, kojic acid loaded chitosan/collagen nanoparticles were produced using an ionic gelation and ultrasonic approach to enhance dermal delivery and anti-pigmentation effects. Increasing the amount of collagen in the nanoparticles led to larger particle size and higher entrapment efficiency of kojic acid. The nanoparticles were found to be spherical in shape and kojic acid was in an amorphous form. Skin permeability tests showed that the nanoparticles delivered more kojic acid to the dermal layers compared to plain gel. The nanoparticles were non-toxic and non-irritating, and exhibited stronger inhibition of melanin formation compared to free kojic acid. These findings suggest that the produced nanoparticles have potential as a nano-vehicle for dermal administration of kojic acid, providing new options for managing hyper-melanogenesis problems.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2024)
Article
Engineering, Biomedical
Hue Thi Nguyen, Anh-Tuan Le, Thanh Thuy Nguyen, Tran Quang Huy, Thuy Thi Thu Nguyen
Summary: In this study, a chitosan and emodin formulation was prepared to enhance the solubility of emodin and exhibited synergic antibacterial activity against drug-resistant bacterial strains. The enhanced solubility of the formulation suggests its potential as a candidate for the treatment of infectious diseases caused by drug-resistant bacterial pathogens.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2024)
Article
Engineering, Biomedical
Jiu Ge, Mengting Li, Jiahui Fan, Christian Celia, Yijun Xie, Qing Chang, Xiaoyong Deng
Summary: Bacterial infections pose a significant threat to human health, and the emergence of multidrug-resistant bacteria has reduced the effectiveness of antibacterial treatments. In this study, chitosan/silver nanoparticle complexes were developed to inhibit bacterial proliferation and induce membrane damage. The results demonstrated that increasing the chitosan concentration enhanced the antibacterial impact, and the nanoparticles showed broad-spectrum antimicrobial activity. The study provides valuable insights into the development of nano-antibacterial agents as a potential substitute for traditional antibiotics in medical applications.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2024)