Article
Physics, Fluids & Plasmas
Sylvain Losserand, Gwennou Coupier, Thomas Podgorski
Summary: Red blood cells (RBCs) flowing in a microchannel experience dispersion in the flow direction due to velocity profile nonuniformity, but they tend to focus along the center line due to flow-induced deformations and wall effects. Dispersion of RBC transit times through a capillary is directly related to their transverse migration properties. An experimental method is presented to characterize this phenomenon by injecting pulses of dilute RBC suspensions and measuring their length evolution along the channel, while varying mechanical parameters. Experimental results compared to a model incorporating longitudinal advection and transverse migration show that this method provides a simple evaluation of migration characteristics directly related to cell mechanical properties.
PHYSICAL REVIEW FLUIDS
(2023)
Article
Mechanics
Daegeun Yoon, Rahul Mishra, Donghyun You
Summary: A computational study was conducted on blood flow in a stenosed microvessel, focusing on platelet behaviors near the stenosis with deformable red blood cells. The motion of RBCs is the main cause of time-dependent oscillations in flow rates, while the contribution of particles to fluctuations is minimal. Changes in stenosis geometry have a greater impact on particle concentration distribution than changes in hematocrit or driving force.
Article
Chemistry, Analytical
Alzbeta Bohinikova, Iveta Jancigova, Ivan Cimrak
Summary: The study uses dissipative particles to simulate the inner viscosity of red blood cells, which improves the accuracy of the original model without significantly increasing computational complexity.
Article
Chemistry, Analytical
Naoki Takeishi, Hiroshi Yamashita, Toshihiro Omori, Naoto Yokoyama, Masako Sugihara-Seki
Summary: This study numerically investigated the behavior of single red blood cells in a circular microchannel, revealing that the axial or nonaxial migration of red blood cells depends on their stable deformed shapes, and the equilibrium radial position of the red blood cell centroid correlates well with energy expenditure associated with membrane deformations.
Article
Surgery
Kasiemobi E. Pulliam, Bernadin Joseph, Amy T. Makley, Charles C. Caldwell, Alex B. Lentsch, Michael D. Goodman, Timothy A. Pritts
Summary: The study showed that washing packed red blood cells during storage can decrease the development of red blood cell storage lesions, reducing microvesicle accumulation and cell-free hemoglobin, with no impact on red blood cell viability.
Article
Veterinary Sciences
Barbara Steblaj, Jasmin Galli, Paul Torgerson, Annette Kutter
Summary: The aim of this retrospective study was to investigate the association between leukoreduction of packed red blood cell units and transfusion reactions in dogs. The results showed no correlation between leukoreduction and reduction in transfusion reactions or better outcomes.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Medicine, General & Internal
Olivier Hequet, Camille Boisson, Philippe Joly, Daniela Revesz, Kamila Kebaili, Alexandra Gauthier, Celine Renoux, Severine Creppy, Elie Nader, Jean Francois Nicolas, Frederic Berard, Fabrice Cognasse, Marc Vocanson, Yves Bertrand, Philippe Connes
Summary: This study analyzed the clinical safety of using the RCE/RBC-primed procedure in low-weight children with SCA, showing a low incidence of complications with only seven transient grade 2 adverse events observed in 65 RCE sessions. The RCE/RBC-primed method achieved expected post-apheresis hematocrit and fraction of cell remaining values, improving RBC deformability and reducing the sickling tendency during deoxygenation. Both the automatic and priming procedures were found to enhance blood rheological features in children with SCA.
FRONTIERS IN MEDICINE
(2021)
Article
Cell Biology
Brian S. Ferguson, Leslie E. Neidert, Matthew J. Rogatzki, Keith R. Lohse, L. Bruce Gladden, Heidi A. Kluess
Summary: The study found no significant difference in the release of ATP from RBCs of different densities under hypoxic and normoxic conditions, and the release of ATP was linearly correlated with the release of Hb.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Article
Medicine, Research & Experimental
Yujie Kong, Xue Tian, Rui He, Chenyue Li, Haixia Xu, Li Tian, Zhong Liu
Summary: The study revealed that as storage time progressed, numerous exosomal miRNAs accumulated in RBC suspensions, connected to multiple immune signaling pathways. Among them, miRNA-1246 and miRNA-150-3p were identified as potential key mediators affecting the immunoregulation functions of exosomes in RBC suspensions.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Chemistry, Analytical
Yang Jun Kang
Summary: This study proposes a method to quantify erythrocyte sedimentation by analyzing image intensity and interface in blood flow. Compared to the conventional ESR method, this method can accurately detect erythrocyte sedimentation and quantify the viscosity and pressure of blood.
Article
Spectroscopy
N. Mithun, Jijo Lukose, Ganesh Mohan, Shamee Shastry, Santhosh Chidangil
Summary: Crystalloid fluids have a greater impact on deoxygenation of red blood cells compared to blood plasma, as shown in Raman Tweezers spectroscopy analysis. Additionally, the ability of cells in blood plasma to withstand laser-induced deoxygenation is better than those in crystalloid fluids at higher laser powers. Principal component analysis of Raman spectral data effectively differentiates between cells in plasma and crystalloid fluids, demonstrating the effect of external induced stress on red blood cells.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Biology
Angiolo Farina, Antonio Fasano, Fabio Rosso
Summary: This paper presents a mathematical model that can reproduce the Fahr Aeus effect, a phenomenon in blood microcirculation. The model is validated by experiments and shows remarkable agreement with observed behavior, as well as a comprehensive comparison with an existing empirical formula.
JOURNAL OF THEORETICAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Joo-Yeun Oh, Chae Yun Bae, Malgorzata Kasztan, David M. Pollock, Robert T. Russell, Jeffrey Lebensburger, Rakesh P. Patel
Summary: The reduction of oxidized Prx-2 can be further slowed in stressed red blood cells, limiting the protective role of this antioxidant protein. This finding is of significance in understanding red blood cell-related diseases.
Review
Medicine, Research & Experimental
Nicola Conran, Stephen H. Embury
Summary: Sickle cell anemia is a hereditary hemoglobinopathy characterized by abnormal hemoglobin polymerization that triggers pathological mechanisms leading to various severe complications. Recent research has focused on the role of leukocytes in vaso-occlusive processes and the importance of adhesion by different cell types, including endothelial cells, platelets, leukocytes, and red blood cells.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2021)
Article
Cell Biology
Claudia Bernecker, Eva Maria Matzhold, Dagmar Kolb, Afrim Avdili, Lisa Rohrhofer, Annika Lampl, Martin Troetzmueller, Heike Singer, Johannes Oldenburg, Peter Schlenke, Isabel Dorn
Summary: Functional characterization of cultured red blood cells from human induced pluripotent stem cells (cRBC_iPSCs) was conducted in this study. The results showed that cRBC_iPSCs have similar morphology and maturity stage to native red blood cells, highlighting their potential for future applications.
Letter
Engineering, Chemical
Rachid Chebbi
Article
Thermodynamics
Ibrahim T. Masoud, Nabil Abdel-Jabbar, Muhammad Qasim, Rachid Chebbi
APPLIED THERMAL ENGINEERING
(2016)
Article
Engineering, Chemical
Rachid Chebbi
CHEMICAL ENGINEERING COMMUNICATIONS
(2017)
Article
Engineering, Chemical
Rachid Chebbi
JOURNAL OF ADHESION SCIENCE AND TECHNOLOGY
(2016)
Article
Engineering, Chemical
Rachid Chebbi
JOURNAL OF CHEMICAL ENGINEERING OF JAPAN
(2016)
Article
Nanoscience & Nanotechnology
Rachid Chebbi
Article
Physics, Multidisciplinary
Rachid Chebbi
Article
Energy & Fuels
Rachid Chebbi, Muhammad Qasim, Nabil Abdel Jabbar
Article
Physics, Multidisciplinary
Rachid Chebbi
FRONTIERS IN PHYSICS
(2019)
Article
Engineering, Mechanical
Basma Baioumy, Rachid Chebbi, Nabil Abdel Jabbar
Summary: Using a momentum integral model, researchers investigated laminar Bingham fluid flow in the entrance region of a circular pipe, with the model converging to fully developed solution in the filled region and providing velocity, pressure drop, and skin friction coefficient profiles, in good agreement with experimental data.
JOURNAL OF FLUIDS ENGINEERING-TRANSACTIONS OF THE ASME
(2021)
Article
Chemistry, Multidisciplinary
Rachid Chebbi
Summary: The study focuses on the dynamics of spreading and absorption of droplets on porous substrates through fundamental principles and relevant approximations, with minimal computational work required for the proposed model. Results are compared to published experimental data for perfect wetting, demonstrating good agreement for both droplet dynamics and penetration dynamics in the porous substrate.
Article
Environmental Sciences
Rachid Chebbi
Summary: The spreading of oil on water increases the interfacial area between the two phases and is affected by the hydrodynamics induced by the viscous oil in the water column. This study investigates the mass transfer dynamics of oil dissolution in water in the viscous-gravity spreading regime. The results provide insights into the behavior of oil spills near and far from the leading edge of the spill.
ENVIRONMENTAL FLUID MECHANICS
(2022)
Article
Chemistry, Multidisciplinary
Rachid Chebbi
Summary: This study examines the thermocapillary migration of a drop placed on a solid plate. By extending the Brochard model, the analysis considers the influence of both Marangoni and Poiseuille flow components on the migration dynamics.
Article
Physics, Multidisciplinary
Rachid Chebbi
Summary: In narrow tubes, red blood cells concentrate in the core region, leaving a cell-free layer. This affects the tube hematocrit level and the apparent blood viscosity. Blood flow, mass transfer, and diffusion influence solute concentration profiles. The Krogh tissue cylinder concept and the marginal zone concept are used to model solute transfer from blood to tissues. The model considers advection, diffusion, membrane transport, and tissue diffusion and reaction. The present study provides an analytical solution and can be extended to other kinetic models, accounting for Fahraeus and Fahraeus-Lindqvist effects. The model is validated for glucose transport.