Doc Toxin Is a Kinase That Inactivates Elongation Factor Tu

The Fic protein Doc uses an inverted substrate to phosphorylate and inactivate EF-Tu

(2013) Daniel Castro-Roa et al.   Nature Chemical Biology

Conserved Inhibitory Mechanism and Competent ATP Binding Mode for Adenylyltransferases with Fic Fold

(2013) Arnaud Goepfert et al.   PLoS One

Bacterial Persistence and Toxin-Antitoxin Loci

(2012) Kenn Gerdes et al.   Annual Review of Microbiology

Comprehensive comparative-genomic analysis of Type 2 toxin-antitoxin systems and related mobile stress response systems in prokaryotes

(2012) Kira S Makarova et al.   Biology Direct

Adenylylation control by intra- or intermolecular active-site obstruction in Fic proteins

(2012) Philipp Engel et al.   NATURE

Cloning, expression, purification, and biochemical characterisation of the FIC motif containing protein of Mycobacterium tuberculosis

(2012) Saurabh Mishra et al.   PROTEIN EXPRESSION AND PURIFICATION

Artificial activation of toxin–antitoxin systems as an antibacterial strategy

(2012) Julia J. Williams et al.   TRENDS IN MICROBIOLOGY

New-found fundamentals of bacterial persistence

(2012) Cyrielle I. Kint et al.   TRENDS IN MICROBIOLOGY

Toxin-Antitoxin Systems Influence Biofilm and Persister Cell Formation and the General Stress Response

(2011) Xiaoxue Wang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Comparative Analysis ofHistophilus somniImmunoglobulin-binding Protein A (IbpA) with Other Fic Domain-containing Enzymes Reveals Differences in Substrate and Nucleotide Specificities

(2011) Seema Mattoo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Eukaryote-Like Serine/Threonine Kinases and Phosphatases in Bacteria

(2011) S. F. F. Pereira et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Modulation of Rab GTPase function by a protein phosphocholine transferase

(2011) Shaeri Mukherjee et al.   NATURE

Legionella pneumophila regulates the small GTPase Rab1 activity by reversible phosphorylcholination

(2011) Y. Tan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fic domain-catalyzed adenylylation: Insight provided by the structural analysis of the type IV secretion system effector BepA

(2011) Dinesh V. Palanivelu et al.   PROTEIN SCIENCE

Adenylylation: renaissance of a forgotten post-translational modification

(2011) Aymelt Itzen et al.   TRENDS IN BIOCHEMICAL SCIENCES

“Persisters”: Survival at the Cellular Level

(2011) Clinton C. Dawson et al.   PLoS Pathogens

AMPylation: something old is new again

(2011) Andrew Woolery   Frontiers in Microbiology

Allostery and Intrinsic Disorder Mediate Transcription Regulation by Conditional Cooperativity

(2010) Abel Garcia-Pino et al.   CELL

Structural basis of Fic-mediated adenylylation

(2010) Junyu Xiao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dali server: conservation mapping in 3D

(2010) Liisa Holm et al.   NUCLEIC ACIDS RESEARCH

The Mechanism for Activation of GTP Hydrolysis on the Ribosome

(2010) R. M. Voorhees et al.   SCIENCE

Crystal Structures of Phd-Doc, HigA, and YeeU Establish Multiple Evolutionary Links between Microbial Growth-Regulating Toxin-Antitoxin Systems

(2010) Mark A. Arbing et al.   STRUCTURE

Advances and pitfalls of protein structural alignment

(2009) Hitomi Hasegawa et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The Fic Domain: Regulation of Cell Signaling by Adenylylation

(2009) Carolyn A. Worby et al.   MOLECULAR CELL

Fido, a Novel AMPylation Domain Common to Fic, Doc, and AvrB

(2009) Lisa N. Kinch et al.   PLoS One

Doc of Prophage P1 Is Inhibited by Its Antitoxin Partner Phd through Fold Complementation

(2008) Abel Garcia-Pino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The RosettaDock server for local protein-protein docking

(2008) S. Lyskov et al.   NUCLEIC ACIDS RESEARCH

Bacterial addiction module toxin Doc inhibits translation elongation through its association with the 30S ribosomal subunit

(2008) M. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AMPylation of Rho GTPases by Vibrio VopS Disrupts Effector Binding and Downstream Signaling

(2008) M. L. Yarbrough et al.   SCIENCE