The Prolyl Peptidases PRCP/PREP Regulate IRS-1 Stability Critical for Rapamycin-induced Feedback Activation of PI3K and AKT

Prolylcarboxypeptidase promotes angiogenesis and vascular repair

(2013) G. N. Adams et al.   BLOOD

Selective Requirement of PI3K/PDK1 Signaling for Kras Oncogene-Driven Pancreatic Cell Plasticity and Cancer

(2013) Stefan Eser et al.   CANCER CELL

Insulin-Like Growth Factor Signaling as a Therapeutic Target in Pancreatic Cancer

(2012) Simon Rieder et al.   Anti-Cancer Agents in Medicinal Chemistry

Targeting Phosphoinositide 3-Kinase Pathways in Pancreatic Cancer – from Molecular Signalling to Clinical Trials

(2012) Marco Falasca et al.   Anti-Cancer Agents in Medicinal Chemistry

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Development of targeted therapies for pancreatic cancer

(2011) Philip A Philip   LANCET ONCOLOGY

Phosphoproteomic Analysis Identifies Grb10 as an mTORC1 Substrate That Negatively Regulates Insulin Signaling

(2011) Y. Yu et al.   SCIENCE

The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling

(2011) P. P. Hsu et al.   SCIENCE

Inhibition of the mammalian target of rapamycin (mTOR) in advanced pancreatic cancer: results of two phase II studies

(2010) Milind M Javle et al.   BMC CANCER

Insulin Receptor Substrate Regulation of Phosphoinositide 3-Kinase

(2010) H. E. Metz et al.   CLINICAL CANCER RESEARCH

Crosstalk between Insulin/Insulin-like Growth Factor-1 Receptors and G Protein-Coupled Receptor Signaling Systems: A Novel Target for the Antidiabetic Drug Metformin in Pancreatic Cancer

(2010) E. Rozengurt et al.   CLINICAL CANCER RESEARCH

Prolylcarboxypeptidase Regulates Proliferation, Autophagy, and Resistance to 4-Hydroxytamoxifen-induced Cytotoxicity in Estrogen Receptor-positive Breast Cancer Cells

(2010) Lei Duan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The PI3K Pathway As Drug Target in Human Cancer

(2010) Kevin D. Courtney et al.   JOURNAL OF CLINICAL ONCOLOGY

Advanced or Metastatic Pancreatic Cancer: Molecular Targeted Therapies

(2010) Soley Bayraktar et al.   MOUNT SINAI JOURNAL OF MEDICINE

Pancreatic Cancer

(2010) Manuel Hidalgo   NEW ENGLAND JOURNAL OF MEDICINE

Pancreatic cancer: molecular pathogenesis and new therapeutic targets

(2009) Han H. Wong et al.   Nature Reviews Gastroenterology & Hepatology

Molecular targeted therapies for pancreatic cancer

(2008) Daniel Borja-Cacho et al.   AMERICAN JOURNAL OF SURGERY