Journal
JOURNAL OF BIOLOGICAL RHYTHMS
Volume 24, Issue 2, Pages 114-125Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/0748730409332029
Keywords
seasonal; hamster; microarray; fertility; transcriptome; infertility
Categories
Funding
- Wellcome Trust [WT083643MA]
- MRC Centre for Obesity and Related metabolic Diseases (MRC-CORD)
- MRC training grant
- Royal Society Wolfson Research Merit Award
- BBSRC [S09882]
- MRC [MC_U142684167, MC_U105170643] Funding Source: UKRI
- Medical Research Council [MC_U105170643, MC_U142684167] Funding Source: researchfish
Ask authors/readers for more resources
Spermatogenesis is an essential precursor for successful sexual reproduction. Recently, there has been an expansion in the knowledge of the genes associated with particular stages of normal, physiological testicular development and pubertal activation. What has been lacking, however, is an understanding of those genes that are involved in specifically regulating sperm production, rather than in maturation and elaboration of the testis as an organ. By using the reversible (seasonal) fertility of the Syrian hamster as a model system, the authors sought to discover genes that are specifically involved in turning off sperm production and not involved in tissue specification and/or maturation. Using gene expression microarrays and in situ hybridization in hamsters and genetically infertile mice, the authors have identified a variety of known and novel factors involved in reversible, transcriptional, translational, and posttranslational control of testicular function, as well those involved in cell division and macromolecular metabolism. The novel genes uncovered could be potential targets for therapies against fertility disorders.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available