TheBordetellaAdenylate Cyclase Repeat-in-Toxin (RTX) Domain Is Immunodominant and Elicits Neutralizing Antibodies

Improving pertussis vaccination

(2014) Guy A.M. Berbers et al.   Human vaccines & immunotherapeutics

Calcium, Acylation, and Molecular Confinement Favor Folding ofBordetella pertussisAdenylate Cyclase CyaA Toxin into a Monomeric and Cytotoxic Form

(2014) Johanna C. Karst et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reduced Risk of Pertussis Among Persons Ever Vaccinated With Whole Cell Pertussis Vaccine Compared to Recipients of Acellular Pertussis Vaccines in a Large US Cohort

(2013) Maxwell A. Witt et al.   CLINICAL INFECTIOUS DISEASES

Quantification of the Adenylate Cyclase Toxin of Bordetella pertussisIn Vitroand during Respiratory Infection

(2013) Joshua C. Eby et al.   INFECTION AND IMMUNITY

Protective role of adenylate cyclase in the context of a live pertussis vaccine candidate

(2013) Annabelle Lim et al.   MICROBES AND INFECTION

Acellular pertussis vaccines protect against disease but fail to prevent infection and transmission in a nonhuman primate model

(2013) J. M. Warfel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure-Based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial Virus

(2013) J. S. McLellan et al.   SCIENCE

Novel vaccine formulations against pertussis offer earlier onset of immunity and provide protection in the presence of maternal antibodies

(2013) Monika Polewicz et al.   VACCINE

Unexpectedly Limited Durability of Immunity Following Acellular Pertussis Vaccination in Preadolescents in a North American Outbreak

(2012) Maxwell A. Witt et al.   CLINICAL INFECTIOUS DISEASES

Contribution of Bordetella Filamentous Hemagglutinin and Adenylate Cyclase Toxin to Suppression and Evasion of Interleukin-17-Mediated Inflammation

(2012) Michael W. Henderson et al.   INFECTION AND IMMUNITY

Number and Order of Whole Cell Pertussis Vaccines in Infancy and Disease Protection

(2012) Sarah L. Sheridan et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Identification of a Region That Assists Membrane Insertion and Translocation of the Catalytic Domain ofBordetella pertussisCyaA Toxin

(2012) Johanna C. Karst et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Newly Emerging Clones of Bordetella pertussis Carrying prn2 and ptxP3 Alleles Implicated in Australian Pertussis Epidemic in 2008–2010

(2012) Sophie Octavia et al.   JOURNAL OF INFECTIOUS DISEASES

Immunity to the respiratory pathogen Bordetella pertussis

(2012) R Higgs et al.   Mucosal Immunology

Antibody isolation from immunized animals: comparison of phage display and antibody discovery via V gene repertoire mining

(2012) I. Saggy et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Antibodies Recognizing Protective Pertussis Toxin Epitopes Are Preferentially Elicited by Natural Infection versus Acellular Immunization

(2011) Jamie N. Sutherland et al.   Clinical and Vaccine Immunology

Role of CD11b/CD18 in the Process of Intoxication by the Adenylate Cyclase Toxin of Bordetella pertussis

(2011) Joshua C. Eby et al.   INFECTION AND IMMUNITY

Rational Design of a Meningococcal Antigen Inducing Broad Protective Immunity

(2011) M. Scarselli et al.   Science Translational Medicine

Antibody Response Patterns to Bordetella pertussis Antigens in Vaccinated (Primed) and Unvaccinated (Unprimed) Young Children with Pertussis

(2010) J. D. Cherry et al.   Clinical and Vaccine Immunology

Calcium-Induced Folding of a Beta Roll Motif Requires C-Terminal Entropic Stabilization

(2010) Mark A. Blenner et al.   JOURNAL OF MOLECULAR BIOLOGY

Characterization of the Regions Involved in the Calcium-Induced Folding of the Intrinsically Disordered RTX Motifs from the Bordetella pertussis Adenylate Cyclase Toxin

(2010) Ana-Cristina Sotomayor Pérez et al.   JOURNAL OF MOLECULAR BIOLOGY

Bordetella pertussis CyaA-RTX subdomain requires calcium ions for structural stability against proteolytic degradation

(2010) Pichaya Pojanapotha et al.   PROTEIN EXPRESSION AND PURIFICATION

Bordetella Adenylate Cyclase Toxin Mobilizes Its β2 Integrin Receptor into Lipid Rafts to Accomplish Translocation across Target Cell Membrane in Two Steps

(2010) Ladislav Bumba et al.   PLoS Pathogens

Rapid generation of fully human monoclonal antibodies specific to a vaccinating antigen

(2009) Kenneth Smith et al.   Nature Protocols

Genomic analysis of the adenylate cyclase-hemolysin C-terminal region of Bordetella pertussis, Bordetella parapertussisand Bordetella bronchiseptica

(2009) Viviane Chenal-Francisque et al.   RESEARCH IN MICROBIOLOGY

The Adenylate Cyclase Toxins of Bacillus anthracis and Bordetella pertussis Promote Th2 Cell Development by Shaping T Cell Antigen Receptor Signaling

(2009) Silvia Rossi Paccani et al.   PLoS Pathogens

Suppression of T-Lymphocyte Activation and Chemotaxis by the Adenylate Cyclase Toxin of Bordetella pertussis

(2008) S. R. Paccani et al.   INFECTION AND IMMUNITY

RTX Calcium Binding Motifs Are Intrinsically Disordered in the Absence of Calcium

(2008) Alexandre Chenal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Small Molecule-Induced Allosteric Activation of the Vibrio cholerae RTX Cysteine Protease Domain

(2008) P. J. Lupardus et al.   SCIENCE