Article
Engineering, Biomedical
Dongsheng Yu, Yazhou Wang, Jifeng Chen, Shuang Liu, Shaohui Deng, Chengbo Liu, Iain McCulloch, Wan Yue, Du Cheng
Summary: Semiconducting polymer (SP) has been optimized through engineering the backbone and alkyl side-chains for co-delivery with pH-sensitive prodrug copolymer, leading to a synergistic photothermal therapy and chemotherapy combination. The SP-encapsulated nanoparticles exhibit high photothermal conversion efficiency and rapid DOX release under acidic conditions, resulting in efficient tumor treatment and potential synergistic effects in vivo.
ACTA BIOMATERIALIA
(2022)
Article
Biochemistry & Molecular Biology
Gyu Ri Park, Min A. Gwak, Yun Hyeok Choi, Won Ho Park
Summary: Malignant tumors are a significant health issue, therefore, there is increasing interest in developing pH-sensitive polymers for targeted drug delivery. In this study, gallic acid (GA) was used to enhance the pH-sensitivity of chitosan (CS) hydrogel beads, which showed excellent swelling/deswelling abilities at different pH values. The reversible breakage/recovery of imine crosslinks in the CS-GA hydrogel beads was confirmed, and the beads demonstrated potential as a drug delivery system sensitive to acidic tumor sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Multidisciplinary
Jie Li, Zhongshi Wang, Han Han, Zhonghua Xu, Shasha Li, Ying Zhu, Yuejian Chen, Liang Ge, Yuan Zhang
Summary: A novel injectable drug delivery platform using self-assembled peptide hydrogels as carrier materials was developed. The pH-responsive ionic-complementary octapeptide FOE allows for sustained drug release.
CHINESE CHEMICAL LETTERS
(2022)
Article
Chemistry, Applied
Zhilang Xu, Die Yang, Tao Long, Lun Yuan, Shi Qiu, Defu Li, Changdao Mu, Liming Ge
Summary: pH-responsive nanoparticles based on modified hydroxyethyl starch have been developed as an effective drug delivery system for cancer chemotherapy. These nanoparticles can accumulate in tumors and selectively release drugs in the acidic microenvironment, providing a sustained release of the drug.
CARBOHYDRATE POLYMERS
(2022)
Article
Polymer Science
Muhammad Akhlaq, Abul Kalam Azad, Inam Ullah, Asif Nawaz, Muhammad Safdar, Tanima Bhattacharya, A. B. M. Helal Uddin, Syed Atif Abbas, Allan Mathews, Sukalyan Kumar Kundu, Mireia Mallandrich Miret, H. C. Ananda Murthy, H. P. Nagaswarupa
Summary: The study aimed to develop and assess Gel/PVA hydrogels as a pH-sensitive matrix for delivering methotrexate to the colon. Various evaluations and analyses confirmed the potential application of these hydrogels as drug delivery systems for controlled release of methotrexate to the colon.
Review
Biotechnology & Applied Microbiology
Udaykumar Vegad, Megha Patel, Dignesh Khunt, Ozbej Zupancic, Sanjay Chauhan, Amrit Paudel
Summary: In recent decades, there has been significant progress in the design and development of biomaterials based on non-cellulosic biological macromolecules. Stimuli-responsive hydrogels made from non-cellulosic biological macromolecules have gained attention due to their unique physicochemical properties, biological characteristics, and sustainability. pH-responsive hydrogels have the ability to release therapeutic substances in response to pH changes, leading to tailored drug administration, reduced side effects, and improved treatment efficacy. pH-sensitive biopolymers such as chitosan, alginate, hyaluronic acid, guar gum, and dextran have been widely used in various applications, including drug delivery.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Polymer Science
Justin B. Safari, Alain M. Bapolisi, Rui W. M. Krause
Summary: This study developed a pH-sensitive chitosan-based hydrogel for controlled delivery of anti-hepatitis B drug TDF. The hydrogels showed pH and ionic strength sensitivity, with high drug encapsulation efficiency and pH-dependent drug release. Cytotoxicity studies demonstrated cytocompatibility, suggesting potential as a smart delivery system for oral anti-hepatitis B drugs.
Article
Pharmacology & Pharmacy
Muhammad Sarfraz, Ume Ruqia Tulain, Alia Erum, Nadia Shamshad Malik, Arshad Mahmood, Mansur Abdullah Sumaira, Sidra Aslam, Mansur Abdullah Sandhu, Muhammad Tayyab
Summary: The study assessed the potential of quince seed mucilage as an excipient in a graft copolymer for oral-controlled drug delivery systems. The graft copolymer was synthesized using a free radical polymerization method and various concentrations of monomers. The drug-loaded hydrogel showed sustained release patterns and improved pharmacokinetic parameters compared to a commercially available product.
Article
Chemistry, Physical
Niloufar Khosravi, Leila Youseftabar-Miri, Faten Divsar, Sara Hallajian, Kaynaz Hafezi
Summary: A biocompatible and biodegradable hydrogel nanocomposite was synthesized for controlled and sustained release of gabapentin. The hydrogel composite exhibited high drug encapsulation and loading efficiency, and the drug release followed the Higuchi kinetics model and Fick-ian diffusion mechanism. The chitosan-based hydrogel showed excellent biocompatibility and thermosensitive properties, making it a promising drug carrier.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Multidisciplinary
Jean Schoeller, Karin Wuertz-Kozak, Stephen J. J. Ferguson, Markus Rottmar, Jonathan Avaro, Yvonne Elbs-Glatz, Michael Chung, Rene M. Rossi
Summary: The ability of poly(ethylene-co-vinyl alcohol) nanofibers to release ibuprofen for the treatment of chronic wounds was evaluated. The electrospinning of different compositions of poly(ethylene-co-vinyl alcohol) copolymers was optimized, and the release kinetics of ibuprofen from the nanofibers at different temperatures were studied. The scaffolds also showed no cytotoxicity to normal human fibroblasts, indicating their potential for use in chronic wound treatment.
NANOSCALE ADVANCES
(2023)
Article
Materials Science, Multidisciplinary
Roberto Bernasconi, Emanuele Mauri, Arianna Rossetti, Stefano Rimondo, Raffaella Suriano, Marinella Levi, Alessandro Sacchetti, Salvador Pane, Luca Magagnin, Filippo Rossi
Summary: Targeted drug delivery is a promising approach that utilizes stimuli-responsive materials to control drug release with spatial and temporal precision. This study describes coating magnetically controlled microdevices with functionalized alginate-based hydrogels for drug release at specific pH values, showcasing the potential for spatially and temporally controlled release. The functional microtransporters hold promise for in-vivo applications, particularly in environments with pH differences like the digestive tract.
MATERIALS & DESIGN
(2021)
Article
Polymer Science
Bianca Andrade de Campos, Natalia Cristina Borges da Silva, Lucas Szmgel Moda, Pedro Vidinha, Ligia Passos Maia-Obi
Summary: pH-sensitive degradable hydrogels are smart materials that degrade upon pH variation. This study focused on the development of a hydrogel using HPG and OA, and investigated its formation process, as well as drug release for oral administration.
Article
Polymer Science
Madhappan Santhamoorthy, Thi Tuong Vy Phan, Vanaraj Ramkumar, Chaitany Jayprakash Raorane, Kokila Thirupathi, Seong-Cheol Kim
Summary: In this study, a dual pH- and thermo-sensitive copolymer hydrogel system was prepared and characterized. The hydrogel showed temperature-responsive drug release behavior and high drug loading efficiency. It demonstrated good biocompatibility on liver cancer cells, making it a potential drug delivery carrier for solid tumor-targeted therapy.
Article
Polymer Science
Madhappan Santhamoorthy, Ramkumar Vanaraj, Kokila Thirupathi, Selvakumari Ulagesan, Taek-Jeong Nam, Thi Tuong Vy Phan, Seong-Cheol Kim
Summary: In this study, a dual-stimuli-responsive hydrogel was synthesized by incorporating N-isopropyl acrylamide (NIPAm) and glycidyl methacrylate (GMA) monomer. The hydrogel showed slow drug release at physiological pH and low temperature, but enhanced drug release at acidic pH and higher temperature. The hydrogel also exhibited biocompatibility and intracellular fluorescence imaging ability. These findings suggest the potential applications of this hydrogel system in various biomedical fields.
Article
Chemistry, Analytical
Berrin Kucukturkmen, Wali Inam, Fadak Howaili, Mariam Gouda, Neeraj Prabhakar, Hongbo Zhang, Jessica M. Rosenholm
Summary: Microfluidics has been used to coat mesoporous silica nanoparticles (MSNs) with polymeric layers for achieving high protein loading and retention. This study demonstrates the potential of microfluidic technologies in the design of protein delivery systems, allowing for multicomponent systems and preservation of protein stability.
Article
Engineering, Biomedical
Vijaykumar V. Alange, Ravindra P. Birajdar, Raghavendra V. Kulkarni
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2017)
Article
Chemistry, Physical
K. K. Saxena, K. S. Suresh, R. V. Kulkarni, K. V. Mani Krishna, V. Pancholi, D. Srivastava
JOURNAL OF ALLOYS AND COMPOUNDS
(2018)
Article
Materials Science, Biomaterials
Ravindra P. Birajdar, Sudha B. Patil, Vijaykumar V. Alange, Raghavendra Kulkarni
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2020)
Article
Polymer Science
Ravindra P. Birajdar, Sudha B. Patil, Vijaykumar V. Alange, Raghavendra V. Kulkarni
JOURNAL OF MACROMOLECULAR SCIENCE PART A-PURE AND APPLIED CHEMISTRY
(2019)
Review
Biochemical Research Methods
Debkumar Chakraborty, Swaathi Shelvapulle, Kakarla Raghava Reddy, Raghavendra V. Kulkarni, Yashoda Malgar Puttaiahgowda, S. Naveen, Anjanapura V. Raghu
JOURNAL OF MICROBIOLOGICAL METHODS
(2019)
Review
Biochemical Research Methods
A. Ashwini, H. N. Ramya, C. Ramkumar, Kakarla Raghava Reddy, Raghavendra V. Kulkarni, V. Abinaya, S. Naveen, Anjanapura V. Raghu
JOURNAL OF MICROBIOLOGICAL METHODS
(2019)
Article
Biochemical Research Methods
Sudha B. Patil, Syed Z. Inamdar, Kakarla Raghava Reddy, Anjanapura V. Raghu, Sarvesh K. Soni, Raghavendra V. Kulkarni
JOURNAL OF MICROBIOLOGICAL METHODS
(2019)
Article
Biochemistry & Molecular Biology
R. Chandramouli Reddy, Basavaraj Devaranavadagi, Saeed M. Yendigeri, Shrilaxmi Bagali, Raghavendra Kulkarni, Kusal K. Das
BIOLOGICAL TRACE ELEMENT RESEARCH
(2020)
Review
Environmental Sciences
M. S. Jyothi, Kakarla Raghava Reddy, K. Soontarapa, S. Naveen, Anjanapura V. Raghu, Raghavendra V. Kulkarni, D. P. Suhas, Nagaraj P. Shetti, Mallikarjuna N. Nadagouda, Tejraj M. Aminabhavi
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2019)
Article
Computer Science, Artificial Intelligence
Aditya Kompella, Raghavendra V. Kulkarni
NEURAL COMPUTING & APPLICATIONS
(2020)
Article
Biophysics
Rashmi Boppana, Sushil Yadaorao Raut, G. Krishna Mohan, Biswanath Sa, Srinivas Mutalik, Kakarla Raghava Reddy, Kusal K. Das, Mallanagouda S. Biradar, Raghavendra V. Kulkarni
COLLOIDS AND SURFACES B-BIOINTERFACES
(2019)
Article
Pharmacology & Pharmacy
Sudha B. Patil, Syed Z. Inamdar, Kusal K. Das, Krishnamachari G. Akamanchi, Aravind V. Patil, Arun C. Inamadar, Kakarla Raghava Reddy, Anjanapura V. Raghu, Raghavendra V. Kulkarni
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2020)
Article
Computer Science, Artificial Intelligence
Aditya Kompella, Raghavendra Kulkarni
Summary: The proposed RVS approach is a semi-supervised, one-dimensional RNN method for video salient object detection, which processes each frame independently without considering temporal information. By training the RNN with superpixel features, it significantly reduces training time compared to other deep learning algorithms. Extensive evaluations show that the RVS approach outperforms state-of-the-art methods on several benchmark video datasets.
NEURAL COMPUTING & APPLICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Ganesh D. Wagh, Snehalata B. Autade, Raghavendra Kulkarni, Krishnacharya G. Akamanchi
NEW JOURNAL OF CHEMISTRY
(2020)
Article
Pharmacology & Pharmacy
Biswanath Sa, Sudipta Mukherjee, Sanjit K. Roy
INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH
(2020)
Article
Engineering, Biomedical
Mehlika Karamanlioglu, Serap Yesilkir-Baydar
Summary: This study determined the influence and ideal ratios of different amounts of coconut oil in gelatin-based films as wound dressings. Increasing coconut oil content improved the mechanical properties, thermal stability, cell viability, and wound healing ability of the films. CO-2 and CO-4 showed the best performance among the samples.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2024)
Article
Engineering, Biomedical
Yu-Min Chen, Chihoko Tokoda, Yasuhiko Tabata
Summary: The objective of this study is to establish strategies to uniformly proliferate cells in a three-dimensional nonwoven PET/EVOH scaffold by simple adjustments in seeding and culture methods and the scaffold design. The combination of dynamic and static seeding methods resulted in the highest seeding efficiency. Stirring culture allowed cells to proliferate to a greater extent, while opening holes in the scaffold improved cell distribution. Two 1-mm holes were found to be optimal for homogeneous cell proliferation. Different cell types showed similar behavior in the scaffold, indicating the applicability of the established procedure. The nonwoven PET/EVOH scaffold serves as a potential cell culture substrate for efficient cell proliferation.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2024)
Article
Engineering, Biomedical
Majid Saeedi, Katayoun Morteza-Semnani, Jafar Akbari, Seyyed Mobin Rahimnia, Fatemeh Ahmadi, Hanieh Choubdari, Amir Lotfi, Seyyed Mohammad Hassan Hashemi
Summary: In this study, kojic acid loaded chitosan/collagen nanoparticles were produced using an ionic gelation and ultrasonic approach to enhance dermal delivery and anti-pigmentation effects. Increasing the amount of collagen in the nanoparticles led to larger particle size and higher entrapment efficiency of kojic acid. The nanoparticles were found to be spherical in shape and kojic acid was in an amorphous form. Skin permeability tests showed that the nanoparticles delivered more kojic acid to the dermal layers compared to plain gel. The nanoparticles were non-toxic and non-irritating, and exhibited stronger inhibition of melanin formation compared to free kojic acid. These findings suggest that the produced nanoparticles have potential as a nano-vehicle for dermal administration of kojic acid, providing new options for managing hyper-melanogenesis problems.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2024)
Article
Engineering, Biomedical
Hue Thi Nguyen, Anh-Tuan Le, Thanh Thuy Nguyen, Tran Quang Huy, Thuy Thi Thu Nguyen
Summary: In this study, a chitosan and emodin formulation was prepared to enhance the solubility of emodin and exhibited synergic antibacterial activity against drug-resistant bacterial strains. The enhanced solubility of the formulation suggests its potential as a candidate for the treatment of infectious diseases caused by drug-resistant bacterial pathogens.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2024)
Article
Engineering, Biomedical
Jiu Ge, Mengting Li, Jiahui Fan, Christian Celia, Yijun Xie, Qing Chang, Xiaoyong Deng
Summary: Bacterial infections pose a significant threat to human health, and the emergence of multidrug-resistant bacteria has reduced the effectiveness of antibacterial treatments. In this study, chitosan/silver nanoparticle complexes were developed to inhibit bacterial proliferation and induce membrane damage. The results demonstrated that increasing the chitosan concentration enhanced the antibacterial impact, and the nanoparticles showed broad-spectrum antimicrobial activity. The study provides valuable insights into the development of nano-antibacterial agents as a potential substitute for traditional antibiotics in medical applications.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2024)
