Review
Cell Biology
Youssef Siblini, Fares Namour, Abderrahim Oussalah, Jean-Louis Gueant, Celine Chery
Summary: Stem cells rely on methionine for maintenance and differentiation, with one-carbon metabolism playing a crucial role. Cultivating stem cells under methionine-restricted conditions decreases their stemness capacities and alters the expression of stem cell markers. Genes like SIRT1 and PGC-1 alpha/PPAR-alpha are important in regulating the metabolism of stem cells. Methionine restriction holds potential applications in regenerative medicine and cancer treatment.
Article
Pharmacology & Pharmacy
Zhihui Yin, Xinyue Geng, Zhengyi Zhang, Ying Wang, Xiaoyan Gao
Summary: The study investigated the antioxidant activity of rhein against Aβ (1-42) oligomer-induced mitochondrial oxidative stress and found that rhein reduced ROS levels, protected mitochondrial function, and prevented oxidative stress-related apoptosis in neurons. Rhein also activated mitochondrial biogenesis through the SIRT1/PGC-1 α pathway, acting as an antioxidant defense system against Aβ-induced oxidative stress.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Weilin Xu, Jun Yan, Umut Ocak, Cameron Lenahan, Anwen Shao, Jiping Tang, Jianmin Zhang, John H. Zhang
Summary: Activation of MC1R using BMS-470539 significantly attenuated early brain injury following SAH by suppressing oxidative stress, apoptosis, and mitochondrial fission through the AMPK/SIRT1/PGC-1 alpha signaling pathway, improving neurological deficits and memory impairments.
Article
Integrative & Complementary Medicine
Meng Hui, Wang Qi-yan, Li Ning, He Hao, Lu Wen-ji, Wang Qi-xin, Sun Xiao-qian, Jiao Shi-hong, Wang Yong, Tu Peng-fei
Summary: Danqi Tablet (DQT) has a cardioprotective effect on ischemic heart model rats, increasing ATP production in myocardial cells and inhibiting inflammation. It regulates energy metabolism through the AMPK/SIRT1-PGC-1 alpha pathway, suggesting a potential target for treating ischemic heart disease.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2021)
Article
Oncology
Yu Chen, Jingfan Zhang, Ping Li, Cong Liu, Ling Li
Summary: The study showed that N1-methylnicotinamide (MNAM) can improve insulin resistance in the skeletal muscle of type 2 diabetes mellitus (T2DM) mice by activating the SIRT1/PGC-1 alpha signaling pathway, thereby regulating insulin signal transduction pathway, increasing glucose utilization, and reducing lipid deposition.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Agriculture, Dairy & Animal Science
Guoyan Wang, Jun Zhang, Shengru Wu, Senlin Qin, Yining Zheng, Chao Xia, Huijun Geng, Junhu Yao, Lu Deng
Summary: Cattle have a unique mechanism for efficient hepatic gluconeogenesis, involving the high expression of specific genes and the activation of the mTORC1 signaling pathway. These findings are important for understanding the mechanism underlying the quantitative differences in hepatic gluconeogenesis efficiency between cattle and non-ruminant animals.
Article
Clinical Neurology
Can Hao, Bingjie Ma, Nan Gao, Tian Jin, Xiaoming Liu
Summary: A study on the effects of TSPO agonist Ro5-4864 on autophagy and nuclear SIRT1/PGC-1 alpha signaling in spinal dorsal horn revealed that Ro5-4864 could improve autophagy impairment and promote mitochondrial biogenesis, potentially providing a new treatment strategy for NP.
JOURNAL OF PAIN RESEARCH
(2022)
Review
Immunology
Xianxiu Wan, Nisha Jain Garg
Summary: Trypanosoma cruzi, a digenetic parasite, replicates in mammalian hosts, triggering immune responses and cellular damage, leading to the release of reactive oxygen and nitrogen species. Mitochondrial dysfunction is proposed as a major source of oxidative stress in chronic infection, contributing to Chagas disease pathology. SIRT1, a histone deacetylase, may improve mitochondrial function and control oxidative and inflammatory stress in Chagas disease.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Oncology
Lei Wang, Mengmeng Yang, Huihan Jin
Summary: The study demonstrated that PI3K/AKT phosphorylation enhances ERR alpha activity in NOZ cells by upregulating the expression levels of PGC-1 alpha and PGC-1 beta, promoting the invasion and proliferation of gallbladder cancer cells.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Pharmacology & Pharmacy
Qingshan Yang, Yucong Shi, Tao Jin, Bowen Duan, Shujin Wu
Summary: In this study, it was found that AGEs reduced AMPK alpha/SIRT1/PGC-1 alpha signaling in chondrocytes, leading to mitochondrial dysfunction and increased oxidative stress, inflammation, and apoptosis. Activation or overexpression of AMPK alpha, SIRT1, and PGC-1 alpha reversed the impairments of mitochondrial biogenesis, oxidative stress, and inflammation in AGEs-induced chondrocytes.
Article
Genetics & Heredity
Khalil Saadeh, Karan R. Chadda, Shiraz Ahmad, Haseeb Valli, Nakulan Nanthakumar, Ibrahim T. Fazmin, Charlotte E. Edling, Christopher L. -H. Huang, Kamalan Jeevaratnam
Summary: Mitochondrial dysfunction linked to metabolic disorders like obesity and diabetes is strongly associated with cardiac arrhythmias, as shown in a murine Pgc-1 alpha(-/-) model. Molecular analysis revealed downregulation of genes related to various cardiac functions in the ventricles, along with increased tissue fibrosis. These findings suggest altered transcription of key genes involved in cardiac electrophysiological activation in arrhythmic substrate associated with Pgc-1 alpha deficiency.
MOLECULAR GENETICS AND METABOLISM REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Janusz Blasiak, Joanna Szczepanska, Michal Fila, Elzbieta Pawlowska, Kai Kaarniranta
Summary: Activation and application of telomerase in AMD patients can improve macular function, reduce senescence, and increase therapeutic potential by activating autophagy and removing cellular debris. PGC-1alpha may be involved in AMD pathogenesis through oxidative stress reduction, VEGF regulation, and autophagy improvement, forming a coordinated regulatory loop with TERT.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Obstetrics & Gynecology
Koki Shimura, Yosuke Tarumi, Maya Fujii, Kanae Ogawa, Eiko Maeda, Yukiko Tanaka, Hiroyuki Okimura, Hisashi Kataoka, Osamu Takaoka, Fumitake Ito, Akemi Koshiba, Khaleque N. Khan, Izumi Kusuki, Jo Kitawaki, Taisuke Mori
Summary: This study investigates the effects of a low-nutrient microenvironment on endometriosis. The results show that under the low-nutrient condition, stromal cells from ovarian endometrioma (OESCs) have higher proliferation and exhibit changes in gene and protein expression related to angiogenesis, inflammation, anti-apoptosis, and local estrogen production.
REPRODUCTIVE SCIENCES
(2023)
Article
Chemistry, Medicinal
Sung Hyun Son, Su Mi Lee, Mi Hwa Lee, Young Ki Son, Seong Eun Kim, Won Suk An
Summary: Mitochondrial dysfunction contributes to kidney injury related with cardiovascular disease, and omega-3 fatty acids may protect renal tubular cells by upregulating Nrf1 and Nrf2 to promote mitochondrial biogenesis. This protective mechanism may be attributed to the increased expression and deacetylation of PGC-1 alpha triggered by SIRT1/3.
Article
Agriculture, Dairy & Animal Science
Weiwei Wang, Qinping Yu, Qingyun Cao, Hui Ye, Changming Zhang, Zemin Dong, Dingyuan Feng, Jianjun Zuo
Summary: MicroRNA-27a (miR-27a) regulates the expression of MYH7 and PGC-1a, affecting the composition of muscle fiber types in pigs. MiR-27a inhibits the expression of MYH7 and PGC-1a, along with the downstream targets MEF2C, NRF-1, mtTFA, COX ?, Cytc, and SDH, which are involved in mitochondrial biogenesis and oxidative metabolism. These findings have significant implications for genetic or nutritional control of muscle fiber phenotype and pork quality.
JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
(2023)
Article
Hospitality, Leisure, Sport & Tourism
Timothy M. Griffin, Albert Batushansky, Joanna Hudson, Erika Barboza Prado Lopes
JOURNAL OF SPORT AND HEALTH SCIENCE
(2020)
Editorial Material
Rheumatology
Timothy M. Griffin, Jacob E. Friedman
NATURE REVIEWS RHEUMATOLOGY
(2020)
Article
Engineering, Environmental
Benqing Zhou, Qiang Wu, Meng Wang, Ashley Hoover, Xin Wang, Feifan Zhou, Rheal A. Towner, Nataliya Smith, Debra Saunders, Jun Song, Junle Qu, Wei R. Chen
CHEMICAL ENGINEERING JOURNAL
(2020)
Article
Multidisciplinary Sciences
Nataliya Smith, Debra Saunders, Megan Lerner, Michelle Zalles, Nadezda Mamedova, Daniel Cheong, Ehsan Mohammadi, Tian Yuan, Yi Luo, Robert E. Hurst, Beverley Greenwood-Van Meerveld, Rheal A. Towner
Article
Clinical Neurology
Rheal A. Towner, Nataliya Smith, Michelle Zalles, Sara Morris, MacKenzie Toliver, Debra Saunders, Megan Lerner, Gaurav Kumar, Robert C. Axtell
Summary: ELTD1 is associated with tumor angiogenesis, with overexpression detected in GBM, where targeting it with an antibody can decrease tumor volumes and increase animal survival. This study also found associations between ELTD1 and MS, as it was readily detected in the brains of EAE mice and predominantly found in the corpus callosum. Additionally, the study showed compromised blood-brain barrier and altered cerebral blood flow in the brains and spinal cords of EAE mice compared to controls using imaging techniques.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2021)
Article
Biochemistry & Molecular Biology
Lakshmi Kiran Chelluri, Yamuna Mohanram, Rashi Jain, Chandra Shekar Mallarpu, Meenakshi Ponnana, Deepak Kumar, Venkata Vamsi Krishna Venuganti, Ravindranath Kancherla, Rao VL. Papineni, Rheal Towner, Partha Ghosal
Summary: This study presents a scientific approach to fabricate a nanoprobe for labeling cardiac precursor cells, allowing for efficient tracking of their distribution in vivo via MRI. The results indicate high accumulation of the nanoprobe in cardiac muscles compared to liver and spleen, suggesting its potential benefits in treating heart failure.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Pharmacology & Pharmacy
Rheal A. Towner, Beverley Greenwood-Van Meerveld, Ehsan Mohammadi, Debra Saunders, Nataliya Smith, Grannum R. Sant, Harrison C. Shain, Thomas H. Jozefiak, Robert E. Hurst
Summary: The novel high MW SuperGAG biopolymer has been shown to restore bladder impermeability and reduce pain response in both OVX rat and URO-MCP1 mouse models. The use of CE-MRI imaging proved to be useful in evaluating the efficacy of the therapy in restoring bladder impermeability.
PHARMACOLOGY RESEARCH & PERSPECTIVES
(2021)
Article
Geriatrics & Gerontology
Rheal A. Towner, Rafal Gulej, Michelle Zalles, Debra Saunders, Nataliya Smith, Megan Lerner, Kathryn A. Morton, Arlan Richardson
Summary: Rapamycin has been shown to have neuroprotective properties in rat neuroinflammatory pathologies and has high translational capability in inhibiting neuroinflammation.
Article
Geriatrics & Gerontology
Kamil A. Kobak, Marcus M. Lawrence, Gavin Pharaoh, Agnieszka K. Borowik, Frederick F. Peelor, Patrick D. Shipman, Timothy M. Griffin, Holly Van Remmen, Benjamin F. Miller
Summary: This study demonstrated the importance of accounting for a change in protein mass during D2O labelling studies, while also exploring the contribution of protein synthesis and breakdown to denervation-induced muscle atrophy. Conflicting results were found between steady- and non-steady-state calculations on myofibrillar protein synthesis and breakdown during periods of muscle loss. Additionally, collagen accumulation was largely from a decrease in collagen breakdown during denervation.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Article
Cell Biology
Michelle Zalles, Nataliya Smith, Debra Saunders, Megan Lerner, Kar-Ming Fung, James Battiste, Rheal A. Towner
Summary: The study compared the effectiveness of anti-ELTD1 and OKN-007 therapies in treating GBM, finding that both significantly increased animal survival, reduced tumor volumes, and normalized vasculature. These therapies show promise as potential single-agent multi-focal therapies for GBM patients.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Cell Biology
Ammaji Rajala, Kenneth Teel, Mohd A. Bhat, Albert Batushansky, Timothy M. Griffin, Lindsey Purcell, Raju V. S. Rajala
Summary: Insulin-like growth factor I (IGF-1) is a neurotrophic factor that binds to insulin-like growth factor 1 receptor (IGF-1R). Reduced expression of IGF-1 is associated with various disorders. IGF-1R is expressed in the retina and plays a crucial role in photoreceptors.
CELL DEATH & DISEASE
(2022)
Article
Rheumatology
Terese Geraghty, Alia M. Obeidat, Shingo Ishihara, Matthew J. Wood, Jun Li, Erika Barboza Prado Lopes, Carla R. Scanzello, Timothy M. Griffin, Anne-Marie Malfait, Rachel E. Miller
Summary: This study investigates the relationship between age and knee osteoarthritis (OA) and OA-related pain in mice. The findings show that aging in mice is associated with cartilage degeneration, pain-related behaviors, and changes in immune cell populations in the dorsal root ganglion. These findings provide potential new avenues for the development of OA therapies.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Endocrinology & Metabolism
Yao Fu, Albert Batushansky, Michael Kinter, Janet L. L. Huebner, Virginia B. B. Kraus, Timothy M. M. Griffin
Summary: Leptin plays a role in the development of obesity-associated osteoarthritis, especially in women. This study used rat models to investigate the separate effects of leptin and body weight on knee osteoarthritis. The results showed that both leptin and increased body weight contribute to osteoarthritis, but through different mechanisms.
Article
Cell Biology
Kamil A. Kobak, Albert Batushansky, Agnieszka K. Borowik, Erika Prado Barboza Lopes, Frederick F. Peelor, Elise L. Donovan, Michael T. Kinter, Benjamin F. Miller, Timothy M. Griffin
Summary: This study used a stable-isotope method to investigate chondrocyte dynamics and found that age-associated changes in cartilage matrix protein content and synthesis occurred without detectable changes in the relative number of proliferating cells.
Article
Psychology, Biological
Andriy Yabluchanskiy, Adam Nyul-Toth, Anna Csiszar, Rafal Gulej, Debra Saunders, Rheal Towner, Monroe Turner, Yuguang Zhao, Dema Abdelkari, Bart Rypma, Stefano Tarantini
Summary: This review discusses the multifaceted effects of aging and the contributions of age-related pathologies on structural and functional integrity of the cerebral microcirculation as they has been investigated in animal models of aging, highlighting potential confounding factors in the interpretation of BOLD fMRI.