Article
Nanoscience & Nanotechnology
Min Wu, Yitao Zhao, Meihan Tao, Meimei Fu, Yue Wang, Qi Liu, Zhihui Lu, Jinshan Guo
Summary: The study demonstrates the ability of l-malate to promote cellular bioenergetics and the development of a porous scaffold that supports cell growth and enhances wound healing through regulating metabolic microenvironment.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Materials Science, Paper & Wood
Jun Liu, Yifei Shi, Lu Cheng, Jianzhong Sun, Sujie Yu, Xuechu Lu, Santosh Biranje, Wenyang Xu, Xinyu Zhang, Junlong Song, Qianqian Wang, Wenjia Han, Zhen Zhang
Summary: Nanocellulose is considered a promising biomaterial for biomedical applications, with the potential to improve wound healing. A study demonstrated the construction of bioactive cellulose nanofibrils scaffolds with controlled release of charged basic fibroblast growth factors, which can enhance cell proliferation and improve drug bioavailability.
Article
Polymer Science
Mahalakshmi Pandian, G. Reshma, C. Arthi, Mar Masson, Jayakumar Rangasamy
Summary: Wound healing is a complex process, and the presence of bacteria can hinder this process, resulting in infectious wounds. Numerous biomedical and biomaterial research efforts have been made over the past 20 years to address this issue. Polymeric scaffolds and hydrogels are the best candidates for developing effective drug-delivery biomaterials.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Shenfang Zha, Yohanes Kristo Sugiarto Utomo, Li Yang, Guizhao Liang, Wanqian Liu
Summary: The study developed a biodegradable nanofibrous scaffold for diabetic wound healing, which showed excellent mechanical properties and biocompatibility. The scaffold provided a beneficial microenvironment for cell adhesion and growth, and promoted collagen deposition and re-vascularization, ultimately accelerating diabetic wound healing.
Review
Pharmacology & Pharmacy
Anna Yusuf Aliyu, Oluwatoyin A. Adeleke
Summary: Chronic wounds in poorly managed diabetics are difficult to heal due to long-term uncontrolled blood glucose levels. To prevent complications, special medical care is needed. Nanofibrous scaffolds are a promising treatment due to their flexibility, ability to load bioactive compounds, and biomimetic environment for cell proliferation.
Review
Biotechnology & Applied Microbiology
Hamed Nosrati, Reza Aramideh Khouy, Ali Nosrati, Mohammad Khodaei, Mehdi Banitalebi-Dehkordi, Korosh Ashrafi-Dehkordi, Samira Sanami, Zohreh Alizadeh
Summary: The skin serves as the body's primary barrier against external pathogens and maintaining homeostasis. Damage to the skin can have significant impacts on health and quality of life. Tissue engineering aims to enhance tissue regeneration, with improving angiogenesis being one of the most effective treatments for skin tissue regeneration.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Polymer Science
Maria Budai-Szucs, Marco Ruggeri, Angela Faccendini, Attila Leber, Silvia Rossi, Gabor Varga, Maria Cristina Bonferoni, Peter Valyi, Katalin Burian, Erzsebet Csanyi, Giuseppina Sandri, Franca Ferrari
Summary: This study designed and developed nanofibrous scaffolds based on biopolymers to restore tissue integrity and treat bacterial infections in periodontitis. The scaffolds were characterized by their chemical and physical properties, as well as preclinical properties, demonstrating effectiveness in supporting cell adhesion and proliferation while inhibiting bacterial growth. The scaffold composed of gelatin and low molecular weight chitosan showed promising results in vitro for both fibroblast and osteoblast adhesion and proliferation as well as inhibiting the growth of specific bacteria involved in periodontitis.
Article
Biochemistry & Molecular Biology
Mohamadreza Tavakoli, Marjan Mirhaj, Sheyda Labbaf, Jaleh Varshosaz, Somayeh Taymori, Franoosh Jafarpour, Saeedeh Salehi, Shaghayegh Amini Mosleh Abadi, Azadeh Sepyani
Summary: The study developed a freeze-dried chitosan/polyvinylpyrrolidone sponge with the addition of platelet-rich fibrin (PRF) as a wound dressing. The addition of 1% PRF significantly improved the mechanical properties of the sponge and showed effective antibacterial activity. The release of growth factors from PRF and the increased proliferation and angiogenic potential of cells were observed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Biotechnology & Applied Microbiology
Jianghui Qin, Fang Chen, Pingli Wu, Guoming Sun
Summary: Wound healing is a complex biological process with bioengineered scaffolds playing a key role in regenerative therapy. Although advancements have been made, challenges remain in achieving ideal treatment for deep cutaneous injuries. Designing innovative scaffolds, precursor development, and therapeutic interventions hold promise for future wound healing strategies.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Dharshan Sivaraj, Kellen Chen, Arhana Chattopadhyay, Dominic Henn, Wanling Wu, Chikage Noishiki, Noah J. Magbual, Smiti Mittal, Alana M. Mermin-Bunnell, Clark A. Bonham, Artem A. Trotsyuk, Janos A. Barrera, Jagannath Padmanabhan, Michael Januszyk, Geoffrey C. Gurtner
Summary: Cutaneous wounds are becoming a growing global health burden due to an aging population and increasing incidence of diseases. Cell therapy combined with hydrogels shows potential in improving treatment efficacy for wound healing.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hengji Zhao, Yushu Zhang, Chao Zhou, Chunling Zhang, Bo Liu
Summary: Natural polysaccharide-based hydrogels provide effective skin protection during trauma and exhibit good antibacterial properties.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Pablo Edmundo Antezana, Sofia Municoy, Maria Ines Alvarez-Echazu, Pablo Luis Santo-Orihuela, Paolo Nicolas Catalano, Taleb H. Al-Tel, Firoz Babu Kadumudi, Alireza Dolatshahi-Pirouz, Gorka Orive, Martin Federico Desimone
Summary: This review discusses the latest developments in skin tissue engineering using 3D bioprinting as a new tool. It provides an overview of current bioprinting methods and summarizes bioink formulations, parameters, and properties. Representative examples and advances in the field, as well as limitations and future needs, are also discussed.
Review
Pharmacology & Pharmacy
Ziwei Jiang, Zijun Zheng, Shengxiang Yu, Yanbin Gao, Jun Ma, Lei Huang, Lei Yang
Summary: Nanofiber scaffolds have unique properties that make them a revolutionary drug delivery platform for wound healing, but there are challenges in achieving controlled drug loading and release. This comprehensive study reviews the applications and recent advances in drug-laden nanofiber scaffolds for skin-wound management. Methods for preparation and polymers used in nanofiber production are introduced, along with different drug delivery methods. The article also discusses the application of drug-loaded nanofiber scaffolds for wound healing and stimulus-responsive drug delivery schemes.
Article
Chemistry, Multidisciplinary
Lauren J. Pruett, Christian H. Jenkins, Neharika S. Singh, Katarina J. Catallo, Donald R. Griffin
Summary: By incorporating heparin microislands to reorganize and protect endogenous local growth factors at the microscale, a new approach to growth factor organization has been shown to significantly improve wound healing outcomes. This method allows for the tuning of microenvironment heterogeneity and control of cell migration in vitro.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Immunology
Rafaela Vaz Sousa Pereira, Mostafa EzEldeen, Estefania Ugarte-Berzal, Erik Martens, Bert Malengier-Devlies, Jennifer Vandooren, Jan Jeroen Vranckx, Patrick Matthys, Ghislain Opdenakker
Summary: This study found that using physiological fibrin hydrogels in skin wound healing in mice can modulate immune cells and molecules, leading to faster wound repair. The hydrogels can reduce neutrophil numbers, increase non-classical Ly6Clow monocytes and resolutive macrophage populations, and decrease the expression of pro-inflammatory cytokines. Additionally, the hydrogels can increase the counts of dermal endothelial cells, fibroblasts, and keratinocytes, promote keratinocyte migration, and accelerate wound healing.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Engineering, Biomedical
Andre Hemmler, Andrew Lin, Nikolaus Thierfelder, Thomas Franz, Michael W. Gee, Deon Bezuidenhout
INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING
(2020)
Article
Engineering, Biomedical
Kevin L. Sack, Eric Aliotta, Jenny S. Choy, Daniel B. Ennis, Neil H. Davies, Thomas Franz, Ghassan S. Kassab, Julius M. Guccione
ACTA BIOMATERIALIA
(2020)
Article
Cardiac & Cardiovascular Systems
Hugo Krynauw, Jannik Buescher, Josepha Koehne, Loes Verrijt, Georges Limbert, Neil H. Davies, Deon Bezuidenhout, Thomas Franz
CARDIOVASCULAR ENGINEERING AND TECHNOLOGY
(2020)
Review
Cardiac & Cardiovascular Systems
Peter Zilla, Manfred Deutsch, Deon Bezuidenhout, Neil H. Davies, Tim Pennel
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2020)
Article
Engineering, Biomedical
Rushdi Hendricks, Elena Hofmann, Jade Peres, Sharon Prince, Jos Hille, Neil H. Davies, Deon Bezuidenhout
Summary: Obstructive sleep apnoea is a serious condition affecting nearly one billion adults globally, with CPAP being the gold standard treatment. A study on tongue tethering devices implanted in sheep showed a hybrid biological tendon-like tether formed after 32 weeks, with a break-strength of 60 N exceeding the force needed to prevent upper airway collapse.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2021)
Article
Cell & Tissue Engineering
Candice de Boer, Bridget Calder, Dee Blackhurst, David Marais, Jonathan Blackburn, Martina Steinmaurer, Nicholas J. Woudberg, Sandrine Lecour, Jason Lovett, Kathy Myburgh, Deon Bezuidenhout, Paul Human, Neil H. Davies
Summary: This study aimed to develop a multi-step purification protocol to isolate serum exosomes and evaluate their regenerative potential. The purification process of UC DG SEC significantly improved the removal of lipoproteins from serum exosomes, leading to enhanced cellular proliferation and potential angiogenic response in vivo. The purified exosomes showed increased levels of exosome-related proteins and reduced amounts of lipoproteins, indicating a more accurate identification of serum exosome functional activity and composition.
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2021)
Article
Computer Science, Interdisciplinary Applications
Tamer Abdalrahman, Neil H. Davies, Thomas Franz
Summary: This study proposes a micromechanical hierarchical approach to capture the mechanical contribution of actin stress fibres in single cells, employing the Mori-Tanaka homogenization method. By utilizing a finite element model, the impact of stress fibre volume fractions and substrate elastic modulus on strain in cell membrane, cytoplasm, and nucleus was assessed, showing changes in peak strain in these regions.
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING
(2021)
Article
Engineering, Chemical
Harry Ngwangwa, Fulufhelo Nemavhola, Thanyani Pandelani, Makhosasana Msibi, Israel Mabuda, Neil Davies, Thomas Franz
Summary: This study evaluates the passive mechanical property differences in the three main walls of the rat heart based on biaxial tensile test data. The findings suggest that there are variations in the mechanical properties of different ventricle walls, including differences in the toe region strain range, strain energy storage, and anisotropy. These findings emphasize the importance of considering wall-specific material parameters to accurately model ventricular mechanics.
Article
Biophysics
Riham K. Ahmed, Tamer Abdalrahman, Neil H. Davies, Fred Vermolen, Thomas Franz
Summary: Cells mechanically interact with their environment to sense various mechanical cues and this has profound effects on cellular behavior, including motility. This study aims to develop a mathematical model to predict the motility of individual cells in a colony on planar elastic substrates. The model takes into account cell-substrate interaction, substrate deformation from neighboring cells, and other factors such as friction, randomness, and cell death and division. The model can accurately simulate collective cell motility on planar elastic substrates and has the potential to be extended to other cell and substrate shapes and the inclusion of chemotactic cues.
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2023)
Article
Materials Science, Biomaterials
Ellen Ngarande, Emma Doubell, Ousman Tamgue, Manuel Mano, Paul Human, Mauro Giacca, Neil Hamer Davies
Summary: This study investigates the use of a modified fibrin hydrogel combined with Invivofectamine((R)) 3.0 as a delivery system for small interfering RNA (siRNA). PEGylation of the fibrin hydrogel allows for controlled release of siRNA-lipopolyplexes and improves the stability of fibrin. In vitro and in vivo experiments demonstrate that the combination of the lipid nonviral transfection vector and fibrin enhances siRNA transfection efficacy and muscle growth in mice.
REGENERATIVE BIOMATERIALS
(2023)
Article
Cell Biology
Martin Kiwanuka, Ghodeejah Higgins, Silindile Ngcobo, Juliet Nagawa, Dirk M. Lang, Muhammad H. Zaman, Neil H. Davies, Thomas Franz
Summary: This study investigated the effect of paclitaxel on the intracellular stiffness of human oesophageal cancer cells in vitro. It was found that paclitaxel-treated cells exhibited higher stiffness in the 2D environment and increased stiffness in the 3D environment at 24 hours. However, no significant differences in stiffness were observed at 48 hours. The treated cells also showed larger size and more circular shape in the 2D environment. There were no significant morphological differences between treated and untreated cells in the 3D environment.
INTEGRATIVE BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Hugo Krynauw, Rodaina Omar, Josepha Koehne, Georges Limbert, Neil H. Davies, Deon Bezuidenhout, Thomas Franz
SN APPLIED SCIENCES
(2020)
