Selenoprotein H Suppresses Cellular Senescence through Genome Maintenance and Redox Regulation

Interplay between Selenium Levels, Selenoprotein Expression, and Replicative Senescence in WI-38 Human Fibroblasts

(2014) Yona Legrain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Free Radical Theory of Aging Is Dead. Long Live the Damage Theory!

(2013) Vadim N. Gladyshev   ANTIOXIDANTS & REDOX SIGNALING

Expression and characterization of recombinant human phospholipid hydroperoxide glutathione peroxidase

(2013) Xiao Han et al.   IUBMB LIFE

Age and gender effects on DNA strand break repair in peripheral blood mononuclear cells

(2012) Christian Garm et al.   AGING CELL

Topological domains in mammalian genomes identified by analysis of chromatin interactions

(2012) Jesse R. Dixon et al.   NATURE

Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation

(2012) Marzia Fumagalli et al.   NATURE CELL BIOLOGY

Persistent Amplification of DNA Damage Signal Involved in Replicative Senescence of Normal Human Diploid Fibroblasts

(2012) Masatoshi Suzuki et al.   Oxidative Medicine and Cellular Longevity

A Stochastic Step Model of Replicative Senescence Explains ROS Production Rate in Ageing Cell Populations

(2012) Conor Lawless et al.   PLoS One

DNA damage induces reactive oxygen species generation through the H2AX-Nox1/Rac1 pathway

(2012) M A Kang et al.   Cell Death & Disease

Selenium toxicity but not deficient or super-nutritional selenium status vastly alters the transcriptome in rodents

(2011) Anna M Raines et al.   BMC GENOMICS

DNA damage response activation in mouse embryonic fibroblasts undergoing replicative senescence and following spontaneous immortalization

(2011) Raffaella Di Micco et al.   CELL CYCLE

γH2AX foci analysis for monitoring DNA double-strand break repair: Strengths, limitations and optimization

(2011) Markus Löbrich et al.   CELL CYCLE

Molecular biomarker panels for assessment of selenium status in rats

(2011) Roger A Sunde   EXPERIMENTAL BIOLOGY AND MEDICINE

Adaptive dysfunction of selenoproteins from the perspective of the triage theory: why modest selenium deficiency may increase risk of diseases of aging

(2011) Joyce C. McCann et al.   FASEB JOURNAL

Role for p53 in Selenium-Induced Senescence

(2011) Min Wu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Four faces of cellular senescence

(2011) Francis Rodier et al.   JOURNAL OF CELL BIOLOGY

Marginal selenium deficiency down-regulates inflammation-related genes in splenic leukocytes of the mouse

(2011) Anna P. Kipp et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

PARG is recruited to DNA damage sites through poly(ADP-ribose)- and PCNA-dependent mechanisms

(2011) Oliver Mortusewicz et al.   NUCLEIC ACIDS RESEARCH

The essence of senescence

(2010) T. Kuilman et al.   GENES & DEVELOPMENT

Selenium Compounds Activate ATM-dependent DNA Damage Response via the Mismatch Repair Protein hMLH1 in Colorectal Cancer Cells

(2010) Yongmei Qi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selenium Compounds Activate Early Barriers of Tumorigenesis

(2010) Min Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ataxia Telangiectasia Mutated (ATM)-mediated DNA Damage Response in Oxidative Stress-induced Vascular Endothelial Cell Senescence

(2010) Hong Zhan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Upregulation of human selenoprotein H in murine hippocampal neuronal cells promotes mitochondrial biogenesis and functional performance

(2010) Natalia Mendelev et al.   MITOCHONDRION

The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing

(2010) Joon-Il Jun et al.   NATURE CELL BIOLOGY

Selenoproteins Are Essential for Proper Keratinocyte Function and Skin Development

(2010) Aniruddha Sengupta et al.   PLoS One

Nucleolus as an oxidative stress sensor in the yeastSaccharomyces cerevisiae

(2010) Anna Lewinska et al.   REDOX REPORT

Abundance of Ribosomal RNA Gene Copies Maintains Genome Integrity

(2010) S. Ide et al.   SCIENCE

ATM Activation by Oxidative Stress

(2010) Z. Guo et al.   SCIENCE

DNA damage response and cellular senescence in tissues of aging mice

(2009) Chunfang Wang et al.   AGING CELL

Overexpression of human selenoprotein H in neuronal cells ameliorates ultraviolet irradiation-induced damage by modulating cell signaling pathways

(2009) Natalia Mendelev et al.   EXPERIMENTAL NEUROLOGY

Evaluation of different methods detecting intracellular generation of free radicals

(2009) Jiří Wilhelm et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion

(2009) S. E. Golding et al.   MOLECULAR CANCER THERAPEUTICS

Hydroxyurea Induces Hydroxyl Radical-Mediated Cell Death in Escherichia coli

(2009) Bryan W. Davies et al.   MOLECULAR CELL

Four selenoproteins, protein biosynthesis, and Wnt signalling are particularly sensitive to limited selenium intake in mouse colon

(2009) Anna Kipp et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

(2009) Francis Rodier et al.   NATURE CELL BIOLOGY

Osteo-Chondroprogenitor–Specific Deletion of the Selenocysteine tRNA Gene, Trsp, Leads to Chondronecrosis and Abnormal Skeletal Development: A Putative Model for Kashin-Beck Disease

(2009) Charlene M. Downey et al.   PLoS Genetics

Age and natural metabolically-intensive behavior affect oxidative stress and antioxidant mechanisms

(2008) Jason B. Williams et al.   EXPERIMENTAL GERONTOLOGY

Selenium deficiency activates mouse liver Nrf2–ARE but vitamin E deficiency does not

(2008) Raymond F. Burk et al.   FREE RADICAL BIOLOGY AND MEDICINE

Selenoproteins

(2008) Jun Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Oncogene-Induced DNA Damage Model for Cancer Development

(2008) T. D. Halazonetis et al.   SCIENCE